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moderate hypothermia
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  亚低温
    Effects of moderate hypothermia on p-ERK/p38 MAPK signal pathway following hypoxic-ischemic brain injury in neonatal rats
    亚低温对新生大鼠缺氧缺血性脑损伤p-ERK/p38 MAPK的影响
短句来源
    Objective To study the effect of moderate hypothermia on cerebral mitochondrial succinate dehydrogenase (SDH) activities, mitochondrial complex Ⅱ activity and the capacity of ATP synthesization in newborn rats with hypoxic-ischemic brain damage (HIBD).
    目的 研究亚低温治疗对缺氧缺血脑损伤 (hypoxic -ischemicbraindamage ,HIBD)新生大鼠的脑线粒体琥珀酸脱氢酶 (succinatedehydrogenase ,SDH)复合酶Ⅱ的活性及ATP合成能力的影响 ,以探讨亚低温治疗的神经保护机制。
短句来源
    Methods The TBI model were generated by the fluid percussion method in 20 piglets,and these piglets were then randomly divided into normal temperature group(intracranial temperature(37.5℃)38℃,n=10) and moderate hypothermia group(intracranial temperature(34℃)±(0.2℃),n=10).
    方法将幼猪TB I模型(液压法)随机分为常温对照组(颅温37.5℃~38.5℃;n=10)和亚低温组(34℃±0.2℃;n=10)。
短句来源
    Objective To investigate the effects of moderate hypothermia management on p-ERK/p38 MAPK signal pathway following hypoxic-ischemic brain damage (HIBD) in neonatal rats.
    目的探讨丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPK)信号转导通路p-ERK/p38部分活化在亚低温治疗新生大鼠缺氧缺血性脑损伤(hypoxic-ischemic braindamage,HIBD)中的作用及意义。
短句来源
    Conclusions Hypothermia therapy can inhibit the apoptosis after cerebral hypoxia-ischemia by moderate hypothermia through p-ERK1/2p-p38MAPK signal transduction pathway.
    结论亚低温治疗可通过p-ERK/p38MAPK信号转导通路抑制HIBD后的细胞凋亡。
短句来源
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  中度低温
    Methods: From March 1996 to April 2003, 208 infants were operated under moderate hypothermia and high perfusing flow, the blood flow was 80~150 ml/(kg·min), 200 ml/(kg·min) less than 10 kg weight, critical congenital heart disease were applied with modified ultrafiltration (MUF), perfusion pressure kept 30~80 mmHg.
    方法回顾该院1996年3月~2003年4月208例婴幼儿先心病术中体外循环情况,采用中度低温、中高流量灌注,灌注流量80~150 ml/kg·min,10 kg以下高达200 ml/kg·min。 预充液以胶体为主,晶胶比为0.06~0.6。
短句来源
    110 operations under moderate hypothermia(temperature ranged from 26℃ to 28℃),27 operations under deep hypothermia(temperature ranged from 16℃ to 18℃) and low flow(50ml/(kg·min)),and 67 operations under deep hypothermia circulation arrest.
    手术均在体外循环下完成,中度低温(26℃~28℃)110例,深低温(16℃~18℃)停循环67例,深低温低流量[50m l/(kg.m in)]27例。
短句来源
    Of the 681 cases,64 cases were treated with general anesthesia in normal thermia,468 with extracorporeal circulation in mild and moderate hypothermia, and 149 with extracorporeal circulation in deep hypothermia.
    常温全麻64例,浅低温和中度低温体外循环468例,深低温低流量体外循环149例。
短句来源
    22 cases were done with deep hypothermic circulatory arrest, 15 cases were subjected to mild hypothermia, moderate hypothermia was used in 8 cases.
    体外循环 (CPB)中采用深低温停循环 2 2例 ,中度低温 1 5例 ,浅低温 8例。
短句来源
    The study included 129 with moderate hypothermia, 12 with deep hypothermia and low flow (DHLF), 8 with continuously perfusion in main pulmonary for patients with severe PH during the CPB;
    129例为中度低温,12例复杂先心病应用深低温灌注技术,8例合并重度肺高压的婴幼儿利用氧合血持续肺灌注。
短句来源
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  中低温
    There were 31 cases with moderate hypothermia high flow rate, 11 cases with deep hypothermic low flow rate, 9 cases with deep hypothermic circulatory arrest, and 2 cases with normothermia high flow rate.
    中低温高流量灌注 3 1例 ,深低温低流量 (DHLF) 11例 ,深低温停循环 (DHCA) 9例 ,常温体外循环 2例。
短句来源
    38 adopted moderate hypothermia moderate flow perfusion,and another 2 underwent deep hypothermia low flow perfusion(DHLF). The urine during CPB was 50~1 000(324.7±268.9) ml.
    38例采用中低温中低流量灌注,2例采用深低温低流量CPB,CPB中尿量50~1000(324.7±268.9)毫升(ml)。
短句来源
    Clinical comparison of mild hypothermia beating-heart and moderate hypothermia arrested-heart intracardiac procedure in pediatrics
    婴幼儿浅低温心脏不停跳和中低温停跳心内直视手术临床对比
短句来源
    Sixty-seven infants with congenital heart diseases underwent open heart surgery with CPB.Their Hb were 80~100g/L after hemodilution. In most cases, moderate hypothermia and high flow rate were employed.
    67例患先心病的婴儿在体外循环下接受心脏直视手术,稀释后血色素都维持于80~100g/L,对大多数病例均采用中低温高流量灌注。
短句来源
    CONCLUSION: The effect of mild hypothermia beating heart CPB is superior to that of moderate hypothermia arrested heart CPB in pediatric cardiac surgery.
    结论 :浅低温体外循环心脏不停跳技术在婴幼儿心肌保护、改善术后呼吸功能及维持酸碱平衡等方面均优于中低温体外循环心脏停跳技术 .
短句来源
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  “moderate hypothermia”译为未确定词的双语例句
    The study included 44 with deep hypothermia circulatory arrest (DHCA), 7 with deep hypothermia low flow rate (DHLF), 23 with DHCA+DHLF, 37with moderate hypothermia bypass and another 18 underwent NCPB. RESULTS CPB times were (75.7±41.5)min, (48.9±424.1)min, and (33.9±15)min.
    5 2例采用改良超滤 (MUF)方法 ,4例进行常规超滤 (CUF)方法 ,90例运用常规超滤结合改良超滤方法。 结果 CPB时间为 ( 75 .7± 41.5 )min ,主动脉阻断时间是 ( 48.9± 2 4.1)min,停循环时间为 ( 3 3 .9± 15 .1)min,低流量时间为 ( 62± 2 8.9)min。
短句来源
    Protective Effect and Underlying Mechanisms of Moderate Hypothermia and Huperzine a on Neonatal Rats Brain after Hypoxia-ischemia
    亚低温、石杉碱甲对新生大鼠缺氧缺血脑损伤的保护作用及机制
短句来源
    The Study of the Moderation Effects of Moderate Hypothermia on Cerebral Energy Metabolism in Immature Rats with Hypoxic-Ischemic Brain Damage
    亚低温对新生鼠缺氧缺血脑损伤的能量代谢的作用
短句来源
    Protective Effects of Allopurinol and Moderate Hypothermia on Hypoxic-ischemic Brain Damage in Neonatal Rats
    别嘌呤醇和亚低温对新生大鼠缺氧缺血性脑损伤的保护作用
短句来源
    Methods Between 1995 and 2001, 5 patients with TOF PA underwent radical repair with moderate hypothermia cardiopulmonary bypass.
    方法  1995~ 2 0 0 1年 ,5例 2岁以下TOF PA患儿均施行根治手术 ,其中 ,肺动脉瓣膜性闭锁 2例 ,肺动脉瓣闭锁 +肺动脉干发育不良 3例。
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  moderate hypothermia
Several studies in animal models of ALF set the stage for the clinical application of moderate hypothermia in man.
      
Global forebrain ischemia with concurrent moderate hypothermia (30°C) was induced in gerbils by 10-minute bilateral carotid artery occlusion followed by recirculation periods of 1 hour (h), 6h, 24h, and 48h.
      
The present study examined the effect of moderate hypothermia on the expression of heat shock protein (HSP)-72 following transient forebrain ischemia in gerbils by immunohistochemistry.
      
We have demonstrated that moderate hypothermia early in the course of meningitis decreases leukocyte sequestration within the brain parenchyma.
      
Preliminary intraperitoneal injection of dalargin had practically no effect on oxidative modification of plasma proteins during moderate hypothermia.
      
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A total of 22 cases of cor triatriatum with an average age of 7. 46 years underwent surgical treatment from January 1983 to March 1992 in Fu Wai Hospital ,among them 15 cases were true cor triatriatum, the others were atypical. They constituted only 0-31% of the surgical cases of congenital heart disease at the same period. The main associated anomalies were atrial septal defect in 16 cases and others such as ventricular septal defect, left superior vena cava etc. in 9. Cyanosis in 7 cases, squatting in 4. 18...

A total of 22 cases of cor triatriatum with an average age of 7. 46 years underwent surgical treatment from January 1983 to March 1992 in Fu Wai Hospital ,among them 15 cases were true cor triatriatum, the others were atypical. They constituted only 0-31% of the surgical cases of congenital heart disease at the same period. The main associated anomalies were atrial septal defect in 16 cases and others such as ventricular septal defect, left superior vena cava etc. in 9. Cyanosis in 7 cases, squatting in 4. 18 were diagnosed by echocardiography preoperatively and 4 were identified during operation. Operations were performed with cardiopulmonary bypass under moderate hypothermia. Abnormal diaphragm in the left atrium was completely excised and other associated anomalies were also corrected, the early results were good except one postoperative death. The authors experienced: ①For the diagnosis of cor triatriatum preoperatively, the finding of abnormal diaphragm image in the left atrium by echocardiography is helpful and further invasive examination is not needed. Routine examination of the left atrium is necessary during atrial septal defect correction as cor triatriatum is of ten misdiagnosed as atrial septal defect. ②Cor triatriatum with small restrictive aperture in the diaphragm and early severe symptoms is strongly indicated for early surgical treatment. ③The technique of surgery is not difficult and good exposure of the abnormal diaphragm would help to prevent important adjacent structures from injury. The margin of excision of the diaphragm should be finely sutured to prevent late myocardial rupture. Myocardial protection during and after operation should be emphasized due to the small left ventricle.

我院自1983年1月至1992年3月间共手术治疗小儿三房心22例。其中完全型15例,部分型7例。手术均在低温体外循环下进行。术后死亡1例,其余均痊愈出院。本文着重讨论了本病的诊断、鉴别及手术要点。

Sixty-seven infants with congenital heart diseases underwent open heart surgery with CPB.Their Hb were 80~100g/L after hemodilution.In most cases, moderate hypothermia and high flow rate were employed.They were divided into Group A(n=30)and B(N=37)according to the different fundamental way.In Group A,12 cases needed hemofiltration during CPB because of oliguria.In Group B dopamine 3~4μg/kg/min was infused continuously during CPB.In 7 cases of this group,centrifuged residual blood in the heart-lung machine...

Sixty-seven infants with congenital heart diseases underwent open heart surgery with CPB.Their Hb were 80~100g/L after hemodilution.In most cases, moderate hypothermia and high flow rate were employed.They were divided into Group A(n=30)and B(N=37)according to the different fundamental way.In Group A,12 cases needed hemofiltration during CPB because of oliguria.In Group B dopamine 3~4μg/kg/min was infused continuously during CPB.In 7 cases of this group,centrifuged residual blood in the heart-lung machine was transfused back to them.The results showed marked difference existed between the two groups on mean vol.of urine,plasma free Hb,arterial lactic acid and hemoglobinuria(p<0.01 or<0.05) at the termination of CPB.The results of Group B were better.The authors pointed out:It is of great benefit to keep water and electrolytes balance of infants,to prevent over dilution and maintain appropriate colloid pressure,to take the sufficient flow and low dose of dopamine during CPB and to use the centrifuged residual blood for infants.

67例患先心病的婴儿在体外循环下接受心脏直视手术,稀释后血色素都维持于80~100g/L,对大多数病例均采用中低温高流量灌注。按基本方法的差异分为A(30例)、B(37例)两组。A组中12例因尿少在CPB过程中加用了血液超滤;B组在CPB过程中持续输注多巴胺3~4μg/kg/min,该组机器中的余血7例经离心后将血球部份输回体内。两组在CPB结束时,在平均尿量、血浆游离血红蛋白和动脉血乳酸含量及血色素尿均存在明显差异(p<0.01或<0.05)。作者认为防止过度稀释,维持适当的胶体渗透压,在CPB过程中充分的流量和应用低浓度多巴胺增加排尿及机器余血离心后输回,对减轻婴儿水负荷,维持水电解质平衡有较大的临床意义。

URPOSE To evaluate the early result and to discuss the indication and perioperative management of primary surgical closure of ventricular septal defects (VSD) in small infants.METHODS Thirty eight small infants met the criteria for inclusion in the study. The age and body weight were (8.1±3.4) months and (6.8±1.8)kg respectively. The locations of VSD were at the inlet septum in 24 patients and at the subarterial septum in 14 patients. The pulmonary systolic pressure in 9 cases underwent cardiac catheterization...

URPOSE To evaluate the early result and to discuss the indication and perioperative management of primary surgical closure of ventricular septal defects (VSD) in small infants.METHODS Thirty eight small infants met the criteria for inclusion in the study. The age and body weight were (8.1±3.4) months and (6.8±1.8)kg respectively. The locations of VSD were at the inlet septum in 24 patients and at the subarterial septum in 14 patients. The pulmonary systolic pressure in 9 cases underwent cardiac catheterization before operation was (7.7±2.0)kPa and the pulmonary resistance was (58.7±12.1)kPa·s/L. Patients were divided into two groups based on the age: group Ⅰ infants aged 6 months or less (n=14) and group Ⅱ aged more than 6 months (n=24). Primary surgical closure was performed under moderate hypothermia (n=27) or deep hypothermia with low perfusion volume (n=11) cardiopulmonary bypass.RESULTS No early or late deaths occurred in both groups. Major complications occurred similarly in both groups (21.4% in group Ⅰ versus 16.7% in group Ⅱ, P>0.05). No patients have required a second operation. The pulmonary pressure decreased significantly early after the closure of VSD.CONCLUSIONS Findings imply that early surgical closure of VSD is indicated in patients with nonrestrictive VSD associated with congestive heart failure or growth retardation.

目的探讨1岁以下婴儿室间隔缺损一期根治术指征及围术期处理。方法对38例12月龄以下婴儿室间隔缺损行一期根治术。平均年龄(8.1±3.4)月,平均体重(6.8±1.8)kg。超声心动图证实室间隔缺损,膜部流入道型24型,双动脉干下型14例,缺损直径7~15mm,并提示21例伴有不同程度肺动脉压力升高。9例行右心导管检查,肺动脉收缩压为(7.7±2.0)kPa,肺循环阻力为(58.7±12.1)kPa·s/L。采用中度低温(n=27)或深低温低流量(n=11)体外循环技术行一期根治术。年龄6个月以下者为组Ⅰ(n=14),大于6月龄者为组Ⅱ((n=24)。结果全组手术无死亡。主要并发症为气胸和肺不张,两组相比无显著差异。术后早期肺动脉压力即降至正常,心功能明显改善。结论1岁以下婴儿室间隔缺损一期根治术手术安全,疗效满意。

 
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