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signals transduction
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  信号转导
     We speculate that TSPG may directly and/or indirectly promote the stromal cells and lymphocytea to produce GM-CSF and other cytokine and induce bone marrow hematopoietic cells to express GM-CSF receptors (GM-CSFRot), leading to the regulation of the GM-CSFR-mediated signals transduction pathway and the proliferation of human CFU-GM.
     上述结果表明,TSPG可能通过直接和/或间接途径促进淋巴细胞与骨髓基质细胞合成与分泌GM-CSF,诱导骨髓造血细胞表达GM-CSFRα,并刺激GM-CSFRα和Shc的酪氨酸可逆磷酸化,从而通过调控GM-CSF的信号转导过程,促进CFU-GM的增殖。
短句来源
     Objective:To set up a eukaryotic system for high expressing human CD137 and to investigate the role of CD137 and CD137L on signals transduction of cells.
     目的 :构建CD137真核高效表达系统 ,深入研究CD137及其配体在细胞信号转导中的作用。
短句来源
     Objective Effects of CD3 McAb,CD28 McAb,PHA and lowdose γray irradiation on T lymphocytes were investigated to explore factors of influencing T cell signals transduction.
     目的 观察CD3单抗、CD2 8单抗、PHA和低剂量辐射对淋巴细胞增殖的影响 ,探讨影响T淋巴细胞信号转导的因素。
短句来源
     This article reviewed actions of some proteins in relating to GPCRs, signals transduction in rheumatoid arthritis (RA), including G protein-coupled receptor kinases (GRKs), arrestin, regulators of G protein signal (RGS) and G protein-coupled inflammatory receptors.
     该文综述了与类风湿关节炎相关的G蛋白偶联受体(Gpro-tein-coupledreceptors,GPCRs)信号转导的一些蛋白作用,包括G蛋白偶联受体激酶、视紫红质抑制蛋白(arrestin)、G蛋白信号转导调节因子、G蛋白偶联致炎受体等。
短句来源
     G Protein and its Functions in Signals Transduction of Cell
     G蛋白及其在细胞信号转导中的作用
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  信号传导
     Preparation of the agonist/antagonist monoclonal antibodies against B7 and CD28 molecules and analysis of their effects on costimulatory signals transduction
     B7:CD28激发/拮抗型单抗的研制及其在共刺激信号传导中的调节作用研究
短句来源
     Research on the signals transduction and apoptosis of trophoblast cells in early pregnancy terminated by mifepristone
     米非司酮影响早孕滋养细胞的信号传导和凋亡的机制研究
短句来源
     Objective\ To investigate the effects of RU486 on first trimester trophoblast cells in the events of signals transduction and apoptosis.
     目的 探讨米非司酮 (RU486 )在早孕滋养细胞信号传导及其凋亡中的影响。
短句来源
     The effect process of hyaluronan in epithelial cell was summarized, from binding to cellular surface receptor to activating signals transduction route as well as expressing protein and resulting in cellular proliferation and transferration. 
     阐述了透明质酸寡聚糖对上皮细胞作用的过程,即从与细胞表面受体结合到激活信号传导途径,以及表达成蛋白质进行细胞增生和转移.
短句来源
     Associated genes were sifted in rats’degenerated intervertebral discs, especially lots of cell signals transduction associated genes expression, which indicated signal-transmitted between in and out of cells participated in intervertebral discs degeneration.
     筛选出大鼠退变椎间盘中相关基因 ,特别是有较多的细胞信号和传递蛋白类基因表达 ,说明细胞内外的信号传导介导了椎间盘退变过程。
短句来源
  “signals transduction”译为未确定词的双语例句
     Study on the Mechanism of Signals Transduction of HIF-1α Facilitating the Human Umbilical Vein Endothelia Cells' Proliferation
     HIF-1α对人脐静脉内皮细胞增殖信号通路的初步研究
短句来源
     IFNγ affects collagen α_1(Ⅰ) mRNA gene expression signals transduction pathway in rat hepatic stellate cells
     IFNγ影响肝星状细胞α_1(Ⅰ)mRNA表达信号的传递途径
短句来源
     2. Resistance signals transduction of inducers in cucumber seedlings. Mechanical stress inducer and chemical SA inducer were used to treat the first real leaves of cucumber seedlings. Before induced, the leaves were treated by RGD(Arg-gly-Asp) and DGR, while the controls were not treated by RGD and DGR.
     2. 诱导子在黄瓜幼苗中抗病信号的转导:在诱导之前,处理组植株用一定浓度的RGD(Arg-gly-Asp)序列的多肽和与前者序列相反的DGR 多肽处理,空白对照组用对应量的水处理。
短句来源
     Conclusion\ RU486 supressed the signals transduction of first trimester trophoblast cells on PKC and raf-1,MEK-1 central pathways,by which their proliferation and differentiaton were negatively affected,inducing them into the apoptosis program.
     结论 RU486抑制早孕滋养细胞PKC信号通路及raf- 1瀑布激酶链和分裂激活蛋白 ,抑制增生分裂分化并诱导凋亡发生 ;
短句来源
     And to probe into correlation between the fator of Signals transduction RAB5A and tumor matastasis. Methods:immunhistochemical tehniques was used Results:there wasn't expression of Rab-5A in normal tissues but genes differentially expressed in carcinomas(P<0.01);
     方法 :本实验用免疫组化技术结果表明 :Rab - 5A的表达在正常组织中不表达 ,而在癌组织中有不同程度的表达 (P <0 .0 1)。
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  signals transduction
Besides their well-defined intracellular roles in transmembrane signals transduction, guanine derivatives play important roles by acting from the outside of neural cell membranes.
      
The systems of photo- and pheromone signals transduction in unicellular eukaryotes
      
The complex biology of the cancer cell leads us to search combination strategies to act simultaneously in different points of signals transduction pathways to enhance the anticancer effect.
      


It was found that toosendanin possesses special action against the oriental army worm, Mythimna Separata (Wlk.) It does not kill the insects quickly but it acts as a potent antifeedant to the annywonn by inhibiting the chemorecepton in the mouth parts and also in terfering the signal transduction process in the central nervous system of the larvae. The treated larvae showed characteristic symptoms and abnormal behaviour. There is a possibility of using toosendanin as an antifeedant and toxicant in the...

It was found that toosendanin possesses special action against the oriental army worm, Mythimna Separata (Wlk.) It does not kill the insects quickly but it acts as a potent antifeedant to the annywonn by inhibiting the chemorecepton in the mouth parts and also in terfering the signal transduction process in the central nervous system of the larvae. The treated larvae showed characteristic symptoms and abnormal behaviour. There is a possibility of using toosendanin as an antifeedant and toxicant in the control of the young larval population of the annywonn in the field.

川楝素对粘虫幼虫具有特殊的作用,它的作用与杀虫脒有相似之处,它不直接杀死害虫,而通过对害虫化学感受器和中枢神经系统的双重作用,引起害虫产生拒食反应,并出现行为反常及其它神经中毒症状。

The biochemical basis of pericyte loss in early diabetic retinopathy is still an open question. In studies on the mechanism by which retinal peri-cytes degenerate, we first established a bovine retinal capillary pericyte (BRCP) cell line. Subcultured BRCP grown in high (10-40mmol/L) glucose media were used as an experimental model. We found that high concentrations of glucose suppress the mitotic rate and cell birth rate of cultured BRCP. High concentrations of glucose inhibit myo-inositol transport and result...

The biochemical basis of pericyte loss in early diabetic retinopathy is still an open question. In studies on the mechanism by which retinal peri-cytes degenerate, we first established a bovine retinal capillary pericyte (BRCP) cell line. Subcultured BRCP grown in high (10-40mmol/L) glucose media were used as an experimental model. We found that high concentrations of glucose suppress the mitotic rate and cell birth rate of cultured BRCP. High concentrations of glucose inhibit myo-inositol transport and result in decreased intracellular myo-inositol content. This inhibition can be partially reversed by sorbinil, an aldose reductase inhibitor (ARI). Myo-inositol is a precursor of inositol phospholipids (IPLs), whose metabolism is responsible for a number of signal transduction processes. Phosphoinositidase (Plase) cleaves the phos-phodiester bond of phosphotidylinositol 4,5 diphosphate (PIP2) to produce two second messengers, inositol trisphosphate (IP3) and diacylglycerol (DG). Further experiments showed that IP3 and DG synergistically activate BRCP proliferation in vitro. High concentrations of glucose altered the formation of both IPLs and inositol phosphate esters (IPEs) in an organ culture of retinal micro-vessels. This alteration can be reversed by adding either high concentrations of myo-inositol or ARI to the medium. Plase activity was attenuated to 82% or 55% when glucose in the growth medium was increased from 5 to 15 or 30 mmol/L, respectively. When IPLs from BRCP were analyzed by HPLC and TLC, we observed the reduction of three IPLs, including the substrate of Plase, PIP2. The reduced levels of IPLs were restored by adding either free myo-inositol or ARI to the high-glucose medium. These findings suggest that the alteration in IPL metabolism in BRCP may be related to insufficient myo-inositol or to an activated sorbitol pathway under high glucose conditions. The supplementation of either inositol or ARIs may be used as in vitro therapy for the treatment of "diabetic pericytes".

在高浓度葡萄糖条件下(模拟糖尿病条件)培养视网膜毛细血管周细胞,由于调控细胞增殖的第二信使——肌醇磷脂代谢产物减少,使周细胞增殖活力降低。在高葡萄糖条件下,周细胞内肌醇水平下降、山梨醇通路被激活;外加肌醇或阻断山梨醇通路则可使异常的肌醇磷脂代谢得到不同程度的纠正,周细胞增殖活力亦随之回升。提示外加肌醇和阻断山梨醇通路是防止糖尿病周细胞衰亡的有效体外治疗。

The subunit α_0 of guanine nucleotide- binding protein, in the areas of rat brain and spinal cord was localized by immunohistochemical methods. It was found that in the rat brain, specific α_0-like immunoreactivity(α_0-Li) displayed regional heterogeneity, a high density of α_0-Li revealed in neuropil, and somatic membranes as well as the neuronal processes.Most intense α_0-Li can be seen in substantia nigra(pars reticulata), interpcduncular nucleus, habenulo-interpeduncular tract, strata oriens and radiatum...

The subunit α_0 of guanine nucleotide- binding protein, in the areas of rat brain and spinal cord was localized by immunohistochemical methods. It was found that in the rat brain, specific α_0-like immunoreactivity(α_0-Li) displayed regional heterogeneity, a high density of α_0-Li revealed in neuropil, and somatic membranes as well as the neuronal processes.Most intense α_0-Li can be seen in substantia nigra(pars reticulata), interpcduncular nucleus, habenulo-interpeduncular tract, strata oriens and radiatum of the hippocampus, and substantia gelatinosa of the spinal cord. There are also areas of moderate staining ie: the molecular layer of cerebral and cerebellar cortex, habenula, caudate-putamen complexes, the midline nuclei of thalamus and hypothalamus, periaqueductal grey, grey layers of superior colliculus, the olivo-cerebellar tract and the spinal tract of the trigeminal nerve as well. By contrast, the immunoreactvity of α_0 in septal nuclei, globus pallidus, red nucleus, and the regions adjacent canalis centralis of the spinal cord showed much weaker. In addition, on the membranes and the processes of the neuronal cell bodies in the periaqueductal grey, substantia nigra, reticular formation, medial geniculate body and the nucleus of the trapezoid body were α_0-Li positive.The results of AChE staining revealed that the AChE-positivc nerve terminals was coinsident with the presence of α_0-Li in the following regions. For instance: the molecular layer of cerebral cortex, hippocampus, spinal tract of the trigminal nerve, and substantia gelatinosa of the spinal cord, where both the α_0-Li and the AChE activity were positive. It is suggested that α_0 subunit of Go-protein in brain might play roles in membrane signal transduction, and might have some relationship with cholinergic nerve.

本研究应用兔抗鸟核苷酸调节蛋白α_0亚单位(简称α_0)多克隆血清(抗体),采用免疫组织化学方法对大鼠脑和脊髓内一些结构中的α_0作了定位观察.发现α_0样免疫反应性(α_0-Li)在大鼠脑内的分布比较广泛,各脑区表现出分布不均,神经网织中呈高密度,神经元核周质缺乏或其少,α_0-Li主要位于胞体膜及其突起上.最强的α_0-Li见于黑质(网织部),脚间核及缰—脚间束,海马多形细胞层,辐射层和脊髓胶状质;中度染色者有:大脑皮质、小脑皮质及海马的分子层,缰核,尾壳复合体,中脑导水管周围灰质,上丘灰质,延髓三叉神经脊束及延髓橄榄小脑束,丘脑和下丘脑中线核群。但隔核,苍白球,红核,脊髓中央管周围灰质α_0-Li相对较弱.另外,发现在中脑导水管周围灰质、黑质、中脑网状结构、内侧膝状体及斜方体核区内一些神经元核周质及其突起上,存在有α_0-Li.AChE染色证明,0在一些α_0—Li阳性区域:大脑皮质分子层,海马,延髓三叉神经脊束及脊髓胶状质等,也富含AChE阳性(胆碱能?)神经末梢.结果提示,脑内G_0蛋白的α_0亚单位在膜信息传递中可能与胆碱能神经成分有一定关系。

 
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