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acute ischemic stroke     
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  acute ischemic stroke
Association of the IVS9-675C > A polymorphism of the HIF-1α gene with acute ischemic stroke in the Moscow population
      
The IVS9-675C >amp;gt; A polymorphism of the HIF-1α gene was analyzed in patients with acute ischemic stroke and in a control group.
      
Clinical analysis of first-ever acute ischemic stroke involving the territory of paramedian mesencephalic arteries
      
In the USA, recombinant tissue plasminogen activator (rt-PA) has been approved for therapy of acute ischemic stroke (AIS) within a 3 hour time window based on the results of the NINDS [1] trial.
      
New frontiers on acute ischemic stroke therapy 27-29 May 1991, Valletta, Malta
      
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おhis is a report on the functional change of vascular endothelial cell (VEC) in acute ischemic stroke with qi-deficiency and blood_stasis syndrome and effects of the formula with the function of replenishing qi and promoting blood circulation. A design of randomized double_blinded controlled trial was adopted in this study. Sixty_six cases were divided into two groups. Group 1(n=34) was treated with Naoshuangkang,a formula with the function of replenishing qi and promoting blood circulation; and group...

おhis is a report on the functional change of vascular endothelial cell (VEC) in acute ischemic stroke with qi-deficiency and blood_stasis syndrome and effects of the formula with the function of replenishing qi and promoting blood circulation. A design of randomized double_blinded controlled trial was adopted in this study. Sixty_six cases were divided into two groups. Group 1(n=34) was treated with Naoshuangkang,a formula with the function of replenishing qi and promoting blood circulation; and group 2 (n=32) received placebo. Furthermore, a normal control group (n=17) was conducted for comparing with the patient groups. The results showed that:①Before treatment, the blood concentrations of active substances (tPA, NO, 6_keto_PGF1α, CGRP and AT Ⅲ),secreted by VEC in patient groups, were significantly lower than those in normal control group(P<0.01)while the concentrations of PAI, TXB2 and ET were notably higher(P<0.01) in patient groups. ②At the end of the four_week treatment, the levels of PAI,TXB2 and ET decreased significantly, near the level of normal control group (P>0.05),while the level of tPA and AT Ⅲ increased significantly, both close to normal control group (P>0.05).However, the concentrations of NO and 6_keto_PGF1α in the treatment groups were still lower than those in normal control group (P<0.01),and the concentrations of NO and 6_keto_PGF1α in group 1 were remarkably higher than those in group 2 (P<0.01). The results described above demonstrated that the development of acute ischemic stroke with qi_deficiency and blood_stasis syndrome had close relationship with functional changes of VEC, the increased vasoconstriction active substances and decreaseded vasodilatation active substances. The latter may be the predominant change during this course. Drugs with the function of replenishing qi and promoting blood circulation may effectively enhance VEC to secrete more NO and PGI2.

为研究以益气活血法拟定的脑栓康处方治疗急性缺血性中风(脑血栓形成)气虚血瘀证的作用,将符合条件的66例患者随机分为试验组34例和安慰剂组32例,以双盲法进行临床观察和检测血管内皮细胞功能的相关指标,另设17例正常对照组进行比较。结果:治疗前试验组和安慰剂组的tPA、6_keto_PGF1α、ATⅢ、NO、CGRP含量(或活性)均低于正常对照组水平(P<0.01),PAI、TXB2、ET含量(或活性)均高于正常对照组水平(P<0.01)。经4周治疗后,自身前后比较:两组tPA、6_keto_PGF1α、NO、ATⅢ、CGRP含量(或活性)均升高(P<0.001),PAI、TXB2、ET含量(或活性)均降低(P<0.001)。两组治疗前后差值组间比较:试验组PAI、TXB2、ET含量(或活性)降低,tPA、ATⅢ、CGRP含量(或活性)升高,和安慰剂组比较,差异无显著意义(P>0.05),试验组6_keto_PGF1α、NO含量升高比安慰剂组高(P<0.01)。治疗后与正常对照组比较:两组的PAI、TXB2、ET含量(或活性)降低及tPA、ATⅢ含量(或活性)升高已接近正常对照组水平(P>0.05);NO、CG?

To explore the methodology for establishing diagnostic criteria of TCM syndromes in stroke, 106 cases of acute ischemic stroke with qi_deficiency blood_stasis syndrome were accepted for the study. Their tongue pictures, pulse condition and clinical manifestations were observed systematically and the data were treated with reliability analysis, principal component analysis and cluster analysis. According to the statistical analyses and clinical practice, the diagnostic criteria should cover both disease...

To explore the methodology for establishing diagnostic criteria of TCM syndromes in stroke, 106 cases of acute ischemic stroke with qi_deficiency blood_stasis syndrome were accepted for the study. Their tongue pictures, pulse condition and clinical manifestations were observed systematically and the data were treated with reliability analysis, principal component analysis and cluster analysis. According to the statistical analyses and clinical practice, the diagnostic criteria should cover both disease differentiation and syndrome differentiation. The items of disease differentiation should include hemiparalysis, deviation of the eye and mouth, stiff tongue, dysphasia or aphasia and CT findings. Those of syndrome differentiation includes paralysis, fatigue, somnolence, cyanotic lips and sunken small pulse as the primary items, and localized headache, sweating, palpitation, weakness, pale complexion, loose stool or incontinence of stool and urine, engorged and purple sublingual veins or dark purplish tongue as the secondary items. This study may serve as a methodological basis for establishing the diagnostic criteria of stroke.

为探讨建立中风病证候诊断标准的方法 ,观察了 10 6例急性缺血性中风气虚血瘀证患者 ,对其证候指标 :舌、脉、症状进行了可靠性分析、主成分分析和聚类分析。根据统计分析结果并结合临床实际 ,初步提出急性期缺血性中风气虚血瘀证的诊断标准 ,包括辨病和辨证两个方面。辨病可见半身不遂、口舌歪斜、舌强语蹇或不语 ,CT检查符合缺血性中风改变 ;辨证必须有肢体瘫软、倦怠嗜卧、口唇紫暗 ,脉沉细等主症 ,并可兼见头痛而痛处不移、汗出、心悸、乏力、面色白 ,大便溏或二便自遗、舌背脉络瘀胀青紫或舌紫暗等次要症状。这将为进一步建立确切的中风病证候诊断奠定方法学的基础

Objective:To investigate the relation between serum inflammatory cellular factor and different syndrome in patients with type Ⅱ diabetes mellitus (DM Ⅱ) complicated acute ischemic stroke.Methods:30 cases were randomly divided into Fengtan Yuzu type (风痰瘀阻型) group and non Fengtan Yuzu type group,their plasma levels of interleukin6(IL6),tumor necrosis factorα(TNFα) and high blood coagulation state before therapy were measured by radioimmunoassay (RIA) method and compared with healthy subject group.Results:The...

Objective:To investigate the relation between serum inflammatory cellular factor and different syndrome in patients with type Ⅱ diabetes mellitus (DM Ⅱ) complicated acute ischemic stroke.Methods:30 cases were randomly divided into Fengtan Yuzu type (风痰瘀阻型) group and non Fengtan Yuzu type group,their plasma levels of interleukin6(IL6),tumor necrosis factorα(TNFα) and high blood coagulation state before therapy were measured by radioimmunoassay (RIA) method and compared with healthy subject group.Results:The plasma levels of IL6,TNFα and the platelet agglutination rate (PAgT),fibrinogen (FG) and external thrombosis length(ETL) in patients with Fengtan Yuzu type were significantly higher than those in non Fengtan Yuzu type and healthy subject group ( P <0 05 or P <0 01).The levels of TNFα and IL6 were positively correlated with the PAgT,FG and ETL in Fengtan Yuzu type(all P <0 01).Conclusions:The high levels of TNFα and IL6 in acute ischemic stroke resulted from type Ⅱ diabetes mellitus may be the important pathophysiological basis of Fengtan Yuzu syndrome.It can play a role in the pathological process of diabetes mellitus with acute ischemic stroke.

目的 :探讨 型糖尿病缺血性中风不同证型与血清炎症细胞因子的关系。方法 :应用放射免疫分析法测定患者入院时血浆白介素 6 (IL 6 )、肿瘤坏死因子α(TNFα)的水平及血液高凝状态指标 ,并与非风痰瘀阻证及正常人对照组作比较。结果 :风痰瘀阻证组糖尿病合并脑梗死者 TNFα、IL 6和血小板聚集率(PAg T)、血浆纤维蛋白原 (FG)、体外血栓长度 (ETL)显著高于非风痰瘀阻证组及正常人对照组 (P<0 .0 5或P <0 .0 1)。风痰瘀阻型患者 TNFα、IL 6与 PAg T、FG、ETL均呈明显正相关 (P均 <0 .0 1)。结论 :高TNFα和 IL 6可能是 型糖尿病缺血性中风风痰瘀阻证重要的病理生理基础 ,并在疾病发生发展过程中起重要作用。

 
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