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rats
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    The Study on Dynamic Changes of Apoptosis and Proliferation of Lung Cells, Interstitial Fibrosis and Their Mechanisms in Premature Rats with Hyperoxia-induced CLD
    高氧致CLD早产肺细胞凋亡、增殖和间质纤维化的动态变化及其机制研究
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    Apoptosis, Proliferation and Differentiation of Alveolar Epithelial Cells and Protective Effects of KGF on Premature Rats with Hyperoxia-induced CLD
    高氧致CLD早产肺泡上皮细胞凋亡、增殖和分化的动态变化及KGF对其调节作用研究
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    The Study of Young Rats with Acute Lung Injury on the Alterations of Alveolar Epithelial Type Ⅱ Cell and SP-A and SP-D and the Interference of Dexamethasone
    急性肺损伤幼肺Ⅱ型上皮细胞和SP-A及SP-D变化及地塞米松干预研究
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    The Study on Dynamic Changes of AQP、SP and Occludin Expression in Pulmonary Alveolar Epithelia and Their Effects on Chronic Lung Disease Induced by Hyperoxia in Newborn Rats
    高氧致CLD新生肺泡上皮细胞AQP、SP、Occludin表达的动态变化及其影响作用的研究
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    Expression of μ-Calpain in Neonatal Rats after Hypoxic-ischemic Brain Damage and Protective Effect of Its Inhibitor MDL28170
    新生实验性缺氧缺血性脑损伤后μ-Calpain的活性变化及其抑制剂的脑保护作用研究
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    The Effects of orexin, NPY, POMC and leptin on Obese Rats
    中枢神经多肽orexin、NPY、POMC及外周leptin在单纯性肥胖发生机制中的作用
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    AN IMMUNOHISTOCHEMICAL STUDY OF PERIVASCULAR MACROPHAGES IN BRAINS OF SPONTANEOUSLY HYPERTENSIVE RATS
    AN IMMUNOHISTOCHEMICAL STUDY OF PERIVASCULAR MACROPHAGES IN BRAINS OF SPONTANEOUSLY HYPERTENSIVE RATS
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    After 1,4,7,10,14 days of exposure,the rats were killed,whole lung RNA were isolated and cytochrome b mRNA were detected with reverse transcription polymerase chain reaction(RT-PCR).
    两组分别于高氧或空气暴露后1、4、7、10和14d时提取肺组织RNA,采用半定量逆转录聚合酶链反应(RT-PCR)测定Cytb mRNA表达;
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    Objective To investigate the preventive and therapeutical effect of exogenous calcitonin gene related peptide(CGRP) on pulmonary hemorrhage induced by endothelin-1(ET-1) in newborn rats.
    目的观察外源性降钙素基因相关肽(CGRP)防治内皮素(ET)-1致肺出血的作用。
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    μl 4×10 -6 ? mol/L exogenous ET-1 (group B,C,D and E,n=10). After 30 minutes,the rats in group B,C,D and E were intratracheally injected with 20 μl exogenous CGRP of different concentration from 6.7×10 -8 to 6.7×10 -6 ?
    A组经气管插管内给予生理盐水30μl,实验组给予4×10-6mol/L的外源性ET-130μl,半小时后,C、D、E组分别经气管插管内给予6.7×10-8、6.7×10-7、6.7×10-6mol/L的外源性CGRP20μl,了解其对肺出血的治疗作用。
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  rats
HEPATOPROTECTIVE EFFECTS OF PICROLIV IN ALCOHOL-FED ALBINO RATS
      
A slightly elevated fasting blood glucose profile, 1.5 fold higher serum insulin levels and impaired glucose tolerance was prevalent in ethanol treated rats.
      
In the present study, the effect of picroliv, an irridoid glycosidic fraction of Picrorhiza kurroa, on the above said parameters of these alcoholic rats was studied.
      
Picroliv significantly reverted most of the above said altered blood and hepatic parameters in the alcohol-fed male and female rats to almost normal levels.
      
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
      
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The clinical data of 80 cases ad-mitted patients With infective endoc-arditis were analysed from 1970 to Ju-ne,1989.In most cases(82.5%)infectiveendocarditis developed on pre-exi-sting organic cardiac lesions with rh-eumatic heart disease ranked first andcongenital heart disease second.Posto-perative infection of heart was 5.0%.Healthy heart was associated with th-is disease in only 12.5%.Blood cultur-es of 72 cases were positive in 41.7%,including Staphylococcus aureus in33.3%,group A betahemohytic strepto-cocci...

The clinical data of 80 cases ad-mitted patients With infective endoc-arditis were analysed from 1970 to Ju-ne,1989.In most cases(82.5%)infectiveendocarditis developed on pre-exi-sting organic cardiac lesions with rh-eumatic heart disease ranked first andcongenital heart disease second.Posto-perative infection of heart was 5.0%.Healthy heart was associated with th-is disease in only 12.5%.Blood cultur-es of 72 cases were positive in 41.7%,including Staphylococcus aureus in33.3%,group A betahemohytic strepto-cocci in 23.3%,Staphylococcus albusin 13.3% and streptococccus viridansin 6.7%.Examination of 40 cases wi-th ultrasonic cardiogram or Cross-Sectional ultrasonic Cardiogram Wer-e positive in 57.5%.Misdiagnosed rat(?)e was 36.3%.healing rate was 37.5%,mortality was 28.8% of the 80 cases.Pr-ognosis of the disease was dependenton early diagnosis mainly and treatm-ent in time.

本文对我院1970~1989年6月收治的80例感染性心内膜炎进行分析。大多数(82.5%)发生在器质性心脏病基础上,其中以风湿性心脏病居首位,先天性心脏病次之。心脏术后感染占5.0%;原来无心脏病者占12.5%。72例进行血培养,阳性率为41.7%,其中金黄色葡萄球菌占33.3%;甲型溶血性链球菌占23.3%;白色葡萄球菌占13.3%;草绿色链球菌占6.7%。40例行超声心动图检查,阳性率为57.5%。本组误诊占36.3%,治愈37.5%,死亡28.8%。本病的预后,主要取决于能否早期诊断和治疗。

A comprehensive study of epilepsy and mental retardation in childhood has been conducted inrecent years by the pediatric neurology group, (First) Teaching Hospital, Beijing Medical University.The relationship between neuropeptides(CCK-8, Somatostatin ), neurotransmitter (GABA) and seizuresusceptibility has been studied in vivo, and in neuronal cell cultures. The effect of iron-induced lipidperoxidation on GABA uptake and release was studied in rats. The following aspects were included inneuropharmacological...

A comprehensive study of epilepsy and mental retardation in childhood has been conducted inrecent years by the pediatric neurology group, (First) Teaching Hospital, Beijing Medical University.The relationship between neuropeptides(CCK-8, Somatostatin ), neurotransmitter (GABA) and seizuresusceptibility has been studied in vivo, and in neuronal cell cultures. The effect of iron-induced lipidperoxidation on GABA uptake and release was studied in rats. The following aspects were included inneuropharmacological studies:(1) The effeet of phenytoin on learning behavior in animal models.(2) A clinical double-blind crossover study of the new anticonvulsant-antiepilepsirin".(3) Carba-mazepine distribution in brain areas of rats. Long-term 24 hour EEG monitoring has been used tostudy the wakeful and nocturnal EEG patteras of benign epilepsy with centro-temporal spikes, and tostudy the EEG patterns of 77 cases with different types of seizures. Epidemiological study of febrileconvulsions in 6 837 children and mental retardation in 85 170 children has been conducted.

我院小儿神经学组近年来对癫痫及智力低下进行了综合研究。在整体动物及神经细胞水平研究了神经肽(CCK,Som)与神经递质(GABA)之间的关系;初步探讨了铁诱发癫痫的化学机制;研究了抗癫痫药对发育中脑的影响;用双盲交叉法观察了新药“抗病灵”的疗效;利用24小时脑电图从临床电生理角度进一步探讨了癫痫的发病机制,解决了癫痫难以观察的问题。还在全国范围内进行了智力低下的流行病学调查,并分析其原因。

Postnatal development of auditory brainstem responses(ABR)and auditory middle latency responses(M LR)had been studied continously for three months in the same group of rat pups.After birth,ABR and MLR were evoked at 14 and 17 days respectively.The peak latencies of ABR's waves shortened rapidly at first postnatal month,which occurred more quickly in the wave origi- nated from the lower structures of the auditoy brainstem pathway.The peak latencies of MLR's waves obviously shortened also,at first postnatal month,which...

Postnatal development of auditory brainstem responses(ABR)and auditory middle latency responses(M LR)had been studied continously for three months in the same group of rat pups.After birth,ABR and MLR were evoked at 14 and 17 days respectively.The peak latencies of ABR's waves shortened rapidly at first postnatal month,which occurred more quickly in the wave origi- nated from the lower structures of the auditoy brainstem pathway.The peak latencies of MLR's waves obviously shortened also,at first postnatal month,which occurred more quickly in the wave originated from the lower structures of auditory pathway.These results suggested that fisrt month af- ter birth was the most important period for development of function of auditory nervous system in rats,which proceeded in a centripetal sequence from the most peripheral to the rostral structures.

连续3个月观察同一批新生 SD 纯种大鼠听觉脑干电反应(ABR)和中潜伏期听觉电反应(MLR)的生后发育.ABR 在生后第14天引出,而 MLR 在生后第17天方出现;ABR 各波峰潜伏期在生后一月内迅速递减,且源自脑干较低位结构的波的波峰潜伏期缩短较快;MLR 各波峰潜伏期在生后一月内也明显缩短,且较低位起源的波的波峰潜伏期较早达成年大鼠值.上述结果表明生后一月是大鼠听觉神经系统功能发育最重要时期,且按由低到高、逐级向上的向中性模式进行.

 
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