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      n-methyl-d-aspartate     
相关语句
  n-甲基-d-天冬氨酸
    Effect of D-serine on N-methyl-D-aspartateinduced efflux  of cGMP from rat hippocampus
    D-丝氨酸对N-甲基-D-天冬氨酸诱导大鼠海马cGMP释放作用的影响
短句来源
    Suppression of morphine withdrawal signs by low doses of ketamine, a N-methyl-D-aspartate receptor antagonist
    N-甲基-D-天冬氨酸受体拮抗剂氯胺酮抑制大鼠吗啡戒断症状的表达
短句来源
    Protection of propofol on cultured PC12 cells impaired by N-methyl-D-aspartate
    丙泊酚对N-甲基-D-天冬氨酸所致PC12细胞损伤的保护作用
短句来源
    Regulation of Excitatory Amino Acid Release by N-Methyl-D-Aspartate Receptors in Rat Hippocampus
    N-甲基-D-天冬氨酸受体对清醒大鼠海马谷氨酸释放的调节作用
短句来源
    Effects of the blocker of N-methyl-D-aspartate receptor MK801 on the electrophysiological changes of CA1 neurons during hypoxia in isolated hippocampal slices of rats
    离体海马脑片CA1区锥体细胞缺氧期间电生理指标变化与N-甲基-D-天冬氨酸受体阻断剂MK801干预后的变化(英文)
短句来源
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  n-甲基-d-天门冬氨酸
    Reversing effect of histamine on neuron death induced by N-methyl-D-aspartate
    组胺对N-甲基-D-天门冬氨酸诱发的神经元损伤的改善作用
短句来源
    Ketamine is a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor.
    氯胺酮(ketamine,Ket)属N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体非竞争性拮抗剂。
短句来源
    Memantine hydrochloride is an amantadine derivative. It is a moderate affinity, non-competitive N-methyl-D-aspartate (NMDA) antagonist.
    盐酸美金胺是盐酸金刚烷胺衍生物,它是具有中等亲和力的非竞争性的N-甲基-D-天门冬氨酸(NMDA)受体拮抗剂。
短句来源
    They inhibit NMDA (N-methyl-D-aspartate) receptors; moreover,different conantokin species present different NMDA receptor subunit specificity. It can induce sleep-like symptoms in young mice when delivered intracranially.
    芋螺睡眠肽是一类非竞争性的N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体的选择性抑制剂,并且具有受体亚型特异性,颅内注射芋螺睡眠肽后,实验鼠会呈现一种睡眠样症状。
短句来源
  n-甲基-d-门冬氨酸
    Protection of risperidone against N-methyl-D-aspartate induced injury in rat cortical neuronal cultures
    利培酮对N-甲基-D-门冬氨酸诱导的大鼠皮层神经细胞损伤保护作用的研究
短句来源
    N-methyl-D-aspartate (NMDA) receptors play an important role in the pathological processes of ischemic neuron injury.
    兴奋性氨基酸受体N-甲基-D-门冬氨酸(NMDA)受体在脑缺血损伤的病理过程中起重要作用。
短句来源
    MK-801 (Dizocilpine) is a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, which can easily penetrate blood-brain barrier[1] .
    MK-801[(+)-5-methyl-10,11-dibenzol a,d-cyclohepten-5,10-imine meleate],中文名地佐西平,是一种化学合成的非竞争性NMDA(N-甲基-D-门冬氨酸)受体拮抗剂,其作用强、易透过血脑屏障。
短句来源
    Objective To explore the effect of risperidone on N-methyl-D-aspartate (NMDA)-induced injury in rat cortical neuronal cultures.
    目的探讨利培酮对N-甲基-D-门冬氨酸(NMDA)诱导的大鼠皮层神经细胞损伤的作用。
短句来源
    The discovery of novel classes of ion channels and their mechanisms of analgesia has provided pharma-ceutical researches with a large number of novel targets for pain therapy, including: tetrodotoxin-resistant (TTXr) Na+ ionchannel blockers, N-type Ca2+ ion channel blockers, acid-sensitive ion channel (ASICs) blockers, nicotinic acetylcholinereceptor (nAChRs) agonists, N-methyl-D- aspartate (NMDA) receptor antagonists, g-aminobutyric acid receptor subtypeA (GABAA) receptor agonists, P2X receptor antagonists and vanilloid receptor (VR) regulators.
    新型离子通道及镇痛机理的发现,为药学研究提供了大量镇痛新靶点,包括河豚毒抗性-Na+(TTXr-Na+)通道阻滞剂、N-型Ca2+通道阻滞剂、酸敏离子通道(ASICs)阻滞剂、烟碱型乙酰胆碱受体(nAChRs)激动剂、N-甲基-D-门冬氨酸(NMDA)受体拮抗剂、g-氨基丁酸A亚型(GABAA)受体激动剂、P2X受体拮抗剂和香草素受体(VR)调节剂。
短句来源
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  n甲基d天冬氨酸
    Objective: To elucidate whether ketamine, a non-competitive antagonist of the N-methyl-D-aspartate(NMDA) receptor, could suppress the withdrawal signs of morphine when it has no effect on the motor functions in rats.
    目的 :观察N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)受体拮抗剂氯胺酮 (ketamine)在不影响运动功能的条件下 ,是否能抑制吗啡依赖大鼠的戒断症状。
短句来源
    AIM To investigate the potential neuroprotective effect of haloperidol on oxygen/glucose deprivation (OGD)- and N-methyl-D-aspartate (NMDA)-induced injuries on rat hippocampal slices in vitro and hippocampal neurons in primary culture, and the possible mechanism.
    目的 观察氟哌啶醇对大鼠离体海马脑片和原代神经元的缺糖 缺氧 (OGD)和N 甲基 D 天冬氨酸 (N methyl D aspartate ,NMDA)损伤的潜在保护作用及其机制。
短句来源
    ObjectiveTo study the protective effect of memantine on the regulation of N-methyl-D-aspartate(NMDA) receptor in dichlo rvos-poisoned rat brain,and to understand the mechanism of its role in organoph osphate poisoning.
    目的 研究美金刚对敌敌畏染毒大鼠脑组织N 甲基 D 天冬氨酸 (NMDA)受体的保护作用及其治疗有机磷农药中毒的机制。
短句来源
    Objective To observe the influence of propofol on amino acid levels in cultured PC12 cells impaired by N-methyl-D-aspartate, and explore the possible protective action mechanism of anesthetic propofol.
    目的观察静脉麻醉药异丙酚对N甲基D天冬氨酸(NMDA)致PC12细胞损伤时氨基酸水平的影响,并探讨异丙酚细胞保护作用的可能机制。
短句来源

 

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  n-methyl-d-aspartate
The effects of intracerebroventricular (icv) agonists and antagonists of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors on the general anesthesia of propofol were studied.
例句来源      
It has been demonstrated that the key target of these peptides are N-methyl-D-aspartate glutamate receptors.
例句来源      
Activation of rat cerebellum granule cells by N-methyl-D-aspartate (NMDA, 10-4-10-3 M) results in progressive increase in reactive oxygen species (ROS) and suppression of the ouabain-sensitive part of Na/K-ATPase activity.
例句来源      
Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice.
例句来源      
Background and purpose A low-affinity, use-dependent N-Methyl-D-Aspartate (NMDA) antagonist AR-R15896AR has neuroprotective properties in animal models of ischaemic stroke.
例句来源      
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         The ability of tetrandrine (Tet),as a Ca2+ antagonist isolated from a traditionalChinese herb,to reduce cortical neuronal injury was quantitatively examined in cell cultures derivedfrom fetal rats by measurement of lactate dehydrogenase(LDH)released to the extracellular bathingmedia.Cell cultures exposed to excitotoxins-glutamate(Glu),N-methyl-D-aspartate(NMDA),β-N-oxalylamino-L-alanine(BOAA, on non-NMDA receptors)and β-N-methyla...
            兴奋性氨基酸类神经毒剂与粉防己碱(Tet)共同作用于原代培养胎鼠大脑皮层神经元24h,发现10-7,10-6mol·L-1Tet明显降低谷氨酸(Glu),β--oxalylamio-L-alae(BOAA)和β-methylamio-L-alae(BMAA)导致的培养液乳酸脱氢酶(LH)活性增高,细胞形态损害减轻,细胞数量增加。对AA介导的神经元损伤改变无影响。提示Tet对某些Glu类神经毒剂引起的胎鼠大脑皮层神经元损伤有一定保护作用,其机制可能是抑制细胞膜a+通道开放,阻止膜去极化而影响电压依赖性Ca2+通道启动。对A受体可能亦有一定作用。
文摘来源
         The microdialysis technique was utilized to study the effects of exogenous D-serine on the cGMP level in the perfusate of rat hippocampus. Addition of N-methyl-D-aspartate (NMDA) 250 μmol·L1 to the perfusate resulted in a striking increase of cGMP in perfusate. The cGMP response elicited by NMDA was prevented by 7-chlorokynurenic acid (7CKA), a selective antagonist at the glycine site of the NMDA receptor. Dserine completely reversed the antagonis...
            ┐丝氨酸对┐甲基┐┐天冬氨酸诱导大鼠海马cGMP释放作用的影响金英刘晓娟王化洲(锦州医学院药理学教研室,锦州121001)很久以来,人们一直认为高级脊椎动物几乎不产生也不利用-氨基酸系列[1].然而,最近越来越多的实验表明在成年哺乳动物包括人...
文摘来源
         Cultured neurons obtained from rat cortex were used to examine the protective effect of (-) S·R daurisoline (Dau) against N methyl D aspartate (NMDA) induced neurotoxicity. Cell viability was estimated by using trypan blue dye exclusion and MTT assay.Intracellular free Ca 2+ concentration ([Ca 2+ ] i ) was measured by using AR CM MIC cation measurement system with Fura 2/AM as Ca 2+ senstive fluorecent indicator. It was ...
            蝙蝠葛苏林碱(aurisolie,au)是从防己科植物蝙蝠葛根茎中提取的生物碱,(-)-S·R-au是其人工合成非对映异构体.研究表明它的药理活性比天然品强很多[1].我们最近报道(-)-S·R-au能抑制谷氨酸(Glu)对原代培养的大鼠皮...
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