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drug sensitivity     
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  药物敏感性
     Effect of Bcl-2 and Bcl-xl siRNA on Drug Sensitivity of HepG2 Cells
     Bcl-2,Bcl-xlsiRNA对HepG2细胞药物敏感性的影响
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     Effects of TSG101 siRNA on the growth and drug sensitivity of SH-SY5Y cells
     TSG101小干扰RNA对SH-SY5Y细胞生长和药物敏感性的作用
短句来源
     The effect of siRNA-Her2/neu on the drug sensitivity of Her2/neu-overexpressing lung adenocarcinoma cell line
     靶向Her2/neu基因小干扰RNA对肺腺癌Calu-3细胞株药物敏感性的影响
短句来源
     Effects of DARPP-32 on the drug sensitivity of SH-SY5Y cells
     DARPP-32基因对SH-SY5Y细胞药物敏感性的调节作用
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     Ko143, a sp ecific inhibitor of BCRP, was used to detect the drug sensitivity of positive PA 317/Tet-on/TRE-BCRP cells to mitoxantrone.
     采用BCRP特异性抑制剂Ko143的干扰试验来检测PA317/Tet-on/TRE-BCRP细胞对米托蒽醌的药物敏感性;
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  药敏
     The overall coincident rate of drug sensitivity in vitro and curative effect in vivo was 81.2%[(45+11)/69].
     本研究体外药敏和体内疗效的总符合率为 81.2 % [( 4 5+11) /69]。
短句来源
     2) Drug sensitivity rate of yeast to amphotericin B,ketoconazole,miconazole,itraconazole,fluconazole,cytosine,terbinafine were 71.79%,100%,84.62%,41.03%,97.44%,97.44%,84.62% respectively.
     对从临床分离的39株念珠菌进行7种抗真菌药物MIC敏感性测定,药敏检测结果二性霉素B为71.79%,酮康唑为100%,咪康唑为84.62%,伊曲康唑为41.03%,氟康唑为97.44%,5-氟胞嘧啶为97.44%,特比奈芬为84.62%。
短句来源
     Application of SMMC-7721 Hepatocarcinoma Cells in Anticancer Drug Sensitivity Test Using the ~3H-TdR Incorporation
     应用~3H-TdR掺入法对SMMC-7721细胞株药敏试验条件的探讨与应用
短句来源
     The drug sensitivity test of the 45 strains showed that the sensitivity rate was 100% for vancomycin, and 73.3% , 48.9% and 48.9% for rifampin, trimethoprim-sulfamethoxazole and amoxicillin-clav respectively.
     药敏试验显示 ,45例MRSA菌株均对万古霉素敏感 ,对利福平、复方新诺明和阿莫西林的敏感率依次是 73.3% ,48.9%和 48.9% ;
短句来源
     Analysis of Mycoplasma IST Cultivation Results and Drug Sensitivity
     支原体IST培养结果及药敏分析
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  药物敏感
     Drug Sensitivity rates of Gram-negative bacteria to sefotaxime B and imipenem were between 73.3%~100.0%.
     主要G-杆菌对多粘菌素B、泰能的药物敏感率为73.3%~100.0%。
短句来源
     (2) Drug sensitivity rates to mycoplasma were roxithromycin 94.6%, doxycycline 54.5% and ofloxacin 32.8%.
     (2 )两组妇女中 ,支原体阳性患者的药物敏感率分别为 ,罗红霉素 94 6 %、强力霉素 5 4 5 %、氧氟沙星 32 8%。
短句来源
     Methods:The effects of O 6 BG on drug sensitivity in multidrug resistant human leukemic cell line K562/DOX were studied by MTT colorimetric assay.
     方法 :以 O6 -苄基鸟嘌呤 (O6 - BG)作为耐药逆转剂 ,用 MTT法体外药物敏感试验 ,观察 0 6 - BG对多药耐药白血病细胞株 K5 6 2 / DOX的药物敏感性的影响。
短句来源
     rug sensitivity of leukemia cells in 66 patients with leukemia was detected by MTT assay,at the same time,multidrug resistance P-170 was tested by immunohistochemical assay using amonoclonal antibody to P-170.The results showed that drug sensitivity in P-170 positive patientswere significantly lower than that in P-170 negative patients(P<0.05).
     采用MTT法检测66例患者白血病细胞的药敏,同时采用单抗JSB-1,检测白血病细胞P-170的表达,结果表明:P-170表达阳性组药物敏感程度明显低于阴性组(P<0.05)。
短句来源
     Analysis of pathogen and drug sensitivity test in 94 cases of neonatal septicemia.
     新生儿败血症94例病原及药物敏感试验分析
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  药敏试验
     Application of SMMC-7721 Hepatocarcinoma Cells in Anticancer Drug Sensitivity Test Using the ~3H-TdR Incorporation
     应用~3H-TdR掺入法对SMMC-7721细胞株药敏试验条件的探讨与应用
短句来源
     The drug sensitivity test of the 45 strains showed that the sensitivity rate was 100% for vancomycin, and 73.3% , 48.9% and 48.9% for rifampin, trimethoprim-sulfamethoxazole and amoxicillin-clav respectively.
     药敏试验显示 ,45例MRSA菌株均对万古霉素敏感 ,对利福平、复方新诺明和阿莫西林的敏感率依次是 73.3% ,48.9%和 48.9% ;
短句来源
     The drug sensitivity tests results showed that PA was resistance to imipenem(3.0%), ciprofloxacin(4.8%), amikacin(6.7%), pereracillin/thiamazole (9.0%), ceftazidime(13.3%).
     药敏试验结果显示铜绿假单胞菌对抗生素的耐药依次为亚胺培南(3·0%)、环丙沙星(4.8%)、氨基糖甙类抗生素(6.7%),氧哌嗪青霉素/他巴唑(9·0%),头孢他啶(13.3%)。
短句来源
     CFU-GM Culture and Analysis of Drug Sensitivity of Bone Marrow Cell of Leukemic Patients
     白血病患者骨髓细胞CFU-GM培养及药敏试验分析
短句来源
     The consistency rate between results of the drug sensitivity test and that of the multiplex-PCR was 89.9%.
     药敏试验结果与基因检测结果的符合率为89.9%。
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      drug sensitivity
    Drug sensitivity tests for 20 commonly used medicines were carried out using a K-B method.
          
    This review describes the basis of DNA microarray technology and methodology, and focuses on their application in molecular classification of tumors, drug sensitivity and resistance studies, and identification of biological markers of cancer.
          
    The chemosensitivity of some drug-resistant sublines was changed after PTEN transfection, but the drug sensitivity of parental cell lines remained unaffected.
          
    This cell line may retain its original drug sensitivity and may be useful in screening for new compounds with activity against this disease.
          
    Tetrazolium blue (MTT) assay was used to evaluate the differences in drug sensitivity of HCC-9204 cells after Bax-transfection.
          
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    Sixteen cases of histoid leprosy were found among 499 in-patients in Qinhu Leprosarium during the period of 1974 to 1979. It was estimated that the incidence of histoid leprosy was 3.2% of the total in-patients and 6.8% of the LL-BL patients respectively. Clinical studies suggested that all these cases were sulfone resistant. In eight cases of histoid leprosy drug sensitivity on M. leprae were tested by the technique of growing bacilli in the foot-pads of mice fed with various concentrations of DDS diet....

    Sixteen cases of histoid leprosy were found among 499 in-patients in Qinhu Leprosarium during the period of 1974 to 1979. It was estimated that the incidence of histoid leprosy was 3.2% of the total in-patients and 6.8% of the LL-BL patients respectively. Clinical studies suggested that all these cases were sulfone resistant. In eight cases of histoid leprosy drug sensitivity on M. leprae were tested by the technique of growing bacilli in the foot-pads of mice fed with various concentrations of DDS diet. Six of them revealed DDS resistant, while low grade DDS resistance could not be excluded in the other two cases. Blood sulfone levels were determined and no evidence of poor absorption of DDS was found. All these cases gave negative Mitsuda reactions. There was no significant difference of ERFC tests and PHA-lymphocyte transformation tests between the histoid cases and the active BL-LL patients, as well as the BT-TT patients.Authors suggested that the emergence of sulfone resistant strains of M. leprae might be one of the etiologic factors in inducing histoid leproma. Prolonged irregular sulfone intake or insufficient dosage of DDS resulted in the development of sulfone resistance.

    本文报告1975~1977年在江苏太县溱湖医院发现组织样麻风瘤16例。其一般临床表现与瘤型、界线类偏瘤型麻风相似,组织样损害分为四型;临床资料提示其为耐砜类药物菌株所致。8例中之6例经鼠足垫试验证实为耐氨苯砜菌株,组织病理学诊断为典型组织样麻风瘤4例,不典型12例;对部分病人进行了免疫学检查。作者认为麻风杆菌耐砜类药物突变株可能是产生组织样损害的原因之一。

    Classification and drug sensitivity in 351 strains of dysentery bacilli confirmed fay fecal specimen culture were analysed at our out patient department of gastroenteric diseases in the summer and autumn of 1979 and 1980. The most prevalent dysentery bacilli were Shigella flexneri (76.1-87.6%) in Bengbu. However, Sh. boydii was more common in Bengbu than in other areas (12.3% and 5.1% in1979 and 1980 respectively) . It is worthy of special attention that Sh. boydii may give rise to the local and fulminant...

    Classification and drug sensitivity in 351 strains of dysentery bacilli confirmed fay fecal specimen culture were analysed at our out patient department of gastroenteric diseases in the summer and autumn of 1979 and 1980. The most prevalent dysentery bacilli were Shigella flexneri (76.1-87.6%) in Bengbu. However, Sh. boydii was more common in Bengbu than in other areas (12.3% and 5.1% in1979 and 1980 respectively) . It is worthy of special attention that Sh. boydii may give rise to the local and fulminant epidemics. The sensitivity tests of bacilli to the 12 antimicrobial drugs were made. Gentamycin, Kanamycin and Neomycin were the highest in sensitivity, Furazolidon and TMP were inferior. The tolerant strains of dysentery bacilli are increasing year by year.

    一、蚌埠市1979~1980年痢疾杆菌的主要流行菌是福氏菌,占76.1~87.8%,鲍氏菌所占比例也较高.作者指出对其能否酿成局灶性爆发性流行,应予高度警惕.二、对常用的十二种抗菌药物作了敏感试验,以庆大、卡那及新霉素、痢特灵、TMP等敏感率较高,但耐药菌株有逐年增加的趋势,应予重视.

    Drug-sensitive P. berghei maintained by syringe passage for over 20 years was passed successively to clean mice under increasing selection pressure of pyronaridine base. Of the 5 mice administered single oral doses of 8 mg/kg (1.2 times its ED_(50)) in Passage 1, four mice were free from parasitemia 3~4 days after drug administration. From passage 2 onwards, an escalation of 2 mg/kg of pyronaridine per passage was performed. Five mice of Passage 2 were dosed with 10 mg/kg, but their parasitemia remained positive,...

    Drug-sensitive P. berghei maintained by syringe passage for over 20 years was passed successively to clean mice under increasing selection pressure of pyronaridine base. Of the 5 mice administered single oral doses of 8 mg/kg (1.2 times its ED_(50)) in Passage 1, four mice were free from parasitemia 3~4 days after drug administration. From passage 2 onwards, an escalation of 2 mg/kg of pyronaridine per passage was performed. Five mice of Passage 2 were dosed with 10 mg/kg, but their parasitemia remained positive, This result suggested the commencement of drug resistance. By Passage 23, which was reached in about 5 1/2 months, a test dose of 2, 400 mg/kg (1.8 times its LD_(50)) was given to a group of mice to assess the drug sensitivity. Though some of the mice died of the dosage, none of the survivors was free of plasmodium parasite. It was evident that a pyronaridine-resistant line of P. berghei was fully developed as the parasites could tolerate a higher dose of pyronaridine than the hosts, bearing approximately a 300-fold resistance to pyronaridine when compared with the parent line.The virulence of pyronaridine-resistant line was much lower than that of its parent line. The sensitivity of pyronaridine-resistant line to 6 erythrocytic schizontocides [chloroquine, piperaquinoline, amopyroquine, M-6407 (a 4-aminoquinoline), mepacrine, qinghaosu] was also decreased significantly. By testing these drugs at doses over 3~10 times those effective to the parent line parasites, pyronaridine-resistant line failed to respond to the 6 drugs, indicating the presence of cross resistance of pyronaridine-resistant line to the 6 schizontocidal agents. However, when the pyronaridine pressure was lifted for 5 passages, the pyronaridine-resistant line was reverted to a pyronaridine sensitive line.

    用本所传代已二十余年、对药物敏感的伯氏鼠疟原虫作种源,每转种一代给小白鼠口服单次量咯萘啶。第1代剂量为8 mg/kg,其后剂量每代增加2 mg/kg。转种至第23代,剂量达2,400mg/kg时,虽部分小鼠死亡,存活小鼠的原虫血症仍不转阴,此时原虫的抗药性为亲代原虫的300倍以上。抗咯萘啶鼠疟原虫(RPB_2)对氯喹、喹哌、吡咯喹、M-6407、阿的平与青蒿素等有一定程度的交叉抗药性。用对亲代原虫有效量的3~10倍治疗RPB_2原虫时,不能使原虫血症转阴。如不再用药,连续转种5代,RPB_2可恢复对咯萘啶的敏感性。

     
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