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antiepileptic drug
相关语句
  抗癫痫药
     Cytochrome P450 Enzyme System and Antiepileptic Drug Metabolism
     细胞色素P450酶系与抗癫痫药物的代谢
短句来源
     Gabapentin hydrochloride, an antiepileptic drug, was synthesized by Knoevenagel reaction from cyclohexanone and acetonitrile, Michael addition reaction, Pd-C catalytic hydrogenation and hydrolysis to give 2-hydroxy-2-azaspiro[4.5]decan-3-one, which was subjected to reduction by Raney Ni catalytic hydrogenation, hydrolysis and salt formation with an overall yield of 14%.
     环己酮与乙腈经Knoevenagel反应、Michael加成反应、Pd-C催化氢化还原和水解反应制得2-羟基-2-氮杂螺[4.5]癸烷-3-酮,再经RaneyNi催化氢化还原和水解、成盐制得抗癫痫药盐酸加巴喷丁,总收率14%。
短句来源
     Antiepileptic drug hypersensitive syndrome: clinical analysis of 11 cases
     抗癫痫药物过敏反应综合征11例分析
短句来源
     Study on embryonic skeleton developmental influence of antiepileptic drug topiramate in rats
     抗癫痫药妥泰对大鼠胚胎骨骼发育影响的研究
短句来源
     Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases
     回顾性分析357例次小儿抗癫痫药物血药浓度
短句来源
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  抗癫痫药物
     Cytochrome P450 Enzyme System and Antiepileptic Drug Metabolism
     细胞色素P450酶系与抗癫痫药物的代谢
短句来源
     Antiepileptic drug hypersensitive syndrome: clinical analysis of 11 cases
     抗癫痫药物过敏反应综合征11例分析
短句来源
     Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases
     回顾性分析357例次小儿抗癫痫药物血药浓度
短句来源
     Monitoring of Antiepileptic Drug Serum Concentrations in 194 Children
     194例小儿抗癫痫药物血药浓度监测
短句来源
     Objective To study the effect of inhibitor of multidrug resistance-associated protein (MRP) probenecid in the regulation of concentration of carbamazepine and phenytoin in the extracellular fluid of cerebral cortex of rat, to indicate that MRP decrease the concentration of antiepileptic drug in extracellular fluid of cerebral cortex and deduce whether expression of MRP in brain is involved in multidrug resistance mechanisms of refractory epilepsy.
     目的观察多药耐药蛋白(multidrug resistance-associated protein MRP)拮抗剂丙磺舒对大鼠大脑皮层细胞外液卡马西平和苯妥英钠含量的影响,证明MRP能够减少皮层内抗癫痫药物的浓度,探讨脑内表达MRP和难治性癫痫多药耐药的关系。
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  “antiepileptic drug”译为未确定词的双语例句
     PHARMACOKINETICS STUDY OF ANTIEPILEPTIC DRUG SC1001 Na IN RABBITS
     抗癫痫新药SC1001Na在家兔体内的药代动力学
短句来源
     Association of a polymorphism in MDR1 C3435T with response to antiepileptic drug treatment in ethic Han Chinese children with epilepsy
     儿童癫癎对药物反应性与多药耐药基因MDR1C3435T多态性的相关性研究
短句来源
     Monitoring of antiepileptic drug serum concentrations and the clinical significance in 223 children
     223例小儿抗癫癎药物血药浓度监测及其临床意义
短句来源
     Objective To study the toxicity of topiramate (TPM), an antiepileptic drug, on embryonic development in rats.
     目的 研究妥泰 (topiramate,TPM)对大鼠胚胎发育的毒性。
短句来源
     In the experimental group, after 5 mL of the venous blood was collected in each of the patients and the P gp were investigated with the method of the immunocytochemistry, 34 patients with intractable epilepsy (M 20, F 14; age 24 a± s 12 a) received flunarizine 5-10 mg, po , qn, for 6-8 wk, as an add on antiepileptic drug.
     实验组用免疫组化法测定P糖蛋白(P gp) ,加用氟桂利嗪 5~ 10mg ,po ,qn ,2wk随访 1次 ,6~ 8wk后评价临床疗效 ,发作减少 50 %者为有效。
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  antiepileptic drug
The objective of the present study was to elucidate the effect of rofecoxib (selective COX-2 inhibitor) alone or in combination with newer antiepileptic drug tiagabine (γ-amino acid reuptake inhibitor) against pentylenetetrazol (PTZ) (80 mg/kg, i.
      
In this study we compared nefopam to carbamazepine (CBZ), a reference antiepileptic drug (AED), for their ability to protect cerebellar neuronal cultures from neurodegeneration induced by veratridine (VTD).
      
The objective of this study was to evaluate an interaction of the novel antiepileptic drug felbamate (2-phenyl-1,3-propanediol dicarbamate) with conventional antiepileptic drugs against maximal electroshock-induced convulsions in mice.
      
The antiepileptic drug "Lamotrigine (LTG)" inhibits presynaptic glutamate release and may therefore provide a novel approach for PD therapy.
      
We have treated 5 patients suffering from Parkinson's disease with the antiepileptic drug "lamotrigine" which does not appear to be an NMDA-antagonist but acts functionally as a glutamate antagonist by inhibition of presynaptic glutamate release.
      
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Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having...

Experiments were conducted on fiftymale rabbits to identify the concomi-tant changes both of the EEG and thebehavior as an epileptic pattern causedby the adminstration of Coriaria Lac-tone and to find out an adequate doseof this drug to induce a high frequencyof epileptic seizure with a low mor-tality rate. Coriaria Lactone, manufactured bythe pharmaceutical laboratory of Si-chuan Medical College, is an activeconstituent of Loranthus on Coriariasinica Maxim, a medicinal herb, whichhas long been known having beneficialeffect on some form of psychosis intraditional Chinese medicine and wasrecently demonstrated effective for thetreatment of schizophrenia by psychia-trists in our and other hospitals. Anepileptic-like convulsion was usuallyfound in those patients using the drugas a cure. In our previous experimentsthe effects of Coriaria Lactone onbehavior and EEG of the rabbit wereobserved.It was found that the Coria-ria Lactone caused convulsion andEEG changes which were much thesame as those of the epileptic patients,and there seemed to be a dose-depen-dent effect. These findings raised thepossibility of inducing epileptic seizureby Coriaria Lactone. In our present work,further observa-tions were made. Thus, when theexperimental animal was conscious andunrestrained the EEG of the animalwas recorded by telemetric methodwhich made the simultaneous observa-tion of both EEG and behavior seizurespossible. The fifty rabbits, weighing2.0-2.8 kg, were divided arbitrarilyinto four groups, three of which weredesigned for testing the optimum dosageand the remaining one for examiningthe possibility that conventional anti-epileptics, sodium phenobarbital, couldantagonize the effects induced by theoptimum dosage. The results were: 1. In group of 2mg/kg dosage therewas no effect. In group of 3mg/kg dosage the effect was significant: therate of seizure was 100%, i.e. all theanimals tested in this group had aseizure, with a death rate of 13.3%,whereas in group of 4mg/kg dosagethe death rate was 66.7% which muchhigher than that of the former group(P<0.01 ) though the rate of seizure(100% ) was the same. From thesedata it showed that 3 mg/kg could bethe optimum dosage of Coriaria Lac-tone for inducing an epileptic seizure. 2. The seizure revealed by EEG re-cording and behavior observation (insome cases cinematograph was taken)showed typical epileptic characteris-tics. On the other hand, this CoriariaLactone-caused seizure was antagonizedby preinjection of sodium phenobarbital(50mg/kg) 2 hours before the injectionof Coriaria Lactone. Thereby, it wasshown from both the obverse and thereverse sides that Coriaria Lactonewas an effective agent for inducingepileptic seizure. 3. Repeated injections of Coriaria Lac-tone (3mg/kg ) induced correspondingrepeated seizures when the dosage usedand the time interval chosen weresuitable. This suggested that the accu-mulation action of Coriaria Lactonewas not significant in the body. Although a researcher in his experi-ment may observe the behavior and EEGrecord separately, we think it best torecord both the indices at the sametime because antiepileptic drugs affectthe behavior and EEG of epilepsyseizure differently. Some drugs havea depressant effect on EEG seizurewhile others do not affect the beha-vioral seizure. Still some others justact in the reverse manner. In our pre-sent experiment we observed both thebehavioral and EEG seizure patternsby Coriaria Lactone at the same time. In our investigation an easy andeffective model of animal was offered.

本文报告以家兔作为实验动物,用马桑内酯造成癫痫模型。所用方法简便可靠。本模型可用于探索马桑内酯治疗精神分裂症的作用机理,也可用于探索癫痫发生机理及筛选抗癫痫药物。

China valpramide was used totreat 48 cases of various types ofepileptic seizures. Dosage for adultswas 900-1500mg/d, for children200-900mg/d. The therapeutic coursewas 3-7 months. The therateuticeffects were excellent (decrease inseizures>75%), good (decrease iaseizures 50-75%) , fair (decrease inseizures 25-50%), poor (decrease inseizures<25%), and worse (increasein seizures). The antiepileptic effectsof valpramide found to be: excellent37 (69.8%), good 8 (15.1%), fair4 (7.5%), poor (3.7%) and worse(1.9%)....

China valpramide was used totreat 48 cases of various types ofepileptic seizures. Dosage for adultswas 900-1500mg/d, for children200-900mg/d. The therapeutic coursewas 3-7 months. The therateuticeffects were excellent (decrease inseizures>75%), good (decrease iaseizures 50-75%) , fair (decrease inseizures 25-50%), poor (decrease inseizures<25%), and worse (increasein seizures). The antiepileptic effectsof valpramide found to be: excellent37 (69.8%), good 8 (15.1%), fair4 (7.5%), poor (3.7%) and worse(1.9%). The effectiveness antiepi-leptic of valpramide (seizures decreas-ing by above 50%) was 84.9%.Comparison of the EEG before andafter therapy showed remarkableimprovement in 23 cases, after therapythe EEG complete normalization 26.1 %and improvement in 43.5%, Theimprovement of epileptogenic dischargesof the EEG also supported the effec-tiveness of the antiepileptic drug. Serum amino acids were analyzedin nine normal and in the same numberof epileptic children. The significantchanges between the normal and theepileptics were decreased in glutamicacid 161.0±33.1μmol/L to 93.3± 38.3μmol/L (P<0.01), in metheonine62. 5± 3 .6μmol/L to 29. 8±13. 7μmol/L(P<0.01), and in taurine 156±56.1μmol/L to 102.4±49.4μmol/L (P<0.02) . The significant changes inserum amino acids after valpramidetherapy were: the increase in glycine350.6± 97.4μmol/L to 519.9± 94.6μmol/L (P<0 .02), the decrease in tryp-tophan 51.5±9.5μmol/L to 29.6± 9.7μmol/L (P<0.01), and the increasein metheonine 29.8±13.7μmol/L to48. 1±9.6μmol/L (P<0.02) . Fromthe above results and with referenceto the data presented by other scien-tists it is suggested that tliere may besome relationship between changes ofserum amino acids and the developmentepilepsy and the therapeutic mechanismof valpramide and it is worthy offurther study.

作者观察48例癫痫患者服用国产癫健安的临床疗效,有效率达84.9%,脑电图观察说明有抑制癌性放电作用,也支持该药的抗癫痫效应。通过9例癫痫患者服药前后血清氨基酸的分析发现癫健安可使血清蛋氨酸、甘氨酸升高,色氨酸降低,这些改变可能与该药的抗痫机理有关。

Serum copper and zinc levels were determined with AA-275 atomic absorptionspectrophotometer in 62 epileptic patients under antiepileptic treatment and 70 normalindividuals.Both Cu and Zn levels were significantly higher in the epileptic group thanin the controls,but Zn/Cu ratio was lower in the epileptic group.When the epilepticswere under dilantin or dilantin plus luminal and valium treatment,serum Cu and Znlevels were still higher than those of the controls.The serum Cu and Zn levels werenot affected by valproate...

Serum copper and zinc levels were determined with AA-275 atomic absorptionspectrophotometer in 62 epileptic patients under antiepileptic treatment and 70 normalindividuals.Both Cu and Zn levels were significantly higher in the epileptic group thanin the controls,but Zn/Cu ratio was lower in the epileptic group.When the epilepticswere under dilantin or dilantin plus luminal and valium treatment,serum Cu and Znlevels were still higher than those of the controls.The serum Cu and Zn levels werenot affected by valproate administration,also did not correlate with serum levels ofdilantin,but rather related in some way to the type of antiepileptic drug administered.

本文用原子吸收光谱仪测定70例癫痫患者的血清微量元素铜(Cu)、锌(Zn)的浓度.结果示癫痫组血清 Cu、Zn 平均浓度虽高于对照组(有显著差异),但 Zn/Cu 比值较正常组小。单服苯妥英钠及苯妥英钠合用鲁米那、安定,其血清 Cu、Zn 浓度亦高于对照组;服丙戊酸钠后对血 Cu、Zn 的影响不大。发现苯妥英钠的药物血浓度与血清 Cu、Zn 浓度间无相关性。血清 Cu、Zn 浓度与抗痫药物的类别有相关性

 
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