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hematopoietic recovery
相关语句
  造血恢复
    In order to study the therapeutic effect of rhG CSF in acute radiation sickness, different doses of rhG CSF (1.25, 2.50 and 5.00 μg/d) were given to 6.5Gy γ ray irradiated C57/BJ mice and its effect on hematopoietic recovery was evaluated.
    为研究重组人粒细胞集落刺激因子(rhG-CSF)对急性放射病的治疗作用,观察了不同剂量的rhG-CSF对6.5Gy照射小鼠造血恢复的影响。
短句来源
    Nerve growth factor promotes wound healing and hematopoietic recovery in irradiated mice
    神经生长因子同时促进放创复合伤小鼠创面愈合和造血恢复的实验研究
短句来源
    Objective To study the severity of iatrogenic acute radiation syndrome, treatment,hematopoietic recovery and related complications in patients subjected to total body irradiation (TBI) or total lymphatic irradiation (TLI) prior to hematopoietic stem cell transplantation.
    在造血干细胞移植治疗肿瘤过程中用全身照射(TBI)或全淋巴照射(TLI)预处理,研究受照不同剂量患者发生医源性急性放射病严重程度,治疗方法和造血恢复及相关合并症。
短句来源
  “hematopoietic recovery”译为未确定词的双语例句
    Results WBC began to increase on the 17th day after treatment, and WBC recovered to 5.1×109/L on the 19th day, platelet to over 30×109/L, and RCT to normal. Bone marrow image showed hematopoietic recovery of the three cell lineages.
    结果17天白细胞开始上升,19天重建造血:白细胞数>5×109/L,中性粒细胞绝对值>4×109/L,血小板>30×109/L,网织红细胞恢复正常。
短句来源
    rhIL-11 is a multi-effective cytokine and has been applied in stimulating hematopoietic recovery and protecting intestine from injury.
    为了研究rhIL-11在中子急性放射病中的治疗效果,我们在国内外研究的基础上,应用骨髓细胞集落培养和流式细胞术探讨了rhIL-11对120只中子骨髓型急性放射病小鼠造血系统的刺激作用和对小肠上皮的保护作用。
短句来源
    IL-11 is a multi-effective cytokine that contributes to bone marrow hematopoietic recovery.
    IL-11是一种多能细胞因子,其对γ射线辐射后骨髓造血功能损伤具有明显治疗作用。
短句来源
    Further experiments demonstrated the IL 6 level in 7.5 Gy irradiated mice was about three times higher than that of 5.0 Gy irradiated mice and the expression of hIL 6 in vivo showed significant effect on hematopoietic recovery.
    治疗组照后 2 8天时蛋白表达仍维持在较高水平。 不同照射剂量治疗组的结果相比 ,7.5Gy照射组hIL 6水平约为 5 .0Gy照射组的两倍。
短句来源
    For the treatment of CRWI, promoting wound healing and the hematopoietic recovery should be considered simultaneously.
    对放创复合伤创面促愈的一个重要原则是要同时考虑增加创伤局部造血细胞和修复细胞的数量,促进其功能。
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  hematopoietic recovery
Granulocyte colony-stimulating factor (G-CSF) 5 μg/kg was administered daily from day +5 to +10 in order to accelerate hematopoietic recovery, or 48 h after the last VNB-PTX when a leukapheresis was planned (after the third or fourth cycle).
      
Survival of wounded-irradiated mice may be due to enhanced hematopoietic recovery as measured by endogenous spleen colony (E-CFU-s) formation.
      
In children during the hematopoietic recovery after chemotherapy, immature marrow cells in great numbers, even with an highly homogenous immunophenotype identical to the malignant clone's, are not sufficient for the diagnosis of relapse.
      
We have also attempted to establish some guidelines for cord blood-donor choice based on cord blood cell dose and number of HLA disparities that have been found to be associated with hematopoietic recovery.
      
To improve the delayed hematopoietic recovery after cord blood transplantation, certain approaches have been investigated such as ex vivo expansion of cord blood cells, double cord blood transplantation and reduced intensity conditioning regimen.
      
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In order to study the therapeutic effect of rhG CSF in acute radiation sickness, different doses of rhG CSF (1.25, 2.50 and 5.00 μg/d) were given to 6.5Gy γ ray irradiated C57/BJ mice and its effect on hematopoietic recovery was evaluated. It was shown that peripheral WBC,RBC and platelet counts recovered much quicker in the mice treated with the factor; the bigger was the dose of rhG CSF, the quicker did the peripheral blood cells recover. The forming rates and contents of CFU GM, BFU E and CFU...

In order to study the therapeutic effect of rhG CSF in acute radiation sickness, different doses of rhG CSF (1.25, 2.50 and 5.00 μg/d) were given to 6.5Gy γ ray irradiated C57/BJ mice and its effect on hematopoietic recovery was evaluated. It was shown that peripheral WBC,RBC and platelet counts recovered much quicker in the mice treated with the factor; the bigger was the dose of rhG CSF, the quicker did the peripheral blood cells recover. The forming rates and contents of CFU GM, BFU E and CFU Mix in the bone marrow and spleen 10 days postirradiation all increased more evidently and dose dependently in the treated mice. Endogenous spleen colony forming units on day 10 also increased with the dose of rhG CSF, becoming statistical signifficant in the 5.00 μg group as compared with the control. These results demonstrate that rhG CSF could not only promote the hemopoietic recovery of the granulocyte lineage but also accellerate the production of RBC and platelet; so, rhG CSF might be a potential medicine of first choice for treating acute radiation sickness.

为研究重组人粒细胞集落刺激因子(rhG-CSF)对急性放射病的治疗作用,观察了不同剂量的rhG-CSF对6.5Gy照射小鼠造血恢复的影响。结果表明,予受照小鼠每日rhG·CSF1.25、2.50及5.00μg治疗后,外周血白细胞、红细胞及血小板的恢复明显加快,以5.00Vg剂量组效果为最佳;照射后10d骨*及脾脏CFU+GM、暴增型红系祖细胞集落(BFU-E)及混合型祖细胞集落(CFU·Mix)含量及生成率均明显高于对照组,并具有剂量相关性;内源性脾结节数随给药剂量的加大而增加。表明rhG-CSF不仅能加速粒系造血恢复,而且对红系及巨核系造血恢复也有明显的促进作用,因而有希望成为放射病治疗药物之一。

Objective To study the severity of iatrogenic acute radiation syndrome, treatment,hematopoietic recovery and related complications in patients subjected to total body irradiation (TBI) or total lymphatic irradiation (TLI) prior to hematopoietic stem cell transplantation. Methods 100 tumor patients (91 with leukemia and 9 with other tumors),after receiving 500~1000cGy (in an average of 738 6cGy) of TBI or TLI with super high dose chemotherapy as conditioning regimen during the process of hemopoietic...

Objective To study the severity of iatrogenic acute radiation syndrome, treatment,hematopoietic recovery and related complications in patients subjected to total body irradiation (TBI) or total lymphatic irradiation (TLI) prior to hematopoietic stem cell transplantation. Methods 100 tumor patients (91 with leukemia and 9 with other tumors),after receiving 500~1000cGy (in an average of 738 6cGy) of TBI or TLI with super high dose chemotherapy as conditioning regimen during the process of hemopoietic stem cell transplantation,developed severe or even extremely severe,mainly bone marrow form acute radiation syndrome. Results The patients' white blood cell count once dropped to (0~0 15)×10 9/L,platelet count fell to (1~17)×10 9/L,bone marrow was depleted with only a few non hemopoietic cells and rare hemopoietic cells,and a high risk of complicating with infection and hemorrage was observed.Treated with a variety of measures including protective isolation,supportive care,administration of growth factors such as GM CSF or G CSF,blood component transfusion and effective antibiotics, 92 cases restored their normal hemopoiesis,while 8 cases died of infection or hemorrage.The clinical course of these patients indicated that a majority of the patients with severe and extremetly severe,iatrogenic acute radiation syndrome involving bone marrow could restore their normal hemopoiesis,and hemopoietic stem cell transplantation played an important role in the treatment. Conclusion Hemopoietic stem cell transplantation and administration of growth factors are very useful for the treatment of acute radiation syndrome.

在造血干细胞移植治疗肿瘤过程中用全身照射(TBI)或全淋巴照射(TLI)预处理,研究受照不同剂量患者发生医源性急性放射病严重程度,治疗方法和造血恢复及相关合并症。方法100例患者(白血病91例,其他肿瘤9例)接受500~1000cGyTBI或TLI和超大剂量化疗作预处理。结果均发生医源性急性放射病,白细胞降至(0~0.15)×109/L,骨髓空虚,合并各种感染和出血。经造血干细胞移植,抗感染,应用GM-CSF或G-CSF积极支持治疗及保护隔离措施,92例造血恢复,8例死于不同感染和出血。结论造血干细胞的移植起主要治疗作用,不同造血因子用于治疗急性放射病,可能是一种有希望的方法

Hemorrhage is one of major clinical features of the patients exposed to large dose of ionizing radiation and a sudden decrease of peripheral platelet counts in hemorrhage complication may bring the patients into life threatening situation. Cytokines had been used to improve thrombocytopoiesis in various radiation induced thrombocytopenia. Current measures for this purpose involve repeated injection of recombinant cytokines, which bring much inconvenient and agony to the patients, or gene therapy with viral...

Hemorrhage is one of major clinical features of the patients exposed to large dose of ionizing radiation and a sudden decrease of peripheral platelet counts in hemorrhage complication may bring the patients into life threatening situation. Cytokines had been used to improve thrombocytopoiesis in various radiation induced thrombocytopenia. Current measures for this purpose involve repeated injection of recombinant cytokines, which bring much inconvenient and agony to the patients, or gene therapy with viral vectors that could not obviate the risk of infection. This work tried to determine the possibility of gene therapy with plasmid vectors for radiation induced hematopoietic injury. After a single intramuscular injection of plasmid hIL 6 cDNA on 6.5 Gy irradiated mice, the IL 6 level began to increase from the day 4, reached the peak value about the day 11 and maintained at a higher level on the day 28, but the hIL 6 level showed less changes in unirradiated mice. Further experiments demonstrated the IL 6 level in 7.5 Gy irradiated mice was about three times higher than that of 5.0 Gy irradiated mice and the expression of hIL 6 in vivo showed significant effect on hematopoietic recovery. Not only the platelet nadir in peripheral blood, but also the number of colony forming cells in bone marrow rose. It is concluded that radiation could significantly enhance the gene transfer efficiency of plasmid DNA and gene therapy with plasmid vectors for treating radiation induced hematopoietic injury might be more effective than other diseases without DNA repair.

出血是大剂量电离辐射后所致损伤的主要临床症状之一 ,且可发展成致命的出血综合征。国内外均尝试在辐射或化疗动物模型上用一些细胞因子促进血小板恢复 ,以减少出血。但由于多次注射等不尽人意 ,因此人们仍在进行新措施的研究。用病毒载体进行基因治疗有一定的优势 ,但也有可能增加感染的几率。本实验尝试运用质粒载体对辐射损伤进行基因治疗。本研究观察了辐射对体内质粒载体基因转移效率的影响 ,以及转移hIL 6基因后对照射小鼠造血恢复的影响。经 6 .5Gy照射的小鼠一次肌内注射表达IL 6的质粒DNA后 ,用ELISA方法检测血浆IL 6水平 ,以蛋白表达量评价基因转移效率。结果显示 ,治疗组从照后 4天hIL 6开始增加 ,于照后 11天左右达峰值 ,而此时对照组仍处于低水平。治疗组照后 2 8天时蛋白表达仍维持在较高水平。不同照射剂量治疗组的结果相比 ,7.5Gy照射组hIL 6水平约为 5 .0Gy照射组的两倍。体内高表达的hIL 6明显促进照射小鼠造血恢复 ,治疗组不仅血小板的最低值明显提高 ,而且骨髓细胞中CFU GEMM和CFU Meg也明显增加。外周血血小板数的增加部分是由于网织血小板的增加 ,说明巨核细胞释放...

出血是大剂量电离辐射后所致损伤的主要临床症状之一 ,且可发展成致命的出血综合征。国内外均尝试在辐射或化疗动物模型上用一些细胞因子促进血小板恢复 ,以减少出血。但由于多次注射等不尽人意 ,因此人们仍在进行新措施的研究。用病毒载体进行基因治疗有一定的优势 ,但也有可能增加感染的几率。本实验尝试运用质粒载体对辐射损伤进行基因治疗。本研究观察了辐射对体内质粒载体基因转移效率的影响 ,以及转移hIL 6基因后对照射小鼠造血恢复的影响。经 6 .5Gy照射的小鼠一次肌内注射表达IL 6的质粒DNA后 ,用ELISA方法检测血浆IL 6水平 ,以蛋白表达量评价基因转移效率。结果显示 ,治疗组从照后 4天hIL 6开始增加 ,于照后 11天左右达峰值 ,而此时对照组仍处于低水平。治疗组照后 2 8天时蛋白表达仍维持在较高水平。不同照射剂量治疗组的结果相比 ,7.5Gy照射组hIL 6水平约为 5 .0Gy照射组的两倍。体内高表达的hIL 6明显促进照射小鼠造血恢复 ,治疗组不仅血小板的最低值明显提高 ,而且骨髓细胞中CFU GEMM和CFU Meg也明显增加。外周血血小板数的增加部分是由于网织血小板的增加 ,说明巨核细胞释放血小板的速度加快。以上结果表明电离辐射可以明显提高IL 6质粒DNA的体内转染效率 ,为质粒载体基因的方法治疗辐射?

 
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