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moderate hypothermia
相关语句
  中度低温
    Effects of moderate hypothermia on alveolar capillary membrane permeability in endotoxin-induced acute lung injury in rats
    中度低温对内毒素诱导急性肺损伤大鼠肺泡毛细血管膜通透性的影响
短句来源
    Objective To investigate the effects of moderate hypothermia on the permeability of alveolar capillary membrane in acute lung injury (ALI) induced by lipopolysaccharide (LPS) .
    目的探讨中度低温对脂多糖(LPS)诱导急性肺损伤(ALI)大鼠肺泡毛细血管膜通透性的影响。
短句来源
    Conclusion Moderate hypothermia significantly decreases the increased permeability of alveolar capillary membrane in a rat model of ALI induced by LPS.
    结论中度低温对ALI大鼠可通过减轻肺内PMN聚集,降低肺泡毛细血管膜通透性,在一定程度上减轻了肺损伤。
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  moderate hypothermia
Several studies in animal models of ALF set the stage for the clinical application of moderate hypothermia in man.
      
Global forebrain ischemia with concurrent moderate hypothermia (30°C) was induced in gerbils by 10-minute bilateral carotid artery occlusion followed by recirculation periods of 1 hour (h), 6h, 24h, and 48h.
      
The present study examined the effect of moderate hypothermia on the expression of heat shock protein (HSP)-72 following transient forebrain ischemia in gerbils by immunohistochemistry.
      
We have demonstrated that moderate hypothermia early in the course of meningitis decreases leukocyte sequestration within the brain parenchyma.
      
Preliminary intraperitoneal injection of dalargin had practically no effect on oxidative modification of plasma proteins during moderate hypothermia.
      
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The experience of XIJING oxygenator performed in 2 076 during open heart surgery with cardiopulmonary bypass(CPB) from May 1989 to June 1997 in Shanghai Chest Hospital was reported. There were 1 026 male patients and 1 050 female patients, aged 4-63 years, and with body weight 12-90kg. The moderate and profound hemodilution and moderate hypothermia were adopted. The ratio of oxygen flow to blood flow was decimal four to one, and gas-blood analysis was monitored. The mean arterial pressure, central venous...

The experience of XIJING oxygenator performed in 2 076 during open heart surgery with cardiopulmonary bypass(CPB) from May 1989 to June 1997 in Shanghai Chest Hospital was reported. There were 1 026 male patients and 1 050 female patients, aged 4-63 years, and with body weight 12-90kg. The moderate and profound hemodilution and moderate hypothermia were adopted. The ratio of oxygen flow to blood flow was decimal four to one, and gas-blood analysis was monitored. The mean arterial pressure, central venous pressure and urinary output were maintained in 8-l0kPa, 0-0.9kPa and 200-1 000ml respectively during cardiopulmonary bypass. In these patients 940 hearts were spontaneously defibrillated (SD), and 1 136 patients were electrically defibrillated during CPB. The gas-blood analysis maintained in normal range, and the operation was successful. Oxygenation effectiveness of XIJING bubble oxygenator was good. Pa,O2 was maintained in more than 20kPa and Pa,co2 in 4. 0-5. 4kPa. There were three lines of defoamer and microfilter in this device. It is an effective oxygenator with higher quality and easy to perform.

我院自1989年5月至1997年6月,在体外循环心内直视手术中应用西京鼓泡式氧合器2076例,其中男性1026例;女性1050例;年龄范围4~62岁;体重范围12~90kg;体表面积在0.5~1.96m~2.全组病例均采用中深度血液稀释和中度低温体外循环方法,氧合器的氧与血比例为0.4~0.8:1,并测定血气分析.体外循环转流时间最长为264分钟;术中平均动脉压维持在8~10kpa,中心静脉压0~0.9kPa.心脏自动复跳940例;电击复跳为1136例.术中尿排量200~1000ml,色清.术中、术后血液气体分析均在正常范围,手术顺利,无意外故障发生.评价氧合器的优劣主要根据三个指标:氧合作用、祛泡功能和血液有形成份破坏程度.该氧合器氧合效果较佳,动脉氧分压在20kPa以上,二氧化碳分压在4.0~5.4kPa.并有三道祛泡装置和微孔过滤器,祛泡性能良好,病人术中、术后均无气栓发生.由于氧与血比例较小,为此对血液有形成份破坏较小,测定血游离血红蛋白均在30mg%以下.西京鼓泡式氧合器集氧合、变温、祛泡、过滤、贮血为一体.使用方便,是国内目前质量较高的氧合器.

Objective To investigate the effects of moderate hypothermia on the permeability of alveolar capillary membrane in acute lung injury (ALI) induced by lipopolysaccharide (LPS) .Methods Thirty-four adult male SD rats weighing 300-350g were randomly divided into 4 groups: control group (n = 8) ; LPS group (n = 10); hypothermia group (n = 8) and LPS + hypothermia group (n = 8) . The animals were anesthetized with intraperitoneal (i.p.) 1% pentobarbital 30 mg·kg-1, intubated and mechanically ventilated...

Objective To investigate the effects of moderate hypothermia on the permeability of alveolar capillary membrane in acute lung injury (ALI) induced by lipopolysaccharide (LPS) .Methods Thirty-four adult male SD rats weighing 300-350g were randomly divided into 4 groups: control group (n = 8) ; LPS group (n = 10); hypothermia group (n = 8) and LPS + hypothermia group (n = 8) . The animals were anesthetized with intraperitoneal (i.p.) 1% pentobarbital 30 mg·kg-1, intubated and mechanically ventilated (RR 80 bpm, VT 20 ml·kg-1, I: E 1:2) . Right external jugular vein and left carotid artery were cannulated for BP and CVP monitoring and blood sampling. ALI was induced by LPS 1.0 mg·kg-1 i.p. and 16h later, intratracheal instillation of LPS 1.5 mg·kg-1. ALI was considered established when PaO2/FiO2 ≤300. Hypothermia was induced by surface cooling. Body T0 was reduced to 32.5-33.0℃. In control and hypothermia groups normal saline was given instead of LPS. Arterial blood samples were taken for blood gas analysis and MAP and CVP were recorded before (T0, baseline) and 1, 2, 3, 4 h after ALI (T1-4) . At the end of experiment (4h after ALI was established) the animals were killed by exsanguination. The lungs were removed. Lung lavage was performed and the concentration of albumin in bronchoalveolar lavage fluid (BALF), the left lung wet/dry weight ratio, myeloperoxidase (MPO) activity of lung tissue were measured. Lung tissue was also taken for histologic examination by transmission electron microscopy.Results There was no significant difference in hemodynamics among the 4 groups. PaO2/FiO2 and PaCO2 remained unchanged in the control group and hypothermia group. PaO2 /FiO2 was significantly decreased and PaCO2 was significantly increased as compared to the baseline values (T0) in LPS group (P < 0.01). Hypothermia inhibited the increase in PaCO2 but had no effect on the decrease in PaO2/FiO2 induced by LPS. LPS significantly increased the lung W/D weight ratio, the concentration of albumin in BALF and MPO activity of the lung tissue as compared with the control group (P < 0.01 or 0.05) . Moderate hypothermia significantly reduced the increase in lung W/D ratio, albumin concentration in BALF and lung tissue MPO activity induced by LPS but the lung W/D weight ratio in LPS + hypothermia group was still significantly higher than that in control group (P < 0.05) . Electron microscopic examination showed that the alveolar capillary membrane was severely damaged in LPS group and moderate hypothermia significantly attenuated the injury to the alveolar capillary membrane. Conclusion Moderate hypothermia significantly decreases the increased permeability of alveolar capillary membrane in a rat model of ALI induced by LPS.

目的探讨中度低温对脂多糖(LPS)诱导急性肺损伤(ALI)大鼠肺泡毛细血管膜通透性的影响。方法34只雄性SD大鼠,随机分为4组。腹腔注射LPS 1.0 mg·kg-1,16 h后在机械通气下气管内滴注1.5 mg·kg-1LPS(0.5 ml)方法建立ALI模型。正常对照组(C组,n=8):只给予等量的生理盐水;内毒素组(L组,n=10):给予LPS;低温组(H组,n=8):将体温降低并维持在32.5-33.0℃, 但不给予LPS;内毒素复合低温组(L+H组,n=8):给予LPS,并且当氧合指数(PaO2/FiO2)≤300mm Hg 时将体温降低并维持在32.5-33.0℃。分别于ALI时、ALI后1、2、3、4 h记录平均动脉压(MAP)和中心静脉压(CVP),同时测定动脉血气的变化。于ALI后4 h处死大鼠,检测支气管肺泡灌洗液(BALF) 中白蛋白浓度、左肺湿/干重(W/D)及肺组织髓过氧化物酶(MPO)活性,电镜下观察肺泡毛细血管膜形态结构的变化。结果L组PaO2/FiO2降低(P<0.01),PaCO2在ALI后3、4 h升高(P<0.01);与L组比较,L+H组PaO2,FiO2差异无统计学意义...

目的探讨中度低温对脂多糖(LPS)诱导急性肺损伤(ALI)大鼠肺泡毛细血管膜通透性的影响。方法34只雄性SD大鼠,随机分为4组。腹腔注射LPS 1.0 mg·kg-1,16 h后在机械通气下气管内滴注1.5 mg·kg-1LPS(0.5 ml)方法建立ALI模型。正常对照组(C组,n=8):只给予等量的生理盐水;内毒素组(L组,n=10):给予LPS;低温组(H组,n=8):将体温降低并维持在32.5-33.0℃, 但不给予LPS;内毒素复合低温组(L+H组,n=8):给予LPS,并且当氧合指数(PaO2/FiO2)≤300mm Hg 时将体温降低并维持在32.5-33.0℃。分别于ALI时、ALI后1、2、3、4 h记录平均动脉压(MAP)和中心静脉压(CVP),同时测定动脉血气的变化。于ALI后4 h处死大鼠,检测支气管肺泡灌洗液(BALF) 中白蛋白浓度、左肺湿/干重(W/D)及肺组织髓过氧化物酶(MPO)活性,电镜下观察肺泡毛细血管膜形态结构的变化。结果L组PaO2/FiO2降低(P<0.01),PaCO2在ALI后3、4 h升高(P<0.01);与L组比较,L+H组PaO2,FiO2差异无统计学意义,但PaCO2在ALI后3、4 h降低(P<0.05)。与C组比较,L 组BALF中白蛋白浓度、W/D及肺组织MPO活性升高(P<0.01或0.05);而L+H组上述指标则较L 组下降(P<0.01或0.05)。电镜结果:C、H组肺泡毛细血管膜结构基本正常;L组毛细血管内皮明显剥脱;而L+H组毛细血管内皮剥脱程度较L组减轻。结论中度低温对ALI大鼠可通过减轻肺内PMN聚集,降低肺泡毛细血管膜通透性,在一定程度上减轻了肺损伤。

 
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