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chromosome analysis     
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  染色体分析
     MALIGNANT TRANSFORMATION OF C_3H/10T1/2CELLS INDUCED BY ~3H-TdR AND ITS CHROMOSOME ANALYSIS
     ~3H-TdR诱发C_3H/10T1/2细胞恶性转化及其染色体分析
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     Chromosome Analysis in a Family with t(2:6) Balanced Translocation
     t(2;6)平衡易位家系的染色体分析
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     chromosome Analysis in A Family with t(2;7) Balanced Translocation
     一个平衡易位t(2;7)家系的染色体分析
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     Trait observation, isozyme and chromosome analysis were made on the 78 clones collected in Fujian.
     在福建省境内搜集了78份割手密无性系,并进行性状观察和同工酶、染色体分析
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     Chromosome Analysis in A Family with t(9;13) Balanced Translocation
     一个平衡易位t(9;13)家系之染色体分析
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  染色体检查
     Chromosome Analysis of 816 Cases and the Clinical Significance
     816例染色体检查结果的分析及临床意义
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     CHROMOSOME ANALYSIS IN 855 CASES
     855例染色体检查结果分析
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     Chromosome analysis of 304 newborns by umbilical cord blood culture
     304例新生儿脐血的染色体检查
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     \ Results\ Positivity rate and accuracy rate of chromosome analysis were 91.3% and 93.4% respectively,compared with 89.1% and 90.1% of AgNOR technique.
     结果胸水细胞染色体检查敏感性91.3%,准确率93.4%; AgNOR技术敏感性89.1%,准确率90.1%;
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     \ Positivity rate of chromosome analysis was 94.1%,speciality rate of that was 86.8%, accuracy rate of that was 90.7%.
     染色体检查特异性94.1%,敏感性86.8%,准确率90.7%;
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  细胞遗传学分析
     Chromosome Analysis of 1133 Cases in Genetic Counseling Clinic
     1133例遗传门诊病例的细胞遗传学分析
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     The chromosome analysis of 464 outpatients for genetic counselling
     464例遗传咨询者细胞遗传学分析
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     The chromosome analysis of 206 cases for genetic counseling in Ningde district.
     宁德地区206例遗传咨询者细胞遗传学分析
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     Study on chromosome analysis about 1056 cases and its clinical value
     1056例细胞遗传学分析与临床意义的探讨
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     Objective:To explore the clinical value of chromosome analysis.
     目的:探讨细胞遗传学分析与临床意义。
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  “chromosome analysis”译为未确定词的双语例句
     Chromosome analysis and phenotype location analysis on a patient with the karyotype of 45,XX,-13/46,XX,r(13)/46,XX,r(13;13)/47,XX,2r(13)(p13q32.3)
     一例45,XX,-13/46,XX,r(13)/46,XX,r(13;13)/47,XX,2r(13)(p13q32.3)患者及其表型定位研究
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     Chromosome analysis showed that the frequency of cell chromosome number to be 2n = 64 was 91.3%~92.8%.
     细胞染色体众数2n=64的细胞数占91.3%~92.8%;
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     Chromosome analysis was used to observe the chromosome aberration rates after L02 and HepG2 cells were treated with 0.625μmol/LAs2O3 for 2 w, 4 w,6 w.
     0.625μmol/LAs2O3处理L02和HepG2细胞24、、6周,以处理0周作为对照组,染色体核型分析检测细胞染色体畸变;
短句来源
     The cell cycle analysis showed that the G0/G1 was 74 61%,G2/M in 7 78%,S in 17 6%,G2/G1=1 87 and D1=2 40.The chromosome analysis showed a heteroploid feature and the success rate of heterotransplantation was 100 0%.
     细胞周期测定 :G0 / G1期74 .6 1% ,G2 / M期 7.78% ,S期 17.6 % ,G2 / G1=1.87,DI=2 .4 0 ; 染色体众数为 6 9条 ;
短句来源
     The cell cycle analysis showed:G1 55.6% ,G2 21.9% and S 22.5% ,G2/G1=1.90.The chromosome analysis showed a hypotriploid feature and success rate of heterotransplantation was 100% .
     细胞倍增时间为33h,细胞周期测定显示:G1期为55.6%,G2期为21.9%,S期为22.5%,G2/G1为1.90。 染色体具有亚三倍体核型。
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  chromosome analysis
History of contemporary chromosome Analysis: The fundamental contribution of Caspersson's works
      
The chromosome analysis demonstrated that the genetic materials in reconstructed blastocyst cells were the same as that in panda somatic cells.
      
Chromosome analysis showed that the RCE cells exhibited chromosomal aneuploidy with the modal chromosome number of 44.
      
The results showed that the cells kept heredity stabilization by chromosome analysis for at least 20 passages.
      
Blood from fetal heart was collected for fetal chromosome analysis.
      
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The paper presents in detail the technique of leucocytes culture from human peripheral blood for the study of human chromosomes. The techniques involve both the standard method and the semi-micro method with some modifications which have been developed in this laboratory to suit our purposes. With the aid of these techniques, cytogenetic analyses for 7 different cases belonging to 4 different types of congenital defects were made, and the main results are briefly described as follows:1. Down's syndrome...

The paper presents in detail the technique of leucocytes culture from human peripheral blood for the study of human chromosomes. The techniques involve both the standard method and the semi-micro method with some modifications which have been developed in this laboratory to suit our purposes. With the aid of these techniques, cytogenetic analyses for 7 different cases belonging to 4 different types of congenital defects were made, and the main results are briefly described as follows:1. Down's syndrome (4 cases). Most of the cells analyzed in each case showed 47 chromosomes, and the extra chromosome was found to be one of the smallest chromosome in the karyotype. This finding is apparently in agreement with trisomic G-type as previously reported in the literatures. It is highly probable that the origin of this aberration may arise from non-disjunction of one pair of the smallest chromosomes occured in o?genesis, since there is an indication in the rise of the frequencies of Down's syndrome with the age of the mother.2. Testicular feminization syndrome (1 case). The case reported here involves the finding of the same syndrome in 3 successive generations in one family. Chromosomal analysis was available from only one patient and the result demonstrated that most cells showed a chromosome number of 46 with the normal male XY complement, which was found to be in conformity with the discovery that the chromatin was negative on nuclear sexing. This finding is in obvious disagreement with XXY constitution as suggested by some authors to account for the clinical manifestations of this syndrome. Together with the reports of some other workers, analysis of the familial history of the case gives further evidence in support of the suggestion by Grumbach and Barr that this syndrome may be inherited as due to either a sex-linked recessive or a sex-limited dominant factor, though the existing genetic evidence does not suffice to distinguish between the two possibilities.3. Anorchism (1 case). Chromosome analysis of the patient in question revealed the diploid chromosome number to be 46, including an X and a Y chromosome. The nuclear chromatin pattern was also demonstrated to be of male type. Since this case was a sporadic one, it could be assumed to have been originated by mutation. 4. Female pseudohermaphroditism (1 case). A preliminary analysis of the patient revealed the possibility of being an XO(45)/XY(46) mosaic. But this can not be ascertained without further verification from the observations on the skin and bone marrow cultures.

本文详细地介绍了以外周血液培养来研究人类染色体的技术,这些都是我们实验室几年来根据国外文献作了一些修改,以适合于我们的具体条件而拟订的.同时应用这些方法对若干病例作了细胞遗传学的研究,主要结果如下:1.四例先天愚型:在这些病例中,绝大多数中期细胞的染色体数均为47.核型分析表明为G-三体型.一般认为这是由于母亲在卵细胞形成时发生了染色体不分离的结果.2.睾丸女性化:这里报导了一个很大的家系,这一综合症的患者在该家系中已络续出现了三代.其中的一个病人用于白细胞的染色体研究.结果是正常人的双倍体数(2n=46), 具有正常男性的核型,即XY.口腔粘膜及多形核嗜中性球的性染色质扦查为阴性.这种结果显然不符合于这样的假设,即认为该种综合症的性染色体组成是XXY.结合以往一些作者的研究,我们认为该综合症是以伴性隐性或限性的常染色体显性而遗传的.但从现有证据尚不足以区分这两种的可能性.3.无睾畸形:白细胞的双倍体数为2n=46,显示正常的男性核(XY).性染色质为阴性.鉴于该病例为散发性的,我们认为它有可能起因于基因突变.4.女性假两性畸形:由白细胞的初步分析,认为可能是XO(45)/XY(46)嵌合体.但为了肯定其确切...

本文详细地介绍了以外周血液培养来研究人类染色体的技术,这些都是我们实验室几年来根据国外文献作了一些修改,以适合于我们的具体条件而拟订的.同时应用这些方法对若干病例作了细胞遗传学的研究,主要结果如下:1.四例先天愚型:在这些病例中,绝大多数中期细胞的染色体数均为47.核型分析表明为G-三体型.一般认为这是由于母亲在卵细胞形成时发生了染色体不分离的结果.2.睾丸女性化:这里报导了一个很大的家系,这一综合症的患者在该家系中已络续出现了三代.其中的一个病人用于白细胞的染色体研究.结果是正常人的双倍体数(2n=46), 具有正常男性的核型,即XY.口腔粘膜及多形核嗜中性球的性染色质扦查为阴性.这种结果显然不符合于这样的假设,即认为该种综合症的性染色体组成是XXY.结合以往一些作者的研究,我们认为该综合症是以伴性隐性或限性的常染色体显性而遗传的.但从现有证据尚不足以区分这两种的可能性.3.无睾畸形:白细胞的双倍体数为2n=46,显示正常的男性核(XY).性染色质为阴性.鉴于该病例为散发性的,我们认为它有可能起因于基因突变.4.女性假两性畸形:由白细胞的初步分析,认为可能是XO(45)/XY(46)嵌合体.但为了肯定其确切的核型,还有待于对病者的皮肤和骨髓作进一步的研究.

One hundred and fifty-five children in Peking with mental retardation were examined karyologically with the aid of peripheral blood culture techniques. A total of 74 patients were found to have abnormal karyotypes. The results of chromosome analysis are as follows:1. Forty patients had the clinical and cytogenetic features of Down's syndrome, of which 36 were trisomic for chromosome 21 [47, XX(or XY), + 21]; 2 were translocation between D group and G group [46, XX, - D, +t(DqGq)]; 2 were translation...

One hundred and fifty-five children in Peking with mental retardation were examined karyologically with the aid of peripheral blood culture techniques. A total of 74 patients were found to have abnormal karyotypes. The results of chromosome analysis are as follows:1. Forty patients had the clinical and cytogenetic features of Down's syndrome, of which 36 were trisomic for chromosome 21 [47, XX(or XY), + 21]; 2 were translocation between D group and G group [46, XX, - D, +t(DqGq)]; 2 were translation between G group and G group [46, XX (or XY), - G, +t(GqGq)].2. 2 patients had trisomic 18 [47, XX, +18].3. 7 had large short arm of G group [46, XX (or XY), Gp +].4. 1 had translocation of long arm in E group chromosome [46, XY, Eq+].5. 1 had large short arm of a D group [46, XX, Dp + ].6. 1 had translocation of long arm in a G group [46, XY, Gq+].7. 1 had an extra small chromosome of the G group [47, XY, + Gq - ].8. 21 had large Y chromosome [46, XYq+].9. 81 had normal chromosome complements [46, XX (or XY)].The clinical and cytogenetic characteristics of the patients were discribed, the relationships between chromosomal abnormality and mental retardation were discussed.

本文应用染色体组型分析法,研究了155例先天性大脑发育不全儿童的染色体,分析结果可以分成如下几种类型。先天愚型:第21染色体三体征[47,XX(或XY),+21]36例,D/G易位[46,XX,-D,+t(DqGq)]2例,G/G易位[46,XX(或XY),-G,+t(GqGq)]2例;第18染色体三体征[47,XX(或XY)+18]2例;E组染色体长臂易位(46,XY,Eq+)1例;G组长臂易位(46,XY,Gq+)1例;一个额外的G组小染色体(47,XY,+Gq-)1例;此外还有大Y染色体(46,XYq+)21例;G组短臂增大[46,XX(或XY),Gp+]7例;D组短臂增大(46,XX,Dp+)1例。有染色体改变者共74例,未见染色体改变者81例。染色体组型分析可以作为大脑发育不全等遗传疾病诊断的工具之一。

Inspite of many works done bothin human and animal tumors, the rela-tionship between chromosome changesand neoplastic transformation is stillan unsolved problem. With the excep-tion of PhI chromosome in chronicmyelocyte leukamia, no marker chromo-some specific for any histological typeof tumors has been found. But withthe advent of banding technique forchromosome analysis, this importantproblem deserves further study. In thispaper, we will report the results ofsuch a study on the chromosomes...

Inspite of many works done bothin human and animal tumors, the rela-tionship between chromosome changesand neoplastic transformation is stillan unsolved problem. With the excep-tion of PhI chromosome in chronicmyelocyte leukamia, no marker chromo-some specific for any histological typeof tumors has been found. But withthe advent of banding technique forchromosome analysis, this importantproblem deserves further study. In thispaper, we will report the results ofsuch a study on the chromosomes ofhuman hepatoma cells. Since primary cultures were moresuitable for chromosome analysis, smallfragments of surgical specimens obtainedfrom three patients were cultured, andprimary outgrowths of epithelial-likecells established. Tumor cells wereharversted at early culture passages.Well spread metaphase chromosomeswere prepared by routine proceduresafter the treatment with colchicine andhypotonic solution, and stained withGiemsa stain. Chromosome counts in-dicated that one of the explants hasa hyperdiploid constitution with amodal chromosome number of 51-60,while the other two cultures are neartetraploid with 104-117 chromosomes.According to Denver classification,the chromosomes of hepatoma cellswere arranged in groups to determinethe karyotype, and compared with thatof lymphocyte from peripheral blood.The result of this analysis indicatedthat chromosome alteration in humanhepatoma seems to be occurred not atrandom, and some more or less definitecorrelation can be traced. In the firstplace, the D and G group chromosomestended to undergo loss, particularly inthe first case of hepatoma. Monosomyas well as nullisomy of the chromosome15 was found in the karyotype of 90%of tumor cells analysed, and similarchanges in the chromosome 21 or 22appeared in about 30% of tumor cells.The acrocentric chromosome 15 maybe translocated to the chromosome 11or 16, or simply missed from the cell.Secondly, in contrast to changes foundin D and G groups, the E and F groupchromosomes tended to increase in number. These metacentric or sub-metacentric chromosomes may overdivide to become octosomy per cell.It is suggested that chromosome im-balance created by the great excess ofchromosomes E and F groups overthose of G and D groups in humanhepatoma cells may be closely asso-ciated with the malignant transforma-tion of liver cells, and that our findingstend to support the gene imbalancehypothesis as proposed by Rabinowitzand Sachs (1970). So far we haveonly analysed three cases and thecorrectness of the above generalizationsrequire more case analysis in the future. Futheremore, the identification ofthe individual chromosome in moreprecise manner can be made by theuse of G bands pattern, so that chromo-some aberrations usually not detectablewith conventional stains can be observedby this banding technique. In thepresent experiment, chromosomes werebanded by the trypsin, ASG and ureaprocedures. Idiogram of chromosomebands reported in Paris conference(1972) was used as reference standardfor the identification of the bandsdisclosed in hepatoma chromosomes.Careful analysis revealed that the shortarm of one of the chromosome 1appeared longer than its correspondinghomologous one. An extraband ofdeep staining material which is presentin the short arm of this marker chromo-some can be shown to be due to thetranslocation of G group chromosome(e.g. chromosome 21 ) onto the chromo-some 1. Other translocations may alsooccur between G group chromosomesand the chromosome 2 or chromosome4. It is well known that chromosometranslocation often results in a upsetof the inherent relationship within thegenome and leads to the expressionof malignancy. The possible bearingof such tranlocation to the malignantcharacters of human hepatoma requiresfurther investigation.

(一)人体肝癌体外原级培养细胞的中期染色体计数表明,第1例肝癌为超二倍体(2.46倍),其他两例为超四倍体(4.28和4.42倍),染色体众数分别为57,111和116个。(二)肝癌细胞染色体组型分析显示,D组和G组等近顶端着丝点染色体比其他各组号减少了,特别在第一例肝癌的超二倍体细胞中,缺少15号染色体的细胞高达90%,大多成为单体状态,甚或缺体。在所有三例肝癌细胞中,15号染色体平均只有全部染色体倍体数的一半。(三)在三例肝癌细胞中,包括超二倍体和超四倍体细胞,E组和F组等中间或近中间着丝点染色体平均比全部染色体倍体数增加两倍。上述这两类染色体数目变化各异,一增一减,导致肝癌细胞的各组号染色体之间相对比例失调。(四)检查分带类型指出,肝癌细胞内一个1号染色体的短臂比另一同源染色体增长一段,在这短臂末端额外多出一条着色较深的带纹,推测是由于G组(21号)染色体易位所形成。相似的现象较少地出现在2号和4号染色体长臂的末端。由于易位,使得染色体之间固有关系改变了。(五)肝癌细胞中出现双着丝点染色体、半环状染色体和微小染色体等,染色体还发生间隙、断裂和缺损等畸变。

 
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