Combining the immunogold-silver staining method and the image quantitative analysis, aging changes in serotonin-like (5-HTL) neurons of the raphe nuclei of the brainstem were observed in young (2 months), adult (10 months) and old (24 months) Wistar rats.
Aging changes in acetylcholinesterase positive (AChE-P) neurons of the globus pallidus were investigated histochemically and morphometrically in young (3 months old) and old (24 months old) Spragur-Dawley male rats.
By using ABC immunohistochemical method and image quantitative analysis, the aging changes of neurotensin-like (NT) and dynorphin-like (DYN) neurons of the central nucleus of amygdala and the anti- = aging effect of radix achyranthis bidentatae (RAB) were observed.
Aging changes of tyrosine hydroxylase (TH) -immuno reactive neurons in the locus coeruleus were examined in young (3 month-old). adult(12 month-old) and aged(20 month-old) Wistar male rats, using the IGSS method and image quantitative analysis. The results obtained are as follows: ① The number of TH-immunoreactive neurons docreased markedly (P<0.01)in adult rats and docrcased further in old rats.
Kesults showed that the decline of hypothalamus function in aging male rats might be the main cause of the aging change of gonadal function and the tonifying herbs could improve the function and they may be able to delay occurence of aging changes in the hypothalamus or the higher central regulation control.
Occasional denervated postsynaptic regions were encountered in old neuromuscular junctions, but the predominant characteristics of aging changes were not those of denervation.
The defectiveness of Armos fibres in thermal aging changes less significantly than for SVM fibres.
There is a growing consensus that the aging changes are caused by free radical reactions; mainly initiated by the mitochondria at an increasing rate with age, while life span is determined by the rate of such damage to the mitochondria.
Aging changes can be attributed to development, genetic defects, the environment, disease, and the major contributor, the inborn aging process.
Articular cartilage aging changes that may lead to articular cartilage degeneration include fraying and softening of the articular surface, decreased size and aggregation of proteoglycan aggrecans and loss of matrix tensile strength and stiffness.