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hematopoietic recovery     
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  造血恢复
     Accelerating Hematopoietic Recovery in Allogeneic Bone Marrow Transplantation Mice by Co-infusion of Marrow Stromal Cells Transduced with Dual Genes of IL-3/IL-6
     异基因骨髓移植小鼠联合输注IL-3/IL-6双基因转导的骨髓基质细胞促进造血恢复
短句来源
     Halotype lymphocytes [mean 5.0×10 7/kg, (4.5-6.5)×10 7/kg] irradiated with 7.5 Gy were infused to patients when WBCs were more than 1×10 9/L. Hematopoietic recovery and survival of patients were observed.
     当患者白细胞恢复至 1.0× 10 9/L时 ,输注经 7.5Gy照射的单倍体淋巴细胞 (平均 5 .0× 10 7/kg) ,观察患者造血恢复、疾病转归和长期生存率。
短句来源
     Effects of Transplantation with GM-CSF Gene Modified Bone Marrow Cells on Hematopoietic Recovery in Mice
     移植GM-CSF基因修饰的骨髓细胞对小鼠造血恢复的影响
短句来源
     After the hematopoietic recovery, the levels of CD_3 + T cell, CD_ 19 + B cells and CD_ 16 +CD_ 56 + NK cells were all below that of pre-transplantation.
     在造血恢复后 ,所有CD3+ 细胞、CD1 9+ 细胞和CD1 6+ CD56+ 细胞均未恢复至移植前状态。
短句来源
     Method Sixteen patients receiving auto-PBSCT and 24 allo-PBSCT donors were studied for CD34 + and CD34 + CD38 - cell ratios in the 115 MPB and their leukapheresis product samples by way of flow cytometry, and the time of hematopoietic recovery was observed in the two groups.
     方法应用流式细胞仪分别检测16名auto-PBSCT患者和24名allo-PBSCT供者MPB及分离产品的115份标本,比较CD34+、CD34+CD38-细胞所占比例及两组患者早期造血恢复情况。
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  造血功能重建
     Results All of the eight patients obtained prompt hematopoietic recovery. The time of ANC≥0.5×10~9/L and platelet ≥20×10~9/L was nine days (range:8-14 d) and 11 days(8-17 d,respectively).
     结果8例病人均获快速造血功能重建,中性粒细胞≥0.5×109/L时间为8~14 d,平均9 d,血小板≥20×109/L时间为8~17 d,平均11 d。
短句来源
     Conclusions BMMSC could improve the hematopoietic recovery after allo-BMT.
     结论BMMSC能促进异基因骨髓移植后造血功能重建
短句来源
     Analysis of Associated Factors Affecting Hematopoietic Recovery After Autologous Hematopoietic Stem Cell Transplantation
     影响自体干细胞移植后造血功能重建相关因素分析
短句来源
     The results demonstrated that there were a rapid hematopoietic recovery and mild complication with autologous peripheral blood stem cell transplantation(APBSCT) in comparison with autologous bone marrow transplantation(ABMT) .
     结果 :自体外周血干细胞移植 (APBSCT)比自体骨髓移植 (ABMT)造血功能重建快 ,并发症轻。
短句来源
     The hematopoietic recovery with granulocyte colony stimulating factor( G CSF) was more rapid in ABMT but the time of bone marrow failure was not shortened with G CSF in APBSCT.
     ABMT加用重组人粒细胞集落刺激因子 (G- CSF)可加快造血功能重建 ; APBSCT加用 G- CSF并不能缩短骨髓衰竭时间。
短句来源
  造血重建
     Conclusion Both MNC count and CD 34 + cell count can reliably predict hematopoietic recovery after APBSCT.
     结论 MNC计数和CD3 4 + 细胞计数均能可靠预测自体外周血干细胞移植后的造血重建
短句来源
     Methods:Half matched BMT was performed in C 57 BL 6 murine model of acute radiation disease to observe the survival rate,hematopoietic recovery,GVHD and GVL in the mice,controlled with unmatched allogeneic BMT group.
     方法 :以 C57BL - 6小鼠急性放射病为模型 ,进行半相合小鼠骨髓移植 ,同时设异基因骨髓移植为对照 ,观察移植后小鼠存活率、造血重建、GVHD或 GVL作用。
短句来源
     TPO can stimulate hematopoietic recovery after radiation injury.
     TPO可促进辐射损伤后的造血重建 ,有可能解决急性放射病中血小板恢复滞后的问题。
短句来源
     Investigation was carried out on the effects of stem cell factor (SCF) in combination with interleukin 3(IL 3) on expansion of mice 5FU treated 3 days′ bone marrow cells(d3 5FU BMC )in vitro using the method of colony culture and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells .
     采用集落培养的方法研究了干细胞因子( S C F) 联合白介素3( I L3) 对小鼠5氟尿嘧啶(5 F U ) 处理3 d 的骨髓细胞(d35 F U B M C) 的体外扩增作用及其对致死量照射小鼠造血重建功能的影响。
短句来源
     Methods Hematopoietic recovery (peripheral blood cell counts, bone marrow aspirates, bone marrow biopsy, in vitro culture of hematopoietic progenitors), immunity of T lymphocyte, quality of life and side effects of the therapy were assessed in 50 SAA patients who have survived more than 3 years after IST.
     方法 对 50例IST后存活 3年以上SAA患者长期随访 ,了解其造血重建 (血常规、骨髓象、骨髓活检、造血祖细胞体外培养 )、T淋巴细胞免疫、生活质量及治疗不良反应等情况。
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  造血损伤
     It also could increase the CFU-GM, CFU - MK, CFU-S derived from the splenocyte and bone marrow cells in the chemotherapy-treated mice. The data demonstrated that fibroblast-mediated G-CSF gene therapy could significantlyreduce the hematopoietic damage to less extent, and accerelate hematopoietic recovery after chemotherapy.
     其脾脏和骨髓CFU-GM、CFU-MK、CFU-S水平显著地高于对照组,表明成纤维细胞介导的G-CSF基因疗法可显著降低大剂量化疗后造血损伤程度,并明显加速受损的造血功能的恢复。
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  hematopoietic recovery
Granulocyte colony-stimulating factor (G-CSF) 5 μg/kg was administered daily from day +5 to +10 in order to accelerate hematopoietic recovery, or 48 h after the last VNB-PTX when a leukapheresis was planned (after the third or fourth cycle).
      
Survival of wounded-irradiated mice may be due to enhanced hematopoietic recovery as measured by endogenous spleen colony (E-CFU-s) formation.
      
In children during the hematopoietic recovery after chemotherapy, immature marrow cells in great numbers, even with an highly homogenous immunophenotype identical to the malignant clone's, are not sufficient for the diagnosis of relapse.
      
We have also attempted to establish some guidelines for cord blood-donor choice based on cord blood cell dose and number of HLA disparities that have been found to be associated with hematopoietic recovery.
      
To improve the delayed hematopoietic recovery after cord blood transplantation, certain approaches have been investigated such as ex vivo expansion of cord blood cells, double cord blood transplantation and reduced intensity conditioning regimen.
      
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In an effort to evaluate the possible effect of cryopreserved autologous bone marrow infusions in man,11 patients with cancer were treated with high-dose chemotherapy or large-field radiotherapy followed by an infusion of cryopreserved autologous bone marrow harvested before the treatment. The result indicated that cryopreserved autologous bone marrow infusions hastened hematopoietic recovery in the patients who had received the above mentioned treatment, and the effect could be beneficial to the patients....

In an effort to evaluate the possible effect of cryopreserved autologous bone marrow infusions in man,11 patients with cancer were treated with high-dose chemotherapy or large-field radiotherapy followed by an infusion of cryopreserved autologous bone marrow harvested before the treatment. The result indicated that cryopreserved autologous bone marrow infusions hastened hematopoietic recovery in the patients who had received the above mentioned treatment, and the effect could be beneficial to the patients. The methods of harvesting autologous bone marrow cryopreservation and determination of cell vitality were described and discussed. It may be concluded that the procedure is safe for clinical trial. It seems to be a promising approach that may offer hope to cancer patients who have failed to respond to conventional therapeutic modalities.

本文报道了11例恶性肿瘤患者,大剂量化疗或大面积(全身)放射治疗后,使用冷冻保存的自身骨髓对加速造血功能恢复的初步效果。回输冷冻保存的自身骨髓,对受药物或射线抑制的造血系统有促进恢复和重建造血功能之效应。讨论了14例患者自身骨髓采取、冷冻保存和活性测定的方法,证明临床使用是安全可靠的。自身骨髓输注,对常规治疗无效的患者提供了新的治疗途径,但尚处于试验阶段,需累积更多的病例资料才能加以肯定。

In the present study, the contents of pluripotential stem cell (CFU-S) and granulopoietic progenitor (CFU-GM) in bone marrow, and morphological characteristics of hematopoietic tissue were tested at different time after injection of human placental lipopolysaccharide or protein-free serum in normal and γ-ray-irradiated mice. Our study showed that both of these placental extracts could not only stimulate hematopoiesis in normal mice but also accelerate hematopoietic reconstitution, and increase the survival of...

In the present study, the contents of pluripotential stem cell (CFU-S) and granulopoietic progenitor (CFU-GM) in bone marrow, and morphological characteristics of hematopoietic tissue were tested at different time after injection of human placental lipopolysaccharide or protein-free serum in normal and γ-ray-irradiated mice. Our study showed that both of these placental extracts could not only stimulate hematopoiesis in normal mice but also accelerate hematopoietic reconstitution, and increase the survival of mice exposed to 7.5 Gy. From these results, we consider that administration of these extracts might be useful in accelerating hematopoietic recovery in patients with chemotherapy or radiotherapy induced neutropenia.

正常或经不同剂量γ线照射的小鼠,由腹腔注射人胎盘脂多糖或无蛋白血清后不同时间,取股骨检测骨髓CFU-S和CFU-GM含量,同时对脾脏和股骨作形态检查。结果表明,两种胎盘制剂对造血均有促进作用,且有不同程度的辐射防治效果,能加速辐射损伤后的造血重建,表现在脾指数、骨髓有核细胞数以及造血干、祖细胞恢复较早。脾脏与骨髓的形态变化亦相符合。

This paper reports the effect of fetal liver infusion(FLI)on the hematopoietic recovery of the bone marrow after cyclophosphamide(CTX)in rats bearing Walker carcinosarcoma 256(W_(256)).The results showed that the amount of ~3H-TdR incorporated into marrow hematopoietic cells in FLI group and CTX+FLI group was higher than that in control groups(P<0.01 and P<0.05 respectively).The peripheral white blood cell count(WBC)and reticulocyte count(Ret)in CTX+FLI group were higher than those in CTX group(P<0.001...

This paper reports the effect of fetal liver infusion(FLI)on the hematopoietic recovery of the bone marrow after cyclophosphamide(CTX)in rats bearing Walker carcinosarcoma 256(W_(256)).The results showed that the amount of ~3H-TdR incorporated into marrow hematopoietic cells in FLI group and CTX+FLI group was higher than that in control groups(P<0.01 and P<0.05 respectively).The peripheral white blood cell count(WBC)and reticulocyte count(Ret)in CTX+FLI group were higher than those in CTX group(P<0.001 and P<0.05 respectively).The data indicate that FLI may promote the reversal of the bone marrow depression caused by chemotherapy.

对环磷酰胺(CTX)化疗后的瓦克癌肉瘤大鼠采用胎肝细胞输注(FLI)观察骨髓造血功能的变化。FLI 组和 CTX+FLI 组骨髓造血细胞的~3H-TdR 掺入量分别高于生理盐水组和 CTX 组(P<0.01和 P<0.05),CTX+FLI 组外周血白细胞计数和网织红细胞计数明显高于 CTX 组(P<0.001和 P<0.05)。FLI 具有促进化疗后骨髓造血功能恢复的作用。

 
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