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sulfonylureas
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  磺酰脲
     Studies on the Synthesis and Herbicidal Activity of N-thiophosphoryl Sulfonylureas
     N-硫代磷酰基磺酰脲的合成及除草活性研究
短句来源
     Comparative molecular field analysis(CoMFA) method was applied to the study of the three-dimensional quantitative structure activity relationship(3D-QSAR) on two series of N-(4-substituted pyrimidin-2-yl)-2-methyl carboxylate-benzyl sulfonylureas and N-(4-substituted pyrimidin-2-yl)-2-substituted phenoxy sulfonylureas.
     采用比较分子力场分析 ( Co MFA)方法 ,对两类单取代嘧啶类似物、 6个 N-( 4 -取代嘧啶 -2 -基 ) -2 -甲氧羰基苄基磺酰脲 ( 1 a~ 1 f)和 1 4个 N -( 4 -取代嘧啶 -2 -基 ) -2 -取代苯氧基磺酰脲 ( 2 a~ 2 n)进行三维定量构效关系 ( 3 D-QSAR)研究 .
短句来源
     SYNTHESIS HERBICIDAL ACTIVITIES OF PYRIDIN-2-YL-AMINO SULFONYLUREAS
     2-吡啶氨基磺酰脲的合成及除草活性
短句来源
     Four E. coli AHAS Ⅱ mutants (W464A,W464F,W464L,W464Y) and wild type were characterized for the sensitivities to commercial inhibitors(chlorimuron ethyl,chlorsulfuron,imazethapyr,imazaquin) and some newly synthesized alkylthio-containing sulfonylureas.
     利用大肠杆菌AHASⅡ中464位的色氨酸突变体(W464A、W464F、W464L、W464Y),研究了野生型和突变酶对商品化除草剂(氯嘧磺隆、氯磺隆、咪唑乙烟酸、咪唑喹啉酸)以及烷硫基磺酰脲的敏感性。
短句来源
     NONLINEAR QSAR STUDIES OF HERBICIDAL SULFONYLUREAS AND SULFONAMIDES
     磺酰脲(胺)类除草剂的非线性QSAR研究
短句来源
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  磺酰脲类
     3D-QSAR Analysis of New Sulfonylureas Related to Their Herbicidal Activity
     新磺酰脲类化合物除草活性的3D-QSAR分析
短句来源
     The linear ranges of 10 sulfonylureas were 0.1-10.0 (mg/L), and the correlation coefficients were (0.999 6)-(0.999 7) .
     10种磺酰脲类除草剂的质量浓度在0 1~10 0mg/L范围内其浓度与峰面积的线性关系良好,相关系数为0 9996~0 9997;
短句来源
     Methods Those patients(fasting venous plasma glucose ≤7 mmol/L and 2-hour postprandial venous plasma glucose≥11.1mmol/L)in all the 36 Type-2 diabetes mellitus patients were also given oral Acarbose(50mg,tid) for 3 weeks besides rational dietary, sports, and oral sulfonylureas/metformin.
     方法 对 36例 2型糖尿病患者 ,在合理饮食、运动和口服磺酰脲类 二甲双胍降血糖药治疗基础上 ,空腹静脉血糖≤ 7.0mmo1 L ,餐后 2h静脉血糖≥ 11.1mmol L者加服拜唐苹 50mg ,一日 3次 ,观察 3周。
短句来源
     A method was developed for the determination of sulfonylureas by RP HPLC. The results showed that the standard deviation was 0.28, the coefficient of variation 0.30%, linear correation 0.9999, and the recovery 99.5%~100.51%.
     采用反相高效液相色谱外标法测定了磺酰脲类化合物的含量 ,方法的标准偏差为 0 2 8,变异系数为 0 30 % ,线性相关系数为 0 9999,回收率为 99 5%~ 1 0 0 .51 %。
短句来源
     A study on the safety and injury of sulfonylureas herbicides to cereal crops
     磺酰脲类除草剂对禾谷类作物的安全性及药害研究
短句来源
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  “sulfonylureas”译为未确定词的双语例句
     Results The average fasting blood glucose(FBG) was(9.4±7.5)mmol/L and the average postprandial 2 h blood glucose(PG2h)(or random blood glucose) was(14.2±7.2)mmol/L in 3 months before stopping the sulfonylureas.
     结果停用口服降糖药之前3个月内平均血糖为(9.4±7.5)mmol/L,餐后2 h血糖(或随机血糖)为(14.2±7.2)mmol/L;
短句来源
     ①In comparison of the indexes before and after the exercise therapy between the metformin group and metformin+sulfonylureas group,levels o f blood glucose[(7.10±1.80),(9.41±1.70) mmol/L] were obviously decreased as co mpared with those before therapy[(7.03 ±0.88),(9.01±1.62) mmol/L](P< 0.01);
     ①运动疗法治疗前后二甲双胍组、二甲双胍和磺脲类合用组各参数比较:两组治疗后血糖值较治疗前均明显降低[(7.10±1.80),(9.41±1.70)mmol/L;(7.03±0.88),(9.01±1.62)mmol/L,(P<0.01)]。
短句来源
     The average FBG was(6.5±0.5)mmol/L and PG2h was(8.1±(0.8))mmol/L when continuing the sulfonylureas treatment in one months. It increased significantly to compare the blood glucose before the treatment of insulin to that after the treatment of insulin(P<(0.05)).
     在改用原来口服降糖药后,1个月内平均空腹血糖为(6.5±0.5)mmol/L,餐后2 h血糖为(8.1±0.8)mmol/L,与应用胰岛素前相比,血糖降低的差异均有统计学意义(P<0.05)。
短句来源
     The molecular mechanism of sulfonylureas in timulateing insulin secretion
     磺脲类降糖药对HIT细胞胰岛素分泌刺激作用的分子机制研究
短句来源
     Changes of C Peptide and Insulin Levels in Type 2 Diabetes Mellitus with Secondary Sulfonylureas Failure
     继发磺脲类药物失效的2型糖尿病患者血清C肽及胰岛素水平变化
短句来源
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  sulfonylureas
Synthesis of some sulfonamides, disubstituted sulfonylureas or thioureas and some structurally related variants.
      
Some new benzenesulfonamides, disubstituted sulfonylureas, and sulfonylthioureas substituted basically with 3-(2-thienyl or 3-pyridyl)-indeno[1,2-c]pyrazol(in)e counterpart were synthesized to be evaluated for their in vitro antitumor activity.
      
Epoxidation of Stereoisomeric Sulfonylureas of the Norbornene Series
      
Five types of oral antihyperglycemic drugs are currently approved for the treatment of diabetes: biguanides, sulfonylureas, meglitinides, glitazones, and α-glucosidase inhibitors.
      
Peaks of breakdown products of sulfonylureas were characterized by their UV spectra and the presence or absence of nitrogen and chlorine from their NPD and ECD response.
      
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After a period of treatment with Insulin, the condition of the 5 cases of Insulin dependent diabetics under our observation was improved and stable. Then Insulin was withdrawn or given only with a small dosage, or they were treated with diet alone or sulfonylureas, and their condition was still stable for half to one year. The fact can prove that the β cells can still have part of their function and condition of the patients can improve spontaneously. It's so called." honeymoon period" of the patients....

After a period of treatment with Insulin, the condition of the 5 cases of Insulin dependent diabetics under our observation was improved and stable. Then Insulin was withdrawn or given only with a small dosage, or they were treated with diet alone or sulfonylureas, and their condition was still stable for half to one year. The fact can prove that the β cells can still have part of their function and condition of the patients can improve spontaneously. It's so called." honeymoon period" of the patients. When they get stim ulated, the ketoacidosis will occur in them again. So to follow up these patients is very important.

观察5例初发的胰岛素依赖型糖尿病患者,经用胰岛素治疗一段时间后,病情稳定好,有的仅用小剂量或停用胰岛素,单用饮食疗法或口服磺脲类药,病情也能稳定半年到一年。这说明这些患者胰岛尚有部分功能。其病情可自然暂时缓解。即所谓糖尿病患者的“蜜月期”。这些病人在应激情况下,可再次出现酮症或酮症酸中毒。因此,对这些病人应注意随访观察。

35 out of 41 cases, proved tobe diabetes mellitus noninsulin-dependent, got clinical improvement with glipi-zide. In addition, 12 out of 21 cases, resisting to other sulfonylureas, had also symptom release. The course of therapy took usually 5-12 months. Following the medication, all of these 47 cases had their blood sugar, GHB, GPP and urinary sugar excretion remarkably reduced. Besides 2 hours after meal,concentrations of serum insulin also strikingly increased, while those of HDL-ch, HDL2 and HDL3 did...

35 out of 41 cases, proved tobe diabetes mellitus noninsulin-dependent, got clinical improvement with glipi-zide. In addition, 12 out of 21 cases, resisting to other sulfonylureas, had also symptom release. The course of therapy took usually 5-12 months. Following the medication, all of these 47 cases had their blood sugar, GHB, GPP and urinary sugar excretion remarkably reduced. Besides 2 hours after meal,concentrations of serum insulin also strikingly increased, while those of HDL-ch, HDL2 and HDL3 did the same. Evidently, glipizide is an effective and safe remedy for most cases of noninsulin-dependent diabetes mellitus.

应用格列吡嗪治疗62例NIDDM患者。在新近诊断未经治疗的41例中,有效35例(85%),21例各种磺脲化合物治疗失效者,有效12例(57%)。治疗有效者,治疗后血糖、GHb、GPP、24h尿糖均较治疗前显著减低,餐后2小时血清胰岛素浓度明显升高,HDL-ch、HDL_2或HDL_3也较治疗前显著增高。副反应少见。研究表明,格列吡嗪是治疗NIDDM较有效而安全的药物。

A study of therapeutic effect of sulfonylureas agent,glybenclamide on 11 NIDDMpatients was presented.Alterations of serum concentration of glucose,insulinC-peptide and glucagon were observed after treatment.The results indicated thatprolonged use of glybenclamide might bring forth remarkable improvement of β-cellfunction,e.g.the basal and postprandial serum insulin,C-peptide level all increasedsignificantly,thus,not only the fasting blood glucose declined but also theresponse of the β-cell to glucose was...

A study of therapeutic effect of sulfonylureas agent,glybenclamide on 11 NIDDMpatients was presented.Alterations of serum concentration of glucose,insulinC-peptide and glucagon were observed after treatment.The results indicated thatprolonged use of glybenclamide might bring forth remarkable improvement of β-cellfunction,e.g.the basal and postprandial serum insulin,C-peptide level all increasedsignificantly,thus,not only the fasting blood glucose declined but also theresponse of the β-cell to glucose was enhanced to some extent.The mechanism wasdue to direct inhibition of excretion of islet α-cell by glybenzcyclamide or secon-dary to the improvement of β-cell function remained to be further investigated.

本文观察了11例Ⅱ型糖尿病(NIDDM)患者服用优降糖治疗前后血糖、胰岛素、C 肽和胰高糖素的变化,以探讨对胰岛β、α细胞功能的影响。结果表明:长期服用优降糖可显著改善胰岛β细胞功能,使患者基础及糖刺激后血清胰岛素、C 肽均增加,这样,不仅可降低空腹血糖,还可使β细胞对糖负荷的反应能力明显增强。此外,尚发现胰高糖素有不同程度降低,系优降糖直接抑制α细胞的分泌,抑或继发于β细胞功能的改善,有待进一步研究。

 
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