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combined administration
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  联合用药
     Results:Combined administration of SOD, SOD and Zn, SOD, Zn and Vc significantly increased Na-K ATPase and Mg-ATPase activities (P<0.01).
     结果 :SOD,SOD和 Zn,SOD、 Zn和 Vc联合用药均可使 Na- K ATP酶、Mg- ATP酶活性显著增高 (P <0 .0 1)。
短句来源
     Study on the combined administration of antiviral antibiotic 17997 in vitro
     抗病毒抗生素17997体外联合用药研究
短句来源
     The study on the mechanisms of As2O3 against the cancer of the liver has gone deeply and combined administration in the treatment is being studied;
     As2O3抗肝癌机制研究已逐步深入,还开展了联合用药研究等;
短句来源
     CONCLUSIONS:The initial drug resistance rate ranks higher in Shenzhen as compared with the average level in the whole nation,resistance rates of RFP and INH double after combined administration.
     结论:深圳市的结核分枝杆菌初治耐药率较高,经联合用药后,RFP和INH的复治耐药率升高1倍左右。
短句来源
     About half of normal metabolizers could not reach efficacious VPA Csss when VPA and PHT are combined administrated. Conclusions These data suggest that CYP2C19 polymorphism significantly impact the metabolism of VPA particularly in the combined administration with PHT.
     在VPA与PHT联合用药过程中,约半数CYP2C19正常代谢患者VPA血药浓度不能达到治疗血药浓度。
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  联合给药
     Interaction of combined administration of intrathecal morphine with subcutaneous morphine or buprenorphine
     吗啡与丁丙诺啡的蛛网膜下腔与皮下联合给药的相互作用(英文)
短句来源
     To analyze the mode of interaction of combined administration of intrathecal morphine with subcutaneous morphine or buprenorphine.
     目的:观察大鼠吗啡与丁丙诺啡(或吗啡)的蛛网膜下腔与皮下联合给药的相互作用。
短句来源
     Methods The experiments of antihypoxia and endurance to tiredness of Korean epimedium herb and Ginseng were done on old mice with the method of single or combined administration. MDA level in plasma and tissue was measured with the sulfobarbital method, and SOD activity was measured with the Eistners method, respectively.
     方法 采用单独和联合给药的方法对老龄小鼠进行抗缺氧实验 ,耐疲劳实验 ,按硫代巴比妥法测定血浆和组织MDA ,按EistnerFF法测定红细胞SOD的活性。
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     Conclusion The combined administration of rhIL-11 and rhG-CSF significantly improved the recovery of hematopoietic and immunological function of neutron-irradiated beagles. ;
     结论rhIL-11+rhG-CSF联合给药可明显促进中子照射所致骨髓型急性放射病狗的造血和免疫功能恢复,为细胞因子应用于中子急性放射病的临床治疗提供了实验依据。
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  “combined administration”译为未确定词的双语例句
     RESULTS The pharmacokinetic parameters of combined administration group wereρ_(max)=(9.58±3.12)μg·L~(-1), AUC_(0~24h)=(83.67±20.17)μg·h·L~(-1);
     结果阿莫西林和灯盏花乙素合并给药组的ρ_(max)= (9.58±3.12)μg·L~(-1),AUC_(0-24h)=(83.67±20.17)μg·h·L~(-1);
短句来源
     An Experimental Study of the Inhibition of the Expression of CYP3A1, CYP2E1 and mdr1 Genes of the Liver by Combined Administration of Cyclosporin and Berberine Hydrochloride
     环孢素与小檗碱合用抑制肝CYP3A1、CYP2E1、mdr1基因表达的实验研究
短句来源
     Study on CYP1A2 and CYP2E1 mRNA expression in liver of rats by combined administration of Dioscorea bulbifera L.and Angelica sinensis
     黄药子与当归配伍对大鼠肝脏CYP1A2、CYP2E1基因mRNA表达的影响
短句来源
     Results After the cefotaxime and the sulbactam individually given or combined administration, the main pharmacokinetic parameters α, β, AUC 0-∞ , AUC 0-t , t 1/2α , t 1/2β , CL and Vc had no significance difference by analysis of variance and paired samples T test (α=0 05).
     复方制剂与单方制剂中头孢噻肟和舒巴坦的药动学参数α、β、AUC0-∞、AUC0-t、t1/2α、t1/2β、CL和Vc经方差分析和配对t检验,均无显著性差异(α=0.05)。
短句来源
     Methods MTT colorimetry assay and 3H-TdR incorporation assay were performed to evaluate the inhibition effects upon the proliferation of glioma cells,and to compare the sensibility of combined administration of CBP,Vm-26,MTX,and NIM with that of the administration of CBP+NIM,Vm-26+NIM,MTX+NIM,CBP+Vm-26+MTX,of these of four respectively.
     方法采用MTT比色法及3H-TdR渗入法测定脑胶质瘤细胞增殖抑制作用,比较脑胶质瘤细胞对CBP、Vm-26、MTX及NIM单用、联用的敏感性。
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  combined administration
combined administration of high-and lowmolecular-weight microbial autoregulators (extracellular RNase fromBacillus intermedius and anabiosis inducing factord1) are reported for the first time for cultured cells of higher eukaryotes.
      
Studies of the effects of combined administration of the autoregulators demonstrated that pretreatment of the cells with low-dosed1 decreased the toxicity of RNase.
      
We suggest that some neuropeptides may possess a "hidden" physiological activity which becomes evident only after their combined administration or endogenous release.
      
Our results showed that a combined administration of L.
      
Complete block of the hypertension by the combined administration of phentolamine, propranolol, and nitroglycerin failed to abolish the efferent neural events, including postexcitatory depression, in all but one dog.
      
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15-methyl-PGF_(2α),HCG,HCG and 15-methyl-PGF_(2α),theophylline,theophyl-line and 15-methyl-PGF_(2α)were given separately as intravenous injections to pseudo-pregnant rabbits.Sixty minutes after administration of the drugs,the rabbitswere anaesthetized with sodium pentobarbital and the ovaries were taken outand assayed for cAMP and progesterone.In the group after 15-methyl-PGF_(2α)injection,the progesterone and cAMPcontents of the ovary decreased obviously compared with those of the control group.However,when...

15-methyl-PGF_(2α),HCG,HCG and 15-methyl-PGF_(2α),theophylline,theophyl-line and 15-methyl-PGF_(2α)were given separately as intravenous injections to pseudo-pregnant rabbits.Sixty minutes after administration of the drugs,the rabbitswere anaesthetized with sodium pentobarbital and the ovaries were taken outand assayed for cAMP and progesterone.In the group after 15-methyl-PGF_(2α)injection,the progesterone and cAMPcontents of the ovary decreased obviously compared with those of the control group.However,when HCG was given intravenously,remarkable increases in both theprogesterone and cAMP contents of the ovary were produced.It is well known thatcAMP is the second messenger for LH action in stimulating the synthesis of pro-gesterone by the ovary.Following the combined administration of HCG with15-methyl-PGF_(2α),the progesterone and cAMP contents of ovary did not increaseand were similar to those of the control group.This shows that the effects of HCGin stimulating synthesis of progesterone and increasing the content of cAMP inthe ovarian tissue might be antagonized by 15-methyl-PGF_(2α).The result sug-gests that the mechanism of luteolytic action of 15-methyl-PGF_(2α)appears to berelated to the lowering of the cAMP level of the ovary.After theophylline was administered,it caused a significant rise of the levelof progesterone and cAMP in the ovarian tissue.Since theophylline is an inhibitorof phosphodiesterase,this result might indicate that in the pseudo-pregnant rabbitovary endogenous cAMP is inactivated by phosphodiesterase,and that the con-version of endogenous cAMP into 5'-AMP by phosphodiesterase may be a regula-tory mechanism in the control of ovarian progesterone synthesis.In the groupgiven theophylline and 15-methyl-PGF_(2α)simultaneously the progesterone and cAMPcontents of ovary were similar to those of control group.This shows that the effectof theophylline in stimulating the synthesis of progesterone and increasing the con-tent of cAMP in the ovary might be antagonized by 15-methyl-PGF_(2α).This resultfurther supports the assumption that the mechanism of luteolysis by 15-methyl-PGF_(2α) is probably closely related to lowering the cAMP level in the ovarian tis-sue.

于假孕第7天的家兔,分別静脉注射15-甲-PGF_(2α)、HCG、HCG+15-甲-PGF_(2α),茶碱,茶碱+15-甲 PGF_(2α),观察用药后卵巢内 cAMP 和孕酮含量的变化。结果表明15-甲-PGF_(2α)能使卵巢内孕酮相 cAMP 含量明显下降,HCG 能促进孕酮合成,使卵巢内孕酮和cAMP 含量增加。HCG 和15-甲-PGF_(2α)联合应用则卵巢中孕酮和 cAMP 的含量与对照组比较均无显著差别,这表明15-甲-PGF_(2α)对 HCG 增加细胞内 cAMP 含量和促进孕酮合成均有颉颃作用,以上结果提示15-甲-PGF_(2α)的溶黄体作用与降低卵巢内 cAMP 水平是相关的。注射茶碱后卵巢内 cAMP 和孕酮含量均较对照组显著增加,茶碱是磷酸二酯酶抑制剂,表明茶碱增高孕酮的合成可能与提高卵巢细胞内 cAMP 水平是有关的,也表明磷酸二酯酶促进 cAMP转变为5′AMP 的过程也参与假孕兔卵巢孕酮合成的调节。茶碱与15-甲-PGF_(2α)合并应用后卵巢中 cAMP 和孕酮含量均不增加,与对照组比较无明显差別,表明15-甲-PGF_(2α)有颉颃茶碱使卵巢细胞内 cAMP 含量增加...

于假孕第7天的家兔,分別静脉注射15-甲-PGF_(2α)、HCG、HCG+15-甲-PGF_(2α),茶碱,茶碱+15-甲 PGF_(2α),观察用药后卵巢内 cAMP 和孕酮含量的变化。结果表明15-甲-PGF_(2α)能使卵巢内孕酮相 cAMP 含量明显下降,HCG 能促进孕酮合成,使卵巢内孕酮和cAMP 含量增加。HCG 和15-甲-PGF_(2α)联合应用则卵巢中孕酮和 cAMP 的含量与对照组比较均无显著差别,这表明15-甲-PGF_(2α)对 HCG 增加细胞内 cAMP 含量和促进孕酮合成均有颉颃作用,以上结果提示15-甲-PGF_(2α)的溶黄体作用与降低卵巢内 cAMP 水平是相关的。注射茶碱后卵巢内 cAMP 和孕酮含量均较对照组显著增加,茶碱是磷酸二酯酶抑制剂,表明茶碱增高孕酮的合成可能与提高卵巢细胞内 cAMP 水平是有关的,也表明磷酸二酯酶促进 cAMP转变为5′AMP 的过程也参与假孕兔卵巢孕酮合成的调节。茶碱与15-甲-PGF_(2α)合并应用后卵巢中 cAMP 和孕酮含量均不增加,与对照组比较无明显差別,表明15-甲-PGF_(2α)有颉颃茶碱使卵巢细胞内 cAMP 含量增加和促进孕酮合成的作用,实验结果进一步支持了15-甲-PG-F_(2a)溶黄体作用机制可能与细胞内 cAMP 水平降低有关。

1.It did not prove very ideal to use trichosanthine alone,for the termination of earlypregnancy,for the success rate was only 60 %.2.It proved better to administer trichosanthin together with reserpine or with tes-tosterone propionate,the success rate being 90% respectively.3.By simultaneously administering trichosanthin,reserpine and testosterone propion-ate to rodents(mouse,rat and rabbit),a success rate 100% were obtained.4.Effective quantities for each mouse:trichosanthin 0.4 mg,reserpine 0.1 mg andtestosterone...

1.It did not prove very ideal to use trichosanthine alone,for the termination of earlypregnancy,for the success rate was only 60 %.2.It proved better to administer trichosanthin together with reserpine or with tes-tosterone propionate,the success rate being 90% respectively.3.By simultaneously administering trichosanthin,reserpine and testosterone propion-ate to rodents(mouse,rat and rabbit),a success rate 100% were obtained.4.Effective quantities for each mouse:trichosanthin 0.4 mg,reserpine 0.1 mg andtestosterone propionate 2.0 mg.5.Test for acute toxicity of the combined administration on mice:LD_(50)=154.3 ± 0.8845 mg/kgThe applicable limit:154.3 ± 1.769 mg/kg(95%)Trichosanthin:reserpine:testosterone propionate=1:1:121The combined administration caused to rodents only temporary and reversible struc-tural and Visceral changes.

本文主要是应用复方天花粉进行抗早孕的动物实验研究:1.天花粉对小白鼠抗早孕的效果不理想,成功率为60%。2.天花粉与利血平或天花粉与睾丸酮合用效果比单独用天花粉好,成功率各为90%。3.天花粉、利血平、睾丸酮三者合并给药,对小动物(小鼠、大鼠、家兔)的抗旱孕成功率为100%,效果稳定、可靠。4.有效剂量:每只小白鼠天花粉0.4毫克,利血平0.1毫克,睾丸酮2.0毫克。5.毒理试验:“三合一”对小白鼠急性毒性试验LD_(50)=154.3±0.8845毫克/公斤,可信限为154.3±1.769毫克/公斤(95%)。天:利:丙=1:1:121。“三合一”对小动物机体和脏器的变化是暂时的,可逆的。

Imercury and cadmium on biogenic amines of the rat brain were investigated. The combined administration of methylmercury and cadmium decreased the level of 5-HIAA and increased the levels of NE and DA. No mutual interrelationship between the toxic effects of these two agents was found when they were used in combination.An increase in MHPG-SO4 content in urine may reflect an accelerated synthesis and/or degradation in NE in the brain. In the present study methylmercury significantly increased the level...

Imercury and cadmium on biogenic amines of the rat brain were investigated. The combined administration of methylmercury and cadmium decreased the level of 5-HIAA and increased the levels of NE and DA. No mutual interrelationship between the toxic effects of these two agents was found when they were used in combination.An increase in MHPG-SO4 content in urine may reflect an accelerated synthesis and/or degradation in NE in the brain. In the present study methylmercury significantly increased the level of MHPG-SO4 in urine. This may prove to be a useful parameter for further study in population putatively exposed to methylmercury toxicity.These results were obtained in animals without obvious neurologic symptoms, suggesting early changes of the functions of the central nervous system.

甲基汞与氯化镉联合给大鼠腹腔注射,使脑组织5-羟色胺(5—HT)的代谢产物5-羟吲哚乙酸(5—HIAA)含量降低,使去甲肾上腺素(NE)和多巴胺(DA)的含量增加。联合染毒的作用与甲基汞或氯化镉单独的作用不同。在联合染毒时,甲基汞与氯化镉表现为各自的独立作用。 尿中去甲肾上腺素的代谢产物3-甲氧基,4-羟基苯乙二醇硫酸结合物(MHPG-SO_4)可以反映脑中NE的合成和降解,本实验观察到注射甲基汞的大鼠尿MHPG-SO_4含量明显增高。 上述结果都是在染毒后未出现明显的神经症状情况下观察到的,提示大鼠脑功能的早期改变。尿MHPG-SO_4在反映甲基汞对中枢神经毒作用方面的实际意义如何,值得进一步研究。

 
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