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   susceptibility 在 内分泌腺及全身性疾病 分类中 的翻译结果: 查询用时:0.201秒
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susceptibility
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  易感性
    Study on Polymorphism of HLA-DRB1 and TNFαGenes in Relation to the Susceptibility of Systemic Lupus Erythematosus in Northern Chinese
    中国汉人HLA-DRB1及TNFα基因多态性与SLE遗传易感性的研究
短句来源
    DETECTION OF IDDM SUSCEPTIBILITY IN SHANGHAI HANS WITH HLA-DQA, OLIGONUCLEOTIDE PROBES
    HLA-DQA_1位点寡核苷酸探针检测上海地区汉族IDDM易感性
短句来源
    HLA-DQA AND DQB ALLELES CONTRIBUTE TO SUSCEPTIBILITY TO IDDM
    HLA-DQA_1、-DQB_1等位基因在IDDM易感性中的作用
短句来源
    THE 57TH AMINO ACID OF HLA-DQ BETA CHAIN AND THE IDDM SUSCEPTIBILITY IN SHANGHAI HANS
    HLA-DQβ链57位氨基酸与上海地区汉族IDDM易感性
短句来源
    Correlative analysis of HLA-DQ gene and susceptibility to insulin dependent diabetes mellitus in Chinese
    HLA-DQ基因和中国人胰岛素依赖型糖尿病易感性的相关分析
短句来源
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  遗传易感性
    Study on Polymorphism of HLA-DRB1 and TNFαGenes in Relation to the Susceptibility of Systemic Lupus Erythematosus in Northern Chinese
    中国汉人HLA-DRB1及TNFα基因多态性与SLE遗传易感性的研究
短句来源
    Objective To explore the relationship between genetic polymorphism of CYP2E1,MPO,NQO1,GSTT1,GSTM1 and susceptibility to benzene poisoning(BP).
    目的探讨毒物代谢酶CYP2E1、MPO、NQO1、GSTT1和GSTM1基因多态性与慢性苯中毒遗传易感性之间的关系。
短句来源
    HLA-DPB 1 allele genetic susceptibility in Han nationality with myasthenia gravis in China.
    HLA-DPB_1等位基因对广西汉族重症肌无力的遗传易感性研究
短句来源
    HLA DRB 1 GENES INVOLVED IN THE GENETIC SUSCEPTIBILITY TO RHEUMATIC FEVER IN GUANGDONG HANS
    广东汉人HLA-DRB_1基因的PCR-SSP定型分析及其对风湿热遗传易感性的研究
短句来源
    Study on HLA-DQB1 polymorphism to myasthenia gravis susceptibility in Chinese Jiangzhehu areas
    江浙沪地区HLA-DQB1基因对重症肌无力的遗传易感性研究
短句来源
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  “susceptibility”译为未确定词的双语例句
    Mapping the Disease Gene in a Disseminated Superficial Actinic Porokeratosis Family and Study Susceptibility Genes of Late-onset Type 2 Diabetes Mellitus
    对一个弥漫性浅表性光敏性汗孔角化症家系致病基因的定位和对迟发型2型糖尿病易感基因的研究
短句来源
    Mapping and Studying Susceptibility Gene to Lupus Nephritis
    狼疮性肾炎易感基因的定位和研究
短句来源
    Studies on Susceptibility Genes of Epidemic Iodine Deficiency Disorders
    地方性碘缺乏病易感基因的研究
短句来源
    Positional Cloning and Functional Study of Susceptibility Genes of Type 2 Diabetes in Han People of North China
    中国北方汉族人群2型糖尿病易感基因定位克隆及初步功能分析
短句来源
    Identification of Susceptibility Genes for Type 2 Diabetes in Chinese Han Population
    中国汉族人2型糖尿病易感基因的定位
短句来源
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  susceptibility
The effect of the most promising ones have been looked on the counterparts from mammalian sources and difference in the susceptibility towards enzyme activity inhibition were noted.
      
Direct current magnetic susceptibility measurement in the 2-300 K temperature range supports a high-spin ground state.
      
The presence of a frequency-dependent alternating current susceptibility signal indicates that the individual molecule is acting as magnet.
      
In addition, this method can simulate dispersive media whose electric susceptibility cannot be expressed with Debye or Lorentz types of models.
      
Association of the genetic polymorphism of EPHX1 and EPHX2 with the susceptibility to chronic benzene poisoning
      
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35 insulin-dependent diabetes mellitus (IDDM) patients and 53 normal healthy individuals in Shanghai were HLA typed. Second AOHWC workshop sera including HLA-A, -B, -C and -DE reagents were used. Moreover, phenotype frequencies of the variants of the HLA-linked genetic markers including GLO, Bf and C2 were determined. The results showed that phenotype frequencies of two antigens, i. e., All and Cw4, were decreased in patient group. After applying a correction factor for the number of comparisons made at each...

35 insulin-dependent diabetes mellitus (IDDM) patients and 53 normal healthy individuals in Shanghai were HLA typed. Second AOHWC workshop sera including HLA-A, -B, -C and -DE reagents were used. Moreover, phenotype frequencies of the variants of the HLA-linked genetic markers including GLO, Bf and C2 were determined. The results showed that phenotype frequencies of two antigens, i. e., All and Cw4, were decreased in patient group. After applying a correction factor for the number of comparisons made at each locus, there were still significant differences. Phenotype frequencies of two HLA-DR antigens, i. e., DR3 and DRw9, were increased in IDDM group. The deviation of DR3 was not significant in two groups when corrected for the number of comparisons made for HLA-DR locus. DRW9 was very significantly increased in IDDM patient group (Pcorr. = 0.00062).Our results suggested that there appeared to be two HLA-DR antigens which were associated with IDDM in Chinese population. It is very likely that there do exist two susceptibility genes of IDDM, one linked with DR3 and the other with DRW9.

本文对35名胰岛素依赖型糖尿病病人(IDDM)及53名正常人进行了HLA分型。分型试剂由第二届亚洲大洋洲组织相容性专题讨论会提供包括HLA-A、B、C和DR。同时测定了第六条染色体的遗传标志包括GLO、Bf和C2的变异体。 结果发现病人组A11和CW4的表现型频率减低,校正后仍有显著意义。病人组DR3和DRW9表现型频率与对照组比较有增高,特别是DRW9校正后仍然有非常显著的意义(校正p值为0.00062)。 我们的结果提示中国人IDDM病人可能存在二个HLA-DR抗原与IDDM相关联。

Antigenicity of insulin prepara-tion causes some common undesirableside-effects during the treatment.Antibody formation is mainly elicitedby large molecule contaminants in thepreparation. The purity of insulin preparationsfrom four domestic pharmaceuticalfactories was studied with an importedmonocomponent insulin preparation ascontrol. The results show that thedomestic preparations are heterogenous,exhibiting at least five bands on disc-electrophoresis including the proinsulinband. The proinsulin content in...

Antigenicity of insulin prepara-tion causes some common undesirableside-effects during the treatment.Antibody formation is mainly elicitedby large molecule contaminants in thepreparation. The purity of insulin preparationsfrom four domestic pharmaceuticalfactories was studied with an importedmonocomponent insulin preparation ascontrol. The results show that thedomestic preparations are heterogenous,exhibiting at least five bands on disc-electrophoresis including the proinsulinband. The proinsulin content in domes-tic preparations is 1.20-2.29% deter-mined with RIA, which is about 300times higher than that in MC-insulin(highly purified porcine insulin,Nordisk, Denmark). Chromatographyof the domestic porcine crystallineinsulin on Biogel P-30(or SephadexG-50) yields two UV275nm peaks.Polyacrylamide gel electrophoresisand radio-immunoassay demonstratethat Peak 1 contains proinsulin withstructurally related materials and a"dimer" of insulin, and Peak 2 mainlyconsists of "pure" insulin. Serum insulin antibodies wereexamined in 30 normal subjects, 38diabetic patients not receiving insulinand 28 diabetic patients treated withdomestic insulin for three months toten years. The binding of ~(125)I-insulinto serum (B/T% X±SD) for the abovethree groups was 10.0±2.0 (range6.8-14.8%),11.1±3.5 (4.4-16.5%) and52.3±20.5 (17.0-87.9%) respectively.The present paper defines the detectionlimit for antibody positive as mean +3SD of the normal group, i. e., B/T%16%. Among the diabetic patientstreated with domestic insulin, B/T%of 27 cases were above 16%, resultingin a high positive rate of 96.4%. Thishigh susceptibility to insulin antibodyformation in plasma is obviouslyrelated to the impurity of domesticinsulins。

本文报导国产猪结晶胰岛素制剂的纯度鉴定,胰岛素原的分离和含量测定及接受国产胰岛素治疗的病人血清中胰岛素抗体的检测结果。结果表明,国产结晶胰岛素是不均一性的,放免法测定制剂中胰岛素原量占1.2—2.29%。用Biogel P-30层析可分离胰岛素原。用改良放免法检测了30例正常人,38例糖尿病患者和28例接受国产胰岛素治疗的糖尿病患者血清中抗胰岛素抗体。胰岛素抗体的发生率为96.4%。

Glucose insulin release test together with IGI (insulin genetic index) and determinations of some insulin-antagonistic hormones such as hGH (HPL), TT3, TT4, 135I-T3 MAA absorbing ratio were carried out in 90 normal pregnant women. The results indicated that (1) the fasting plasma glucose level was lower as compared with that of the non-pregnant control group, especially during the second trimester; (2) subclinical hypoglycaemia appeared in about 18% of the pregnant women during the first and second trimesters;(3)...

Glucose insulin release test together with IGI (insulin genetic index) and determinations of some insulin-antagonistic hormones such as hGH (HPL), TT3, TT4, 135I-T3 MAA absorbing ratio were carried out in 90 normal pregnant women. The results indicated that (1) the fasting plasma glucose level was lower as compared with that of the non-pregnant control group, especially during the second trimester; (2) subclinical hypoglycaemia appeared in about 18% of the pregnant women during the first and second trimesters;(3) some insulin-antagonistic hormones, especially HPL (human placental lactogen), which was crossreactive to hGH, augmented load of pancreatic islet; (4) augmentation of load of pancreatic islet might be demonstrated by fasting hyperinsulinemia, elevation of postprandial plasma glucose level especially during the third trimester and increased IGI response during the second trimester-after glucose intake, It was suggested that pregnancy might lead to diabetic susceptibility, and that an over-weight or pregnant woman suspected of diabetes mellitus should be moni-tored carefully with OGTT during gestation.

本文通过正常孕妇葡萄糖胰岛素释放试验,计算IGI,以及部分胰岛素拮抗激素,包括hGH(HPL)、T_3、T_4、~(125)I-T_3 MAA吸收比值测定,发现(1)妊娠期空腹血糖较非孕期低,尤以孕中期为甚;(2)妊娠早、中期有18%左右的亚临床低血糖症;(3)妊娠中胎盘分泌的拮抗激素特别是HPL(与hGH有交叉反应)增加胰岛负荷;(4)胰岛负荷增加表现为空腹高胰岛素血症,以及服糖后血糖升高,尤以孕后期为甚,IGI反应也增强,尤以孕中期为著。上述结果揭示妊娠有致糖尿病倾向,因此对超重或疑有糖尿病孕妇在妊娠期宜密切随访OGTT。

 
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