Changes of gamma-aminobutyrie acid A receptor (GABA_AR-α_1)and N-methyl-D-aspartate receptor-NR_1(NMDAR-NR_1) pro- tein expression in hippocampus were quantitatively and orientatively measured by Western blotting and immunohis- tochemistry method.
Objective To evaluate the inhibiting effect of adenosine on rat retinal ganglion cells (RGC) death induced by P2X7 and N-methyl-D-aspartate (NMDA) receptor.
Objective To study the changes of Ca 2+ concentration mediated by N-methyl-D-aspartate (NMDA) receptor in the neurons in the preoptic area/anterior hypothalamus (PO/AH) of anoxic SD rats by investigating the properties of NMDA receptor.
AIM To investigate if sodium gamma-hydroxybutyrate (GHB-Na) could protect neonatal rats from hypoxia-ischemia and the relationship between N-methyl-D-aspartate receptor 2B subunit (NR2B) expression and brain injury.
目的 探讨γ羟丁酸钠(GHB Na)对缺氧缺血后脑损伤新生大鼠有无保护作用及N 甲基 D 天冬氨酸受体2B亚基(NR2B)与脑损伤的关系。
Objective:To observe the protective effects of MK-801, an antagonist of N-methyl-D-aspartate (NMDA) recepotor, against temporary (TTS) or permanent threshold shifts (PTS) in acoustic trauma.
目的:观察N 甲基 D 天冬氨酸(NMDA)受体的非竞争性拮抗剂MK 801在声损伤中对暂时性阈 移(TTS)或永久性阈移(PTS)的保护作用。
Objective: To observe the effect of compound ketamine oral solution on N-methyl-D-aspartate receptor1 ( NMDAR 1) and gamma-aminobutyric acid A receptors (GABAAR ) in Purkinje neurons of mice.
Objective: To elucidate whether ketamine, a non-competitive antagonist of the N-methyl-D-aspartate(NMDA) receptor, could suppress the withdrawal signs of morphine when it has no effect on the motor functions in rats.
目的 :观察N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)受体拮抗剂氯胺酮 (ketamine)在不影响运动功能的条件下 ,是否能抑制吗啡依赖大鼠的戒断症状。
AIM To investigate the potential neuroprotective effect of haloperidol on oxygen/glucose deprivation (OGD)- and N-methyl-D-aspartate (NMDA)-induced injuries on rat hippocampal slices in vitro and hippocampal neurons in primary culture, and the possible mechanism.
目的 观察氟哌啶醇对大鼠离体海马脑片和原代神经元的缺糖 缺氧 (OGD)和N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)损伤的潜在保护作用及其机制。
The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied.
Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity.
Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke.