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gallstone disease
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  胆石病
     Conclusion The T400K polymorphism of ABCG8 gene plays a genetic role in the cholesterol metabolism,and the K400 carrier is a risk factor of gallstone disease in the male.
     结论:ABCG8基因T400K多态性影响胆固醇代谢,K400携带者是男性胆石病的危险因素。
短句来源
     Relationship between the Ava Ⅱpolymorphism of low-density lipoprotein receptor gene and gallstone disease
     低密度脂蛋白受体基因AvaⅡ位点多态性与胆石病关系的研究
短句来源
     Conditional Logistic Regression Analysis of Risk Factors on Gallstone Disease
     胆石病危险因素的条件Logistic回归分析
短句来源
     Objectives To explore the relationship between the XbaⅠ and EcoRⅠ locus polymorp hisms of apolipoprotein B gene and gallstone disease.
     目的 观察载脂蛋白B(ApoB)基因XbaⅠ、EcoRⅠ位点多态性、血脂水平和胆石病之间的关系。
短句来源
     Objective: To study the relationship between the Xba I ,EcoR I locus polymorphisms of apolipoprotein B gene and gallstone disease.
     目的:研究载脂蛋白B基因XbaⅠ、EcoRⅠ位点多态性和胆石病之间的关系。
短句来源
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  胆囊结石
     ABCG8 T400K polymorphism in gallstone disease and its impact on the serum lipids level
     ABCG8基因T400K多态性与胆囊结石病以及血脂水平的关系
短句来源
     Objective To explore the relationship between the T400K polymorphism of ABCG8 gene and gallstone disease,as well as its impact on the serum lipids level.
     目的:探讨人类ABCG8基因T400K多态性与胆囊结石病的关系,以及对血脂的影响。
短句来源
     A case-control study on the dietary risk factors for gallstone disease
     膳食因素与胆囊结石症关联的研究
短句来源
     Study on the position of genes responsible for gallstone disease in Chinese population
     胆囊结石病致病基因的定位研究
短句来源
     The application of cholecystolithotomy with gallbladder preserved in surgical treatment of gallstone disease
     保胆取石术治疗胆囊结石的临床应用
短句来源
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  胆囊结石病
     ABCG8 T400K polymorphism in gallstone disease and its impact on the serum lipids level
     ABCG8基因T400K多态性与胆囊结石病以及血脂水平的关系
短句来源
     Objective To explore the relationship between the T400K polymorphism of ABCG8 gene and gallstone disease,as well as its impact on the serum lipids level.
     目的:探讨人类ABCG8基因T400K多态性与胆囊结石病的关系,以及对血脂的影响。
短句来源
     Study on the position of genes responsible for gallstone disease in Chinese population
     胆囊结石病致病基因的定位研究
短句来源
     Objectives To explore the relationship among the Xba I locus polymorphisms of apolipoprotein B gene , serum lipid metabolism and gallstone disease.
     目的 探讨载脂蛋白B(ApoB)基因XbaⅠ位点的多态性、血脂水平与胆囊结石病之间的关系。
短句来源
     Relationship among the Xba Ⅰ Locus Polymorphisms of Apolipoprotein B Gene, Serum Lipid Metabolism and Gallstone Disease
     载脂蛋白B基因多态性及血脂水平与胆囊结石病关系的研究
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  “gallstone disease”译为未确定词的双语例句
     Expression of ABCG5 and ABCG8 in gallbladder mucosa associated with cholesterol gallstone disease
     胆囊黏膜ABCG5和ABCG8基因在胆固醇结石病中的作用
短句来源
     Relationship between polymorphisms of the apolipoprotein B gene and cholesterol gallstone disease
     胆固醇结石与载脂蛋白B基因多态性的关系
短句来源
     Conclusions: The X+ allele of Apo B gene is associated with a higher serum cholesterol and higher low density lipoprotein level and it may be regarded as a high-risk gene of cholesterol gallstone disease.
     结论:Apo B的X~+等位基因有增高血清胆固醇和低密度脂蛋白胆固醇的特点,可能是胆固醇结石形成的易感基因。
短句来源
     Expression of liver receptor homolog 1 gene in patients with cholesterol gallstone disease
     胆囊胆固醇结石患者肝脏受体类似物1基因表达差异的研究
短句来源
     Objective To explore the relationship between the mRNA expression of ABCG5 and ABCG8 in gallbladder mucosa and cholesterol gallstone disease (GS).
     目的探讨ABCG5和ABCG8基因在胆囊黏膜中的表达与胆固醇结石病的关系。
短句来源
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  gallstone disease
The physical-chemical, pathophysiologic, and genetic studies of Lith genes in bile, liver, gallbladder, and intestine will be crucial for elucidating the genetic mechanisms of cholesterol gallstone disease in mice and in humans.
      
Gallstone disease, which is strongly associated with obesity, and excessive consumption of alcohol are the major risk factors for benign pancreatic disease, whereas smoking is the most important factor known to cause pancreatic cancer.
      
Epidemiology and risk factors for gallstone disease: Has the paradigm changed in the 21st century
      
Gallstone disease is common and costly, creating over 700,000 cholecystectomies annually.
      
In general, nonsurgical treatment of Mirizzi syndrome is incomplete and places the patients on a path of intensive follow-up, multiple procedures, and the risk to continue suffering from complications of symptomatic gallstone disease.
      
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For investigating possible linkage between HLA system and gallstone disease, the frequency of HLA antigens in 28 patients with gallbladder stones (GBS) and 9 cases with bile duct stones (BDS) were studied and compared with a control group of 100 healthy subjects. A total of 54 antigens of HLA-A (15), -B (32), -C (7) and 17 antigens of locus DR were determined, using a standard lymphocyte microcytotoxicity assay. The percentage of the different antigens in pantients and in controls were compared by the...

For investigating possible linkage between HLA system and gallstone disease, the frequency of HLA antigens in 28 patients with gallbladder stones (GBS) and 9 cases with bile duct stones (BDS) were studied and compared with a control group of 100 healthy subjects. A total of 54 antigens of HLA-A (15), -B (32), -C (7) and 17 antigens of locus DR were determined, using a standard lymphocyte microcytotoxicity assay. The percentage of the different antigens in pantients and in controls were compared by the chi-square test and the Fisher's p value were multiplied by the total number of antigens tested with the corrected p (Pc) value, less than 0.05 of which was considered significant.A significant increase of HLA-CW6, -DR1, -DR3, and -DRW8 was found in patients with gallstones with frequencies of 43.2%, 21.6%, 27% and 40.5% against 9%, 2%, 7% and 9% of controls with PC values 0.0008, 0.007, 0.045 and 0.0008 respectively, the relative risk (RR) value in gallstone group bsing 7.39, 11.35, 4.76 and 6.64.In further comparison of control group with GBS and BDS groups separately, a significantly high frequency of -CW6 and -DR1 was found in GBS group alone with the PC value of 0.0043 and 0.005, RR value of 7.3 and 13.74, whereas 6 of 9 patients in BDS group had antigen -DRW, which was significantly higher than that of the control group (66.7%, vs 9%) with PC value of 0.0027, RR value as high as 17.89. Antigen DR3 did not attain the desired level of significance either in GBS or BDS groups.Comparing with a Japanese report, our 8 patients with intrahepatic stones revealed a different phentype of HLA antigenes.This study has shown that: 1) in patients with gallstones there exists a disease susceptibility gene closely associated with the C and DR locus of the HLA system; 2) GBS and BDS groups reveal different linkage to HLA antigens and 3) in the same intrahepatic stone disease there exists ethnic variations.

本文对37例胆石症病人作了HLA抗原测定并与100名健康人对照比较,发现胆石组HLA-CW_6、-DR_1、-DR_3及-DRW_8的分布频率分别为43.2%、21.6%、27%和40.5%.明显较对照组9%、2%、7%和9%的分布频率为高。其中-CW_6和-DR_1在胆囊结石组具有显著性;而-DRW_8抗原在胆管结石组中显著高于对照组。本组结果提示胆囊结石与胆管结石的易感基因可能存在于HLA不同的位点上。

With the emphasis on the selection of explosives, micro-exploder type and its structural parameters and safty performance, the out-body breaking effects of gallstone example, the action process of micro-exploder blasting and pressure distribution of produced shock wave, and the quantitative composition of blast reaction products, a series of explosion tests and observation were performed in the light of gallstone characteristic and existing conditions in human dile duct system and in view of the requriements...

With the emphasis on the selection of explosives, micro-exploder type and its structural parameters and safty performance, the out-body breaking effects of gallstone example, the action process of micro-exploder blasting and pressure distribution of produced shock wave, and the quantitative composition of blast reaction products, a series of explosion tests and observation were performed in the light of gallstone characteristic and existing conditions in human dile duct system and in view of the requriements of clinical practice. Based on the test results, a series of clinical practice was conducted with micro-explosion to break gallstones in bile duct system (bile duct in liver, choledochus and gallbladder included) , thus solving the theoretical and application problems of micro-explosion technique for breaking gallstone in hurman bile duct system for the first time and providing a new effective means for the treatment of human gallstone disease.

本文结合人体胆道系统结石性能及存在条件特点,从临床医疗要求出发,着重对炸药品种选择,微爆器类型及其结构条件参数和安全性能,结石实物样品体外破碎效果,微爆器爆炸作用过程及其冲击波压力分布和爆炸反应产物数量、组成等进行了一系列的大量试验和观测,在此基础上进行了用微爆器爆炸以破碎胆道系统(包括肝内胆管、胆总管、胆囊)结石的临床手术应用,在世界上首次解决了运用微爆炸技术破碎人体胆道系统结石的有关理论和实践问题,为人体胆石症的治疗提供了一个新的有效手段。

The risk factors of gallstone diseases were investigated with casecontrol study from 1988, 3 to 1988, 6. One hundred and eighty-six outpatients with cholelithiasis ascertained by B-ultrasonic wave served as the cases, and 186 persons without gallstone served as the controls. The ages, sexes and occupations between them were all matched. It was found that the history of b1iliary ascariasis, body mass index(W/H~3), β-lipoprotein, pregnant times, and high lipid diet were the risk factors respectively....

The risk factors of gallstone diseases were investigated with casecontrol study from 1988, 3 to 1988, 6. One hundred and eighty-six outpatients with cholelithiasis ascertained by B-ultrasonic wave served as the cases, and 186 persons without gallstone served as the controls. The ages, sexes and occupations between them were all matched. It was found that the history of b1iliary ascariasis, body mass index(W/H~3), β-lipoprotein, pregnant times, and high lipid diet were the risk factors respectively. The increasing of prevalence was correlated with the increasing of body mass index and pregnant times.

采用病例—对照研究方法,选取186例经B超确诊的门诊胆石病患者为病例组;并以年龄、性别与职业作配比因素,选取186例经B超确诊的非胆石病门诊人群为对照组。用统一表格、统一方法检测了两组人群的体重、身高及血脂,同时询问既往病史、生育史、饮食习惯等。结果发现:既往胆道蛔虫史、体重指数过高、血清高β—脂蛋白和高脂饮食是胆石病的易患因素;而既往肝病史、男性高糖饮食对胆石病的发生无明显影响。

 
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