Methods Cultured BAEC was exposed to MMA~Ⅲ(0.75?μmol/L,0~15?min)without or with acetylcysteine(NAC)pretreatment(1?mmol/L,2?h),or iAs~Ⅲ(100?(μmol/L,)0~60?min).
Objective To study the intervention effect of a new antioxidant N acetylcysteine (NAC) on the apoptosis of neurocytes of newborn rats with hypoxic ischemic encephalopathy (HIE).
OBJECTIVE:To determine the relations of IL 1 mRNA and protein expressive law in ischemical myocardium and reperfusion injury and observe the effect of N acetylcysteine(NAC) on ischemia tissues.
Methods Cultured BAEC was exposed to MMA~Ⅲ(0.75?μmol/L,0~15?min)without or with acetylcysteine(NAC)pretreatment(1?mmol/L,2?h),or iAs~Ⅲ(100?(μmol/L,)0~60?min).
Objective To study the intervention effect of a new antioxidant N acetylcysteine (NAC) on the apoptosis of neurocytes of newborn rats with hypoxic ischemic encephalopathy (HIE).
OBJECTIVE:To determine the relations of IL 1 mRNA and protein expressive law in ischemical myocardium and reperfusion injury and observe the effect of N acetylcysteine(NAC) on ischemia tissues.
Surrogate replacement of Gpx1 with the reactive oxygen species scavenger N-acetyl cysteine and the Gpx1 mimetic ebselen, reverses the Gpx1-/- increased susceptibility to Aβ toxicity.
N-acetyl cysteine (NAC) provides thiol groups to glutathione and to mitochondrial respiratory chain proteins; thus, it may counteract both ROS generation and effects.
The urinary metabolite of acrylamide, mercapturic acid [N-acetyl cysteine-s-propionamiue (APC)],was measured by the Ellman's method using 5, 5-dithio-bis (2-nitrobenzoic) acid, which yields a yellow product. C_(18) cartidge was used for cleaning up and concentrating urine sample. The concentrated sample was eluted with methanol-water. The APC and/or other thiocther were determined by the difference between absorbances with and without alkaline hydrolysis of the eluted solution. The coefficients ...
Cystaminc(CA,10-100μmol·L-1)induced dose-dependent vasorelaxation in rabbitaortic rings(RA R) precontracted with phenylephrine(Phe,1 μmol·L-1).Presence or absence ofendothelium did not influence the vasorelaxation effectof CA. Incubation of RAR with CA(100 μmol·L-1)for 5 h resulted in remarkable reduction of sensitivityto Phe(1 nmol·L-1 -40 μmol·L-1),a right shift ofthe contraciton curve and an increase of EC50.Thedepressant effect was not seen in incubation withcysteamine,cysteine and N-acetyl-...
Objectives:To study the mechanism of dopaminergic neuronal death in substantia nigra of Parkinson's diseaes(PD). Methods:The effect of dopamine(DA) on apoptotic PC12 cell were examined by fluorescence microscopy using the DNA end-labeling methods. Results:DA may induce apoptosis in PC 12 cell,moderate concentrations of DA(0.45mmol/L4) giving maximal number of apoptotic cell (rate of apoptosis:48.7%±6.3%);and the antioxidant N-acetyl-cysteine(NAC) partially prevent DA-induced apoptosis in PC12 ce...