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breast lesions     
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  乳腺病变
     Expression of Bcl-2 and p53 protein in breast lesions
     乳腺病变组织中BcL-2,p53蛋白的表达
短句来源
     Methods S-P labeling technique was used to study expression of p63 protein,S-100 protein,SMA,CK (34βE12) in 10 cases of normal breast tissue and 38 cases of different breast lesions.
     方法 对38例不同类型的乳腺病变分别进行p63、SMA、S -100蛋白、CK(34βE12)免疫标记。
短句来源
     Dynamic Contrast-Enhanced MRI of Breast Lesions
     乳腺病变动态增强MRI研究
短句来源
     Method:75 cases of different breast lesions were immunohistochemically stained for Egr 1 protein antibody.
     方法: 用免疫组织化学法对75 例乳腺病变组织进行 Egr1 检测;
短句来源
     Objective To explore the infection rates of human papillomavirus 16,18 Subtype(HPV16,18) in breast invasive ductal carcinomas,breast atypical ductal hyperplasia and breast benign hyperplasia Methods The expression levels of HPV16,18 in breast lesions were analyzed by In-situ hybridization technique.
     目的探讨乳腺浸润性导管癌、导管不典型增生和良性上皮增生中人乳头瘤病毒(HPV)16、18型感染的差异。 方法用原位杂交法检测乳腺病变组织中HPV16、18型表达。
短句来源
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  乳腺疾病
     Dynamic Contrast-enhanced MRI of Breast Lesions
     乳腺疾病的动态增强MRI研究
短句来源
     400 cases,928 were positive for breast lesions,i. e. hyperplasia of breast in 708 cases(76.29%),fibroadenoma 96(10.34%),breast carcinoma 41(4.42%),and papilloma 14(1.51%).
     结果发病率排列前4位的乳腺疾病依次为乳腺增生性改变708例(76.29%)、纤维腺瘤96例(10.34%)、乳腺癌41例(4.42%)和导管内乳头状瘤14例(1.51%),其他病变则较少见。
短句来源
     Value of dynamic enhanced MRI on differential diagnosis of benign and malignant breast lesions
     动态增强MRI在乳腺疾病良恶性鉴别诊断中的价值
短句来源
     Objective To explore the MRI diagnosis of the breast lesions in SE、STIR and FLASH sequences.
     目的 探讨SE、STIR和FLASH三种扫描序列在乳腺疾病MRI诊断中的作用。
短句来源
     Methods:Conventional MR imaging (spin echo T_1WI,T_2WI and STIR) was used to scan 32 patients with histologically proven benign tumors (19) inflammatory lesions (5) and malignant breast lesions (6) on a GE 1.5T scanner using Breastpa phased array coil.
     方法:使用GE1.5T磁共振扫描仪及阵列线圈对32例乳腺疾病患者行常规SE序列扫描,其中19例为良性肿瘤,5例炎性病变,6例恶性肿瘤,均经手术及病理证实;
短句来源
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  乳腺肿块
     Clinical study on the Mammotome system in the treatment of breast lesions
     Mammotome微创旋切系统治疗乳腺肿块的临床思考
短句来源
     Application of two - dimensional and color Doppler ultrasonography in diagnosis of breast lesions
     二维及彩色多普勒超声在乳腺肿块超声诊断中的应用
短句来源
     Conclusion 99Tcm-MIBI images provides clinically valuable information on patients with palpable breast masses. 99Tcm-MIBI imaging has high sensitivity and accuracy in the diagnosis of breast cancer and in the differentiation between benign and malignant breast lesions.
     结论99Tcm-MIBI显像对乳腺肿块的患者能提供非常有价值的临床信息,对乳腺癌的诊断及良、恶性病变的鉴别有较高的敏感性和准确性。
短句来源
     To investigate the feasibility and significance of DNA quantitative measurement on preoperative fineneedle aspiration (FNA) smears of breast lesions, DNA quantitative measurement was performed on 52 preoperative FNA smears with image cytometry (CAS200).
     为了探讨乳腺肿块术前细针穿刺涂片DNA定量测定的可行性及临床意义,采用CAS200图像细胞仪对52例乳腺肿块术前细针穿刺涂片进行DNA定量测定。
短句来源
     Conclusion Two - dimensional and color Doppler ultrasonography are helpful for the diagnoes and the differetiation of benign and malignant breast lesions.
     结论 二维及彩色多普勒超声有助于乳腺肿块的良恶性鉴别诊断,是乳腺癌诊断中一种有价值的影像诊断方法。
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  乳腺病灶
     Objective To evaluate breast imaging reporting and data system (BI-RADS) in categorization and biopsy of nonpalpable breast lesions (NPBLs).
     目的探讨乳腺影像报告与数据系统(breast imaging reporting and data system,BI-RADS)对于临床触诊阴性乳腺病灶分类的意义及指导乳腺病灶活检的价值。
短句来源
     Methods Forty-six breast lesions in 45 patients underwent real-time contrast-enhanced ultrasonography were grouped as malignant lesions(n=25) and benign lesions(n=21).
     方法用超声造影观察45例患者的46个乳腺病灶,其中恶性肿瘤25个,良性病变21个。
短句来源
     Materials and Methods: 82 breast lesions in 64 patients were performed by ultrasound guided Mammotome system.
     材料和方法:对64例82处乳腺病灶进行了超声引导下Mammotome微创旋切术。
短句来源
     Objective To differentiate benign from malignant breast lesions by analyzing qualitative and quantitative MR characteristics.
     目的 通过分析定性、定量MR特征鉴别良、恶性乳腺病灶
短句来源
     Methods Under the guidance of B- ultrasonography, stereotactic core biopsy using the Mammotome system was perform ed for 87 breast lesions in 81 patients.
     方法对81例87处乳腺病灶行B超引导下Mammotome微创旋切术,评价其对乳腺病灶的诊治效果。
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  breast lesions
BCSG1 is not expressed in normal or benign breast lesions, but expressed at an extremely high level in the vast majority of the advanced staged breast carcinomas and ovarian carcinomas.
      
Methods: 109 masses of 102 patients with breast lesions smaller than 2 cm in diameter were divided into three groups to undergo 99mTc-MIBI imaging and compared with the results of pathology examination.
      
20 cases without breast lesions were selected as control.
      
Negative imaging were found in 31 of 38 benign breast lesions.
      
Of 39 occult breast lesions, positive imaging appeared in 6 and 3 of them were breast cancer, 2 of 3 patients with slightly increased 99mTc-MIBI imaging threshold were breast cancer also.
      
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The aim of this study is to raise the effectiveness and reliability of differentiating malignant cells from benign cells in cytological diagnosis of the breast lesion by fine-needle aspiration biopsy. Cytological smears from 100 cases each of breast cancer, fibroadenoma and mammary dysplasia were studied statistically to make sure of the following morphologic criteria.It was proved that the morphlogical criteria designed by us in 1975 for differential diagnosis of cells of these three kinds of mammary...

The aim of this study is to raise the effectiveness and reliability of differentiating malignant cells from benign cells in cytological diagnosis of the breast lesion by fine-needle aspiration biopsy. Cytological smears from 100 cases each of breast cancer, fibroadenoma and mammary dysplasia were studied statistically to make sure of the following morphologic criteria.It was proved that the morphlogical criteria designed by us in 1975 for differential diagnosis of cells of these three kinds of mammary lesions are good and can be used for clinical purpose. The simplified criteria areas follows: (1) The presence of a cell with a nuclear diameter larger than 20um in the smear; (2) The size of the largest nucleus in a cell cluster is twice or more larger than that of the smallest nucleus; (3) The number of nucleoli is more than 5;(4) The diameter of nucleoli larger than 5um;(5) The mitotic figures appeared in every smear, and (6) The hemi-quantitative analysis of cells on the smears is orer (). If two of the above-mentioned six criteria were found in one smear, the lesion may be diagnosed as malignant. Of course, besides the six criteria mentioned above, the other abnormalities may also be consid-ered in the diagnosis.

本研究的目的在于提高乳腺病变细针穿刺活检鉴别良性恶细胞的细胞学鉴别诊断的有效性及可靠性,对乳癌、纤维腺瘤及乳腺增生各100例的细胞学涂片作了统计学研究及确定形态学指标是否合用。 已证明我们在1975年拟定的三型乳癌病变细胞鉴别诊断的形态学指标是好的可供临床目的应用,简化的指标为:(1)有细胞,其核直径大于20μm;(2)细胞团中有的细胞最大的核为最细核的2倍或以上;(3)核仁数目超过5个;(4)最大核仁直径大于5μm;(5)每片中可见分裂象;(6)片上细胞半定量分析超过,如一个片上可见上述指标的2个时,可诊断为恶性,当然,除此之外,其他异常亦可考虑到诊断。

Six cases of recurrent papillary carcinoma of the breast were followed since 1975. All of these patients had the breast lesions excised locally with incorrect diagnosis of papillomatosis. The criteria of Kraus and Haagensen were used in distinguishing papillary carcinoma from papillomatosis. Review of microscopic sections of all patients showed evidence of transformation from papillomatosis to papillary carcinoma in 2 cases. Simple mastectomy is adequate for patients with active growing papillomatosis....

Six cases of recurrent papillary carcinoma of the breast were followed since 1975. All of these patients had the breast lesions excised locally with incorrect diagnosis of papillomatosis. The criteria of Kraus and Haagensen were used in distinguishing papillary carcinoma from papillomatosis. Review of microscopic sections of all patients showed evidence of transformation from papillomatosis to papillary carcinoma in 2 cases. Simple mastectomy is adequate for patients with active growing papillomatosis. When malignant changes are evident, it would be advisable to treat them as ordinary breast carcinoma.

自1975年以来,共诊治在乳头状瘤病诊断下切除后复发的乳头状癌6例,包括原位癌及侵犯癌各3例。综合Kraus及Haagensen的组织学诊断标准,重新复习全部病理切片,除1例首次病变仅见乳头状瘤病外,无论首发或复发病变,皆可见到乳头状瘤病与乳头状癌组织并存或交错存在,2例可见由良到恶的逐步过渡形态,初步认为本组6例乳头状癌皆系来自轧头状瘤病癌变。当乳头状瘤病出现充满多数腺管的活跃增生时,宜行全乳切除术,癌变后则按一般乳腺癌处理原则进行治疗。

6C6 Monoclonal antibody was produced from a fusion of spleen cells to plasma membrane of a human breast cancer-primed BALB/C mouse with the murine myloma cell line SP2/0. Positive 6C6 hypridomas were single cell cloned. The antibody reacted strongly with the plasma membrane of human breast cancer cells MCF-7. Tissue section of both human mammary carcinomas and benign breast lesion and tumor of non-breast origin as well as apparently normal tissue were tested with immunoperoxidase. 30/36...

6C6 Monoclonal antibody was produced from a fusion of spleen cells to plasma membrane of a human breast cancer-primed BALB/C mouse with the murine myloma cell line SP2/0. Positive 6C6 hypridomas were single cell cloned. The antibody reacted strongly with the plasma membrane of human breast cancer cells MCF-7. Tissue section of both human mammary carcinomas and benign breast lesion and tumor of non-breast origin as well as apparently normal tissue were tested with immunoperoxidase. 30/36 carcinomas of breast reacted positively. 0/7 human normal mammar tissue reacted negative. Little or no appreciable reactivity was observed with benign breast lesion and carcinoma of non-breast origin. Subclasses of 6C6 Monoclonal antibody was

用乳腺癌患者的原发瘤组织制备的细胞膜抗原免疫BALB/C小鼠,取致敏脾脏细胞与SP_(2/0)骨髓瘤细胞融合。融合率为42%,经克隆化培养后得到一株分泌抗人体乳腺癌单克隆抗体杂交瘤细胞,命名为6C_6。其分泌的抗体和乳腺癌细胞系MCF-7呈阳性反应,与其它5种人癌细胞系,1种人正常细胞系及4种鼠类肿瘤细胞系呈阴性反应。免疫组织化学实验表明:6C_6单克隆抗体(简称6C_6McAb)与乳腺癌的反应多呈阳性(30/36),与7例正常乳腺均呈阴性反应。6C_6McAb类别为IgC_1。其抗体经ZetaPrep大容量离子交换圆盘纯化,对乳腺癌原发瘤组织仍具有较高的活性。

 
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