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protective immunity     
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  保护性免疫
     It is supposed that the mechanism of the protective immunity induced by Sj31/32 may be related to the change of TNF α and IL 2 levels in the host.
     由此推测,Sj31/32的保护性免疫机制可能与宿主体内TNF-α及IL-2水平的变化有关。
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     The structural envelope glycoprotein E2(gp55)of CSFV is the major protein responsible for eliciting and conferring protective immunity.
     猪瘟病毒(CSFV)囊膜结构糖蛋白E2(gp55)是激发保护性免疫应答的主要抗原蛋白。
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     Conclusion Antibody might play an important role in the protective immunity elicited by rSj31/32.
     结论 抗体在rSj31/ 32多次免疫诱导的保护性免疫机制中起着重要作用
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     Conclusion NP30 vaccination may induce both cellular and humoral protective immunity to modulate egg granulomas and suppress liver fibrosis of schistosomiasis japonica.
     结论 NP30接种可能诱导体液和细胞两种保护性免疫 ,对血吸虫病虫卵肉芽肿具有负调节作用 ,对血吸虫性肝纤维化有明显的抑制作用
短句来源
     Studies on Protective Immunity Induced by the Anti-idiotypic Monoclonal Antibody-NP30 of Schistosoma japonicum
     日本血吸虫单克隆抗独特型抗体NP30诱导保护性免疫
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  保护性免疫力
     Conclusion Recombinant BCG-Sj26GST vaccine of the schistosome may promote host's Th1 response and enhance its protective immunity against schistosomiasis
     结论 血吸虫重组BCG-Sj26GST疫苗能促进宿主Th1反应,加强宿主抗血吸虫感染的保护性免疫力
短句来源
     PURIFICATION OF 31/32 kDa PROTEINS OF ADULT SCHISTOSOMA JAPONICUM AND STUDIES ON THEIR PROTECTIVE IMMUNITY
     日本血吸虫成虫31/32 kDa蛋白的纯化及保护性免疫力的研究
短句来源
     The effects of adjuvants polyalphaolefin(PAO) and Freund's complete adjuvant(FCA) on the protective immunity induced by Sj31/32 kDa proteins in mice were compared.
     本实验用纯化的日本血吸虫31/32k Da 蛋白( Sj31/32 蛋白)辅以polyalphaolefin( P A O)佐剂免疫小鼠,同时比较了 Sj31/32 蛋白辅以福氏完全佐剂( F C A)对小鼠保护性免疫力的影响。
短句来源
     EFFECTS OF ADJUVANTS ON PROTECTIVE IMMUNITY INDUCED BY Sj31/32 kDa PROTEIN
     佐剂对日本血吸虫31/32kDa蛋白保护性免疫力的影响
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     PRELIMINARY STUDY ON PROTECTIVE IMMUNITY AGAINST SCHISTOSOMA JAPONICUM INDUCED BY DIFFERENT DOSES OF NAKED DNA VACCINE pCDSj32 IN BALB/c MICE
     不同剂量日本血吸虫裸露DNA疫苗pCDSj32诱发小鼠保护性免疫力的初步研究
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  免疫保护性
     Conclusion Co-immunization with SjCTPI-Hsp70 and IL-12 DNA vaccines induces protective immunity against S.japonicum in water buffalo.
     结论用SjCTPI-Hsp70+IL-12免疫水牛可获得一定的免疫保护性作用。
短句来源
     Construction of Immuno-Regulative DNA Vaccines of E.tenella MZ5-7 Gene and Their Protective Immunity in Chicken
     鸡柔嫩艾美尔球虫(E.tenella)MZ5-7基因免疫调节型DNA疫苗的构建及其免疫保护性试验
短句来源
     PROTECTIVE IMMUNITY EFFECTS OF CO-IMMUNIZATION WITH SJC23 DNA VACCINE AND PROTEIN VACCINE
     日本血吸虫23kDa膜蛋白DNA疫苗和蛋白质疫苗联合应用免疫保护性作用的研究
短句来源
     Protective immunity in mice after immunized with recombinant fusion protein encoding p46 kDa antigen of Trichinella spiralis
     旋毛虫编码新生幼虫p46 kDa抗原基因重组融合蛋白对小鼠的免疫保护性研究
短句来源
     Complementary DNA Gene Cloning, Expression and Protective Immunity in Goats of H11 Antigen from Haemonchus Contortus
     捻转血矛线虫H11抗原cDNA基因克隆、表达及山羊免疫保护性试验
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  保护力
     Protective immunity against Schistosoma japonicum induced in mice immunized with recombinant 32 ×10~3 protein
     日本血吸虫重组32×10~3蛋白诱导小鼠保护力的研究
短句来源
     Identification of protective immunity elicited soluble by SIEA 54kD and other antigens
     日本血吸虫未成熟虫卵可溶性抗原54kD等抗原保护力的鉴定
短句来源
     Conclusion Sj14FABP DNA vaccine was shown to induce a partial protective immunity against Schistosoma japonicum infection in Balb/c mice, and IL 12 was found to be a good adjuvant of Schistosoma DNA vaccine.
     结论 pVIVO2 Sj14FABP能够诱导小鼠产生部分抗血吸虫感染的保护力,IL-12是一种有效的血吸虫病DNA疫苗佐剂。
短句来源
     Many studies on immune mechanisms elucidated that the high protective immunity is mediated by CD4+T cell in radiation-attenuated (RA) cercariae mice models.
     大量免疫机制研究表明:在辐照致弱尾蚴免疫小鼠等动物模型中,其诱导的高保护力主要是由CD4+T细胞介导的细胞免疫。
短句来源
     All the data above showed that NTV-JEV has the similar protective efficacy with that of the attenuated live vaccine SA1414-2. NTV-JEV induced protective immunity against challenge not only with the homologous strain GSS but also with the heterologous strain P3.
     上述结果表明,NTV-JEV与乙脑减毒活疫苗SA14-14-2株具有相近的保护力,NTV-JEV不仅可以保护小鼠抵抗同株病毒GSS的攻击,而且可以抵抗异株病毒P3的攻击。
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  protective immunity
The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied.
      
Cloning, expression and protective immunity evaluation of the full-length cDNA encoding succinate dehydrogenase iron-sulfur prot
      
In conclusion, the recombinant vaccine was capable of inducing protective immunity against subcutaneous challenge.
      
japonicum larvae is a promising approach to produce protective immunity against schistosomiasis.
      
And it is found that the protective efficacy is correlated with CTL activity which was considered to be the primary effects of anti-sporozoite protective immunity.
      
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A virulent strain of Escherichia coli had been isolated and found to be the pathogen of piglet dysentery by Mr. Li Xue-liang (Yunnan Institute of Animal Husbandary and Veterinary Medicine) .When 6 x 107 living bacteria of ihe virulent strain were injected subcutaneously into each mouse, all the injected mice would be killed. Ribosomal preparations were isolated from disrupted cells by a modification of the ammonium sulfate precipitation method described by C. G. Kurland(1966), omitting the ultracentrifugation...

A virulent strain of Escherichia coli had been isolated and found to be the pathogen of piglet dysentery by Mr. Li Xue-liang (Yunnan Institute of Animal Husbandary and Veterinary Medicine) .When 6 x 107 living bacteria of ihe virulent strain were injected subcutaneously into each mouse, all the injected mice would be killed. Ribosomal preparations were isolated from disrupted cells by a modification of the ammonium sulfate precipitation method described by C. G. Kurland(1966), omitting the ultracentrifugation step. The ribosomal preparation was proved to be highly immunogcnic for mice and immunization with the preparation elicited significant protective immunity.The effect was obvious when mice immunized subcutancously with ribosomal preparation without adjuvant were challenged subcutancously with 2 -2.4x108 living bacteria two weeks after immunization, ribosomc dose mice challenge dose 30-day survival When immunized mice were challenged subcutaneously with 2.1xl08 living bacteria two months after immunization, immunoprotection was still significant.

以硫酸铵沉淀的方法制备了仔猪白痢病原体——毒性大肠杆菌的核糖体粗制品,而未使用超速离心设备。本工作表明如此制备的核糖体也同样有很高的免疫保护效力。给小鼠皮下注射50或100微克核糖体15天后,用四倍于全数致死量的活菌作皮下攻击,动物百分之百存活(P<0.001),注射25微克,即已可存活86.7%(P<0.001)。皮下给予核糖体500微克后两个月,进行皮下攻击,动物仍可存活94.7%(P<0.001)。皮下免疫注射后进行腹腔攻击,免疫效果即低得多,此点与文献上肺炎双球菌核糖体的情况相似。

Leishmania mexicana amazonensis (Lma)were γ-irradiated from a source of ~(137)Cs. Adosage of 15,000 rad was chosen in accor-dance with the results of our in vitroinvestigations for these immunization exper-iments. A total of 48 mice were dividedinto immunized and non-immunized groups.The mice of the forme: were immunizedwith the antigen at 10~5 parasites/mouse,by 2 subcutaneous injections into the foot-pads,at an interval of 2 weeks.Twelve micewere injected with Hanks' solution to serveas controls. Four weeks...

Leishmania mexicana amazonensis (Lma)were γ-irradiated from a source of ~(137)Cs. Adosage of 15,000 rad was chosen in accor-dance with the results of our in vitroinvestigations for these immunization exper-iments. A total of 48 mice were dividedinto immunized and non-immunized groups.The mice of the forme: were immunizedwith the antigen at 10~5 parasites/mouse,by 2 subcutaneous injections into the foot-pads,at an interval of 2 weeks.Twelve micewere injected with Hanks' solution to serveas controls. Four weeks after the primaryimmunization,mice were challenged subcu-taneously with 12.5×10~6 promastigotes ofLma at the tail base. The effect of immu-nization was assessed by determining lesionsize, weight, and the number of parasitesinside the lesions of the challengesites. The lesion size of the immunizedgroup was significantly smaller than thatof the non-immunized group at 6, 9, and 12weeks after challenge. They were (cm) 0. 64±0. 11 and 0. 94±0. 08; 0. 89±0. 09 and 1. 17±0. 16; 0. 98±0. 11 and 1. 50±0. 17 respectively.Also the immunized and non-immunizedgroups differed significantly in the averageweight of lesions (nodules) on weeks 6, 9, and12. They were (g) 0. 13±0. 04 and 0. 26±0. 07;0. 29±0. 12 and 0. 98±0. 19; 0. 30±0. 16 and1. 31±0. 22 respectively. Individual noduIeswere ground and counted for parasite numberon weeks 6 and 9.The parasite numbers ofthe immunized group were significantlylower than those of the control group (2. 1±0. 7×10~8 and 6. 4±2. 3×10~8; 2. 7±0. 5×10~8 and9. 8±2. 5×10~8 respectively). The results ofmeasuring the lesion size and weight arecorrelated with the number of parasitesinside the lesions. The above resultsindicate that the irradiated Lma (15,000rad) gave definite partial protection toBALB/c mice against the challenges bythe promastigotes of the same species. Itseems that the antibody titres do not corre-late with the above criteria. It may be thatthere is no clear association between antibodytitres and protective immunity, which con-forms with the findings of others.

作者采用经γ射线辐射的墨西哥利什曼原虫,体外感染巨噬细胞,选择出15,000rad剂量辐射虫体免疫动物,获得较好效果。用BALB/c鼠48只进行免疫实验,同种原虫攻击。按攻击部位损伤大小、病变结节重量及其内含原虫数等三项指标衡量免疫效果。免疫组与对照组自攻击感染6周后,三项指标均出现显著差异,说明免疫鼠具有明显的保护力,抗体滴度与保护力之间未出现吻合关系。

Two antigenic substances, i.e. leptospiral erythrocyte sensitizing sub-stance(ESS) and lipopolysaccharide(LPS), were extracted from Leptospira interrogans serovar lai strain 70091. They were incorporated onto liposomal bilayers vespectively to form new immune preparations. Then the protection test in Syrian hamsters and the detection of antibody responses in rabbits were carried out. The results revealed that DPPC:Chol:DCP liposomes could markedly enhance the immunogenicity of the ESS. The survival rate was...

Two antigenic substances, i.e. leptospiral erythrocyte sensitizing sub-stance(ESS) and lipopolysaccharide(LPS), were extracted from Leptospira interrogans serovar lai strain 70091. They were incorporated onto liposomal bilayers vespectively to form new immune preparations. Then the protection test in Syrian hamsters and the detection of antibody responses in rabbits were carried out. The results revealed that DPPC:Chol:DCP liposomes could markedly enhance the immunogenicity of the ESS. The survival rate was 96.6% in the hamsters immunized with liposome-ESS whilst only 36.7% at 40 μg of the ESS per hamster by the Ess alone. The level of antibody response in rabbits was raised too. On the other hand, no protective immunity was detected in hamsters administered with the L-LPS preparations, whether it was used alone 01 carried in liposomes. However, the rabbit antiserum against the L-LPS could induce passive immunity in hamsters.

自黄疸出血群赖型70091株钩体提取了红细胞致敏物(ESS)和脂多糖(L-LPS)两种抗原成分。将它们分别与脂质体组装,形成新的钩体免疫制剂。通过金地鼠的保护力试验和家兔的抗体反应的检测,研究两种抗原的免疫原性和脂质体的免疫增强作用。结果表明,DPPC:Chol:DCP 脂质体能显著增强ESS的免疫原性。单纯ESS在每只地鼠40μg剂量时,只获36.7%的存活率,而脂质体-ESS则达到96.6%,并且这一活性依赖于ESS与脂质体在结构上的组装。该制剂还能增强家兔的抗体反应。此外,经脂质体-ESS制剂保护的存活金地鼠作肾培养,未发现有钩体带菌者。在本实验条件下,无论用单纯的或与脂质体组装的钩体LPS,直接免疫金地鼠,均未获得良好的保护力;然而用L-LPS免疫的兔血清对金地鼠则有良好的被动保护作用。

 
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