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The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17acetoxy function for potent antagonist activity.


in 1998, statistical curvature, and the local influence of the response vector perturbations are investigated in NRDM.


Existence of positive solution for a twopatches competition system with diffusion and time delay and functional response


The parameter estimation and the coefficient of contamination for the regression models with repeated measures are studied when its response variables are contaminated by another random variable sequence.


This paper is devoted to studying a free boundary problem modeling the effects of drug resistance and vasculature on the response of solid tumors to therapy.

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 It is pointed out that the settlement due to deviatoric stresses is incorrectly disregarded in conventional methods of calculation. It is shown that the deviatoric tensor of stress can not be neglected, whereas the time dependent response of the soil skeleton to deviatoric stresses should be taken into account. On the base of his theory on the consolidation and flow of claylayers "the author presents an analysis on several two dimensional problems. It is shown that the total settlement may bo considored... It is pointed out that the settlement due to deviatoric stresses is incorrectly disregarded in conventional methods of calculation. It is shown that the deviatoric tensor of stress can not be neglected, whereas the time dependent response of the soil skeleton to deviatoric stresses should be taken into account. On the base of his theory on the consolidation and flow of claylayers "the author presents an analysis on several two dimensional problems. It is shown that the total settlement may bo considored as consisting of three main compouents, viz. instantaneouss settlement, and settlements due to flow and due to consolidation. Settlement formulas are presented for large values of time. It is concluded that settlements in practice can not be predicted merely from oedometer tests. The consolidation in two dimensional problems turns out to behave quite differently from that of the classical onedimensional case, as the soil can always deform laterally. The deviatoric stresses are responsible for the instantaneous deflection and the continuous flow of the clay mass.  本文指出現行的沉陷計算方法不考虑因均差应力(Deviatorie stresses)而产生的沉陷是不正确的。文中証明了均差应力張量不能忽略,而土壤的結構对均差应力的反应(与时間因素有关)则必須考虑。作者根据他自己的关于粘土層固結与流变的理論,提供几个二維問題的分析,証明了总沉陷可以分为三部分,卽瞬时下沉,因流变而产生的和因固結而产生的沉陷,并且提出了时間为很大数值时的沉陷公式。可以断言,在实际中,沉陷不能單从压縮試验来估計。在二維問題中,土壤的固结与古典的一維固結情形迥然不同,因为土壤总是有横向膨脹的。均差应力就是粘土在荷載下瞬时下沉(Instantaneous deflection)和不断流变的原因。  This paper deals with the forced harmonic responses of the discrete or continuous damped systems to harmonic excitation, where the viscous damping matrix cannot be diagonalized.The general explicit expressions of the response solutions are given. Hence, general and analytical study of some phenomena in vibration is made with these expressions. For example, the"fixed amplitude point" phenomena in the single damping systems have been demonstrated generally; the condition, under which all forces that... This paper deals with the forced harmonic responses of the discrete or continuous damped systems to harmonic excitation, where the viscous damping matrix cannot be diagonalized.The general explicit expressions of the response solutions are given. Hence, general and analytical study of some phenomena in vibration is made with these expressions. For example, the"fixed amplitude point" phenomena in the single damping systems have been demonstrated generally; the condition, under which all forces that exert on the system and have the same phase, will excite same phase responses, is also discussed.  本文讨论阻尼振动系统(离散或连续系统)在周期外激励作用下的强迫响应;系统的阻尼阵不能对角化.导出了强迫响应一般解的显式解析表达式.利用这些解式,本文对某些振动现象作了较普遍的解析讨论.如,从一般角度讨论了单阻尼振动系统特有的“固定振幅点”现象;讨论了同相位外激励作用下产生同相位响应的条件等等.本文导出的解式对一大类系统仅含很低阶的矩阵求逆运算,因而在计算机数值计算上.本方法比之于现有方法,具有程序简单、耗时少和精度高等优点.本方法可平行应用于转子动力学的不平衡响应分析.  The dynamic properties of the unstable (fast) propagation of cracks, especially the rule of the variation of propagating velocity, are discussed. The case to be considered is that the extension of cracks is not very long (as the cases of rapid crack propagation under impulsive load) , the main idea of this paper is that the rapid propagation of cracks may be treated as a vibration problem and is connected to the basic conceptions of fracture mechanics (such as criterior of fracture, etc.) by the principle of... The dynamic properties of the unstable (fast) propagation of cracks, especially the rule of the variation of propagating velocity, are discussed. The case to be considered is that the extension of cracks is not very long (as the cases of rapid crack propagation under impulsive load) , the main idea of this paper is that the rapid propagation of cracks may be treated as a vibration problem and is connected to the basic conceptions of fracture mechanics (such as criterior of fracture, etc.) by the principle of energy equivalence. The rapid propagation of cracks is essentially a specific type of the transient vibration of elastic bodies, with the boundary conditions varying with the time. Under the assumption of equivalence, the above problem may be treated as the initialvalue problem of a damped system with multiple degrees of freedom, considering the nonlinear effect of stiffness due to the extension of crack. After further simplification, it is deduced to a transient response problem of a damped nonlinear system of single degree of freedom under the initial condition of displacement, so that the solution can be obtained numerically. The fundamental conceptions for which the model is constituted, is the principle of the whole amount of energies being equivalent between the model and practical element, and the primary (main) hypothesis is that the fracture energy dissipated during the propagation oi crack is equivalent to the damping energy of the model system. The DCB specimens are taken as an example for explaining the theory and computing procedure. Numerical examples are calculated and compared with experimental results.In order to record the complete procedure of the rapid propagation and arrest of the crack by experiments, a new method of eddycurrent type is developed.Computational results of several specimens of different materials are all coincided well with the experiments. So it can be concluded that the computational model can be used at least for such cases. Further research would be studied for more compli cate cases.  本文研究裂纹快速扩展的动力特性,特别是裂纹扩展速度的规律.主要考虑在裂纹扩展量不很大的情况(如冲击载荷下裂纹快速扩展的情况)下,将裂纹快速扩展止裂过程作为一种瞬态振动问题求解,而通过能量相当(等效)的原则与断裂力学基本概念(断裂准则等)相联系.计算模型的主要假设是:在裂纹快速扩展过程中,断裂能的消耗用等效的阻尼能来表达.经过近似处理,最后归结为求解有阻尼的单自由度非线性系统在初位移下的瞬态响应计算问题.以DCB试件为例说明计算程序,并给出实例计算结果与实验结果和其他工作的比较.用涡流检测法记录裂纹快速扩展的全过程,以提供实验数据。计算结果与各种实验结果符合较好,初步证明所用的计算模型的有效性,可以作进一步的推广研究以及用于更复杂的问题.   << 更多相关文摘 
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