n-methyl-d-aspartate      n-甲基-d-天冬氨酸(98) n-甲基-d-天门冬氨酸(46) n-甲基-d-门冬氨酸(20) n-甲基-d-天门冬氨酸(0) n-甲基-d-天(47)   n-甲基-d-天冬氨酸     DATA SYNTHESIS: The effects of rehabilitation training are related with the expressions of endogenous cerebral protective factor fos immediate early gene, calcitonin gene-related peptide, heat shock protein, glial fibrillary acidic protein, growth associated protein 43, N-methyl-D-aspartate receptor, nitricoxide synthase, proliferating cell nuclear antigen, S-100 albumen, nidogen, brain-derived neurotrophic factor and tubulin.     资料综合:内源性脑保护因子fos即刻早期基因、降钙素基因相关肽、热休克蛋白、胶质纤维酸性蛋白、生长相关蛋白43、N-甲基-D-天冬氨酸受体、一氧化氮合酶、增殖细胞核抗原、S-100蛋白、巢蛋白、脑源性神经营养因子、微管蛋白表达与康复训练效果有关。 短句来源     Objective To study the role of N-methyl-D-aspartate receptor-1 in acute intoxicated en- cephalopathy induced by 1,2-dichloroethane(1,2-DCE).     目的研究N-甲基-D-天冬氨酸Ⅰ型受体(NMDAR1)在1,2-二氯乙烷(1,2-DCE)急性中毒性脑病发病中的作用。 短句来源     Audiogenic seizure can alter N-methyl-D-aspartate receptor subunits NR1, NR2A, NR2B immunoreactivity in epilepsy-prone rat brain     遗传性癫疒间易感大鼠惊厥后脑内N-甲基-D-天冬氨酸受体亚基NR1、NR2A、NR2B蛋白的表达 短句来源     Application development of antagonists of N-methyl-D -aspartate acceptor on brain ischemic damage     N-甲基-D-天冬氨酸受体拮抗剂类药物在脑缺血损伤中的应用进展 短句来源     Effects of electromagnetic pulse on N-methyl-D-aspartate receptor activity in rat hippocampus     电磁脉冲对大鼠脑海马N-甲基-D-天冬氨酸受体活性的影响(英文) 短句来源 更多          n-甲基-d-天门冬氨酸     During cerebral ischemia,N-methyl-D-aspartate receptor(NMDA-R),especially NR2B subunit,changes its struc- ture and function via tyrosine or serine/threonine phosphorylation,and activates the downstream signal pathways to induce excitatory neurotoxicity and cell apoptosis.     脑缺血时,N-甲基-D-天门冬氨酸受体(NMDA-R),尤其是NR2B通过酪氨酸或丝/苏氨酸磷酸化作用其结构和功能发生改变,激活下游细胞信号传导通路,诱导神经元兴奋毒性、细胞凋亡。 短句来源     N-methyl-D-Aspartate (NMDA) induced seizures in Wistar developing rats and ECoG changes     N-甲基-D-天门冬氨酸诱导Wistar乳鼠癫痫发作及脑电图改变 短句来源     N-Methyl-D-Aspartate(NMDA) ,a special nervous mediator, is reported to have close relationship with overflow of ca2+ , which in turn increase the production of free radicals, worsen brain edema,eventurally cause the death of neurons.     中枢神经系统内的神经递质N-甲基-D-天门冬氨酸(N-Methyl-D-Aspartate，NMDA)受体激活可引起钙内流、钙超载，从而导致自由基产生增多，脑水肿加重。 短句来源     Results cDNA microarray analysis showed that the mRNA expression of PSD-93, which correlated with the function of N-methyl-D-aspartate receptors (NMDARs)-nitric oxide (NO) signal transduction pathway, was significantly higher in epilepsy patients than those in the control group. The results of RT-PCR were consistent with the cDNA microarray data.     结果基因芯片检测发现与依赖N-甲基-D-天门冬氨酸受体(NMDARs)-一氧化氮(NO)信号有关的基因PSD-93在癫痫患者中表达上调,RT-PCR实验结果与基因芯片一致。 短句来源     To define the role of MAPK-dependent transcription in the amnesic property of anesthetics, we conducted a series of studies to examine the effect of a prototype intravenous anesthetic propofol on the MAPK response to N-methyl-D- aspartate receptor (NMDAR) stimulation in hippocampal neurons.     为确定MAPK依赖的转录事件在麻醉剂致失忆特性中的作用,我们在海马神经元细胞中做了一系列研究以检测静脉麻醉剂丙泊酚可否改变MAPK对N-甲基-D-天门冬氨酸受体(NMDAR)信号的反应。 短句来源   n-甲基-d-门冬氨酸     The N-methyl-D-aspartate receptor (NMDAR) plays a pivotal role in the process of glutamate-induced excitotoxicity associated with many neurological disorders including stroke, epilepsy, traumatic brain injury and some neurodegenerative diseases, et al.     N-甲基-D-门冬氨酸受体(NMDAR)过度激活所介导的兴奋毒性与脑血管疾病、癫痫、脑脊髓外伤、神经退行性疾病等许多神经、精神疾患的发生发展密切相关。 短句来源     Background: The N-methyl-D-aspartate receptor (NMDAR) plays a pivotal role in the process of glutamate-induced excitotoxicity associated with many neurological disorders including stroke, epilepsy, traumatic brain injury and some neurodegenerative diseases.     背景及目的: N-甲基-D-门冬氨酸受体(NMDAR)过度激活所介导的兴奋毒性与脑血管疾病、癫痫、脑脊髓外伤、神经退行性疾病等许多神经、精神疾患的发生发展密切相关。 短句来源     ve: Using the rat complex partial seizure model induced by kainate, we evaluated the distribution and density of N-methyl-D-aspartate receptor type I (NMDAR1) in the vulnerable brain areas including hippocampus and dentate gyrus, and aimed to find out the antiepileptic mechanisms of vagus nerve stimulation (VNS).     目的:利用红藻氨酸(kainate,KA)致大鼠复杂部分性发作模型,观察海马及齿状回等易损脑区N-甲基-D-门冬氨酸受体1亚单位(NMDAR_1)的变化,以期进一步探明迷走神经刺激治疗癫(疒间)的作用机制。 短句来源   n-甲基-d-天门冬氨酸     During cerebral ischemia,N-methyl-D-aspartate receptor(NMDA-R),especially NR2B subunit,changes its struc- ture and function via tyrosine or serine/threonine phosphorylation,and activates the downstream signal pathways to induce excitatory neurotoxicity and cell apoptosis.     脑缺血时,N-甲基-D-天门冬氨酸受体(NMDA-R),尤其是NR2B通过酪氨酸或丝/苏氨酸磷酸化作用其结构和功能发生改变,激活下游细胞信号传导通路,诱导神经元兴奋毒性、细胞凋亡。 短句来源     N-methyl-D-Aspartate (NMDA) induced seizures in Wistar developing rats and ECoG changes     N-甲基-D-天门冬氨酸诱导Wistar乳鼠癫痫发作及脑电图改变 短句来源     N-Methyl-D-Aspartate(NMDA) ,a special nervous mediator, is reported to have close relationship with overflow of ca2+ , which in turn increase the production of free radicals, worsen brain edema,eventurally cause the death of neurons.     中枢神经系统内的神经递质N-甲基-D-天门冬氨酸(N-Methyl-D-Aspartate，NMDA)受体激活可引起钙内流、钙超载，从而导致自由基产生增多，脑水肿加重。 短句来源     Results cDNA microarray analysis showed that the mRNA expression of PSD-93, which correlated with the function of N-methyl-D-aspartate receptors (NMDARs)-nitric oxide (NO) signal transduction pathway, was significantly higher in epilepsy patients than those in the control group. The results of RT-PCR were consistent with the cDNA microarray data.     结果基因芯片检测发现与依赖N-甲基-D-天门冬氨酸受体(NMDARs)-一氧化氮(NO)信号有关的基因PSD-93在癫痫患者中表达上调,RT-PCR实验结果与基因芯片一致。 短句来源     To define the role of MAPK-dependent transcription in the amnesic property of anesthetics, we conducted a series of studies to examine the effect of a prototype intravenous anesthetic propofol on the MAPK response to N-methyl-D- aspartate receptor (NMDAR) stimulation in hippocampal neurons.     为确定MAPK依赖的转录事件在麻醉剂致失忆特性中的作用,我们在海马神经元细胞中做了一系列研究以检测静脉麻醉剂丙泊酚可否改变MAPK对N-甲基-D-天门冬氨酸受体(NMDAR)信号的反应。 短句来源     查询“n-methyl-d-aspartate”译词为其他词的双语例句 n-甲基-d-天   查询“n-methyl-d-aspartate”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   n-methyl-d-aspartate The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied. 例句来源       It has been demonstrated that the key target of these peptides are N-methyl-D-aspartate glutamate receptors. 例句来源       Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity. 例句来源       Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice. 例句来源       Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke. 例句来源       更多                    Rats after cerebral ischemia and reperfusion were treated with MK-801.It was found that MK-80l could block the combination of the excitatory amino acids with N-methyl-D-aspartate receptors and protect the respiratory capacity of the brain mitochondria.These findings suggest that the administration of MK-801 is able to improve the cerebral mitochondrial respiratory capacity.             用ＭＫ－８０１这种Ｎ－甲基－Ｄ－天门冬氨酸（Ｎ－ｍｅｃｈｙｌＤ－ａｓｐａｒｔａｔｅ，ＮＭＤＡ）受体拮抗剂对脑缺血再灌流大鼠进行治疗，观察其阻滞兴奋性氨基酸与突触后受体结合，从而保护脑线粒体的功效。观察提示，在脑缺血及再灌流期脑线粒体呼吸功能较假手术组有非常显著的降低，用ＭＫ－８０１治疗组的脑线粒体呼吸功能较未治疗组有非常明显的改善，为治疗缺血性脑损伤提供了新的途径。 文摘来源          Using in situ hybridization method, alteration of the mRNA concentration of both the preprocholecystokin(PCCK) and preproenkephalin(PPE) after rat brain injury and the mechenism of this trauma inducing change in neuropeptide neuropeptide gene expression were analysed. The results showed that 48h after in jury of the rat brain,the concentration of mRNA coding for PPE,and PCCK was increased significantly in ipsilateral side specially in the cortical area,hippocampus.The ketamine, a N-meth...             应用原位杂交技术，研究大鼠脑损伤后前胆囊收缩素（ＰＣＣＫ）和前脑啡肽原（ＰＰＥ）ｍＲＮＡ的表达。结果表明，在大鼠脑损伤２４ｈ后同侧脑内ＰＣＣＫ和ＰＰＥｍＲＮＡ量增加，尤其以新皮质和海马显著。给予ＮＭＤＡ受体非竞争性拮抗剂ｋｅｔａｍｉｎｅ可以抑制增加。因此，作者认为在脑损伤后可诱发胆囊收缩素（ＣＣＫ）和脑啡肽（ＥＮＫ）合成增加，并参与脑损伤病理改变，另外这种合成增加可能由ＮＭＤＡ受体介导。 文摘来源          AIM:To study the changes of hippocampal quinolinic acid (QA) concentrations during acute and chronic seizures induced by ip injection of kainic acid (KA, 12 mg kg-1) in rats. METHODS:The extraction and measurement of QA in the hippocampus were performed using a gas chromatography-mass spectrometry method. RESULTS:When acute seizures were fully established 3 h after KA injection, no significant changes of hippocampal QA were found. During,chronic seizures observed on d 30 after KA inj...             目的:观察大鼠海马内喹啉酸(QA)浓度在卡英酸(KA)致癫过程的不同时期的动态变化特点.方法:采用气相色谱—质谱联用法分离并测定海马QA浓度.结果:腹腔注射KA后3h的急性惊厥期海马内QA的浓度较对照组相应值无显著变化;注入KA后30d的慢性惊厥期海马内QA的浓度反而较对照组相应值显著减低55±8％;但在注入KA后2及7d,急性惊厥已基本消失而慢性惊厥尚未出现,但同时海马及海马外某些脑区神经元变性及胶质增生反应显著的时候,海马内QA的浓度却分别较对照组相应值显著增高56±13％及156±13％(P<0.01).结论:海马内QA浓度的增高对KA所致惊厥行为的产生可能不起关键作用,但可能通过激活NMDA受体参与神经元变性及胶质增生反应. 文摘来源   << 更多相关文摘         相关查询:  对查询结果不满意

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