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clinical trials
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  临床试验
     Applications of Mixed Models in Clinical Trials
     混合模型在临床试验统计分析中的应用
短句来源
     RESULTS:A total of4clinical trials were included in our study,in ho-mogeneity test X 2 =0.80,P>0.05,thus a fixed effect model was applied.
     结果共有4个临床试验纳入本次研究,同质性检验X2=0.80,P>0.05,故采用固定效应模型进行分析。
短句来源
     There were four clinical trials which showed that topical retinoids were more effective than that of placebo (RR=1.87, and 95% CI: 1.13 ~ 3.11),especially for noninflammatory lesions (RR=12.70,and 95% CI : 4.09 ~ 39.40).
     有4个临床试验示外用维A酸疗效明显优于安慰剂[RR(相对危险度)=1.87,95%CI(可信区间)为1.13 ̄3.11],尤其对非炎性皮损(RR=12.70,95%CI为4.09 ̄39.40)。
短句来源
     EV Models for Clinical Trials Data
     临床试验数据的EV模型
短句来源
     A DESIGN OF PHASE II CLINICAL TRIALS AND ITS C++ PROGRAMMING
     II期临床试验设计方案及其C++编程
短句来源
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  临床研究
     ONYX-015 and H101 are E1B 55-kDa protein-deficient replicating C group adenoviruses that are currently in clinical trials as antitumor agents.
     ONYX-015和H101为可复制E1B55-kDa蛋白缺陷的C族腺病毒,它们正作为抗癌药物进行临床研究.
短句来源
     Clinical Trials of Platelet Glycoprotein Ⅱb/Ⅲa Inhibitors
     血小板糖蛋白Ⅱb/Ⅲa受体拮抗剂的临床研究
短句来源
     Lowincidence of iris pigmentation and eye-lash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%
     在随机的2个临床研究中使用0.15%异丙基乌诺前列酮后虹膜色素沉着和睫毛变化的低发生率
短句来源
     A Brief Study on the Quality of Clinical Trials in 11 Medical Journals of Traditional Chinese Medicine From 1995 to 2000
     11种地方性中医药期刊1995~2000年临床研究文献质量的初步分析
短句来源
     Background &Objective:Boanmycin(BAM),a single A6component of the bleomycin complex,is effective against a panel of cancers in clinical trials.
     背景和目的:博安霉素(Boanmycin,BAM)是博来霉素的A6组分,临床研究表明对多种肿瘤有效。
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  临床试验的
     Principle and manipulation of clinical trials(6) ——Guidelines for standard operating procedure (continued 1)
     新药临床试验的原理与操作(6)——统计学处理的标准操作规程指南(续1)
短句来源
     Studies for Phase Ⅰ Clinical Trials
     关于Ⅰ期临床试验的研究综述
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     Review and evaluation for the key clinical trials that may change clinical practice of breast cancer
     改变乳腺癌临床实践的重要临床试验的回顾与评述
短句来源
     Data and safety monitoring in clinical trials
     临床试验的数据和安全监察
短句来源
     Methods:Related references published during 1990~2005 were collected and their quality evaluated according to the standard for evidence degree provided by Oxford Evidence-based Medicine Center and design principles in clinical trials.
     方法:收集国内1990~2005年6月公开发表的一清胶囊相关论文,按照牛津循证医学中心证据标准和临床试验的设计原则,对文献进行质量评价。
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  “clinical trials”译为未确定词的双语例句
     Conclusions The evidence that As2O3 at relatively low concentration can inhibit proliferation of U87MG and T98G cells in vitro suggests that As2O3 may be considered for clinical trials on glioma patient.
     结论体外低浓度的As2O3能有效地抑制U87MG和T98G细胞增殖,提示As2O3有希望用于神经胶质瘤患者的治疗。
短句来源
     A New IUD-FRCu200C Design and Clinical Trials
     FRCu200C IUD的研制及临床应用
短句来源
     Clinical Trials of AngⅡ Blockers in Treating Patients with Both Type 2 Diabetes Mellitus and Atherosclerosis, and the Relationship between ACE (I/D), AT_1R (A1166C) Gene Polymorphism and Early Effectiveness of ACEI
     T2DM合并AS患者ACE(I/D)、AT_1R(A1166C)基因多态性与ACEI近期疗效相关性的研究
短句来源
     Others including IL 3,IL 6,IL 11,TPO,NGF,EGF,IL lra,TNF,M CSF have passed animal test and clinical trials. They possesses a good opportunity for clinical use.
     而IL3,IL6,IL11,TPO,NGF,EGF,ILlra,TNF,MCSF等也通过动物试验及临床试用展现出良好的临床应用前景。
短句来源
     A density functional investigation on 1,2-C2B10H12 isonitrile derivatives, as 10B-enriched compounds used in clinical trials for boron neutron capture therapy(BNCT), was reported. The structural and electronic properties of 1,2-C2B10H12 isonitrile derivatives were studied at B3LYP/6-31G(d) level.
     利用密度泛函方法在B3LYP/6-31G(d)水平上对1,2-C2B10H12的两种异腈类衍生物的结构特性进行了研究.
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  clinical trials
The clinical trials have demonstrated that the presence of fluoride ions in the apatite structure suppresses osteoclasts and provides a combined more positive clinical effect as compared to other materials.
      
However, the first clinical trials have demonstrated that the approaches involving autotransplantation of hematopoietic and mesenchymal SCs are effective for treating ischemia of extremities and the consequences of myocardial infarction.
      
Delivery of a mini-gene of D with a specific muscle promoter using a modified adenoassociated virus is currently the most promising method, which will soon be available for clinical trials.
      
It is emphasized that consolidation of funds and efforts of all Russian laboratories dealing with gene and cell therapy of DMD are necessary to complete the experiments and start clinical trials.
      
Laser heating of biological tissue with blood vessels: Modeling and clinical trials
      
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This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull...

This paper reports the results of the clinical use of Corydalis B as an analgesic in 72 patients with various forms of pain. In 64 cases the drug was used in a single dose, usually of 75 mg. by oral route, while in the other 8 cases repeated doses were given orally over a period of 3 to 21 days. The pain was completely abolished or definitely improved in 50 cases (78.1%) of the former group and in all 8 cases of the latter group. The analgesic effect appeared to be most marked in medical cases with dull pain in the chest or abdomen, as in cases of peptic ulcer and lobar pneumonia. Drowsiness was found as a side-effect in 28% of the cases after a single dose of the drug and in 6 of the 8 cases treated with repeated doses. In no case was any serious toxic action noted. According to the preliminary Observations herein reported, further clinical trial with the use of Corydalis B as an analgesic agent seems warranted.

本文报告72例试用延胡索素乙硫酸盐作为鎮痛剂的临床观察,其中64例为单剂用药,主要为一次口服75毫克,另8例为长期口服。单剂用药64例中完全止痛及疼痛减轻者共50例,占78.1%,长期服药8例均有效,鎮痛作用在内科胸腹部鈍痛病例较著。用药后未見重要副作用,单剂用药者28%发生嗜睡。长期用药的8例中6例有嗜睡,血与尿常規、大便次数、血压、心率等均无明显改变。据本文病例的初步临床应用结果,延胡索素乙对钝痛有一定的镇痛效果值,得进一步试用。

Tris-(1-aziridinyl)-phosphine oxide(I, TEPA) and 2-[bis-(2-chloroethyl)-amino]-tetrahydro-1, 3, 2-oxazaphospholidine-2-oxide(Ⅲ, B-518) possess inhibitory action against a variety of animal tumours and have been used clinically. Recently, bis-(1-aziridinyl)-phosphinyl carbamic acid ethyl ester(Ⅱ, AB-100) was found to possess significant activity with low toxicity on experimental animal tumours. In order to examine the relationship between chemical structure and pharmacological activity, bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine...

Tris-(1-aziridinyl)-phosphine oxide(I, TEPA) and 2-[bis-(2-chloroethyl)-amino]-tetrahydro-1, 3, 2-oxazaphospholidine-2-oxide(Ⅲ, B-518) possess inhibitory action against a variety of animal tumours and have been used clinically. Recently, bis-(1-aziridinyl)-phosphinyl carbamic acid ethyl ester(Ⅱ, AB-100) was found to possess significant activity with low toxicity on experimental animal tumours. In order to examine the relationship between chemical structure and pharmacological activity, bis-(1-aziridinyl)-[bis-(2-chloroethyl)-amino]-phosphine oxide(Ⅳ), nitrogen mustards of cyclic phosphoramide ester and thioester (Ⅴ & Ⅵ) were then prepared. Compound Ⅳ, Ⅴ and Ⅵ were prepared by treating N, N-bis-(2-chloroethyl)-phosphoramide dichloride in anhydrous dioxane or benzene with the corresponding amino or mercapto-compounds in the presence of a base such as triethylamine. Compound Ⅳ (designated as AT-222) exhibited broad antitumour effecots on sarcoma 180, spindle cell sarcoma and lymphatic leukemia in mice as well as on Jensen sarcoma and fibrosarcoma in rat, and has been recommended for clinical trials.

双(2-氯乙基)氨基磷酰二氯与乙烯亚胺在脱水苯或对氧六环中并在三乙胺的存在下进行缩合,生成N,N-双(2-氯乙基)-N′,N″-二乙烯基-磷酰胺(Ⅳ);与双巯基或双氨基化合物作用,则生成相应的环状磷酰胺、磷酰胺酯以及磷酰胺硫代酯氮芥类化合物(Ⅴ及Ⅵ).化合物Ⅳ(AT-222)对若干动物肿瘤具有显著的抑制作用,已介绍至临床试用。

Chrysanthemum indicum is effective in lowering blood pressure. Extraction with hot ethanol yielded an active fraction, HC-1. In anesthetized cats, intraduodenal injetions of 50—100 mg/kg of HC-1 produced an average "% of hypotensive areas" in 2 hours varying from -19% to -22%. Four normotensive dogs were fed 50, 100, 130 and 150 mg/kg resp., and the diastolic pressure dropped 0, 24, 8 and 36 mm Hg resp. The hypotensive action was slow and lasted more than 2 hours. Three renal hypertensive dogs were fed daily...

Chrysanthemum indicum is effective in lowering blood pressure. Extraction with hot ethanol yielded an active fraction, HC-1. In anesthetized cats, intraduodenal injetions of 50—100 mg/kg of HC-1 produced an average "% of hypotensive areas" in 2 hours varying from -19% to -22%. Four normotensive dogs were fed 50, 100, 130 and 150 mg/kg resp., and the diastolic pressure dropped 0, 24, 8 and 36 mm Hg resp. The hypotensive action was slow and lasted more than 2 hours. Three renal hypertensive dogs were fed daily 100 mg/kg in the first 2 weeks, and 200 mg/kg for the 3rd week. Weekly tests on EKG, serum BSP retention, and blood NPN revealed no serious alterations. In two of them the blood pressure was brought down significantly. Daily feeding of 300 mg/kg to one healthy dog for 3 weeks brought forth no grave reactions except vomiting at times. HC-1 is marked with (a) high yield, (b) low toxicity, (c) mild action, and (d) certain hypotensive effects in anesthetized and unanesthetized animals. So it may be recommended to clinical trial.

野菊花降压有效。本文实验用热醇提取出有效成分HC-1,并研究其疗效及毒性。麻醉猫小肠注射50—100毫克/公斤,2小时内的降压面积百分比为-19至-22%。正常血压狗4只,分别灌服50,100,130及150毫克/公斤,舒张压分别下降0,24,8及36毫米汞柱,作用缓慢,维持2小时以上。慢性肾型高血压狗3只,前2周每日灌胃100毫克/公斤,第3周每日灌胃200毫克/公斤。其中2狗血压显著降低。这3狗每周作心电图、血清磺溴酞钠存留率及全血非蛋白氮含量的测定,未见到严重毒性反应。另1只正常狗每日服300毫克/公斤,连续3周,除有时呕吐外,亦无其他严重毒性反应。 HC-1产量较高,毒性不大,作用缓和,对麻醉与不麻醉动物有一定降压效果,可以推荐临床试用。

 
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