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antagonistic
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  拮抗作用
    ANTAGONISTIC EFFECTS OF ISOPRENALINE ON 15-METHYL-PROSTAGLANDIN F_(2α)-INDUCED ABORTION IN MICE
    异丙肾上腺素对15-甲基前列腺素F_(2α)致小鼠流产的拮抗作用
短句来源
    THE INFLUENCE OF EPIRUBICIN UPON SARCOMERIC GENE EXPPESSION IN RAT HEART AND THE ANTAGONISTIC EFFECT OF ICRF-187
    表柔比星对大鼠心肌肌小节收缩蛋白基因表达的影响和ICRF-187的拮抗作用
短句来源
    Effect of Fluoride on the Activity of NK Cell and IL-2 and Antagonistic Effect of Boron to Fluoride
    氟对大鼠NK细胞和IL-2的影响以及硼对氟的拮抗作用
短句来源
    ANTAGONISTIC EFFECT OF TETKAHYDKOPROBERBEKINE HOMOLOGUES ON α1-ADRENOCEPTOR
    四氢原小檗碱同类物对α_1肾上腺素受体的拮抗作用
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    Methods:Competitive radioligand binding assay,isolated rabbit thoracic aorta rings and pithed AngⅡ-challenged rats were used to evaluate the antagonistic effects of Ⅰb.
    方法:采用放射性受体配体分析法、家兔离体主动脉环法以及大鼠静脉输注AngⅡ测定血压变化的方法,评价Ⅰb对AngⅡ的拮抗作用
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  “antagonistic”译为未确定词的双语例句
    Studies on D-galactose Aging Model and Its Mechanism of Oxidative Damage and Antagonistic Effects of α-Lipoic Acid
    D-半乳糖衰老模型及其氧化损伤机理与α-硫辛酸的干预作用研究
短句来源
    Antagonistic Effect of Benzylisoquine Compound D_(20) on CaM Activating Phosphodiesterase
    苄基异喹啉类化合物 D_(20)抑制钙调素激活磷酸二酯酶的研究
短句来源
    RESULTS: The sales volume of calcium channel blocker in Hangzhou has accounted for 53.04%, ACEI accounted for about 16.36% and angiotensin n acceptor antagonistic drug accounted for about 19.08% of the total consumption.
    结果:杭州地区的钙通道拮抗剂的用药金额约占抗高血压药总金额的53.04%,血管紧张素转换酶抑制药约占16.36%,血管紧张素II受体拮抗药约占19.08%。
    A Experimental Study of the Antagonistic Efects of Boron and Zinc on Toxicity of Fluoride.
    “硼锌联用”抗氟作用的实验研究
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    Antagonistic effects of new endothelin antagonist CPU0214 on cardiac endothelin receptor binding and vascular activity and its reduction on mean arterial pressure in conscious DOCA-salt hypertensive rats
    新型内皮素受体拮抗剂CPU0214与正常大鼠心肌ET受体结合特点及对清醒DOCA-盐型高血压大鼠的降压作用
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  antagonistic
All compounds were characterized by binding affinity determination for 5-HT2A and 5-HT2C subtypes and antagonistic activity for 5-HT2B receptor in rat stomach fundus.
      
None of the new compounds showed affinity for 5-HT2A and 5-HT2C subtypes, but some of them displayed antagonistic activity in rat stomach fundus at micromolar concentrations.
      
However, a combined antagonistic effect was observed in the treatment of K562 cells with hemin (30 μM, 48 h) followed by thermal stress (42°C, 30 min).
      
The results showed that Cd and As had an antagonistic effect on enhancing the growth of Rorippa globosa plants and Cd uptake and accumulation under the low concentration Cd and As treatments.
      
The antagonistic activity of these bacteria towardsEscherichia coli 08,E.
      
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Reserpine antagonism to morphine analgesia could be clearly demonstrated in mice with methods of applying to the tail nociceptive stimuli, either mechanical, thermal or electrical. The analgesic ED_50 increased 2—7 times. No antagonism, however, was found in the hot-plate method or in experiments with electrical stimulation on the tail if vocalizations, instead of motor responses, were regarded as nociceptive reaction. Pretreatment with a single large dose(2. 5mg/kg) of reserpine could not prevent tolerance...

Reserpine antagonism to morphine analgesia could be clearly demonstrated in mice with methods of applying to the tail nociceptive stimuli, either mechanical, thermal or electrical. The analgesic ED_50 increased 2—7 times. No antagonism, however, was found in the hot-plate method or in experiments with electrical stimulation on the tail if vocalizations, instead of motor responses, were regarded as nociceptive reaction. Pretreatment with a single large dose(2. 5mg/kg) of reserpine could not prevent tolerance formation by short-term repeated morphine administration. α-methyl-DOPA 200 or 400mg/kg injected intraperitoneally did not exert antagonism to morphine administered 2, 6, 12, or 24 hours after. Interactions of reserpine and α-methyl-DOPA on morphine analgesia were also studied. α-methyl-DOPA, given simultaneously with or prior to reserpine, could eliminate the antagonistic action of reserpine to morphine, but failed to do so if given 2 or 4 horus after reserpine. The dependence of the α-methyl-DOPA antagonism to reserpine on the sequence of administering these two drugs may have some bearing on the nature of binding and release of catecholamines, and further studies are thus indicated.

(一) 利血平对抗吗啡鎮痛并不是普遍的现象。在烫尾法、夹尾法及以挣扎为指标时的电刺激尾法实驗中,存在明显的对抗,ED_(50)提高2—7倍。但在热板法及以嘶叫为指标时的电刺激尾法实驗中,没有对抗现象出现。一次大剂量利血平化后,也不能阻止吗啡耐葯性的形成。 (二) α-甲基-DOPA200或400毫克/公斤,注射后2、6、12和24小时再注射吗啡,吗啡的鎮痛作用并不受影响。先注射α-甲基-DOPA,然后注射利血平,或者二药同时注射,則利血平的对抗吗啡鎮痛和排便作用都消失。但先注射利血平,然后给α-甲基-DOPA,則利血平的这些效应仍保存。

The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites...

The effects of combined treatment of Sb-71 with some metal salts such as cupric sulfate, magnesium sulfate, zinc sulfate, cupric chloride, magnesium chloride and zinc chloride were investigated in mice bearing Ehrlich ascites carcinoma. It was found that simultaenous administrations of Sb-71 (15 mg/kg) and cupric sulfate (1.5-3 mg/kg) produced a marked potentiation of inhibition of the growth of the carcinoma, and prolonged significantly the survival time of the mice. The density and the total number of ascites carcinoma cells were considerably decreased than those in the group treated with Sb-71 alone. Cupric sulfate alone at dosages of 1.5-3 mg/kg/day had no therapeutic effect on Ehrlich ascites carcinoma. Magnesium sulfate, zinc sulfate, cupric chloride and magnesium chloride did not influence the carcinostatic activity of Sb-71, whereas zinc chloride showed some antagonistic action against the therapeutic effect of Sb-71.

本文研究了sb-71与几种金属盐合并治疗小白鼠Ehrlich腹水癌的疗效,結果发現用硫酸銅3毫克/公斤、硫酸鋅20毫克/公斤、硫酸鎂30毫克/公斤、氯化鎂30毫克/公斤及氯化銅2.5毫克/公斤与sb-71 30毫克/公斤合并治疗小白鼠Ehrlich腹水癌时,疗效无明显变化,但硫酸銅与sb-71合并治疗組的动物一般情况較好,腹水出現較晚、腹水量亦少。用上述金属盐与sb-71 15毫克/公斤合并治疗时发現硫酸銅1.5,3毫克/公斤能显著地提高sb-71对小白鼠Ehrlich腹水癌的疗效,动物的生存时間較单用sb-71組延长,腹水量、瘤細胞浓度、瘤細胞总数亦显著減少.硫酸銅本身无治疗作用;亦不影响sb-71的毒性.在sb-71 30毫克/公斤治疗小自鼠Ehrlich腹水癌的同时投給氯化鋅3,6毫克/公斤,后者明显地拮抗Sb-7l的疗效,动物生存时間明显地短于单用sb-71組。

(1) After oral administration of 5 mg/kg of HCT to normal intact saline-loaded rats, a significant increase in K~+ excretion in urine was observed only in three out of seven experiments, and in the other four, a tendency of increase could still be noticed, though the changes were statistically non-significant. On the other hand, the same dose of HCT orally administered to adrenalectomized rats, both waterloaded and saline-loaded, did not cause any increase in K~+ excretion in all experiments. However, when a...

(1) After oral administration of 5 mg/kg of HCT to normal intact saline-loaded rats, a significant increase in K~+ excretion in urine was observed only in three out of seven experiments, and in the other four, a tendency of increase could still be noticed, though the changes were statistically non-significant. On the other hand, the same dose of HCT orally administered to adrenalectomized rats, both waterloaded and saline-loaded, did not cause any increase in K~+ excretion in all experiments. However, when a sodium retaining steroid, DOCA, was given in addition to HCT, a significant increase was invariably noticed. This, therefore, may serve as an experimental evidence in direct support of Edmonds' hypothesis, derived from his clinical observations, that aldosterone might play an important role in the Na~+-K~+ exchange in question. (2) Acotazolamide, a potent carbonic anhydrase inhibitor, was found to retain partially its effect of increasing K~+ excretion in adrenalectomized rats, and this was potentiated by the combined use of DOCA. From these results it is evident that the cessation of Na~+-H~+ exchange by carbonic anhydrase inhibition and the level of aldosterone are the two independent conditions essential for the Na~+-K~+ exchange in question. When they are combined, the effect is apparently potentiated. (3) An aldosterone antagonist 7-thioacotyl spirolactone was shown to be capable of antagonizing the effect of DOCA on the K~+ excretion, but without any action on that of acotazolamide. This gives further evidence for the specificity of its aldosterone antagonistic action, and it also supports the view that acotazolamide acts independently.

(一)正常大白鼠盐水負荷时,口服5毫克/公斤HCT,在7次实驗中,有3次实驗表現显著排鉀增多,而另外4次則虽也均有排鉀增高傾向,但統計测驗不显著。推測和各批正常员体內醛固酮水平高低有关。 (二)去腎上腺大白鼠,无論水負荷或盐水負荷,口服5毫克/公斤HCT,在6次实驗中均不能增加鉀排泄,但預先肌肉注射DOCA后,就轉为明显,从而直接証明了ECT的增加排鉀和体內醛固酮水平高低密切相关。 (三)碳酸酐酶抑制剂AAA,在去腎上腺大白鼠仍能表現其增加排鉀的作用,而加用DOCA后就更加明显,可見碳酸酐酶抑制及醛固酮均为影响远端腎小管鈉鉀交换的因素,但其中任何一个因素都非唯一因素,两者作用机制不同,却都能促进鈉鉀交换,故当两者同时存在时,排鉀作用就表現得最为明显。 (四)醛固酮对抗剂SL能糾正利尿药因加用DOCA后引起的排鉀作用,但不能直接对抗AAA所产生的排鉀增多,再次証明SL在鉀排泄上和DOCA也起着专一性的竞爭性对抗作用。

 
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