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enantiomers
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  对映体
    Studies on Rapid Method for Determination of Amino Acids and Separation of Enantiomers of Amino Acids by High Performance Capillary Electrophoresis
    高效毛细管电泳快速测定氨基酸及拆分氨基酸对映体的研究
短句来源
    THE PHARMACOKINETICS OF PROPRANOLOL ENANTIOMERS AND THEIR STEREOSELECTIVE DIFFERENCES
    普萘洛尔对映体的药代动力学与立体选择性差异研究
短句来源
    CHROMATOGRAPHIC CHIRAL SEPARATION OF 2-ARYLPROPIONIC ACID ENANTIOMERS
    手性色谱分离2-芳基丙酸类药物对映体
短句来源
    Simultaneous separation of the enantiomers of verapamil and norverapamil by capillary zone electrophoresis
    毛细管区带电泳同时分离维拉帕米和去甲维拉帕米对映体
短句来源
    Separation and Bioanalysis of Enantiomers of Some Chiral Drugs by HPLC
    几种手性药物对映体的HPLC分离与生物样品分析
短句来源
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  对映异构体
    SEPARATION OF ENANTIOMERS BY HPLC
    对映异构体的HPLC分离
短句来源
    High-performance Liquid Chromatographic Determination of SFZ-47 Enantiomers in Rabbit Plasma
    HPLC法测定兔血浆中SFZ-47对映异构体浓度
短句来源
    Separation of terbutaline enantiomers by capillary zone electrophoresis
    毛细管区带电泳分离特布他林对映异构体
短句来源
    Separation and Determination of Enantiomers of DL-(±) methionine by RP-HPLC
    DL-(±)蛋氨酸对映异构体的拆分及成品中D-(-)蛋氨酸的测定
短句来源
    The binding of (±) -PQT and its enantiomers to bovine serum albumin (BSA)and rabbit plasma was unsaturable when initial drug concentrations from 1 to 32μmol/L were used.
    当透析液药物初始浓度在1~32μmol/L范围内时,(±)-POT及其对映异构体与血浆蛋白的结合属非饱和类型。
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  “enantiomers”译为未确定词的双语例句
    ADVANCES IN DRUG METABOLISM STUDIES ON ENANTIOMERS
    旋光异构体药物代谢研究的进展
短句来源
    A CHIRAL CAPILLARY GAS CHROMATOGRAPHIC METHOD FOR DIRECT DETERMINATION OF ENANTIOMERS OF MEPHENYTOIN IN HUMAN URINE
    手性毛细管气相色谱法测定人尿中美芬妥英光学异构体含量的方法学研究
短句来源
    ( - )-Stepholidine vs 12-chloroscoulerine enantiomers on firing activity of substantia nigral dopamine neurons
    左旋千金藤立定和12-氯斯阔任旋光异构体对黑质多巴胺神经元放电活动的比较(英文)
短句来源
    Methods:The enantiomers of Repaglinide were directly separated on a high performance liquid chromatographic chiral stationary phase consisting of the Kromasil TBB using hexane-2-propanol-acetic acid(96∶4∶0.2)as eluent with flow rate 0.5mL·min-1,detected at wave length 243nm and 30 ℃. Several parameters were optimized.
    方法:使用Kromasil TBB手性固定相,流动相为正己烷-异丙醇-冰醋酸(96∶4∶0.2),流速0.5m L.min-1,检测波长243nm,柱温30℃,并考察了流动相组成、柱温和流速等色谱条件对分离的影响。
短句来源
    Methods:The enantiomers were separated by HPCE on a capillary(50 cm×50 μm,ID) with the running buffer solution of 20 mmol/L of sodium dihydrogen phosphate,which contained 1% sulfated-β-cyclodextrin and was adjusted to pH 3.0 with phosphoric acid.
    方法:采用石英毛细管柱(50μm×50 cm,有效长度41.5 cm),运行缓冲液为20 mmol/L的磷酸二氢钠溶液(含1%的磺化-β-环糊精,磷酸调pH至3.0)。
短句来源
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  enantiomers
Both these models predicted binding affinity of internal and external test set compounds including the enantiomers of compound no.
      
The results of this study may be used in the synthesis of amino acid enantiomers.
      
Kinetic parameters of D- and L-enantiomers of ddCTP analogs and 5'-triphosphates of acyclic nucleosides were evaluated.
      
It is shown that stereospecificity of dNTP analogs and structure of the furanose residue play crucial roles in the interaction with TdT: L-enantiomers are much less potent as substrates compared to their D-counterparts.
      
Enantiomers of the Amino Acid Derivatives of Fullerene C60 Possess Stereospecific Membranotropic Properties
      
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For search of new cerebral vasodilator, (±)-2-hydroxyl-phenylacetic acid (mandelic acid) was resolved with D (-)-2-aminobutanol into enantiomers, from which optical isomers(Ⅵ, Ⅶ) of cyclandelate were prepared respectively by esterification with cis-3.3.5-trimethylcyclohexanol. The following esters were also prepared: the corresponding nicotinate hydrochlorides (Ⅷ, Ⅸ) and 2- (p-chlorophenoxyl) 2-methyl-propionate (Ⅹ,Ⅺ), 2-(p-chlorophenoxy) 2-me thylpropionate (Ⅲ),propionate (Ⅳ) and 2-methylpropionate (Ⅴ)...

For search of new cerebral vasodilator, (±)-2-hydroxyl-phenylacetic acid (mandelic acid) was resolved with D (-)-2-aminobutanol into enantiomers, from which optical isomers(Ⅵ, Ⅶ) of cyclandelate were prepared respectively by esterification with cis-3.3.5-trimethylcyclohexanol. The following esters were also prepared: the corresponding nicotinate hydrochlorides (Ⅷ, Ⅸ) and 2- (p-chlorophenoxyl) 2-methyl-propionate (Ⅹ,Ⅺ), 2-(p-chlorophenoxy) 2-me thylpropionate (Ⅲ),propionate (Ⅳ) and 2-methylpropionate (Ⅴ) of cyclandelate, the 3.4-dimethoxybenzoate (ⅩⅢ, ⅩⅣ) and 3. 4. 5-trimethoxybenzoate (ⅩⅤ, ⅩⅥ) of cis and trans isomers of 3.3.5-trimethylcyclohexanol.

为了寻找扩张脑血管的新药,本文用D(-)-(?)-氨基丁醇将(±)-(?)羟基苯乙酸(扁桃酸)拆分成左、右旋对映体,再分别与顺式3.3.5-三甲基环已醇酯化,制得二个有旋光性的环扁批酸酯(Ⅵ,Ⅶ);此外,还合成了与它们相应的菸酸酯盐酸盐(Ⅷ,Ⅸ)及安妥明酸酯(Ⅹ,Ⅺ)。 (±)环扁桃酸酯的安妥明酸酯(Ⅲ)、丙酸酯(Ⅳ)及2-甲基丙酸酯(Ⅴ)、3.3.5-三甲基环已醇的顺反异构体的3.4-二甲氧基苯甲酸酯(ⅩⅢ、ⅪⅤ)和3.4.5-三甲氧基苯甲酸酯(ⅩⅤ.ⅩⅥ)也分别被合成。

A new total synthesis of the unique indole containing antibiotic, chuangxinmycin was described. This compound was assembled from indole by a scheme that combined the silylation with the trimethylsilyl group displacement directly to produce a 4-sulfur-substituted indole. Further transformations involving acetylation at the indole 3-position, with a spontaneous intramolecular condensation to 1-acetyl-3,4-dehydrochuang-xinmycin ethyl ester and a cis hydrogen addition reaction with concurrent hydrolysis of the ester...

A new total synthesis of the unique indole containing antibiotic, chuangxinmycin was described. This compound was assembled from indole by a scheme that combined the silylation with the trimethylsilyl group displacement directly to produce a 4-sulfur-substituted indole. Further transformations involving acetylation at the indole 3-position, with a spontaneous intramolecular condensation to 1-acetyl-3,4-dehydrochuang-xinmycin ethyl ester and a cis hydrogen addition reaction with concurrent hydrolysis of the ester group furnished racemic chuangxinmycin.Racemic chuangxinmycin (3S, 4R and 3R, 4S enantiomers) when treated with S(-)-α-phenylethyl amine in methanol, (S)-α-phenylethyl amine-(3S, 4R)-chuangxinmycin salt was separated as bar crystals on cooling. (S)-α-phenylethyl amine(3R, 4S)-chuangxinmycin salt isolated as prisms from the mother solution. Both of them were treated with acid to produce (-)-chuangxinmycin and (+)-chuangxinmycin, respectively.Treatment of both (-)-chuangxinmycin and (+)-chuangxinmycin with KOH in dioxane or DMF containing water, followed by separating and purifying, resulted in (+)-epichuangxinmycin and (-)-epichuangxinmycin whose configuration have been confirmed to be 3S, 4S and 3R, 4R by spectral data.Among these four stereoisomers, only that having the natural configuration is active against bacteria. Conversion of The other three into chuangxinmycin was effective by the following route. The stereoisomeric esters were dehydrogenated by DDQ to give the 3,4-dehydro product in high yields, which was in turn hydrogenated and resolved, thus completing the first cycle.

由吲哚出发,经4-三甲基硅吲哚的亲电取代反应,直接得4-乙氧羰甲硫基吲哚;再经C_5乙酰化,分子内环化,立体选择性氢化与水解等制得消旋创新霉素。消旋创新霉素与(一)-α-苯乙胺反应,得两个非对映体盐,分别以酸处理,得(—)和(+)-创新霉素;二者经差向异构化,得(+)和(—)-差向创新霉素,经光谱证实其绝对构型分别为3S,4S和3R,4R,分子中的甲基和羧基均以横键为优势构象。在四种立体异构体中,仅(—)-创新霉素有抗菌活性,其它异构体的酯经脱氢,还原、拆分等循环,可转化成具有抗菌活性的异构体。

The antischistosomal effect of the enantiomers of praziquantel and three praziquantel derivatives were investigated in mice infected with Schistosoma japonicum. The results of the experiments showed that the worm reduction rates in the groups treated with levo-pra-ziquantel in a single dosage of 250mg/kg or 4l7mg/kg, intragastrically were 50.0% and 72.0%, respectively whereas the average number of worms still alive per mouse in the groups treated with dextro-praziquantel at the same single dosage regimes,250mg/kg...

The antischistosomal effect of the enantiomers of praziquantel and three praziquantel derivatives were investigated in mice infected with Schistosoma japonicum. The results of the experiments showed that the worm reduction rates in the groups treated with levo-pra-ziquantel in a single dosage of 250mg/kg or 4l7mg/kg, intragastrically were 50.0% and 72.0%, respectively whereas the average number of worms still alive per mouse in the groups treated with dextro-praziquantel at the same single dosage regimes,250mg/kg or 4l7mg/ kg, intragastrically were not significantly different from that of control group.The three praziquantel derivatives, S-01, S-02 and S-04, in a dosage regime of 0.64 mmol/kg, qd x 3d were screened in infected mice but none of them showed significant antischistosomal effect

左旋吡喹酮250mg/kg和417mg/kg灌胃一次治疗人工感染血吸虫小鼠、减虫率分别为50.0%和71.9%.右旋吡喹酮用上述两种同样剂量灌胃一次治疗感染小鼠,减虫率分别为-5.9%和4.3%,几无抗虫作用.吡喹酮衍生物S-01、S-02和S-04分别用235.5mg/kg,qd×3d;233.0mg/kg,qd×3d和213.8mg/kg,qd×3d(均为0.64mmol/kg/d×3d)治疗感染小鼠,减虫率分别为10%、6%和12%,该三种衍生物抗虫作用均较吡喹酮差.

 
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