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    Changes of Serum Levels of T_4, T_3 and TSH in TRH Stimulation Test among Normal Adults
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The following principle is well-known in Harmonic Analysis: If a real function has a spectral gap at the origin then it must have many sign changes.
      
The study shows that government has made some important changes after the signing of WTO agreement in 1994, but there are still some contentious issues that require attention.
      
The series of vasicine (1) analogues, an alkaloid from Adhatoda vasica Nees., were synthesized with changes in A, B or C rings.
      
Roridin P and Isororidin P induced morphological changes in Pyricularia oryzae, with a minimum concentration (MMCC) value of 6.2 ± 1.1?μmol/L and 7.9 ± 1.5?μmol/L.
      
Based on the literature [1], this paper changes the essential conditionα ∫g(t)/tr(s)ds ≤ 1 into∫g(t)/tr(s)ds ≤θ.
      
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Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations,...

Cardiac output was determined according to Fick's principle, while renaI blood flow (RBF) and glomerular filtration rate (GFR) were measured from the clearances of PAH and creatinine. One hour after an i.v. injection of guanethidine 5 mg/kg, normal dogs showed a very slight hypotension, which was relatively more noticeable in renal hypertensive dogs. The cardiac output, stroke volume, and ventricular work tended to decrease tn normotensive dogs, but tended to augment in hypertensive dogs. These alterations, however, were statistically insignificant. The total peripheral resistance was not much influenced by guanethidine in normal dogs, yet markedly diminished in hypertensive dogs. Diuresis was evident during the 1-hour postmedication period in both models. In hypertensive dogs, i.v. administrations of guanethidine caused a conspicuous rise of RBF and GFR, but a great reduction of the renal vascular resistance. In normal rats, following an i.p. injection of 20 mg/kg, the circulating blood volume (studied with I~(131)-labeled serum protein) exhibited a slight but non-significant increase within 3 hours, and returned to the original level at 24 hours. No significant change was found in DOCA-treated rats. Normal rats receiving guanethidine revealed an increase of blood volumes in all organs, especially spleen and kidney. These results demonstrate that the hypotensive action of guanethidine is not via the reduction of blood volume, but by way of a vasodilator action, which particularly amends the ischemic state of kidney and thus alleviates the pathologic process of renal hypertension.

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通...

本文用正常血压及腎型高血压狗研究胍乙啶对心和腎的血流动力作用,并用大白鼠試驗其对循环及器官血容量的影响。根据Fick氏原則測定心輸出量,同时从腎脏对于对氨基馬尿酸及肌酐的清除率計算腎血流量及腎小球滤过率。靜脉注射胍乙啶5毫克/公斤1小时后,正常狗血压略有降低,高血压狗降压則較为明显。胍乙啶对正常血压狗的心輸出量、心搏量及心室作功量有減 低的趋向,而对腎型高血压狗則略有增加,但均不显著。胍乙啶不影响正常狗的外周血管阻力,而能显著降低腎型高血压狗的总外周阻力,扩张其外周血管。注射胍乙啶后,正常血压及腎型高血压狗的尿量增加均非常显著。腎型高血压狗的腎小球滤过率及腎血流量都非常显著地低于正常狗,腎血管阻力則大大地高于正常狗,靜脉注射胍乙啶后,滤过率及血流量均明显增加,而血管阻力則大大降低。正常大白鼠腹腔注射胍乙啶20毫克/公斤后,3小时內循环血量略有增加,但不显著,6小时后开始恢复,2斗小时后回至原水平。对注射DOCA的大白鼠的循环血量則沒有明显影响。正常大白鼠注射胍乙啶后,各器官及組織內合血量普遍有增加趋势,其中以脾及腎的血容量增加最为明显,說明胍乙啶对这些部位的血管有扩张作用。上述資料証明:胍乙啶的降压作用并非通过循环血量的減少,而是由于外周血管的扩张所致。胍乙啶能扩张腎血管,改善腎缺血状态,从而緩解腎型高血压的病理生理过程。

(1)In the chloralose-urethanized or curarized rabbits,infusion of saline or blood into the right auricle in amount of 8—10 ml/kg at the rate of 0.5—1.0 ml/sec induced bradycardia and hypotension. (2)Section of sino-aortic nerves and bilateral vagotomy did not alter the negative chronotropic effect due to auricular infusion,thus indicating that a local mechanism was responsible for the effect. (3)Distension of the right auricle by inflating an indwelling balloon with various pressures(20—70 mm Hg)also evoked...

(1)In the chloralose-urethanized or curarized rabbits,infusion of saline or blood into the right auricle in amount of 8—10 ml/kg at the rate of 0.5—1.0 ml/sec induced bradycardia and hypotension. (2)Section of sino-aortic nerves and bilateral vagotomy did not alter the negative chronotropic effect due to auricular infusion,thus indicating that a local mechanism was responsible for the effect. (3)Distension of the right auricle by inflating an indwelling balloon with various pressures(20—70 mm Hg)also evoked bradyeardia which persisted after cutting the vagi.Plotting the change in heart rate against pressure within the balloon,a non- linear relationship was revealed.The bradycardia observed could not be attributed to anoxemia resulting from reduced venous return,since the temporary occlusion of superior and inferior venae cavae failed to evoke bradycardia. (4)The blockage of sino-auricular node by local novocaine infiltration as well as by local or general hypothermia(26—28℃)abolished the negative chronotropio res- ponse to the atrial infusion.Therefore it was suggested that such a response occurred as a result of alteration in the functional state of sino-auricular node. (5)Under our experimental conditions,the cardiac acceleration reflex originally found by Bainbridge could not be demonstrated in the rabbits.

(一)在氯醛糖和氨基甲酸乙酯麻醉的兔或未麻醉的箭毒化兔,右心房内输液(输入量为8—10毫升/公斤,输入速度为0.5—1.0毫升/秒),可规律地引起心率减慢和动脉血压下降。(二)右心房输液引起的心率变化,在切断两对缓冲神经和迷走神经后并不消失,说明此种输液效应并非反射作用。(三)经颈外静脉向右心房内引入一小气囊,以不同压力扩张后,也可导致心率减慢。此时气囊内压值与心率变化之间的关系不是完全呈直线式的。切断迷走神经后,效应仍存在;且此效应也不是由于气囊扩张阻断血液回流所致。(四)以奴佛卡因溶液阻断窦房结区后,右心房输液不再引起心率减慢。全身低温或选择性心脏低温(26—28℃)后,大多数实验中的心率在输液后不再变慢,由此说明右心房内输液对心率的影响是刺激直接作用于窦房结而改变其机能活动的结果。(五)在我们的实验条件下,从兔身上不能证示有 Bainbridge 反射的存在。

This paper reports 5 cases of IgD multiple myeloma which is a very uncommon disease. In contrast to the other types of myeloma, these patients were younger in age, the oldest being 53 years of age, and 2 cases were below the age of 40. Their clinical manifestations appeared more severe ; extra-skeletal infiltrations were more common with hepatosplenomegaly in 3 cases and hepatomegaly in 1 case, the lymph nodes were enlarged in 1 case, biopsy of which showed infiltration of tumor cells. Anemia was present in...

This paper reports 5 cases of IgD multiple myeloma which is a very uncommon disease. In contrast to the other types of myeloma, these patients were younger in age, the oldest being 53 years of age, and 2 cases were below the age of 40. Their clinical manifestations appeared more severe ; extra-skeletal infiltrations were more common with hepatosplenomegaly in 3 cases and hepatomegaly in 1 case, the lymph nodes were enlarged in 1 case, biopsy of which showed infiltration of tumor cells. Anemia was present in 3 cases, the hemoglobin level in one case was only 3.5g %.Two cases had thrombocytopenia and purpura. Promyelocytes, myelocytes and nucleated red cells were seen in the peripheral blood smear in 2 cases. Bence-Jones protein was present in 4 cases, but the BUN was normal in all cases. Blood calcium was normal in 4 cases and the alkaline phosphatase level was increased in 3 cases. Serum analysis by cellulose acetate membrane electrophoresis showed the IgD M-protein to move between β and γ1 zones, with a slightly broader base and lower spike. Serum immunoelectrophoresis performed in 4 cases revealed heavy precipitin arcs against the anti-IgD serum. Semiquantitative determinations of IgD by the double immunodiffusion method showed the IgD content was not very high, in one of the cases it was only positive at 1 : 20, but the IgG, IgA and IgM were diminished in 4 cases, and were at the lower limit of normal values in 1 case.Two of the 5 cases were associated with diffuse sclerotic changes of the bones involving the spine, pelvis, ribs,clavicles and femurs which are considered extremely rare.

本文报道少见的IgD型多发性骨髓瘤5例。与其他类型的骨髓瘤比较,发病年龄轻,症状稍重,肝、脾、淋巴结多见有瘤细胞浸润,血清中IgD含量并不很高,而其它类型的Ig含量常减少。有骨质损害。其中有2例伴有更为罕见的弥漫性骨质硬化。

 
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