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   acute exacerbation 在 消化系统疾病 分类中 的翻译结果: 查询用时:0.008秒
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acute exacerbation
相关语句
  急性发作
    Relationship between HBV DNA serum level and acute exacerbation of the disease in chronic hepatitis B patients
    慢性乙型肝炎急性发作与血清HBV DNA含量关系
短句来源
    The Study of Immune Response of Th1/Th2 Cells in Chronic Hepatitis B Patients during Acute Exacerbation
    Th1/Th2细胞在慢性乙型肝炎急性发作的免疫应答研究
短句来源
    To investigate the immune response of Th1/Th2 cells to HBV duplication and subsequent injury of liver cells through detection of Th1/Th2 cells’ ratio, HBV DNA load and liver function indexes in peripheral blood of chronic hepatitis B patients during acute exacerbation.
    目的: 通过检测慢性乙型肝炎急性发作患者外周血Th1及Th2细胞的百分比及Th1/Th2的比值、乙型肝炎病毒(HBV)DNA载量以及肝功能的状况,了解在乙型肝炎病毒复制及肝细胞受损时Th1/Th2细胞免疫应答的变化情况 。
短句来源
    Results: (1) The percentage of Th1 cells(14.52±4.86%) in chronic HBV infectants during acute exacerbation was higher than that these patients after treatment(9.33±2.72%)(P<0.05) and that of normal controls(9.92±4.54%)(P<0.05).
    结果:(1)在慢性乙型肝炎急性发作时Th1细胞百分比(14.52±4.86%)明显高于治疗后(9.33±2.72%)(P<0.05),也比正常对照组高(9.92±4.54%)(P<0.05);
短句来源
    Similarly, the ratio of Th1/Th2 during acute exacerbation was higher than that of normal controls (P<0.05) and that these patients after treatment (P<0.05). There was no statistic difference of Th2 cells percentage between cases and controls(P>0.05).
    急性发作时Th2细胞百分比(1.64±0.59%)与治疗后(1.81±0.75%)相比较无显著性差异(P>0.05),与正常对照组(2.058±0.985%)相比较也无显著性差异;
短句来源
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  “acute exacerbation”译为未确定词的双语例句
    The Relations between the Replication of HBV and the Changes of the Immune Function in Patients with Acute Exacerbation of Chronic Hepatitis B
    慢性乙肝活动期HBV复制与免疫功能变化的探讨
短句来源
    RESEARCHES ON THE CAUSES OF ACUTE EXACERBATION IN CHRONIC HEPATITIS B
    慢性乙型肝炎肝病急性加重的原因探讨
短句来源
    Analysis of T cell receptor BV dominant usage and CDR3 sequences during acute exacerbation in patients with chronic hepatitis B
    慢性乙型肝炎患者外周血T淋巴细胞受体谱系分析及互补决定区3序列测定
短句来源
    Dynamics of Seral HBV Quasispecies in a Patient with Acute Exacerbation of Chronic Hepatitis B
    一例慢性乙型肝炎重型化患者血清HBV准种的动力学研究
短句来源
    Episodes of acute exacerbation (AE) are a common and important feature in the natural history of chronic hepatitis B (CHB).
    再发作是慢性乙型肝炎(CHB)病程中的特点。
短句来源
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  acute exacerbation
Acute exacerbation of COPD is most often caused by pulmonary infections.
      
The term acute exacerbation of chronic obstructive pulmonary disease (COPD) reflects an acute worsening of the stable state with an increase in dyspnea, cough, and count or purulence of sputum.
      
The management of an acute exacerbation is guided mainly clinical severity which has implications on the decision of outpatient management, hospital management or intensive care treatment.
      
If invasive mechanical ventilation is necessary, the potential of dynamic hyperinflation in acute exacerbation has to be considered.
      
Non-invasive ventilation (NIV) has been proposed as an efficient alternative to conventional mechanical ventilation during acute exacerbation of chronic obstructive pulmonary disease (COPD).
      
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In an attempt to investigate the prevalence of infection with cagA+vacA+genes Helicobacter pylori(Hp) in Nanjing area and the relationship between Hp and gastroduodenal diseases,cagA and vacA genes were examined in 104 clinical isolates by means of PCRamplification.Results:(1)The infection rate with cagA+vacA+strains was significantly higher in patients with peptic ulcer than those with chronic gastritis (χ2=106,P<001).(2)The severity of acute inflammation was more apparent in victim with cagA+than with cagA-(χ2=999,P<001),while intestinal metaplasia between the two showed no significance (χ2=164,P>005).(3)Gastric carcinoma occurred frequently in case infected with cagA+vacA+ or cagA-vacA+.The pathology of the 6 with cagA-vacA+ out of 14 speimens were adenocarcinoma.Conclusion:Patieuts with peptic ulcer in Nanjing area were infected prevalently by cagA+vacA+ Hp.The existence and expression of cagA gene were possiblely associated with acute exacerbation of chronic gastritis with no relation to intestinal metaplasia.Whether the exitence and expression of cagA and vacA were possiblely related with pathogenesis of gastric cancer,remain unknown....

In an attempt to investigate the prevalence of infection with cagA+vacA+genes Helicobacter pylori(Hp) in Nanjing area and the relationship between Hp and gastroduodenal diseases,cagA and vacA genes were examined in 104 clinical isolates by means of PCRamplification.Results:(1)The infection rate with cagA+vacA+strains was significantly higher in patients with peptic ulcer than those with chronic gastritis (χ2=106,P<001).(2)The severity of acute inflammation was more apparent in victim with cagA+than with cagA-(χ2=999,P<001),while intestinal metaplasia between the two showed no significance (χ2=164,P>005).(3)Gastric carcinoma occurred frequently in case infected with cagA+vacA+ or cagA-vacA+.The pathology of the 6 with cagA-vacA+ out of 14 speimens were adenocarcinoma.Conclusion:Patieuts with peptic ulcer in Nanjing area were infected prevalently by cagA+vacA+ Hp.The existence and expression of cagA gene were possiblely associated with acute exacerbation of chronic gastritis with no relation to intestinal metaplasia.Whether the exitence and expression of cagA and vacA were possiblely related with pathogenesis of gastric cancer,remain unknown.

为初步探讨南京地区具有cagA、vacA基因幽门螺杆菌(Hp)的感染状况以及cagA、vacA基因的存在与表达和胃、十二指肠疾病的关系,利用PCR技术扩增cagA、va-cA基因,对104份临床分离Hp菌进行检测分析。结果:(1)消化性溃疡患者cagA+、vacA+Hp感染率高于慢性胃炎患者(χ2=10.6,P<0.01);(2)cagA+组胃炎炎症的急性活动程度重于cagA-组(χ2=9.99,P<0.01),而cagA十组肠上皮化生率与cagA-组间无显著差异(χ2=1.64,P>0.05);(3)胃癌患者以cagA+、vacA+菌株及cagA-、vacA+菌株感染多见,胃癌感染后者的6例均为腺癌。结果提示消化性溃疡患者以具有cagA、vacA基因的Hp感染多见;cagA基因的存在与表达可能与炎症的急性活动程度有关,而与肠化生无关;cagA、vacA基因的存在与表达可能均与肿瘤的形成有关,vacA基因是否与腺癌形成有关,有待研究。

Objective In this study, we evaluated the relationship between HBV DNA serum level and acute hepatic exacerbation of the disease in chronic hepatitis B patients.Methods A series of serum samples from 14 patients of acute exacerbation of chronic hepatitis B were analyzed for alteratieus in serum HBV DNA and alanine transaminase (ALT) level before, during, and after episode of an acute exacerbation. The serum HBV DNA concentrations were tested by the quantitative polymerase chain reaction (PCR) using...

Objective In this study, we evaluated the relationship between HBV DNA serum level and acute hepatic exacerbation of the disease in chronic hepatitis B patients.Methods A series of serum samples from 14 patients of acute exacerbation of chronic hepatitis B were analyzed for alteratieus in serum HBV DNA and alanine transaminase (ALT) level before, during, and after episode of an acute exacerbation. The serum HBV DNA concentrations were tested by the quantitative polymerase chain reaction (PCR) using the AmpliSensor assay.Results ①Serum HBV DNA average levle in 11 patients significantly increased from 7.148±2.008(logarithm) at 2~8 weeks before maximum injury of liver to 8.416±2.160 (logarithm), the time that ALT reached its peak, and then, following the declining of ALT level, decreaed to 6.093±1.428 (logarithm). In 9 of 11 cases, the HBV DNA peak value occurred before the ALT peak level or at the same time; ②Two patients who experienced several episodes of acute exacerbation showed that the appearance of acute hepatic injury and the relatively normal liver function occurred alternatively. Whereas, one patient with liver cirrhosis showed persistence of high level viremia in three episodes of acute exacerbation in one year.Conclusion ①This investigation revealed a clear correlation between increasing level of serum HBV DNA and actue exacerbation of patinets with chronic hepatitis B. The findings suggest that host′s immune response which causes acute exacerbation of liver injury in patients with chronic hepatitis B is triggered by the change of viremia and HBV replication; ②Patients with severe chronic active hepatitis and persistent hepatitis B virus repliation are at very high risk of rapid progression to cirrhosis.

目的 研究慢性乙型肝炎急性发作与血清HBVDNA含量的关系。方法 采用荧光标记(AmpliSensor)定量方法,测定一组自发性反复发作的慢性乙型肝炎患者发作前、中和后的血清HBVDNA含量的变化。结果 ①11例患者中有9例(82%)血清HBVDNA含量的高峰值是在最大肝损害之前出现或与丙氨酸转氨酶(ALT)同时达到高峰。而其余2例的高峰值则出现在恢复期;②测定2例数次发作的慢性乙型肝炎患者的系列血清中HBVDNA,也显示了上述特点。并表现出急性肝损害与正常肝功能交替出现的特征。而另1例肝炎肝硬化多次急性发作中,显示持续高水平的病毒血症。结论 血清HBVDNA含量的变化与大部分慢性乙型肝炎的急性发作有着密切的关系,提示乙型肝炎病毒的复制启动和激发了机体的免疫反应,导致了肝细胞的损伤。

Viral hepatitis is one of the most important infectious diseases in China. It is the most common cause of chronic hepatitis and is closely related to hepatocellular carcinoma. In the past 5 years, we have improved the molecular biology techniques for the diagnosis of this group of diseases, including the establishment of direct amplified heat denatured detection of HCV RNA, detection of pre core region mutant of HBV with RT PCR, dot hybridization and the sequence cloning of HCV and HGV. A series of epidemiologic...

Viral hepatitis is one of the most important infectious diseases in China. It is the most common cause of chronic hepatitis and is closely related to hepatocellular carcinoma. In the past 5 years, we have improved the molecular biology techniques for the diagnosis of this group of diseases, including the establishment of direct amplified heat denatured detection of HCV RNA, detection of pre core region mutant of HBV with RT PCR, dot hybridization and the sequence cloning of HCV and HGV. A series of epidemiologic studies including the investigation of epidemiology of HAV in Guangdong, as well as risk factors study on transmission of HCV, HGV and acute exacerbation in chronic hepatitis B patients was carried out. Preliminary basic study on gene therapy and a series of studies on combination of Chinese traditional medicine with western medicine are also in progress. All these achievements have been rapidly applied to clinical practice and played important roles in the advance of diagnosis and treatment in viral hepatitis.

病毒性肝炎是我国最重要的传染病之一,可导致严重慢性肝病,并且与肝细胞癌密切相关。近5年来,我们改进肝炎病毒核酸诊断技术,建立热变性HCVRNA直接扩增技术、RTPCR夹心斑点杂交技术、HBV前C区点突变检测技术,以及克隆HCV、HGV基因序列。此外,对广东甲型肝炎流行病学调查与输血传播HCV、HGV及TTV人群感染的情况、慢性HBV感染者病情反复发作的因素、HCV与肝癌关系、干扰素、Lamivudine的临床治疗观察、基因治疗的应用基础研究,以及中西医结合治疗病毒性肝炎等作了一系列研究。这些技术的改进与研究成果,迅速应用到临床防治工作中,对当前病毒性肝炎诊治工作起到积极的推动作用。

 
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