Regulatory effects of acidic peptide on the levels of N-methyl-D-aspartate receptor,nerve growth factor and beta-amyloid in the brain of rats with Alzheimer disease
Recently more researches focus on the N-methyl-D-aspartate (NMDA) receptor, which involves in development of addiction through interaction with dopamine receptor.
OBJECTIVE:To observe whether acidic peptide can inhibit the production of N-methyl-D-aspartate receptor(NMDAR)and beta-amyloid(β-amyloid)in brain,and accelerate the production and excretion of nerve growth factor(NGF)in rats with Alzheimer disease.
Effect of compound detoxification peptide on the levels of N-methyl-D-aspartate receptor 1 and nitric oxide synthase in the brain of mice with morphine addiction
AIM: To study the effect of compound detoxification peptide on the levels of N-methyl-D-aspartate receptor 1 (NMDAR1) and nitric oxide synthase (NOS) in mice with morphine addiction.
Results The grades of learning and memory in VD mice were worse than those in sham-operation group(P<0.01),and the exp ression of N-methyl-D-aspartate receptor in VD mice was also lower than that of sham-operation group(P<0.01).
结果 模型组小鼠学习、记忆成绩较假手术组明显降低(P<0. 01),其海马N 甲基 D 天门冬氨酸受体蛋白表达也明显下降 (P<0. 01)。
Objective To observe if Cre recombinase can knock out the local gene of the CA1 region of hippocampus in N-methyl-D-aspartate receptor (NMDAR) transgenic adult mice.
目的观察Cre重组酶能否敲除N甲基D天门冬氨酸受体(N methyl D aspartatereceptor,NMDAR)转基因成熟小鼠海马CA1区域的局部基因。
Objective The characteristics of N-methyl-D-aspartate receptor in neuron of hippocampus of mice with vascular dementia (VD ) were observed for the purpose of demonstrating its function in VD pathogenesis .
目的 观测血管性痴呆小鼠海马神经元N 甲基 D 天门冬氨酸 (NMDA)受体免疫组织化学变化特征,以探讨其在血管性痴呆发病中的作用。
Methods The mice were subjected for ischemia-reperfusion repe atedly in bilateral common carotid arteries by knotting to establish the VD mode ls. The behavior abnormalities were investigated by step-down test and water m aze test,and the N-methyl-D-aspartate receptor was observed by immunohistoch emistry technique.
方法 双侧颈总动脉线结,反复缺血—再灌注法制备模型,利用跳台试验和水迷宫试验观测其行为学改变,采用免疫组织化学技术观测小鼠海马神经元N 甲基 D 天门冬氨酸受体蛋白的表达变化。
1. Focal Gene Deletion in the Brain (Knockout of the Adenosine Al Receptor and N-Methyl-D-Aspartate Receptor (NMDAR) in Adult Mice Using Adeno-associated Viral Vector) to Study the Role of Adenosine in Wake/sleep Transition 2. The Corelation between Serotonin Transporter Expression and Learned Helplessness (Animal Model of Depression)
Focal gene deletion in the brain (knockout of the adenosine A1 receptor and N-Methyl-D-Aspartate receptor in adult mice using adeno-associated viral vector) to study the role of adenosine in wake/sleep transitionIn humans, insomnia is endemic to modern society and can severely impair cognitive performance and the ability to accomplish daily tasks.
The behavioral abnormalities were investigated by step-down test and water maze test. Huperzine A was given to the mice in medication group, N-methyl-D-aspartate receptor mRNA in neuron of hippocampus were observed in situ hybridization technique.
Results Huperzine improved the grades of learning and memory in VD mice. The changes of N-methyl-D-aspartate receptor in neuron of hippocampus were ameliorated by Huperzine A.
The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied.
Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity.
Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke.