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concentration     
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  浓度
    The Stimulation of Low Concentration Glycosides on Na/K Pump Current and the Mechanisms of Their Cardiotonic Action in Guinea Pig Ventricular Myocytes
    低浓度强心苷对Na~+/K~+泵电流的兴奋作用及强心作用机制
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    L-1978 Pharmacokinetics Study and Influence on Soman Concentration and AChE Activity in Rat Diaphragm
    L-1978药代动力学研究及对大鼠膈肌梭曼浓度和AChE活性的影响
短句来源
    The Use of the Vertical Diffusion Culture Method for the Determination of the Plasma Isoniazid Concentration
    用直升弥散培养法测定血浆异烟肼浓度
短句来源
    Studies on Maximum Permissible Concentration of Crude Sulfonated Phenanthrene in Surface Water
    地面水中磺化粗菲最大容许浓度的研究
短句来源
    SIMULTANEOUS DETERMINATION OF THE CONCENTRATION OF PHENYTOIN AND PHENOBARBITAL IN NORMAL HUMAN PLASMA BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY
    应用高压液相色谱分析法同时微量测定人血浆中苯妥英钠和苯巴比妥的浓度
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  含量
    Changes of Plasma Free Amino Acid Concentration in Patients with Gastric Cancer
    胃癌患者血浆游离氨基酸含量变化
短句来源
    TXB_1 AND 6-K-PGF_(1α) CONCENTRATION CHANGE IN ACUTE PANCREATITIS DETERMINED BY ELISA METHOD
    酶联免疫吸附法测定急性胰腺炎血栓素B_2、6-酮-前列腺素F_(1α)含量变化
短句来源
    Prostate concentration determination and pharmacokinetics of enoxacinby HPLC
    HPLC测定前列腺中依诺沙星含量及药动学研究
短句来源
    Effect of Intracerebroventricular Injection of Angiotensin Ⅱ on Testosterone Concentration in Male Rat Serum
    脑室注射血管紧张素Ⅱ对雄性大鼠血清睾酮含量的影响
短句来源
    ③drug intervention group: 150 mg/L ox-LDL and 100 mg/L captopril were added. ADMA, nitric oxide (NO), endothim (ET), L-citorulline (L-cit) concentrations and the activity of NOS in the medium were measured after 24 h exposure. ADMA concentration in the medium was determined by high-performance liquid chromatography.
    ③ox-LDL加卡托普利组:同时加入150mg/Lox-LDL及卡托普利100mg/L,共孵24h后,检测上清液中一氧化氮(NO)、内皮素(ET)、一氧化氮合酶(NOS)活性、ADMA含量、反应DDAH酶活性的L-胍氨酸(L-cit)浓度,采用Western blot测定细胞裂解液中DDAH的蛋白表达。
短句来源
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  药浓度
    Determination of the Concentration of Adriamycin in Blood by Polyamide Chromatography Fluorimetry
    聚酰胺柱层荧光分光法测定阿霉素的血药浓度
短句来源
    A COMPUTER PROGRAM FOR CALCULATION OF DRUG CONCENTRATION AFTER MULTIPLE DOSAGE REGIMEN
    计算多次服药后血药浓度的FORTRAN程序
短句来源
    Relationship between the efficacy and plasma concentration of praziquantel in mice and rabbits infected with Schistosoma japonicum
    吡喹酮对感染日本血吸虫小鼠与家兔的疗效和血药浓度的关系
短句来源
    CLINIC VALUE OF SERUM CONCENTRATION MONITORING OF SODIUM PHENYTOIN
    苯妥英钠血药浓度监测的临床价值
短句来源
    Difference of the peak plasma concentration of penicillin in finger and venous blood
    青霉素肌注后峰时手指血与静脉血药浓度差异的探讨
短句来源
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  药物浓度
    RELATIONSHIP BETWEEN PBOPAFENONE DOSE AND SERUM CONCENTRATION
    心律平剂量与血清药物浓度的关系
短句来源
    Concentration of Tinidazole in Gingival Crevicular Fluid after Single Oral Dose
    单剂量口服替硝唑后龈沟液药物浓度监测
短句来源
    DETERMINATION OF DRUG CONCENTRATION IN SERUM AND MYOIDEUM AFTER 5-FLUOROURACIL IMPLANTS WERE IMPLANTED IN RABBIT
    埋入5-氟尿嘧啶植入剂后家兔血清及肌肉组织中药物浓度的测定
短句来源
    The expression of Fas increased with PYM concentration while the expression of Bcl-2 decreased.
    Fas表达随药物浓度增加而递减,Bcl-2表达随药物浓度增加而升高。
短句来源
    The concentration of vancomycin in rabbits aqueous humor at 120 min after nano-vancomycin eye drops administered was 0.83 ± 0.05 μg/ml.
    兔眼房水中万古霉素药物浓度在滴入纳米-万古霉素滴眼液后120min为:0.83±0.05μg/ml。
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      concentration
    More generally, these results apply both to Gabor frames and to systems of Gabor molecules, whose elements share only a common envelope of concentration in the time-frequency plane.
          
    aureus in lower concentration of chloroform extract.
          
    Transfersomal formulation with optimal concentration of Soya phosphatidylcholine (SPC) and sodium deoxycholate (85:15 w/w) showed entrapment efficiency of 39.8±0.032 and deformability index of 16.4.
          
    None of the synthesized compounds appear to be more potent than 1 at a concentration of 10 μM.
          
    Only two of the evaluated compounds (2 and 8) appeared to be allosteric enhancers at high concentration (10 μM).
          
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    Three new 4-amino-2-alkylsulfonyl benzoic acids, namely, 4-amino-2-methylsulfonyl benzoic acid, 4-amino-2-ethylsulfonyl benzoic acid and 4-amino-2-n-propylsulfonyl benzoic acid, have been studied for in vitro in human tuberculosis, hoping that they would surpass the p-amino- salicylic acid in activity. Contrary to our expectations, however, these new compounds have been found to be far less active than the p-amino-salicylic acid itself. The 4-amino-2-n-propyl- sulfonyl benzoic acid possesses an activity in the...

    Three new 4-amino-2-alkylsulfonyl benzoic acids, namely, 4-amino-2-methylsulfonyl benzoic acid, 4-amino-2-ethylsulfonyl benzoic acid and 4-amino-2-n-propylsulfonyl benzoic acid, have been studied for in vitro in human tuberculosis, hoping that they would surpass the p-amino- salicylic acid in activity. Contrary to our expectations, however, these new compounds have been found to be far less active than the p-amino-salicylic acid itself. The 4-amino-2-n-propyl- sulfonyl benzoic acid possesses an activity in the order of 10~(-3) in concentration, while the other two compounds require still higher concentrations. Besides, we have prepared five other new compounds: 4-nitro-o-tolyl-methyl sulfide, 4- nitro-2-methylsulfonyl benzoic acid, 4-nitro-o-tolyl-ethyl sulfide, 4-nitro-o-tolyl-n-propyi sulf- fide and 4-nitro-2-n-propylsulfonyl benzoic acid.

    對-氨基柳酸為現在常用的一種結核病治療藥劑。我們將其中的羥基代以-SO_(2)R,希望能增強其抑制結核桿菌的性能。我們合成了4-氨基-2-甲磺醯苯甲酸,4-氨基-2-乙磺醯苯甲酸和4-氨基-2-正丙磺醯苯甲酸三種新的化合物。在試管中試驗的結果,除最後一種化合物能在千分之一濃度的溶液中具抑制結核桿菌的性能外,其餘兩種化合物抑制結核桿菌的性能則是更低。我們在製備上述三種化合物時,曾附带合成另外五種新的化合物。

    This work was done on six esophageal fistula dogs to observe the effect of sham feeding upon sugar tolerance. Sugar tolerance test was done by the intravenous administration of 40% glucose solution in dosage of 0.5 g/kg body weight.Approximately one minute was required for this injection.Venous blood for sugar determina- tion was taken from the fore legs just before the injection and also 15,30, 45,60,90 and 120 minutes after it.Sham feeding commenced immediately after the injection of glucose and lasted usually...

    This work was done on six esophageal fistula dogs to observe the effect of sham feeding upon sugar tolerance. Sugar tolerance test was done by the intravenous administration of 40% glucose solution in dosage of 0.5 g/kg body weight.Approximately one minute was required for this injection.Venous blood for sugar determina- tion was taken from the fore legs just before the injection and also 15,30, 45,60,90 and 120 minutes after it.Sham feeding commenced immediately after the injection of glucose and lasted usually 14 minutes.The results were as follows: (1)It was observed on 6 dogs and in 15 experiments that the normal sugar tolerance curves (without sham feeding) were fairly uniform.The average peak value of blood sugar concentration in samples taken 15 minutes after glucose administration was 165 mg% and blood sugar concentration returned to the original level within 60—90 minutes. (2)A marked change of the sugar tolerance curves was observed after sham feeding.The average peak value of blood sugar concentration in samples taken 15 minutes after glucose administration was 138 mg % and blood sugar concentration returned to the original level 15—30 minutes sooner than that seen in the experiments without sham feeding. (3)The above experiments were repeated on two of the dogs after bilateral supradiaphragmatic vagotomy and on one dog after denervation of the pancreas.No effect upon sugar tolerance was observed after sham feeding. These results further verify our previous work that the excitation of the vago-insulin system can be brought about by sham feeding.

    本工作用具有食道瘘的狗,观察假饲对糖耐量的影响并分析其机制。糖耐量测验的方法系由静脉注入40%葡萄糖溶液0.5克/千克体重。在注射前以及从注射葡萄糖时开始,每隔15、30、45、60、90及120分钟,分别由静脉取血,分析血糖浓度。假饲是在注射葡萄糖后立即开始的,假饲时间一般为14分钟。实验结果如下:(一)正常糖耐量曲线(不进行假饲)一般是相当恒定的。由静脉注射葡萄糖后15分钟,血糖浓度平均为165毫克%,并且一般在注射后60—90分钟内血糖浓度即恢复至注射前的水平。(二)当由静脉注射葡萄糖后立即进行假饲,结果使正常糖耐量显著增加,也就是使正常糖耐量曲线呈显著的减退性变化:血糖浓度在注射后的15分钟时,平均最高仅达138毫克%,并且在注射后45—60分钟内血糖浓度即恢复至原有水平。(三)当切断膈上的两侧迷走神经或切除胰腺的一切外来神经后,重复以上实验,结果假饲对糖耐量并无影响。因此,本工作更较明确地证明:假饲的进食动作确能唤起中枢神经系统的兴奋,通过迷走神经反射地引起胰岛素的分泌。

    The toxicity and pharmacological properties of p:p'-diaminodiphenoxy heptane, a compoud with schistosomicidal activity.are described. The LD_(50) for mice was 1260 mg./kg. orally and 195 mg./kg.intravenously. Mice became less active and lost appetite after taking the drug orally.Intravenous injection of the compound caused the extremities of mice to paralize for a few seconds.This was followed by clonic convulsion and opisthotonus.Death was due to cardiac arrest. When mice and rats were given small doses of...

    The toxicity and pharmacological properties of p:p'-diaminodiphenoxy heptane, a compoud with schistosomicidal activity.are described. The LD_(50) for mice was 1260 mg./kg. orally and 195 mg./kg.intravenously. Mice became less active and lost appetite after taking the drug orally.Intravenous injection of the compound caused the extremities of mice to paralize for a few seconds.This was followed by clonic convulsion and opisthotonus.Death was due to cardiac arrest. When mice and rats were given small doses of the drug once daily for 14 days,there was no change in blood picture,blood sugar and body temperature. However,the growth of the animals was arrested due to loss of appetite. Oral administation of p:p'-diaminodiphenoxy heptane at a does of 50-100 mg./kg.to dogs caused vomiting in about one and half hours. After abut 24 hours,the pupils of the animals were dilated;light reflex was absent.The dogs did not recover from these effects until after about a month.Intravenous injection of 30 mg./kg.of the drug causdd similar reactions. However,feeding a monkey with 60 mg./kg.through stomach tube did not cause any reaction.This was true even when the monkey was given 20mg./kg.daily for 5 days.The liver function (B.S.P.) and blood N.P.N.levels of the dogs and the monkey fed chronically with the drug were not changed. Intravenous injections of 0.5-2.5mg./kg to anesthetized dogs and cats caused a transient fall of blood pressure.The intestinal movement of the cat was inhibited. Respiration was not affected significantly in the dog.In anesthetized cats,the amplitude of respiration was decreased in most experiments. Addihon of p:p'-diaminodiphenoxy heptane to a bath containing a segment of guinea-pig ileum caused only a slight relaxation of the tissue.However,addition of the drug to a concentration of 1:5000,000-1:50,000 decreased or abolished the reaction of the tissue to acetylcholine,histamine and barium choride.Intravenous injection of 15-20mg./kg.of the drug to rabbits under anesthesia increased the tension of the uterus.

    1.对氮苯氧庚烷对小鼠的半数致死量口服为1260毫克/公斤,静脉注射为195毫克/公斤。小白鼠每日口服50-200毫克/公斤,连续两周,因影响食欲致使体重的增加受到抑制,停药后即渐恢复。2.对氨苯氧庚烷对麻醉猫和狗的血压,在静脉注射时有显著而短暂的降低,剂最愈大或注射速度愈快,血压下降亦愈多。3.对于麻醉猫的迴肠及豚鼠离休迴肠,对氨苯氧庚烷均有明显抑制作用。对氨苯氧庚烷并能对抗组织胺、乙醯胆龄及氯化钡对离体豚鼠迴肠的作用。对在体家兔子宫有收缩作用,而对离体子宫则有抑制作用。

     
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