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tumor necrosis factor
相关语句
  肿瘤坏死因子
     Effects of Tumor Necrosis Factor α on Culture Cardiomyocyte Pretreated by D-galactose
     肿瘤坏死因子α对D-半乳糖预处理心肌细胞的作用
短句来源
     Preparation of Anti Human Tumor Necrosis Factor α Single-Chain Variable Fragment Antibody by Phage Surface Display Technique and Its Humanization
     利用噬菌体表面展示技术制备抗人肿瘤坏死因子α单链抗体及其人源化改造
短句来源
     Expression of Human Tumor Necrosis Factor Alpha in Anabaena sp. PCC7120 and Its Preliminary Purification
     α型人肿瘤坏死因子在鱼腥藻7120中的表达及其初步纯化
短句来源
     Isolation, Characterization and Expression of the Complementary DNA for Human Tumor Necrosis Factor (TNF)
     人肿瘤坏死因子(TNF)cDNA的分离、鉴定及其表达
短句来源
     Structure and Bioactivities Analysis of Human Tumor Necrosis Factor Alpha Mutated in Position 30 and 42 Amino Acid
     人肿瘤坏死因子α30和42位氨基酸突变体结构与生物活性分析
短句来源
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  肿瘤坏死因子α
     Effects of Tumor Necrosis Factor α on Culture Cardiomyocyte Pretreated by D-galactose
     肿瘤坏死因子α对D-半乳糖预处理心肌细胞的作用
短句来源
     Preparation of Anti Human Tumor Necrosis Factor α Single-Chain Variable Fragment Antibody by Phage Surface Display Technique and Its Humanization
     利用噬菌体表面展示技术制备抗人肿瘤坏死因子α单链抗体及其人源化改造
短句来源
     Structure and Bioactivities Analysis of Human Tumor Necrosis Factor Alpha Mutated in Position 30 and 42 Amino Acid
     人肿瘤坏死因子α30和42位氨基酸突变体结构与生物活性分析
短句来源
     Activity assay of tumor necrosis factor and the eflect of actinomycin D
     肿瘤坏死因子α的活性测定与放线菌素D的作用
短句来源
     Effect of morphine on interleukin-1 and tumor necrosis factor a production from mouse peritoneal macrophages in vitro
     吗啡对腹腔巨噬细胞产生白细胞介素-1及肿瘤坏死因子α的体外影响(英文)
短句来源
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  肿瘤坏死因子-α
     Reserch has shown that cytokine and adhesion molecule such as nuclear factor kappa B (NF-κB ) , interelluar adhesion molecule-1 (ICAM-1) , tumor necrosis factor α ( TNF-α) and interleukin-6 ( IL-6) played important roles in occurrence and development of liver inflammation and liver fibrosis,but the reserch about the influence of NF-κB and its regulatory products to AIH was rare relatively.
     研究表明,核因子-κB(nuclear factor kappa B,NF-κB)、细胞间粘附分子-1(interelluar adhesion molecule-1,ICAM-1)、肿瘤坏死因子-α(tumor necrosis factor α,TNF-α)及白细胞介素-6(interleukin-6,IL-6)等炎性细胞因子、粘附分子在肝脏炎症、肝纤维化的发生及发展过程中起重要作用。
短句来源
     Objective To explore the relationship between the polymorphism loci-C863A and-G308A in the tumor necrosis factorαgene(TNF-α) and schizophrenia.
     目的探讨肿瘤坏死因子-α基因(TNF-α)-C863A和-G308A多态性位点在精神分裂症发病机理中的作用。
短句来源
     Objective To explore the effect of mild hypothermia on tumor necrosis factor alpha (TNF-α),interleukin-1β(IL-1β),interleukin-6 (IL-6) and interleukin-8 (IL-8) in serum of patients with severe traumatic brain injury and its clinical significance.
     目的探讨亚低温治疗对重型颅脑损伤患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、IL-8的影响及临床意义。
短句来源
     Objective: To investigate the expression tumor necrosis factor_α(TNF-α) in the pathogenesis of endometriosis(EMs).
     目的:探讨肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)在子宫内膜异位症(endometriosis,EMs)发病机制中的作用。
短句来源
     Objective To observe the effect of β amyloid(Aβ) on interleukin 1β(IL 1β)and tumor necrosis factor alpha (TNF α) expression in vivo and to explore the role of Aβ,IL 1β,and TNF α in the pathogenesis of Alzheimer's disease (AD).
     目的 在体条件下观察 β-淀粉样蛋白 ( Aβ)对白细胞介素 -1 β( IL-1 β)和肿瘤坏死因子 -α( TNF-α)表达的影响 ,探讨它们在 Alzheimer病 ( AD)发病机制中的作用。
短句来源
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  “tumor necrosis factor”译为未确定词的双语例句
     Inhibitory effect of matrine on tumor necrosis factor production and protein kinase C activity
     Inhibitory effect of matrine on tumor necrosis factor production and protein kinase C activity
短句来源
     Changes and Significance of Interleukin-6, Tumor Necrosis Factor and CD_4~+/CD_8~+ Lymphocytes in the Early Stage of Acute Pancreatitis
     急性胰腺炎早期患者IL-6,TNF,CD_4~+/CD_8~+的变化及意义
短句来源
     2. tumor necrosis factor (TNF- a ) (20ng/ml,16h);
     2.TNF-α(20ng/ml,16h);
短句来源
     ntracerebroventricular inwiion (icv ) with 100u Interleukin-- 1, 165g -interferon or 1g tumor necrosis factor could induced fever in rats, the febrile peak was at 1. 67 hours, 2. 5 hours, and 2. 0 hours aftericv, the value of the area under the body temperature--time curve (TRI) was 1. 40 0. 68, 1. 63 0. 73,and 1. 46 0. 30, resistively.
     大鼠脑室注射IL-1、INF-或Y-TNF,均能诱致发热,发热峰值时分别为1.67、2.5和2.0h,发热曲线下面积依次为1.40±0.68、1.63±0.73和1.46±0.30。
短句来源
     Ceridust 3615particles could stimulate monocytes to secret tumor necrosis factor α(TNFα), interleukin 6(IL 6)and interleukin 1β(IL 1β)but no interleukin 10(IL 10).
     【结果】Ceridust3615颗粒可刺激单核细胞分泌白介素-1β(IL-1β)、白介素-6(IL-6)和细胞坏死因子α(TNFα),但未能引起白介素-10(IL-10)的表达。
短句来源
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  tumor necrosis factor
Tumor necrosis factor (TNF)-α-converting enzyme (TACE) is the major protease responsible for processing pro-TNF-α from membrane-anchored precursors to secreted TNF-α.
      
The LPSs studied stimulated the production of tumor necrosis factor (TNF) and nitric oxide (NO) by mouse peritoneal macrophages.
      
The concentration of tumor necrosis factor decreased threefold in the peripheral blood of bulbectomized mice 1.5 months after surgery.
      
Changes in Sphingomyelinase Activity, Tumor Necrosis Factor α Level, and Lipid Peroxidation Intensity in the Course of Developme
      
Changes in sphingomyelinase activity, tumor necrosis factor α expression, and level of lipid peroxidation products in the course of development of cholestatic liver injury have been studied.
      
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TNF (tumor necrosis factors) was obtained from the serum of Japanese Polish Rabbit which was sensitized with Propionibacterium acnes and injected with LPS(lipopolysaccharide). The morphological changes of the cultured rat glioma cells (GAI, C-6) and human glioma cells (marcus) were observed after using TNF. It showed granules appeared in cytoplasma and became most evident on the 3rd day. This study represented the possibility of treatment of human brain glioma with TNF, although it is necessary to further...

TNF (tumor necrosis factors) was obtained from the serum of Japanese Polish Rabbit which was sensitized with Propionibacterium acnes and injected with LPS(lipopolysaccharide). The morphological changes of the cultured rat glioma cells (GAI, C-6) and human glioma cells (marcus) were observed after using TNF. It showed granules appeared in cytoplasma and became most evident on the 3rd day. This study represented the possibility of treatment of human brain glioma with TNF, although it is necessary to further study the effect of TNF on the glioma.

作者研究了由兔产生的肿瘤坏死因子(TNF)对鼠源性脑胶质瘤细胞GAI、C-6和人脑胶质瘤细胞marcus的作用,发现TNF对上述三种细胞都显示了明显的细胞毒作用,肿瘤细胞崩解死亡。本实验提示了将来TNF作为治疗恶性脑胶质瘤的一种新方法的可能性。

Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special varieties around the necrotic...

Using light microscope and electron microscope,we observed the morphological changes in the SMMC-7721 human hepatocellular carcinoma cell line after it was exposed to the rabbit tumor necrosis factor (TNF)and the cytocidal effect of TNF on the heterotransplanted human hepatocellular carcinoma (SMMC-7721 cell line).It was found that the changes occurred earlier in the cell membranes than in the nuclei during the course of TNF killing SMMC-7721 cell line and there was no special varieties around the necrotic area in the heterotransplanted human hepatocellular carcinoma in the nude mice as compared with that appearing in SMMC-7721 cell line,In addition, we detected the DNA contents of TNF treated SMMC-7721 cells and control ones, but there was no significant difference of the DNA contents between them.Ace of ding to the results of this study, we think that the mechanism by wluch TNF exerts its tumour-selective killing effect is probably as follows.TNF binds to a specific plasma membrane receptor and then disturbs synthesis or assembly of cell membrane components, leading the changes of cell structure(for example, swollen microvilli, a number of vesicles and small holes on the surface of tumor cells), and the lysis of tumor cells.

应用光镜和电镜观察了肿瘤坏死因子(TNF)杀伤人肝癌细胞系(SMMC-7721)的过程,同时测定了其DNA含量的变化,并观察了TNF对裸鼠人肝癌移植瘤的作用。结果表明,TNF与SMMC-7721细胞接触后,癌细胞膜系统先有变化,而胞核的变化出现在后。作者认为TNF选择性杀伤肿瘤细胞的机理可能是TNF与癌细胞膜上某种正常细胞不具有的物质发生作用,引起癌细胞的膜系统损伤,终致细胞死亡。

A high level expression vector has been constructed,which contains PR PL promoter, cIts857 gene, multiple cloning sites ( MCS ) and two strong transcription terminators. Foreign gene with ATG signal can be inserted into the MCS, expressing non-fusion protein. Using this vector, we have expressed successfully the human interferon r,human interleukin-2 and human tumor necrosis factor. The foreign gene product accounts for more than 20% of the total cell protein.

我们组建了一个含P_RP_L自动子的原核高效表达载体,它同时含有cI调控基因、多酶切点和两个强的转录终止序列。带起始密码子ATG的外源基因可以插入启动子下游的多酶切点,表达非融合蛋白,产品可供临床使用。我们实验室已用它成功地表达了人γ干扰素、人白细胞介素-2和人肿瘤坏死因子等,表达量均占菌体总蛋白的20%以上。

 
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