Effects of the blocker of N-methyl-D-aspartate receptor MK801 on the electrophysiological changes of CA1 neurons during hypoxia in isolated hippocampal slices of rats
They inhibit NMDA (N-methyl-D-aspartate) receptors; moreover,different conantokin species present different NMDA receptor subunit specificity. It can induce sleep-like symptoms in young mice when delivered intracranially.
The discovery of novel classes of ion channels and their mechanisms of analgesia has provided pharma-ceutical researches with a large number of novel targets for pain therapy, including: tetrodotoxin-resistant (TTXr) Na+ ionchannel blockers, N-type Ca2+ ion channel blockers, acid-sensitive ion channel (ASICs) blockers, nicotinic acetylcholinereceptor (nAChRs) agonists, N-methyl-D- aspartate (NMDA) receptor antagonists, g-aminobutyric acid receptor subtypeA (GABAA) receptor agonists, P2X receptor antagonists and vanilloid receptor (VR) regulators.
Objective: To elucidate whether ketamine, a non-competitive antagonist of the N-methyl-D-aspartate(NMDA) receptor, could suppress the withdrawal signs of morphine when it has no effect on the motor functions in rats.
目的 :观察N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)受体拮抗剂氯胺酮 (ketamine)在不影响运动功能的条件下 ,是否能抑制吗啡依赖大鼠的戒断症状。
AIM To investigate the potential neuroprotective effect of haloperidol on oxygen/glucose deprivation (OGD)- and N-methyl-D-aspartate (NMDA)-induced injuries on rat hippocampal slices in vitro and hippocampal neurons in primary culture, and the possible mechanism.
目的 观察氟哌啶醇对大鼠离体海马脑片和原代神经元的缺糖 缺氧 (OGD)和N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)损伤的潜在保护作用及其机制。
ObjectiveTo study the protective effect of memantine on the regulation of N-methyl-D-aspartate(NMDA) receptor in dichlo rvos-poisoned rat brain,and to understand the mechanism of its role in organoph osphate poisoning.
目的 研究美金刚对敌敌畏染毒大鼠脑组织N 甲基 D 天冬氨酸 (NMDA)受体的保护作用及其治疗有机磷农药中毒的机制。
Objective To observe the influence of propofol on amino acid levels in cultured PC12 cells impaired by N-methyl-D-aspartate, and explore the possible protective action mechanism of anesthetic propofol.
The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied.
Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity.
Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke.
The ability of tetrandrine (Tet),as a Ca2+ antagonist isolated from a traditionalChinese herb,to reduce cortical neuronal injury was quantitatively examined in cell cultures derivedfrom fetal rats by measurement of lactate dehydrogenase(LDH)released to the extracellular bathingmedia.Cell cultures exposed to excitotoxins-glutamate(Glu),N-methyl-D-aspartate(NMDA),β-N-oxalylamino-L-alanine(BOAA, on non-NMDA receptors)and β-N-methyla...
The microdialysis technique was utilized to study the effects of exogenous D-serine on the cGMP level in the perfusate of rat hippocampus. Addition of N-methyl-D-aspartate (NMDA) 250 μmol·L1 to the perfusate resulted in a striking increase of cGMP in perfusate. The cGMP response elicited by NMDA was prevented by 7-chlorokynurenic acid (7CKA), a selective antagonist at the glycine site of the NMDA receptor. Dserine completely reversed the antagonis...
Cultured neurons obtained from rat cortex were used to examine the protective effect of (-) S·R daurisoline (Dau) against N methyl D aspartate (NMDA) induced neurotoxicity. Cell viability was estimated by using trypan blue dye exclusion and MTT assay.Intracellular free Ca 2+ concentration ([Ca 2+ ] i ) was measured by using AR CM MIC cation measurement system with Fura 2/AM as Ca 2+ senstive fluorecent indicator. It was ...