Results and Conclusion: A three dimensional structure model of the ligand binding region of IL 6Rα was obtained, and the possible interaction interface in accord with the heterohexameric IL 6 receptor complex was defined on the model. It provided the direction to the construction of IL 6Rα mutants, and suggested that the double mutant C277D/H280I be an effective antagonist of IL 6 with a higher affinity to IL 6.
In this paper, architecture is presented firstly which can be used to research the cnXMLs message service from message packaging, transport and security. The strategy of cnXMLs message service specification is proposed as a whole, which includes message packaging based on SOAP, reliable messaging, error handing, protocol binding in message transport, and message security plan combining digital signature and transport security protocol.
Allosteric Regulation of Binding and Function at GCPRS
cyclotriazadisulfonamides), viral envelope gp120-binding agents such as plant lectins and glycopeptide antibiotics, HIV integrase inhibitors such as the pyranodipyrimidine V-165, and two new classes of compounds (i.e.
3D-QSAR STUDIES ON SUBSTITUTED DIHYDROPYRIDINES FOR THEIR α1A-ADRENERGIC RECEPTOR BINDING AFFINITY
Both these models predicted binding affinity of internal and external test set compounds including the enantiomers of compound no.
All compounds were characterized by binding affinity determination for 5-HT2A and 5-HT2C subtypes and antagonistic activity for 5-HT2B receptor in rat stomach fundus.