Results:The glossy ganoderma in a large dose(0.9g/kg,qd×10d,ig)could significantly decrease the levels of serum ALT(P<0.01) and AST (P<0.05), reduce the spleen lesion(P<0.05)and the liver damage in mice;
Alcohol abuse is thought to be a risk factor for the cause of liver damage, hyperlipidemia and insulin resistance.
Since leukocytes are much more available than hepatocytes or neuronal cells in humans, we assume that CE in peripheral blood leukocytes (neutrophils and monocytes) can be used as markers for indication of pending liver damage by CPZ.
In this study, we examined the effects of its ethanolic root extract on experimental liver damage in order to evaluate its hepatoprotective effects against hepatotoxicity induced in rats by ethanol at a dosage of 5 g/kg body weight for 60 days.
The degree of liver damage was analysed using serum marker enzyme activities, the total protein, albumin, globulin, ceruloplasmin and liver glycogen contents, and the A/G ratio.
The correlation of serum arylesterase (PON1) activity on phenylacetate determined by an integrated method to classical biochemical indexes of liver damage was investigated for the use of PON1 activity to evaluate liver damage.