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morphine dependent     
相关语句
  吗啡依赖
     Influence of Fufang Ruikangxin Granules on [Ca~(2+)]_i of morphine dependent SK-N-SH cell of human neuroblastoma
     复方瑞康欣对吗啡依赖人神经母细胞瘤SK-N-SH细胞[Ca~(2+)]_i的影响
短句来源
     5 mg·kg-1 NO2 Arg suppressed most abstinent symptoms of morphine dependent rats.
     NO2Arg 5 mg·kg-1可显著抑制吗啡依赖大鼠大多数戒断症状。
短句来源
     Results :The frequency of firing was 3.76 Hz±s 1.18 Hz on ventral pallidal n eurons in the morphine dependent rats and 13.22 Hz±s 2.37 Hz after morphi ne injected.
     结果 :吗啡依赖大鼠腹侧苍白球神经元放电频率给药前为 3 76Hz±s 1 18Hz,注射吗啡后为 13 2 2Hz±s 2 37Hz;
短句来源
     Expression of Gi_2 proteins in brain regions of acute or chronic morphine dependent rats
     急、慢性吗啡依赖大鼠脑内Gi_2蛋白的表达
短句来源
     RESULTS The mRNA level of m 1, m 2, m 3, m 4 and m 5 in spinal cord and m 1 and m 2 in brainstem were increased significantly during morphine dependence, and the levels of m 1, m 2, m 3 and m 4 in spinal cord and m 1 in brainstem were decreased 1 h after the injection of naloxone (4 mg·kg -1 , ip) in morphine dependent rats.
     结果 吗啡依赖大鼠脊髓m1~ 5受体和脑干中m1 和m2 表达较正常对照组明显升高 ,注射纳洛酮 1h后脊髓m1~ 4 和脑干m1 表达较依赖组减少。
短句来源
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  吗啡成瘾
     Changes of mu Opioid Receptor in Brain Regions of Morphine Dependent Rats
     吗啡成瘾大鼠部分脑区mu阿片受体的变化
短句来源
     Methods:After 5 days, a model of morphine dependent rats was established by gradually increasing the doses of morphine subcutaneous injection for rats. MT test group rats was injected with MT(50mg/kg) by peritoneoscope, Meanwhile, Then rats were injected with naloxone (0.5mg/kg).
     方法:给大鼠连续递增皮下注射吗啡5d,建立吗啡成瘾模型,给实验组大鼠腹腔注射MT(50mg/kg)后,用纳络酮催瘾(0.5mg/kg);
短句来源
     Objective:Studying the effect and mechanism of MT on erythrocyte deformability in morphine dependent rats.
     目的:观察褪黑激素(MT)对吗啡成瘾大鼠红细胞变形能力(ED)的影响并对其机制进行初步探讨。
短句来源
     Results The Gi2 protein didn't significantly change in others brain regions(P>0.05)in chronic morphine dependent group and chronic abstinent group Gi2 protein were significantly more decrease in nucleus accumbens (P<0.01)and significantly more increase in locus coeruleus(P<0.05) than the chronic control group.
     结果慢性吗啡成瘾组和戒断组与空白对照组相比,NAc区Gi2蛋白水平明显降低(P<0.01),LC区Gi2蛋白水平却明显升高(P<0.01),其它脑区未发现明显变化。
短句来源
     RESULTS Levels of GFAP and TH in the VTA region of morphine dependent rats were higher than those of control group (P<0.05),while groups treated with THPB were similar to those of control group (P>0.05).
     结果 吗啡成瘾大鼠VTA中GFAP和TH免疫阳性神经元含量持续高于正常对照组 (P <0 .0 5 ) ;
短句来源
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  吗啡依赖性
     The Alteration of NKB in CA_1 of Hippocampus in Morphine Dependent Rats
     吗啡依赖性大鼠海马CA_1区NKB细胞的改变
短句来源
     Result: The CD4 positive rates of normal monkeys and morphine dependent monkeys were 36.83%±s 1.44% and 29.02%±s 0.12%,respectively;
     结果·· :正常猴CD4阳性率为36.83 %±s1.44 % ; 吗啡依赖性猴CD4阳性率为9.02 %±s0.12 % ;
短句来源
     The Alteration of Npy in CA1 of Hippocampus in Morphine Dependent Rats
     吗啡依赖性大鼠海马CA1区NPY细胞阳性表达
短句来源
     Alteration of nerve cells in the hippocampus CA4 region of morphine dependent rats
     吗啡依赖性大鼠海马CA4区神经细胞的改变
短句来源
     AIM: To observe the changes of neurokinin B(NKB) and neuropeptide Y (NPY) in the hippocampus CA4 region of morphine dependent rats, and investigate its pathogenesis.
     目的:观察吗啡依赖性大鼠海马CA4区神经激肽B及神经肽Y细胞的变化,探讨其发病机制。
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  吗啡戒
     Objective:To observe the inhibitory effect of 5-HT1A receptor agonist urapidil and 8-OH-DPAT on withdrawal syndromes in morphine dependent rats.
     目的··:观察5-HT1A受体激动剂乌拉地尔(urapidil)和8-OH-DPAT及阿片μ受体激动剂美沙酮(methadone)对吗啡戒断反应的影响。
短句来源
     Compared with morphine dependent group, the PREG and PREGS levels in rat amygdala of morphine withdrawal group increased by 60% and 40% respectively (P<0.05); the glycine level decreased by 14% (P<0.05).
     与吗啡依赖组比较,吗啡戒断组大鼠杏仁核中的孕烯醇酮和孕烯醇酮硫酸酯水平分别升高60 %和40 %(P<0·05) ,甘氨酸水平降低14 %(P<0·05)。
短句来源
     (2)In morphine abstinent group,the β EP contents in Acc and ARH were significantly lower than that in control group (P<0.05 or 0.01),and were not significantly different from that in morphine dependent group;
     (2) 吗啡戒断大鼠Acc 和ARH 的βEP含量与依赖组比较无显著差异,仍显著低于正常对照组( P< 0 .05 或0 .01) ;
短句来源
     The increased level of NO in plasma and brain homogenate in morphine dependent mice could be reduced by large dose (100 mg·kg-1)of diltiazem.
     100mg·kg-1的盐酸地尔硫可抑制吗啡戒断反应引起的血浆和脑匀浆NO含量的升高。
短句来源
     In substance dependence experiment, withdrawal jumps and loss in body weight precipitated by naloxone in morphine dependent mice were inhibited by co administration of riluzole(2.5 to 10 mg·kg -1 , sc) with morphine in a dose dependent manner.
     在小鼠吗啡依赖模型中 ,利鲁唑 2 .5~ 10mg·kg- 1剂量依赖性地抑制吗啡戒断症状的产生。
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      morphine dependent
    Naloxone-induced morphine withdrawal strongly increased the firing rate of oxytocin neurons in morphine dependent rats.
          
    In morphine dependent rats the administration of naloxone (1.0?mg/kg, SC) precipitated a typical abstinence syndrome associated with a concomitant dramatic increase in extracellular DA and NA by about 200 and 100%, respectively, in the PFC.
          
    On the other hand, N/OFQ over a wide dose range induced abstinence signs with similar potency in morphine dependent and non-dependent rats.
          
    Effects of trepelennamine on brain monoamine turnover in morphine dependent and abstinent mice
          
    Changes induced by sodium cromoglycate in brain catecholamine turnover in morphine dependent and abstinent mice
          
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    The experiment studied the changes of behaviors and brain contents ofmonoamine neurotransmitters in 64 rats with morphine addiction that wereaffected by daily drinking and hypodermic injection of morphine. The resultshowed that both drinking and injection of morphine could bring all of therats into morphine dependent condition at the fourth week of the experiment.The morphine dependent rats obviously preferred solution of morphine andwater to water, and the morphine intake was stabilized...

    The experiment studied the changes of behaviors and brain contents ofmonoamine neurotransmitters in 64 rats with morphine addiction that wereaffected by daily drinking and hypodermic injection of morphine. The resultshowed that both drinking and injection of morphine could bring all of therats into morphine dependent condition at the fourth week of the experiment.The morphine dependent rats obviously preferred solution of morphine andwater to water, and the morphine intake was stabilized at approx. 35mg/kg/day. If the drug stopped suddenly, the rats became active, then the foodintake decreased and body wieght reduced. At the same time, the conditionedfood-seeking running accelerated and the mistakes made at the turninggreatly decreased, The transmitter contents of monoamines in the wholebrain of morphine dependent rats also changed, NE and DA slightlydecreased, but 5--HT and 5--HIAA markedly increased. Whether thesechanges are primary or secondary needs further study.

    本文以64只大鼠为材料,采用饮服和腹腔注射吗啡的方法,建立大鼠对吗啡成瘾性的实验模型,观察它们的行为改变和脑内单胺类神经介质含量的变化,结果发现:两种方法都可使大鼠成瘾,成瘾时间在给药后的第四周左右形成;成瘾后的大鼠对药物产生明显的依赖性,每天对吗啡的摄取量大致稳定在35mg/kg左右;如突然停药大鼠表现出不安静状态,活动增加,体重下降;食物运动性条件反应的反应时与戒断前相比明显缩短,错误次数减少;成瘾后的大鼠脑内单胺类神经介质的含量也发生改变,NE和DA有所下降,而5-HT和5-HIAA则显著升高,对于这种变化是原发性的还是继发性的还需进一步研究。

    Lappaconitin e was isolated from the root of Aconitum sinomantanum Nakai which has been used as an anodyne in the northwestern part of China. In this paper, the analgesic effects of lappaconitine were demonstrated by using the mice hot plate method and the rat tail-flick test after intraperitoneal injection of 6 mg/kg. Assayed with the writhing method, the median analgesic dose (ED_(50)) of lappaconitine in mice was found tO be 3.5 mg/kg. In the 2-day test, no jumping was observed in mice treated with lappaconitine...

    Lappaconitin e was isolated from the root of Aconitum sinomantanum Nakai which has been used as an anodyne in the northwestern part of China. In this paper, the analgesic effects of lappaconitine were demonstrated by using the mice hot plate method and the rat tail-flick test after intraperitoneal injection of 6 mg/kg. Assayed with the writhing method, the median analgesic dose (ED_(50)) of lappaconitine in mice was found tO be 3.5 mg/kg. In the 2-day test, no jumping was observed in mice treated with lappaconitine and then challenged with nalorphine. The single dose suppression test was applied to estimate addiction liability of lappaconitine in morphine-treated rats, the change in body weightwas not significantly different from that seen in the control after given lappaconitine at doses of 8 mg/kg. In three morphine-dependent monkeys, lappaconitine at doses of 2 mg/kg, which was the maximal tolerated dose, did not suppress the withdrawal symptoms evoked by sudden morphine withdrawal or by subcutaneous injection of nalorphine (0.5 mg/kg). In three monkeys, lappaconitine were administrated for 53-92 days, and the physical dependence was determined. During this period no physical dependence was observed. No withdrawal symptoms were observed when challenged with nalorphine at doses of 4-8 mg/kg.Anaesthesia test on rabbit cornea showed that the surface anaesthetic potency of lappaconitine was eight times stronger than that of cocaine. Its local anesthetic activities on sciatic nerve block in mice and intracutaneous wheal test in guinea pig were found to be 5 times and about the same, respectively, as active as cocaine.Iappaconitine was shown to have antithermic effect in normothermic and pyrexial mice after intraperitoneal injection of 3 mg/kg. In rats, after intraperitoneal injection lappaconitine 4 mg/kg qd × 7 days, a marked reduction in formaldehydeinduced edema of the hind paw was noted.

    用热板,扭体反应(小鼠)和光热甩尾法测试表明,刺乌头碱均有镇痛作用。小鼠多次注射刺乌头碱后,再给予烯丙吗啡,不出现跳跃反应。对依赖吗啡大鼠或猴停药后的戒断症状无替代取消作用。猴长期注射刺乌头碱后停药不出现戒断综合症,表明刺乌头碱是一种不成瘾的止痛剂。刺乌头碱有较强的局部麻醉作用。对三联疫苗发热小鼠有解热作用。对大鼠甲醛性“关节炎”有消炎作用。

    Dihydroetorphine (DHE) successfully suppressed abstinence syndrome of morphine dependent rats and monkeys precipitated by naloxone or resulted from morphine withdrawal. The substitute therapeutic effect of DHE in morphine-dependent monkeys was the same as methadone. After 9 d of substitute therapies, methadone treated monkeys ap-peared abstinence syndrome after naloxone precipitation, whereas there were no abstinence syndrome in DHE group.

    二氢埃托啡(DHE)能明显缓解吗啡依赖大鼠和猴用纳洛酮(Nal)催促或停用吗啡后出现的戒断症状,DHE对吗啡依赖猴替代治疗的疗效与美沙酮(Met)相当,经9d替代治疗,Met替代组动物Nal催促后仍出现一定的戒断症状,而DHE替代组动物未见戒断症状.

     
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