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hematopoietic recovery
相关语句
  造血恢复
    Effects of Transplantation with GM-CSF Gene Modified Bone Marrow Cells on Hematopoietic Recovery in Mice
    移植GM-CSF基因修饰的骨髓细胞对小鼠造血恢复的影响
短句来源
    EFFECT OF STROMAL CELL INFUSION ON HEMATOPOIETIC RECOVERY AFTER PERIPHERAL BLOOD STEM CELL TRANSPLANTATION IN MICE
    骨髓基质细胞输注对外周血干细胞移植造血恢复的影响
短句来源
    Accelerating hematopoietic recovery in mice after allogeneic bone marrow transplantation by co-infusion of bone marrow mesenchymal stem cells
    骨髓间充质干细胞促进异基因骨髓移植后造血恢复
短句来源
    Method Sixteen patients receiving auto-PBSCT and 24 allo-PBSCT donors were studied for CD34 + and CD34 + CD38 - cell ratios in the 115 MPB and their leukapheresis product samples by way of flow cytometry, and the time of hematopoietic recovery was observed in the two groups.
    方法应用流式细胞仪分别检测16名auto-PBSCT患者和24名allo-PBSCT供者MPB及分离产品的115份标本,比较CD34+、CD34+CD38-细胞所占比例及两组患者早期造血恢复情况。
短句来源
    The toxicity and hematopoietic recovery of preparative regimen with the total body irradiation twice a day plus cyclophosphamide
    一日两次全身放疗加环磷酰胺预处理方案的毒性和造血恢复
短句来源
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  造血功能重建
    Conclusions BMMSC could improve the hematopoietic recovery after allo-BMT.
    结论BMMSC能促进异基因骨髓移植后造血功能重建
短句来源
    Analysis of Associated Factors Affecting Hematopoietic Recovery After Autologous Hematopoietic Stem Cell Transplantation
    影响自体干细胞移植后造血功能重建相关因素分析
短句来源
    The results demonstrated that there were a rapid hematopoietic recovery and mild complication with autologous peripheral blood stem cell transplantation(APBSCT) in comparison with autologous bone marrow transplantation(ABMT) .
    结果 :自体外周血干细胞移植 (APBSCT)比自体骨髓移植 (ABMT)造血功能重建快 ,并发症轻。
短句来源
    The hematopoietic recovery with granulocyte colony stimulating factor( G CSF) was more rapid in ABMT but the time of bone marrow failure was not shortened with G CSF in APBSCT.
    ABMT加用重组人粒细胞集落刺激因子 (G- CSF)可加快造血功能重建 ; APBSCT加用 G- CSF并不能缩短骨髓衰竭时间。
短句来源
  造血重建
    he methods of mobilization and collection of stem cells in peripheral blood stem cells transplantation(PBSCT)and the association between the number of stem cells transplanted and hematopoietic recovery were studied.
    对22例自体外周血干细胞移植(APBSCT)的三种动员方案、采集方法及移植的外周血干细胞(PBSC)数量与造血重建关系,进行了研究。
短句来源
    Investigation was carried out on the effects of stem cell factor (SCF) in combination with interleukin 3(IL 3) on expansion of mice 5FU treated 3 days′ bone marrow cells(d3 5FU BMC )in vitro using the method of colony culture and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells .
    采用集落培养的方法研究了干细胞因子( S C F) 联合白介素3( I L3) 对小鼠5氟尿嘧啶(5 F U ) 处理3 d 的骨髓细胞(d35 F U B M C) 的体外扩增作用及其对致死量照射小鼠造血重建功能的影响。
短句来源
    Half-matched murine bone marrow and spleen cells mixed with certain percent of syngeneic spleen cells were activated in vitro with IL-2 and underwent mixed half-matched BMT to observe their death rate, hematopoietic recovery of myelocytic lineage, spleen node count, mixed lymphocyte reaction in vivo, chimerism and pathological changes, to compared with GVHD reactions of various transplant models.
    半相合鼠骨髓和脾细胞中混合一定比例的同基因脾细胞,经白细胞介素-2体外活化后,进行活化半相合混合骨髓移植。 观察移植后小鼠死亡率、白细胞系造血重建、脾结节、体内混合淋巴细胞培养、嵌合体及病理学改变,比较不同移植方式的GVHD反应。
短句来源
  “hematopoietic recovery”译为未确定词的双语例句
    The results showed that Group 1 regained its hematopoietic recovery on day 14 post transplant.
    第1组小鼠在预处理后14天左右完全恢复自身造血。
短句来源
    RESULTs: After transplantation, groups of A、B and D rats regained their hematopoietic recovery on day(13.00±0.82)、(13.10±0.88)and(13.70±0.95),respectively(P<0.05).
    结果:移植后,A、B、D组大鼠的外周血象平均恢复时间分别为(13.00±0.82)天、(13.10±0.88)天、(13.70±0.95)天,各组间比较差异无显著性(P<0.05)。
短句来源
    CD34+ cells in the peripheral blood were 0 or<0.5%before mobiliza- tion and increased markedly 6~8 days after rhG-CSF administration,Harvesting should be started at that time and carried out every day until CD34 ̄+ cells reached 5×10 ̄6/kg,(3)The number of PBSC transplant- ed was the key to hematopoietic recovery.
    CD34 ̄+细胞在动员前外周血中多为0或<0.5%,动员后约在用rhG-CSF后6~8天明显增多,就可连续每日采集,如达到≥5×10 ̄5/kg即可停止。 (3)采集与回输的PBSC数量是决定造血重建的关键。
短句来源
    Objective:To investigate the effects of stem cell factor (SCF) in combination with interleukin 1(IL 1) or/and interleukin 3(IL 3) on ex vivo expansion of 5FU treated bone marrow cells and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells.
    目的:观察干细胞因子(SCF)与白细胞介素(IL)-1或IL-3联合对经5氟尿嘧啶(5FU)处理的骨髓细胞的体外扩增作用和体外扩增细胞移植的小鼠造血恢复能力。
短句来源
    Group C rats did not regain their hematopoietic recovery until died.
    而C组大鼠的血象则持续减低无恢复。
短句来源
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  hematopoietic recovery
Granulocyte colony-stimulating factor (G-CSF) 5 μg/kg was administered daily from day +5 to +10 in order to accelerate hematopoietic recovery, or 48 h after the last VNB-PTX when a leukapheresis was planned (after the third or fourth cycle).
      
Survival of wounded-irradiated mice may be due to enhanced hematopoietic recovery as measured by endogenous spleen colony (E-CFU-s) formation.
      
In children during the hematopoietic recovery after chemotherapy, immature marrow cells in great numbers, even with an highly homogenous immunophenotype identical to the malignant clone's, are not sufficient for the diagnosis of relapse.
      
We have also attempted to establish some guidelines for cord blood-donor choice based on cord blood cell dose and number of HLA disparities that have been found to be associated with hematopoietic recovery.
      
To improve the delayed hematopoietic recovery after cord blood transplantation, certain approaches have been investigated such as ex vivo expansion of cord blood cells, double cord blood transplantation and reduced intensity conditioning regimen.
      
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he methods of mobilization and collection of stem cells in peripheral blood stem cells transplantation(PBSCT)and the association between the number of stem cells transplanted and hematopoietic recovery were studied.The investigation was carried in 22 patients(11 acute leukemia,6 multiple myeloma,4 non- Hodgkin’s lymphoma,1 breast cancer).Three regimens for mobilization were carried out as follows :(1)chemotherapy+tetrahydrofolic acid + dexamethasone,(2)chemotherapy + rhGM-CSF + dexamethasone,(3)cbemotherapy...

he methods of mobilization and collection of stem cells in peripheral blood stem cells transplantation(PBSCT)and the association between the number of stem cells transplanted and hematopoietic recovery were studied.The investigation was carried in 22 patients(11 acute leukemia,6 multiple myeloma,4 non- Hodgkin’s lymphoma,1 breast cancer).Three regimens for mobilization were carried out as follows :(1)chemotherapy+tetrahydrofolic acid + dexamethasone,(2)chemotherapy + rhGM-CSF + dexamethasone,(3)cbemotherapy + rhG-CSF + dexamethasone,Besides,CD34/CD33 dual-color direct immunofluo- rescence flow cytometry assay was performed in 7 cases in the rhG-CSF group.The results showed:(1)The mean number of collected cells(MNC) in the rhG-CSF group was MNC(8.29±6.14)×10 ̄8/kg and CFU-GM(21.35±17.24)×10 ̄4/kg, being highest among the 3 groups. (2)The number of cells cor- related with MNC and CFU-GM. CD34+ cells in the peripheral blood were 0 or<0.5%before mobiliza- tion and increased markedly 6~8 days after rhG-CSF administration,Harvesting should be started at that time and carried out every day until CD34 ̄+ cells reached 5×10 ̄6/kg,(3)The number of PBSC transplant- ed was the key to hematopoietic recovery.

对22例自体外周血干细胞移植(APBSCT)的三种动员方案、采集方法及移植的外周血干细胞(PBSC)数量与造血重建关系,进行了研究。22例中急性白血病11例,多发性骨髓瘤6例,非何杰金淋巴瘤4例,晚期乳癌1例。三组动员方案:化疗十四氢叶酸+氟美松;化疗+rhGM-CSF(重组人粒巨噬细胞集落刺激因子)+氟美松;化疗+rhG-CSF(重组人粒细胞集落刺激因子)+氟美松。用流式细胞计双染直接免疫荧光法测定rhG-CSF方案组中7例CD34+/CD33 ̄+细胞。结果表明:(1)rhG-CSF方案组的PBSC产率最高,平均每例MNC(单个核细胞)(8.29±6.14)×10 ̄8/kg,CFU-GM(粒单系祖细胞集落生成单位)(21.35±17.24)×10 ̄4/kg。(2)CD34+细胞数与MNC及CFU-GM数大致相关。CD34 ̄+细胞在动员前外周血中多为0或<0.5%,动员后约在用rhG-CSF后6~8天明显增多,就可连续每日采集,如达到≥5×10 ̄5/kg即可停止。(3)采集与回输的PBSC数量是决定造血重建的关键。

n the  ̄(60)Co radiation accident happened in Shanghaion June 25,1990,seven people were accidentally ex-posed to high doses of relatively homogeneous totalbody radiation in a very short time.Two victims,whoreceived estimated doses of 11 and 12Gy,respectively,were diagnosed as extremely severe bone marrow formof acute radiation sickness, In the critical condition,they received HLA-haplotype identical bone marrowtransplantation at day 7 and day 11 after radiation,re-spectively. One patient,53 years old,had completeengraftment...

n the  ̄(60)Co radiation accident happened in Shanghaion June 25,1990,seven people were accidentally ex-posed to high doses of relatively homogeneous totalbody radiation in a very short time.Two victims,whoreceived estimated doses of 11 and 12Gy,respectively,were diagnosed as extremely severe bone marrow formof acute radiation sickness, In the critical condition,they received HLA-haplotype identical bone marrowtransplantation at day 7 and day 11 after radiation,re-spectively. One patient,53 years old,had completeengraftment and hematopoietic recovery after trans-plantation,which was demonstrated by bone marrowhistology, HLA typing,cytogenetics and moleculartechniques,Acute graft-versus host disease(GVHD)was successfully controlled.Unfortunately,he died ofinterstitial pneumonitis at day 90 after the accident.Another,56 vears old,survived for 25 days after radi-ation and died of pulmonary hemorrhage and systemicfungal infection.

1990年6月25日,上海发生一起钴辐射事故,7人在短时间内受到大剂量、高剂量率、相对均匀的γ线照射。其中两例受照剂量达11Gy和12Gy,诊断为极重度骨髓型急性放射病。两例在紧急情况下分别于受照后第7天和第11天进行了HLA半相合的骨髓移植(BMT)。其中一例53岁,骨髓完全植活,造血重建,并成功防治了急性移植物抗宿主病,但于照后第90天死于间质性肺炎。另一例56岁,于受照后第25天死于肺部出血和深部真菌感染。作者对事故性放射病骨髓移植的适应证、追加预处理等问题进行了讨论。

Objective:To investigate the effects of stem cell factor (SCF) in combination with interleukin 1(IL 1) or/and interleukin 3(IL 3) on ex vivo expansion of 5FU treated bone marrow cells and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells.Methods:5FU treated bone marrow cells (d3 5FU BMC) were cultured in a cytokines containing medium,and the net increments of CFU GM and high proliferative potential colony forming cell (HPP CFC) were evaluated.Results: CFU...

Objective:To investigate the effects of stem cell factor (SCF) in combination with interleukin 1(IL 1) or/and interleukin 3(IL 3) on ex vivo expansion of 5FU treated bone marrow cells and hematopoietic recovery in lethally irradiated mice transplanted with the expanded cells.Methods:5FU treated bone marrow cells (d3 5FU BMC) were cultured in a cytokines containing medium,and the net increments of CFU GM and high proliferative potential colony forming cell (HPP CFC) were evaluated.Results: CFU GM increased by 33.7±18.1 or 18.1±6.3 fold, and HPP CFC by 17.8±10.5 or 12.7±9.1 fold, respectively,in cultures containing SCF with IL 1 or IL 3, as compared with that in control;while SCF alone had little effect.Compared with fresh d3 5FU BMC,transplantation of the expanded bone marrow cells accelerated the recovery of recipients' peripheral blood cell counts by 1~3 days and increased the survival rate of the transplanted animals (d3 5FU BMC group 50% vs expansion group 80%~100%).Conclusion:SCF in combination with IL 1 or IL 3 synergetically ex vivo expands hematopoietic cells.Transplantation of the expanded bone marrow cells accelerates the recipient's hematopoietic reconstitution.

目的:观察干细胞因子(SCF)与白细胞介素(IL)-1或IL-3联合对经5氟尿嘧啶(5FU)处理的骨髓细胞的体外扩增作用和体外扩增细胞移植的小鼠造血恢复能力。方法:在含有细胞因子的液体培养体系中培养5FU处理的骨髓细胞,观察粒-巨噬细胞集落形成单位(CFU-GM)和高增殖潜能集落形成细胞(HPP-CFC)数量的增加以及移植扩增细胞的小鼠外周血细胞恢复。结果:单用SCF无扩增作用,但SCF与IL-1或IL-3联合时,与对照组相比较CFU-GM分别增加33.7±18.1倍和18.1±6.3倍。HPP-CFC分别扩增17.8±10.5倍和12.7±9.1倍。移植体外扩增细胞组与对照组比较,外周血细胞恢复时间缩短1~3天,并且生存率也显著提高。结论:在液体培养体系中SCF与IL-1或IL-3联合对造血细胞扩增有协同作用,并且体外扩增后的骨髓细胞能加速移植受体的早期造血重建。

 
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