The release of S 100 and MBP in patients were associated with the volume of brain lesions ( P < 0.01 ) and the neurological outcome as assessed by NIHSS( P < 0.01 ).
S 100、MBP的血浆浓度与梗死体积呈显著正相关(r≥0.480,P<0.01),与神经功能缺损程度也呈显著正相关(r≥0.443,P<0.01)。
The neurological outcome was evaluated at 72 h after reperfusion. The brain infarct volume was determined by 2, 3, 5-triphenyltetrazolium chloride (TTC) staining.
(4) Within S 、IR and HP+IR group, 6 rabbits of each group were taken out randomly at 4h、12h、24h and 48h after reperfusion. Neurological outcome was assessed according to Jacobs' score, then the animals were sacrificed, and the spinal cords(L3~L4) were removed.
Intrathecal pretreatment with aminoguanidine 1 μmol, a selective iNOS inhibitor, 10 min before Dyn 20 nmol significantly ameliorated Dyn-induced neurological outcome and antagonized the increase of iNOS activities at 4 h after Dyn neurotoxicity.
ObjectiveTo investigate the expression of pro inflammatory cytokine mRNA including interleukin 1β (IL 1β), interleukin 6 (IL 6) and tumor necrosis factor α (TNF α) after spinal cord injury (SCI), and the effect of methylprednisolone (MP) on the expression of the cytokine and neurological outcome after SCI in rats.
Results: The study showed that the rats receiving rhG-CSFhad significant improvement in neurological outcome and less cerebral infarction(Pre-M 35mm3、and Co-M 39.17mm3 vs controls 76.6mm3 P<0.05), No differencebetween the Pre-M and Co-M.
Good neurological outcome(Glasgow Outcome Scale score of 4 to 5) rates in 6 months after injury were 81.3% in the therapeutic group and 47.6% in the control group respectively(P< 0.05). Whereas,there were more cases complicated with subdural effusion in the therapeutic group than those in the control group(43.8% and 9.5%,respectively,P< 0.05).
The first coma rating performed immediately at the time of arrival on scene had no significant prognostic value for prediction of neurological outcome (P = 0.204) and survival (P = 0.103).
Intravenous thrombolysis seemed to be effective in improving functional and neurological outcome in a clearly defined subgroup of patients meeting the inclusion criteria of the studies.
Auditory brainstem responses(ABR)were recorded in 30 cases suffering from severe head injuries.Abnormal recordings were observed in all the patients,and the abnormalities ranged from prolongation of the interperk latency intervals to complete absence of all waves.Based on the results obtained,ABR grading system was considered to be correlated with the neurological outcome of head injuries.ABR could provide objective information about the function of the brainstem and predict brainstem dysfunctio...
In order to investigate the mechanisms of acute cerebral ischemia, and to look for effective drugs on cerebral resuscitation, we made a model of acute complete global brain ischemia, reperfusion and resuscitation on rats according to Garavilla's method.Our results showed that the event of cerebral ischemia and reperfusion injury could resuh in the increase of total brain calcium content, and anisodamine has the same reducing brain calcium contents as diltiazem's, while improving neurological outcom...
We study effect of mild hypothermia in cerebral ischemia and reperfusion injury using a new modal of ischemia.The acute imcomplete ischemia and reperfusion damage model was obtained by occluding verteoral artery and/or bilateral common carotid arteries and changing head position.The change of milol hypothermia(34-35℃) and contrast groups after cerebral ischemia and reperfusion injury were observed.The results show better neurological outcome,lower water content in brain tissue,lower Glu,Asp rele...