Distribution phase half life is 0. 13 h, elimination phase half life is 3. 68 h, the mean plasma clearance is 0. 125 L · h-1 · kg-1 , apparent volume of distribution is 0. 697 L · kg-1 , and the area under curve is 16. 01 g · h · L-1.
Pharmacokinetic paramet-ers were estimated from two-point Bayesian approach, elimination half-life was2.68±0.88 h, volume of distribution was 0.2735±0.0594 L/kg, systematic clearancewas 75.19±19.90 ml/h.
Using the -CHR-(CH_ 2)_ 3-NFCH_ 3(R=H, CH_ 3, CH_ 2CF_ 3, CHO, COCH_ 3) as the computational model, the two possible intramolecular reactions, nucleophilic substitution on nitrogen and elimination reaction, were studied at the theoretical level of MP2(full)/6-31+G(d,p).
As all the product C_2H_3Cl is from the β elimination, an apparent rate constant of the reaction is determined k_ 1a=5.0×10 13×exp(-30000/T)s -1 . The effect of the possible interfere of chain reaction initiated by the C-Cl bond scission and the consequent chain propagation is investigated.
Overall the pharmacokinetic properties of both isomers were similar in rats, monkeys and humans, with β-isomer exhibiting longer elimination half-life, MRT, volume of distribution and clearance, irrespective of the route of administration.
It had been found from the flocculation of disposed water with algae from Dianchi Lake that the transparency and COD elimination reach to 93.5% and 70.3%, respectively, with 15 mg/L PSOAMDA and at pH 6, vs.
Gaussian elimination and LU factoring have been greatly studied from the algorithmic point of view, but much less from the point view of the best output format.
Results indicated that the elimination of matrix-bound phosphine was accelerated under initial pH 1 or 12.
The dependence of toluene elimination capacity on its load was determined in five small-scale reactors filled with glass beads carrying biocatalyst cells.