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    A Study for the Development of Lung Cancer and Chronic Obstructive Pulmonary Disease Related to the GSTM1 Gene Polymorphisms and Oxidative Stress
    GSTM1基因多态、氧化应激与肺癌、慢性阻塞性肺病的相关性研究
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    Experimental Study on the Immunotherapeutic Effect of Newcastle Disease Virus Vaccine, Interleukin-12 and Interleukin-15 to Human Ovarian Cancer
    纽卡斯尔病毒疫苗、白细胞介素-12、15对人卵巢癌免疫治疗作用的实验研究
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    CD_4~+CD_(25)~+ Regulatory T Cells Increasing in Tumor Patients: Possible Involvement in Disease Progression and Immunotherapy
    恶性肿瘤患者CD_4~+CD_(25)~+调节性T细胞上调及其对细胞治疗的影响
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    Anti-tumor Effects and Signal Transduction Mechanisms of HN from Newcastle Disease Virus and VP3 from Chicken Anaemia Virus
    新城疫病毒HN基因与鸡贫血病毒VP3基因抗肿瘤作用及其信号传导机制
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    The Study on Antitumor Effect of Recombinant Nucleic Vaccine Containing HN Gene of Newcastle Disease Virus
    含新城疫病毒HN基因重组核酸疫苗抗肿瘤作用研究
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Mechanisms and Issues Relating to the Use of D1-like Dopamine Receptor Agonists for Age-related Illnesses: Parkinson's Disease a
      
Furthermore, acetylcholinesterase and butyrylcholinesterase inhibitors such as tacrine, donepezil, rivastigmine, and galantamine are currently used to manage Alzheimer's disease.
      
Since amlodipine besylate is a very potent inhibitor of both cholinesterases, amlodipine besylate may, like donepezil, be useful in Alzheimer's disease treatment.
      
According to the protocol of the National Cancer Institute (NCI) in vitro disease-oriented human cells screening panel assay, 13 compounds showed promising broad spectrum antitumor activity.
      
Epidemiologic model of SIS type has a delay corresponding to the infectious period and disease-related deaths, so that the population size is variable.
      
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This work was undertaken to observe the localization of AFP in adult rat tissues other than liver cancer cells. Using the immunoenzyme technique we observed that AFP existed in the mesenteric and axillary lymph nodes and spleen of rats with liver cancers. AFP(+) areas appeared in the medulla of lymph nodes as well as the red pulp of spleen while the white pulp of spleen and the small lymphocytes in the follicles of lymph nodes were AFP(-). The AFP(+) cells were mostly acidophilic and relatively rich in cytoplasm....

This work was undertaken to observe the localization of AFP in adult rat tissues other than liver cancer cells. Using the immunoenzyme technique we observed that AFP existed in the mesenteric and axillary lymph nodes and spleen of rats with liver cancers. AFP(+) areas appeared in the medulla of lymph nodes as well as the red pulp of spleen while the white pulp of spleen and the small lymphocytes in the follicles of lymph nodes were AFP(-). The AFP(+) cells were mostly acidophilic and relatively rich in cytoplasm. The small lymphocytes at the vicinity of AFP (+) lymph sinuses were also AFP(+). It is hoped that this finding might shed some light on the biological functions of AFP and find applications in the treatment of patients with liver cancer in the early stages of the disease.

本文采用AFP免疫酶标记定位技术,在患肝癌大鼠的淋巴组织内观察到有AFP聚集的现象,淋巴滤泡和脾脏白髓均AFP酶标阴性,而AFP阳性细胞分布在淋巴结的髓质和脾脏红髓。对这一现象的生理意义尚有待进一步研究。

In this article, we described a procedure of isolation of basic proteins from brain glioma and stomach cancer, and presented the results of detecting tumor antigenicity by means of a macrophage electrophoretic mobility (MEM) test with lymphocytes isolated from 623 subjects,which consisted of 95 normal persons, 167 cases of brain tumor 65 cases of stomach cancer, 161 cases of miscellaneous malignant tumor, 25 cases of benign tumor and 120 cases suffering from other diseases.Using"glioma basic protein" (GBP)...

In this article, we described a procedure of isolation of basic proteins from brain glioma and stomach cancer, and presented the results of detecting tumor antigenicity by means of a macrophage electrophoretic mobility (MEM) test with lymphocytes isolated from 623 subjects,which consisted of 95 normal persons, 167 cases of brain tumor 65 cases of stomach cancer, 161 cases of miscellaneous malignant tumor, 25 cases of benign tumor and 120 cases suffering from other diseases.Using"glioma basic protein" (GBP) as an antigen, the incidence of positive reactions in the MEM test was 1.2% (1/85) in normal persons, 92 % (145/158) in brain tumors, 94% (16/17) in stomach cancers,91.1% (92/101) in miscellaneous malignancies, 20% (5/25) in benign tumors and 9.1% (8/88) in the rest cases. When using "stomach cancer basic protein"(SBP)as antigen,the positive incidence was found as follows :0% in 10 normal persons, 89% (8/9) in brain tumors, 95% (36/38) in stomach cancers, 92% (55/60) in miscellaneous malignancies and 6.3% (2/32) in the others.The above results demonstrated that more than 90% lymphocytes from patients with brain tumor, stomach cancer, or miscellaneous malignancies, when allowed to react with GBP or SBP, displayed a slowing effect on MEM while that from normal persons or non-tumor patients more than 90% did not show such an effect. Our results are broadly in accord with the observations of Field et al but contrary to that of Forrester et al.

本文介绍了从人脑胶质瘤和胃癌中提取硷性蛋白的方法,并用总数为623人的淋巴细胞(包括健康人95人、脑瘤167例、胃癌55例、其他部位癌肿161例、良性肿瘤25例以及非肿瘤性疾病120例),对以上两蛋白制剂的肿瘤抗原性进行巨噬细胞电泳试验(MEM)的检查。 用脑胶质瘤硷性蛋白(GBP)作为抗原时,MEM试验的阳性率为:正常人为1.2%(1/85)、脑瘤为92%(145/158)、胃癌为94%(16/17),其他部位癌症为91.1%(92/101)、非肿瘤性疾病为9.1%(8/88)、良性肿瘤为20%(5/25)。当用胃癌硷性蛋白(SBP)作为抗原时,其阳性率为:正常人为0%(0/10)、脑瘤为89(8/9)、胃癌为95%(36/38),其他部位癌症为92%(55/60)、非肿瘤性疾病为6.3%(2/32)。 上述结果表明90%以上脑瘤、胃癌及其他部位癌症病人的淋巴细胞,当接触GBP或SBP时,有使巨噬细胞电泳减缓的作用;而在相同条件下90%以上的正常人及非肿瘤性疾病患者无此作用。以上结果初步看来与Field等人所观察到的结果相一致,而与Forres-ter等人的结果却相反。

The normal values of the serum γ-Gt activity in 110 healthy adultdonors were less than 50 units and those of the 9 newborns ranged from107 to 334 units. The γ-Gt of 48 patients suffermg from carcinoma of the liver increasedby 100%, those with γ-Gt over 200 units made up 79.5%. The α-FPdetermination and radioisotopic scanning simultaneously performed in 37cases were positive in 70.6% and 92.5% respectively. In comparison withγ-Gt determination it appeared that the latter was more sensitive thanthe formers. γ-Gt...

The normal values of the serum γ-Gt activity in 110 healthy adultdonors were less than 50 units and those of the 9 newborns ranged from107 to 334 units. The γ-Gt of 48 patients suffermg from carcinoma of the liver increasedby 100%, those with γ-Gt over 200 units made up 79.5%. The α-FPdetermination and radioisotopic scanning simultaneously performed in 37cases were positive in 70.6% and 92.5% respectively. In comparison withγ-Gt determination it appeared that the latter was more sensitive thanthe formers. γ-Gt of 1 patient of carcinoma of the pancreas was 1, 098 units,3 casesof carcinoma of the billiary tract ranged from 76.9 to 663 units. Therise of γ-Gt of these patients was closely related to the obstruction ofbilliary tract and/or metastasis into the liver. There were 13 cases of hepatitis with jaundice, of which 12 caseshad a rise of γ-Gt (66.5-446 units), but one case of severe hepatitisshowed only 50 units. Among 15 patients of cirrhosis of the liver,11 had a rise of γ-Gt, 4 of them returned to normal level in the latestage. One patient of acute schistosomiasis showed high levels of γ-Gt, butupon treatment it gradually decreased to normal. Among 15 cases of billiary tract diseases 13 showed rise in γ-Gt(101.5-516 units), while 2 were normal. In 2 patients with acute billiarydiseases γ-Gt was originally highly raised, later decreased gradually after the drainage. of common bile ducts. It therefore seemed that the rise ofγ-Gt was related to the obstruction of the billiary tract. To sum up, the determination of γ-Gt in serum was definitely valu-able for the diagnosis of diseases of the liver and billiary tract, espe-cially for primary as well as secondary carcinoma of the liver.

本文作者报告用自行合成的γ—L—谷氨酸—α萘胺为基质用改良法测定110名健康献血员、9名新生儿和167例患者血清γ—谷氨酰转肽酶(γ—GT)的结果。作者认为血清γ—GT的测定对肝胆系统疾病,特别是肝癌有一定的诊断价值。

 
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