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inflammation     
相关语句
  炎症
     The essential role of Eotaxin and CCR3 in airways inflammation of allergic asthma
     过敏性哮喘中Eotaxin及CCR3致气道炎症机制的研究
短句来源
     Inflammation in Acute Coronary Syndrome and Anti-inflammation Mechanisms of Statin
     急性冠脉综合征炎症反应及他汀类降脂药的抗炎机制
短句来源
     The Protective Effects and Mechanisms of PPARγ and TZDs on Renal Tubulointerstitial Inflammation and Fibrosis
     PPARγ和TZDs对肾小管间质炎症和纤维化的保护作用及其机制
短句来源
     IL-12 DNA Plasmid and BCG Vaccination to Immunoloregulate Airway Allergic Inflammation of Mice
     BCG、IL-12真核表达质粒对小鼠气道变态反应炎症免疫调节作用的研究
短句来源
     Lipopolisaccharide-Induced Cardiac Inflammation and Left Ventricular Dysfunction: Role of Toll-Like Receptor-4 in the Adult Heart
     Toll样受体4在内毒素诱导的小鼠心肌炎症因子表达和左室功能不全中的作用
短句来源
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     Inflammation in Acute Coronary Syndrome and Anti-inflammation Mechanisms of Statin
     急性冠脉综合征症反应及他汀类降脂药的抗机制
短句来源
     Mechanism Study of Andrographolide on Inflammation
     穿心莲内酯(Andro)抗机制的研究
短句来源
     DIFFERENTIAL DIAGNOSIS BETWEEN INFLAMMATION AND TUMOR OF THE BRAIN STEM: An Analysis of 36 Cases of Stem Encephalitis and 30 Cases of Brain stem Tumor
     脑干与脑干肿瘤的鉴别诊断——36例脑干和30例脑干肿瘤的临床分析
短句来源
     ANTIINFLAMMATORY ACTIVITY OF BUFEXAMAC ON TOPICAL SKIN INFLAMMATION MODEL INDUCED BY FORMALDEHYDE
     丁苯乙肟对甲醛皮肤致模型的抗作用研究
短句来源
     The brain stem inflammation induced human T-cell leukemia virus
     成人T细胞白血病病毒引起的脑干
短句来源
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  炎症反应
     Inflammation in Acute Coronary Syndrome and Anti-inflammation Mechanisms of Statin
     急性冠脉综合征炎症反应及他汀类降脂药的抗炎机制
短句来源
     Effect of PPARγ Gene Silencing on the Control of Cell Inflammation
     PPARγ基因沉默对细胞炎症反应的调控作用
短句来源
     Study on Pathogenic Mechanism for Respiratory Tract Inflammation
     呼吸道炎症反应病因学机制的研究
短句来源
     The Temporal Relationship among Dark Neuron, Cytoskeleton, Inflammation and Histological Changes of Different Fields in Human Cerebral Infarction
     人脑梗死不同时间组织学分区与暗神经元、细胞骨架变化、炎症反应的关系
短句来源
     INFLAMMATION REACTION INDUCED OSTEOGENESIS UNDER PERIOSTEUM IN RATS-AN ANIMALMODEL AND MECHANISM STUDY
     炎症反应诱导大鼠骨膜下成骨──动物模型与机制研究
短句来源
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  炎性
     Role of tumor necrosis factor,interleukin1β and macrophage inflammation proteinl α in infection and organ injury: Therapeufic investigation
     肿瘤坏死因子α、白细胞介素1β和巨噬细胞炎性蛋白1α在感染及器官损伤中的作用及治疗探讨
短句来源
     The IL-8 cooperating with TNF-α may be responsible for the persistence and amplification of airway inflammation with COPD.
     结论BALF中的IL-8与COPD的气道炎症密切相关,IL-8与TNF-α相互作用,通过趋化激活中性粒细胞等炎性细胞共同参与COPD发病。
短句来源
     The pathological sections also showed that the inflammation reaction in LPS+3%CO group was the lightest.
     病理切片的比较亦提示LPS+3%CO组其炎性改变最轻。
短句来源
     Myoloperoxidase(MPO),matrix metalloproteinase-9(MMP-9),soluble CD_40 L(sCD_40L),B-type natriuretic peptide(BNP),Interleukin-6(IL-6) are involved in inflammatory reaction and its regualation. AS the markers of the inflammation,all of these have tightly relationship with the rupture of the unstable atheromatous plagues and may serve as a potential marker of unstable plague.
     骨髓过氧化物酶(MPO)、基质金属蛋白酶-9(MMP-9)、可溶性CD40配体(sCD40L)、B型利钠肽(BNP)和白细胞介素-6(IL-6)等参与这种炎性反应过程及其调节,作为ACS的炎症标志物,与不稳定粥样斑块破裂密切相关,可作为动脉粥样硬化斑块不稳定的标志。
短句来源
     Objective Smoking effects on vascular endothelial dilatation function and on inflammation media such as interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) were to be evaluated in healthy young adults and in passive smokers.
     目的探讨被动吸烟对健康青年人血管内皮舒张功能和白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)等炎性介质的影响。
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  inflammation
Some of them have anti-microbial effects, counteract inflammation, and inhibit tumor progression activities.
      
Leptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding more quickly than orexin-A does, and both of them may contribute to the metabolic disorders in acute inflammation.
      
The effect of hyperlipidemia and inflammation on endothelial functions was studied.
      
Hepatic steatosis, lobular inflammation, hepatocytic ballooning and fibrosis were presented widespread in NAFLD liver tissues.
      
Furthermore, macrovesicular steatosis predominantly located in acinar zone 3 was the main histologic feature of NAFLD and lobular inflammation was usually presented mildly.
      
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Subcutaneous injection of O.1 ml egg-white at the ankle joint of the rat hind leg caused inflammation of the joint which subsided only very slowly. When gentianine was administered intraperitoneally at the dosage of 90 mg/kg 30 minutes prior to the egg-white,the swelling was less severe and disappeared in a shorter time than the control group.In bilateral adrenalectomized rats and in nor- mal rats anesthetized with pentobarbital,however,pretreatment with gentianine neither prevented the development of...

Subcutaneous injection of O.1 ml egg-white at the ankle joint of the rat hind leg caused inflammation of the joint which subsided only very slowly. When gentianine was administered intraperitoneally at the dosage of 90 mg/kg 30 minutes prior to the egg-white,the swelling was less severe and disappeared in a shorter time than the control group.In bilateral adrenalectomized rats and in nor- mal rats anesthetized with pentobarbital,however,pretreatment with gentianine neither prevented the development of egg-white irritation“arthritis”nor speeded the recuperation from the inflammation.Obviously,gentianine affects egg-white ir- ritation“arthritis”in rats under conditions that their adrenals are intact.How- over,gentianine does not act on the adrenals per se;its action is mediated via the nervous and hypophyseal system.Gentianine acts on formalin irritation“arthritis” probably in a similar manner. Pretreatment of the animal with chloroquine,sodium salicylate,cortisone or an alcoholic extract of Gentiana macrophylla did not prevent the development of egg- white irritation“arthritis”.Nevertheless,the swelling of the ankle joint disappeared more rapidly.For formalin irritation“arthritis”,gentianine was more effective than sodium salicylate and as effective as chloroquine,cortisone and an alcoholic extract of Gentiana macrophylla.

从大鼠后足掌部向踝关节皮下注射蛋清0.1毫升,半小时后踝关节卽呈腫胀且消退很慢。如于注射蛋清前半小时腹腔注射秦艽甲90毫克/千克,則踝关节部腫胀程度较轻,且消退亦快。但在去除两侧腎上腺的大鼠及用戊巴此妥纳麻醉的正常大鼠,则预先注射秦艽甲并不能抑制蛋清性“关节炎”的产生,亦不促进其消退。可见秦艽甲对蛋清性“关节炎”的作用必须在动物两侧腎上腺保持完整时才能发生。但秦艽甲并非直接作用于腎上腺,而是通过神经系统的。秦艽甲对因注射甲醛而产生的“关节炎”的作用也是如此。预先注射氯喹、秦艽中性酒精浸剂、水杨酸鈉或考地松,虽不抑制蛋清性“关节炎”的产生,但都能加速关节部腫胀的消退。对因注射甲醛而产生的“关节炎”的治疗作用,秦艽鹼甲甲与氯喹、考地松及秦艽中性酒精浸剂相似,但较水杨酸钠略强。

The root of "San Chi" (Panax major Tng and Panax japonicum. C. A. Mey.) has long been used in Chinese medicine as an analgesic, haemostatic, and antiphlogistic agent. In the present study, the toxicity of "San Chi" for the mice was found to be very low, when an aqueous extract was administered orally to mice at the dosage of 40g/kg no death was observed. Subcutaneous injection of 0.1ml egg-white, formalin, or dextran into the hind paw of normal rats caused a marked swelling of the joint, which subsided very...

The root of "San Chi" (Panax major Tng and Panax japonicum. C. A. Mey.) has long been used in Chinese medicine as an analgesic, haemostatic, and antiphlogistic agent. In the present study, the toxicity of "San Chi" for the mice was found to be very low, when an aqueous extract was administered orally to mice at the dosage of 40g/kg no death was observed. Subcutaneous injection of 0.1ml egg-white, formalin, or dextran into the hind paw of normal rats caused a marked swelling of the joint, which subsided very slowly. When rats were given "San Chi" aqueous extract at the dosage of 10g/kg through a stomach tube, the swelling of the hind paw was inhibited significantly, and subsided more rapidly. In addition, it was found that "San Chi" exerted an inhibiting effect on the rat granuloma induced by cotton-pellet. On the other hand, in bilateral adrenalectomized rats "San Chi", as a rule, prevented the development of the inflammation induced by formalin. In normal rats "San Chi" did not deplete the adrenal ascorbic acid. However, in fasting normal and adrenalectimized ndce, oral administration of "San Chi" extract pro- duced significantly more liver glycogen deposition than could be accounted for by its suger content. Besides, stress condition such as that during swimming depleted the ascorbic acid content of the adrenals in the rats. However, previous administration of "San Chi" ex- tract exhibited an inhibiting effect on such depletion. In addition, "San Chi" may prolong the survival of rats after adrenalectomy. It appears from these results that "San Chi" possesses adreno-corticohormone-like ac- tivity.

本文报告竹节参(罗汉三七)及大叶三七对大鼠实验性“关节炎”的治疗或抑制作用.口服三七水煎剂10克/公斤对注射鸡蛋白、甲醛、右旋糖酐所引起的大鼠实验性“关节炎”及棉球肉芽肿均有明显的抑制作用,对去肾上腺动物的甲醛性关节炎三七水煎剂仍有治疗作用.无论一次或多次口服三七水煎剂均不能使大鼠肾上腺内维生素C含量降低,也不增加肾上腺重量,表明三七水煎剂不能兴奋垂体——肾上腺系统.三七能增加正常饥饿小鼠和去肾上腺饥饿小鼠的肝糖原含量;大鼠连续服用三七后,对非特异性刺激有抑制作用;亦能延长去肾上腺未成年大鼠的生存时间。实验结果表明,三七水煎剂似具有糖皮质激素样作用,其抗炎作用可能与此有关.

The husked cottonseed meal, rawcottonseed oil, extracts of cottonseedmeal and pure gossypol have been fedseparately to adult male rats for 4weeks. It was usually found that thesperms were dead in the caudal epi- didymis and vas deferens and the spermmorphology was abnormal while in thetestis the number of the sperms wasreduced. In some rat the seminiferoustubules degenerated locally and sperma-togenesis was inhibited. In a numberof cases, particularly in the rats admi-nistered with raw cottonseed oil for twomonths...

The husked cottonseed meal, rawcottonseed oil, extracts of cottonseedmeal and pure gossypol have been fedseparately to adult male rats for 4weeks. It was usually found that thesperms were dead in the caudal epi- didymis and vas deferens and the spermmorphology was abnormal while in thetestis the number of the sperms wasreduced. In some rat the seminiferoustubules degenerated locally and sperma-togenesis was inhibited. In a numberof cases, particularly in the rats admi-nistered with raw cottonseed oil for twomonths inflammation of epididymis tookplace in form of cyst-like nodes andphagocytes appeared active in the ep-ididymal tubules where a large numberof dead sperms were stored. Moreover,the cottonseed meal and the gossypolpossessed conspicuous toxicity to rat.The common symptoms of intoxicationappeared as loss of appetite, loweringof the growth rate and even the com-plete retardation of growth, and even-tually death occurred when large doseswere given. The fraction which ext-racted from cottonseed meal withoutgossypol did not possess both antifertilityeffect and obvious toxicity. Three weeks after the cessation ofthe administration of cottonseed meal,raw cottonseed oil or pure gossypolactive sperms reappeared in the vasdeferens. A month after cessation ofthe drug the viability of sperm becamenormal. The results of mating expe-riment agreed with the data of seminalexamination. After cessation of the drugless than a month, only a few malerats showed coital behavior and thefemales did not become pregnant orgave birth to a small litters. Whenthe administration of the drug had beenceased for a month, the number ofrats possessed coital behavior increasedand some recovered fertility. Laternormal fertility resumed in most of theexperimental animals. It can be concluded that only thegossypol contained in cottonseed or itsoil is an effective component for anti-fertility and it is also toxic to theanimals. The toxicity of gossypol iscorrelated to the dosages administered.In fact, a small dosage of gossypol hasnever produced serious effects on theanimals but caused the loss of fertility.The action site of antifertility of gos-sypol, the cause of death of sperms,the toxicology of gossypol and theinduction of male infertility by admi-nistration with raw cottonseed oil werediscussed preliminarily.

分别以脱壳棉籽粉、粗制生棉油、棉籽粉抽提物和纯棉酚,喂成年雄性大白鼠4周,普遍发现在大白鼠的输精管和附睾尾部的精子死亡、精子数目减少并出现畸形;部分大白鼠的睾丸曲精细管呈局部退化,精子发生受到抑制。有不少例子,特别是粗制生棉油灌胃2个月的大白鼠出现附睾炎症(囊肿样结节),在贮有死亡精子的附睾管中吞噬细胞十分活跃。此外,棉籽粉和棉酚对大白鼠显然具有毒性,因棉籽粉或棉酚引起中毒的一般症状表现为食欲减退,生长减慢或停滞,当给以大剂量时可使大白鼠死亡。棉籽粉抽提物不含棉酚的部分,没有抗生育效应也无明显毒性。当停喂棉籽粉、粗制生棉油或棉酚3周后,在大白鼠的输精管里又出现活动的精子。1个月之后,精子的活力正常,合笼的结果和精液检查的结果一致,停药不到1个月,只有少数雄鼠有交配行为,雌鼠不受胎或受胎率很低。停药1个月,有交配行为的雄鼠增加,生殖能力部分恢复。1个月以上,多数雄鼠的生殖能力复原。根据观察可以得出如下结论,棉酚是棉籽或棉籽油中唯一的抗生育有效成分,同时也是一种对动物有毒性的物质。棉酚的毒性和使用的剂量有关。小剂量棉酚不会引起严重的影响但具有抗生育效果。对棉酚抗生育的作用环节、引起精子死亡的原因和毒理以及因食用粗...

分别以脱壳棉籽粉、粗制生棉油、棉籽粉抽提物和纯棉酚,喂成年雄性大白鼠4周,普遍发现在大白鼠的输精管和附睾尾部的精子死亡、精子数目减少并出现畸形;部分大白鼠的睾丸曲精细管呈局部退化,精子发生受到抑制。有不少例子,特别是粗制生棉油灌胃2个月的大白鼠出现附睾炎症(囊肿样结节),在贮有死亡精子的附睾管中吞噬细胞十分活跃。此外,棉籽粉和棉酚对大白鼠显然具有毒性,因棉籽粉或棉酚引起中毒的一般症状表现为食欲减退,生长减慢或停滞,当给以大剂量时可使大白鼠死亡。棉籽粉抽提物不含棉酚的部分,没有抗生育效应也无明显毒性。当停喂棉籽粉、粗制生棉油或棉酚3周后,在大白鼠的输精管里又出现活动的精子。1个月之后,精子的活力正常,合笼的结果和精液检查的结果一致,停药不到1个月,只有少数雄鼠有交配行为,雌鼠不受胎或受胎率很低。停药1个月,有交配行为的雄鼠增加,生殖能力部分恢复。1个月以上,多数雄鼠的生殖能力复原。根据观察可以得出如下结论,棉酚是棉籽或棉籽油中唯一的抗生育有效成分,同时也是一种对动物有毒性的物质。棉酚的毒性和使用的剂量有关。小剂量棉酚不会引起严重的影响但具有抗生育效果。对棉酚抗生育的作用环节、引起精子死亡的原因和毒理以及因食用粗制生棉油导致男性不育症等方面进行了初步讨论。

 
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