Roles Of N-methyl-D-aspartate and non-N-methy1-D-aspartate receptors in the respiratory rhythmical discharge of the hypoglossal nerve in the brainstem slice from neonatal rats
Glutamate play both role in the physiology and pathology through its receptors, among them the N-methyl-D-aspartate (NMDA) has an important role within the process of learning and memory. At present, mostneuroscientists have approved the cell model of learning and memory-------Long-term potentiation (LTP) was based on the NMDA receptor.
Objective To study the changes of Ca 2+ concentration mediated by N-methyl-D-aspartate (NMDA) receptor in the neurons in the preoptic area/anterior hypothalamus (PO/AH) of anoxic SD rats by investigating the properties of NMDA receptor.
Roles Of N-methyl-D-aspartate and non-N-methy1-D-aspartate receptors in the respiratory rhythmical discharge of the hypoglossal nerve in the brainstem slice from neonatal rats
Glutamate play both role in the physiology and pathology through its receptors, among them the N-methyl-D-aspartate (NMDA) has an important role within the process of learning and memory. At present, mostneuroscientists have approved the cell model of learning and memory-------Long-term potentiation (LTP) was based on the NMDA receptor.
Objective To study the changes of Ca 2+ concentration mediated by N-methyl-D-aspartate (NMDA) receptor in the neurons in the preoptic area/anterior hypothalamus (PO/AH) of anoxic SD rats by investigating the properties of NMDA receptor.
Suppressive action produced by β-amyloid peptide fragment 31-35 on long-term potentiation in rat hippocampus is N-methyl-D-aspartate receptor independent:it’s offset by (-) huperzine A
Two major subtypes of ionotropic glutamate receptors(GluRs), N-methyl-D-aspartate (NMDA)-type and a-amino-3-hydroxy-5-methyl-4- isoxazole-propionate( AMPA)-type receptors, are found localized on glutamatergic postsynaptic excitatory synapse. They fulfill coordinately the complex functional roles of glutamatergic neurotransmission.
Following micruinjection of ketamine (180 rnrnol/L, 0. lμl), a kind of N-methyl-D-aspartate (NMDA) receptor antagonist, SO motility was inhibited and the effect of glutamate was abolished.
The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied.
Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity.
Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke.
The purpose of this study is to investigate the effect of microinjecti-on of 2-amino-5-phospho-novalerate (APV), N-methyl-D-aspartate(NMD-A) receptor antagonist, to the CA_3 region of the rat hippocampus on thesynaptic efficacy and relative conditioned behavior during establishmentof conditioned drinking response. The results showed that microinjection of APV caused significantlysuppression of the synaptic efficacy and the establishment of conditioneddrinking ...
The postsynaptic field potentials (PSPs) were recorded radially in the intermediate layers or deep layers respectively after stimulating the deep layers or intermediate layers of the Superior Colliculus in the brain slices of the rat. Long-term potentiation (LTP) was. for the first time, elicited in the deep division of the Superior Colliculus by the tetanic stimulation of 100Hz for 1s . The blocking effect of D, L-amino-5-phosphonovalerate (APV) . a selective antagonist for ##...
Excitutory postsynaptic potentials (EPSPs) and responses of neurons in the compact formation of the neucleus ambiguus (AMBc) to pressure-ejected or bath-applied test subetunces were recorded intracellularly from sagittul slices of Sprague-Dawley rat medulla containing subllucleus centralis of solitary complex (NTSc), AMBc and solitarioambigual pathway. In 5 cells, recorded spontaneous EPSPs could be blocked by morphine (3-5 pmol) to AMBc. Electrical stimulation of NTSc evoked E...