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strand breakage
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  链断裂
     Results Glycolaldehyde at 0 01mmol/L could induce lymphocyte DNA strand breakage and DNA damage rate was 8% and, the average migration distance of DNA was (14 32±2 84)μm.
     结果 当乙醇醛浓度为 0 0 1mmol L时即能引起脾淋巴细胞DNA链断裂损伤 ,DNA损伤率为 8% ,DNA平均迁移距离为 ( 14 32± 2 84 ) μm。
短句来源
     Results Ni 2O 3 could induce DNA double strand breakage in human lung fibroblasts cells as compared with the control group(P<0.01),and the damage ratio clould descend singnificantly by using β-carotene and Ni 2O 3 in human lung fibroblast cells as compared with that of the Ni 2O 3 group(P<0.01).
     结果 氧化镍 (Ni2 O3 )可引起人肺成纤维细胞DNA双链断裂损伤 ,Ni2 O3 与β 胡萝卜素共同处理的人肺成纤维细胞的DNA双链损伤较之Ni2 O3 单独处理组降低 (P <0 .0 1)。
短句来源
     Results K 2Cr 2O 7 and CSS synergistically induced DNA single strand breakage in pUC118 plasmid,whereas either K 2Cr 2O 7 or CSS alone induced much less strand breakage.
     结果 K2 Cr2 O7和CSS可协同诱导DNA单链断裂 ;
短句来源
     Results Acrolein could cause DNA strand breakage but not cause DNA,DNA, DNA,protein crosslinks of lymphocytes of human peripheral blood.
     结果丙烯醛可诱导人外周血淋巴细胞DNA发生链断裂,但不引起DNA-DNA、DNA-蛋白质交联;
短句来源
     The effect of single and double strand breakage and its transforming activity of in vitro plasmid DNA was analysised by 30Kev N+、Ar+ ion beam radiation respectively.
     利用 30Kev的N+ 、Ar+ 离子辐照离体质粒DNA ,分析了不同离子对DNA单双链断裂及转化活性的影响。
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  断股
     Analysis of lightning-caused OPGW strand breakage on 500 kV HuiShan transmission line
     500kV惠汕乙线光纤复合架空地线雷击断股分析
短句来源
     So the main causes for OPGW strand breakage form lightning are the structural design problems.
     因此,OPGW雷击断股的主要原因是结构设计问题。
短句来源
     In this article, the reason of lightning-caused OPGW strand breakage is analyzed, and the methods for improving OPGW performance against lighting strike are discussed.
     文章通过对OPGW光缆雷击断股现象和雷击断股机理的分析,对如何提高OPGW光缆的耐雷水平做了一些探讨和研究。
短句来源
     Reason and Analysis on Optical Fiber Composite Grounding Wires Strand Breakage
     光纤复合接地电缆断股事故原因分析
短句来源
     In this article we analyze some examples of OPGW and find out the inner and external reasons of lightning-caused OPGW strand breakage.
     通过OPGW光缆雷击断股现象和雷击断股机理的分析,得出OPGW光缆雷击断股的内因和外因。
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  “strand breakage”译为未确定词的双语例句
     According to comet assay,it caused DNA strand breakage(DSB) at low level(5 μM,25μM,P<0.01) and caused crosslinks at higher level 125 μM,625 μM,P<0.01).
     而单细胞凝胶电泳法显示甲醛在低浓度(5μM,25μM)时可以引起DNA链的断裂(P<0.01),在较高浓度(125μM,625μM)时可以引起交联作用(P<0.01)。
短句来源
     According to the results of comet assay, it can cause DNA strand breakage (DSB) at low levels (5 and 25μmol·L -1 p<0.01) and cause crosslinks at higher levels (125 and 625μmol·L -1 ,p<0.01).
     而单细胞凝胶电泳的结果则显示甲醛在低浓度(5、25μmol·L-1)时可以引起DNA链的断裂(p<0.01),在较高浓度(125、625μmol·L-1)时可以引起交联作用(p<0.05).
短句来源
     According to comet assay,it can cause DNA strand breakage(DSSB) at low levels(5 μmol/L,25 μmol/L,P<0.01) and cause crosslinks at higher levels(625 μmol/L,P<0.01).
     而彗星实验的结果则显示甲醛在低浓度(5μmol/L,25μmol/L)时可以引起DNA链的断裂(P<0.01),在较高浓度(625μmol/L)时尾部DNA%和尾矩比空白对照显著降低(P<0.01),表明此时甲醛所致的DPC掩盖了DNA断裂的作用.
短句来源
     Methods DNA strand breakage, DNA,DNA crosslinks and DNA,protein crosslinks induced by the acrolein were detected with single cell gel electrophoresis (SCGE).
     方法应用单细胞凝胶电泳技术检测丙烯醛引起的DNA断裂、DNA交联以及DNA-蛋白质交联;
短句来源
     Results 20 μg/ml of Ni 2O 3 could obviously induce DNA strand breakage,the tail length/total length of DNA comet in exposed group was 0.487±0.195,higher than that in control (0.191±0.072, P< 0.01). CpG island in those Ni 2O 3 transformed lung cell was hypermethylated.
     结果 黑色氧化镍可以明显造成人胚肺细胞DNA损伤 ,2 0 μg/ml的Ni2 O3染毒组细胞彗星尾长 /彗星总长为 0 .4 87± 0 .195 ,而对照组为 0 .191± 0 .0 72 ,二者差异有显著性 (P <0 .0 1)。
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  strand breakage
WBC showed a significant increase in DNA strand breakage 6?hr and 24?hr after exercise.
      
Dimethylsulfate also induces excess double-strand breakage in SVM, and these breaks are irreparable.
      
Inhibiting the repair of UV damage leads to greater double-strand breakage in SVM than in DM, and some of these breaks are not repaired; however, repair-associated single-strand breakage and resealing are normal.
      
This mutant cell is also sensitive to killing by the DNA breaking agent, bleomycin, but is relatively insensitive to UV light and ethyl methane sulfonate, suggesting that the defect is specific for agents that produce DNA strand breakage.
      
The complexing of histones with DNA and the resulting condensation of chromatin protects mammalian cell, from radiation-induced strand breakage.
      
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The induction and rejoining kinetics of DNA single strand breaks in irradiated human peripheral lymphocytes (D0=400 rads) and Chinese hamster ovary cells (CHO) (D0=200 rads) were studied by alkaline elution method. Although the radiosensitivity of these two types of mammalian cells is different, the extent of single strand breakage is approximately the same within the range of 100-3000 rads. The ability to rejoin the single strand breaks in the more radiosensitive CHO cells is greater than that in...

The induction and rejoining kinetics of DNA single strand breaks in irradiated human peripheral lymphocytes (D0=400 rads) and Chinese hamster ovary cells (CHO) (D0=200 rads) were studied by alkaline elution method. Although the radiosensitivity of these two types of mammalian cells is different, the extent of single strand breakage is approximately the same within the range of 100-3000 rads. The ability to rejoin the single strand breaks in the more radiosensitive CHO cells is greater than that in lymphocytes. It appears that there is no direct relationship between the efficiency of rejoining of single strand break and radiosensitivity in these two types of cells.

用微孔滤膜碱洗脱法观察了丙线照射引起人血淋巴细胞(D_o为400拉德)及中国仓鼠卵巢成纤维细胞(D_o为200拉德)的DNA单链断裂及其修复。在0~3000拉德范围内,两种细胞DNA单链断裂的程度基本一致,照射剂量与单链断裂的对数之间呈直线相关。800、1500及3000拉德照射后,经过0.5~7小时的孵育,中国仓鼠卵巢成纤维细胞DNA单链断裂的修复优于人血淋巴细胞,说明这两种细胞辐射敏感性与DNA单链断裂修复能力无关。

Neocarzinostatin (NCS) is an antitumor antibiotic of protein native.It has been reported that NCS causes DNA strand breakage,inhibits DNA synthesis and cell division.Chromosome aberration has been induced by NCS in animal cells.But no reports have been published so far about its mutagenic effects on plant cells.Previous results in this laboratory revealed that pingyangmycin (PYM) is a strong mutagen for chromosome aberration induction in plants.Early results also suggested that its high mutagenecity might...

Neocarzinostatin (NCS) is an antitumor antibiotic of protein native.It has been reported that NCS causes DNA strand breakage,inhibits DNA synthesis and cell division.Chromosome aberration has been induced by NCS in animal cells.But no reports have been published so far about its mutagenic effects on plant cells.Previous results in this laboratory revealed that pingyangmycin (PYM) is a strong mutagen for chromosome aberration induction in plants.Early results also suggested that its high mutagenecity might be due to that the damage caused by pingyangmycin could not be repaired by DNA polymerase.Sites of strand scission on NCS-trested DNA bear either terminal 3'-hyd-roxyl or 3'-phosphoryl group.Gaps in DNA bounded by 3'-hydroxyl and 5'-phosphory termini is right termini for repair.Caffeine blocked the 3'-hydroxyl termini and thus inhibits DNA repair,promote chromosome aberration.In this paper induction of chromosome aberration by NCS and PYM alone or with caffeine post-treatment were compared,and the nature of the 3'-termini of the PYM-induced strand breakage was discussed base on the comparison.Experimental results indicated the percentage of chromosome aberrations induced in root tip cell of Vicia faba by NCS-treatment were 27.73%,while by EMS and PYM were 18.58% and 36.03% respectively.Caffeine post-treatment enhanced chromosome aberrations from 27.73% to 46.20% in NCS mutagenesis.The types of aberrations and number of micronuclei were also increased.This is consisted with the early observation that gaps in DNA induced by NCS bear either 3'-hydroxyl or 3'-phosphoryl termini.Caffeine blocked the 3'-hydroxyl group,inhibited the repairing,thus raised the percentage of chromosome aberrations.Caffeine post-treatment did not increase chromosome aberration in PYM mutagenesis suggested that the strand breakages caused by PYM were not terminal 3'-hydroxyl but 3'-phosphoryl group,and no appropriate terminal group were provided for caffeine blocking.

本文报道了新制癌菌素(NCS)能诱发植物染色体畸变,同时观察了利用咖啡因后处理对NCS、PYM诱发染色体畸变的影响,研究了PYM切断DNA断头的性质。结果表明,NCS切割DNA产生3'-羟基末端和3'-磷酸末端;咖啡因能封闭3'-羟基末端抑制DNA的修复,从而提高诱变频率。PYM加咖啡因后处理,其染色体畸变频率与PYM单独处理无明显差异。说明PYM切断DNA所得到的产物,不是3'-羟基末端,而是3'-磷酸末端。

Alkaline elution and a fluorometric DNA assay, recentlydevolped, was proved to be a powerful and sensitive method for the measurement of a variety of DNA lesions. DNA single-strand, breakage following Bleomycin treatment of P388 cells was studied by the method in vitro.The rate of DNA single-strand breakage increased when the drug was added At the final concentrations of 10,30 and 100μg/ml the fraction of DNA remaining on filter membrane were 0.56, 0.42 and 0.22 of the control value, respectively. The...

Alkaline elution and a fluorometric DNA assay, recentlydevolped, was proved to be a powerful and sensitive method for the measurement of a variety of DNA lesions. DNA single-strand, breakage following Bleomycin treatment of P388 cells was studied by the method in vitro.The rate of DNA single-strand breakage increased when the drug was added At the final concentrations of 10,30 and 100μg/ml the fraction of DNA remaining on filter membrane were 0.56, 0.42 and 0.22 of the control value, respectively. The results demonstrated that DNA single-strand breakage relates to the anti tumor mechanism of Bleomycin.

碱洗脱—荧光分析法是最近发展起来的一种检测DNA多种损害的有效而敏感的方法。应用本方法对争光霉素引起P388白血病细胞DNA单链断裂效应进行了探讨。结果显示,争光霉素浓度为10,30和100μg/ml时,膜上DNA存留比分别为对照的0.56,0.42和0.22。本研究证实了该药抗肿瘤机制与其导致瘤细胞DNA单链断裂有关。

 
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