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bioactive compounds
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  bioactive compounds
We conducted the present study in order to look for bioactive compounds in the medicinal plant Rabdosia excisa.
      
The inhibitory effect of several bioactive compounds on the activity of hyaluronidase enzyme purified from Naja naja venom was investigated in vitro.
      
In addition, plant-derived bioactive compounds also inhibited the activity of hyaluronidase dose dependently.
      
Enzymatic synthesis of bioactive compounds by Rhus laccase from Chinese Rhus vernicifera
      
Molecular biochromatography with human serum albumin (HSA) immobilized on silica as stationary phase was used to screen and analyse the bioactive compounds in the typical Chinese medicine ofAngelica sinensis (Oliv.) Diels.
      
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Asymmetric reduction of ketones is of current interest in synthetic organic chemistry and many interesting methodologies have so far been reported for this reaction。 This paper presents a brief view of the asymmetric reduction of ketones catalyzed by chiral oxazaborolidines, with emphasis on the catalytic activity of various oxazaborolidines and the applications of this reaction in organic synthesis,especially in the asymmetric synthesis of bioactive compounds.

唑硼烷催化酮的不对称还原反应是最成功的催化不对称反应之一,本文介绍这一反应,并着重论述各种唑硼烷的催化活性以及这一反应在有机合成中的应用。

A novel bioactive compound(Ⅲ) was obtained as a product of the Ritter reaction of curcumol (Ⅰ).The structure of the compound was elucidated as the title structure mainly by the use two dimensional nuclear magnetic resonance (2-D NMR) techniques(1H-1H COSY,1H-13C COSY, and long range 1H-13C COSY) and the stereo configuration was put forward according to the absolute structre of curcumol.

由莪术醇的Ritter反应,获得了一种新的生理活性化合物(Ⅲ)。应用二维核磁共振技术(1H-1HCOSY,1H-13CCOSY和远程1H-13CCOSY)等光谱学方法,结合莪术醇的绝对构型,提出了标题化合物的立体构型。

The search for bioactive constituents or leading compounds from natural sources especially from Chinese herbal medicine has proved to be one of the most effective ways for the development of new drugs.This paper describes the progress in creating new drugs based on researches on natural products chemistry for many years and some interesting new trends emerging from recent literature. The key point of study on the chemical constituents of individual Chinese herbal medicine has to be shifted to composite Chinese...

The search for bioactive constituents or leading compounds from natural sources especially from Chinese herbal medicine has proved to be one of the most effective ways for the development of new drugs.This paper describes the progress in creating new drugs based on researches on natural products chemistry for many years and some interesting new trends emerging from recent literature. The key point of study on the chemical constituents of individual Chinese herbal medicine has to be shifted to composite Chinese medicine especially for quality control in the future.The main theme of modernization for Chinese traditional medicine in the coming century will be the comprehensive study of the chemical constituents of composite Chinese medicine.Study on the bioactive principle of Chinese herbal medicine involves an integration of chemical study and bioassay with high throughput screening.It should be emphasized that the investigation of bioactive compounds for creating new drugs is the major task of the whole field.An intimate combination of basic study and drug development should be accomplished under a well warrantee policy.Natural product research should be featured by the application of modern spectroscopic techniques,such as HPLC/MS/MS and HPLC/NMR and so on. [

文章展望了从天然产物中创制新药的发展趋势。单味中草药有效成分的研究重点将转向瞄准质控的中药复方化学成分研究。进入 2 1世纪 ,中国天然药物研究要在国际上占有重要位置 ,突破口便是中药复方现代化 ,其关键之一便是化学 (有效 )成分研究。从中草药中发现有效成分或先导物必须采用化学成分与生物活性研究融为一体的机制 ,采用高通量筛选 ,目标就是寻找有效成分或先导物进而创制新药。长短结合 ,正确处理知识创新和新药开发的关系。知识创新须体现在创制新药的应用基础研究中 ,是产生巨大效益的理论基础 ;短程开发是知识累积水平的体现 ,是科研经费的必要补充和保证。改革传统天然产物化学研究模式 ,实施以当代最先进大型谱仪为先导的天然产物研究战略

 
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