The results show that the cooling / heating transformation type of 350? 550 ℃ annealed Ti-50.2Ni alloy is A→R→M/M→A(A is parent phase,R is R phase,M is martensite),that of 600? 800 ℃ annealed alloy is A→M/M→A,and that of the alloy annealed at 400 ℃ for long time is A→R→M/M→R→A.
Fermentation curves were investigated by using 7L bioreactor under the optimum conditions. By contrast with the parent strain, the ethanol yield and the Alcohol Dehydrogenase (ADH) activity of HBF-12 decrease 73.6% and 74%, respectively.
These derivatives exhibited in vitro stability in buffers of pH 2.0 and 7.4 for 6 h and were readily hydrolyzed by human plasma esterases to liberate the parent drug.
All the derivatives were significantly less irritating to the gastric mucosa than the parent drug.
Though only two esters showed antiinflammatory activity similar to that of the parent drug at equivalent dose levels, all the esters were equipotent to indomethacin in the mouse acetic acid-induced writhing assay for analgesic action.
The GA approach uses binary coding to represent the location, and both single parent cross-over operator and single parent mutation operator are used to improve its speed and efficiency.
Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture.