Methods Forty male Wistar rats were randomized into four groups: sham group (SH 0 week n=10),MI two weeks group (MI 2 weeks n=10), MI four weeks group (MI 4weeks n=10) and MI eight weeks group (MI 8 weeks n=10).
From the fourteenth day,the rats of dispressive disorder group and sulpiride-treated group were given routine programme stimula,meanwhile,saline 1.0 ml/kg and sulpiride 32.5 mg/kg were given into the rats every day by intraperitoneal injection respectively. At the prophase,metaphase and anaphase of the stimula,every rat was carried out ethology determination and sugar consumption experiment.
HEPATOPROTECTIVE EFFECTS OF PICROLIV IN ALCOHOL-FED ALBINO RATS
A slightly elevated fasting blood glucose profile, 1.5 fold higher serum insulin levels and impaired glucose tolerance was prevalent in ethanol treated rats.
In the present study, the effect of picroliv, an irridoid glycosidic fraction of Picrorhiza kurroa, on the above said parameters of these alcoholic rats was studied.
Picroliv significantly reverted most of the above said altered blood and hepatic parameters in the alcohol-fed male and female rats to almost normal levels.
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.