RESULTS:Both COS CM and NOV CM could significant promote the intake of 3H TdR by HNSCs,of which the 1/minute of NOV CM group was significantly higher than that of COS CM group(P< 0.05),which indicated that NOV CM contained component that could facilitate hNSCs proliferation, and moreover,there was certain dose effect relationship in NOV CM's facilitation of cellular proliferation.
when HEL cells were exposed to CH at 20,40,80 μg/ml respectively for 1 h,[Ca 2+ ]i increased by 3.0%,53.1% and 116.7% respectively compared with control,both of them showed dose effect relationship( r =0.963, P =0.037 for CSS; r =0.976, P =0.024 for CH).
Results CS 2 could enhance the emission intensity of chemiluminescence and advance the peak time. It had dose effect relationship between CS 2 concentrations (0,10,40,80,120,160 mg/ml) and chemiluminescence peak ( r =0.955, R 2=0.913, P =0.003),as well as CS 2 concentrations and peak time( r =-0.927, R 2=0.860, P =0.008).
There were dose effect relationships between DMF and 45 Ca uptake or 45 Ca release in both mitochondria and microsomes( r =0.918,0.895,0.886,0.846 respectively). Conclusion DMF may induce disturbance of calcium homeostasis in rat kidney.
Results The results showed that HT 2 toxin can damage the cell DNA,and the dose effect relationship is founded that with the dose increasing (800 ng/ml to 1600 ng/ml),the degree of DNA damage is increasing,the tail length are (28.4±5.67)μm and (55.8±10.47)μm,respectively.
②The levers of cAMP and cGMP were significantly higher in the liver of arsenic poisoning rat than those in control group(P<0.05),and compared with that of control group ,the content of nitric oxide in the liver homogenate of arsenic poisoning rats was remarkably increased(P<0.05) and the dose effect relationship existed.
Results The SF 2 values of 60 cases were gained successfully in all 65 cases,and arranged from 0 12 to 0 99.The standard deviations of all SF 2 were from 0 053 to 0 190 and coefficient of variations were from 0 096 to 0 442.The dose effect curves revealed that there was an apparent doseresponse relation,and the results could be well fitting by the L Q model.
The disorder parameter plays a determining role in the manifestation of the dose effect; when it decreases (>amp;lt;0.4), both the magnitude of the dose effect and the time required for its annealing strongly increase.
On the high-dose effect in the case of ion implantation of silicon
In order to gain insight into the mechanism of the so-called high-dose effect, several experiments were performed with ion implantation of phosphorus into silicon.
It was shown that neither the distinct dose effect nor its long annealing time can be explained unless the radiation-chemical aspect of irradiation is taken into account.
In the newborn only the high-dose (above 3×10-6 mol/l) effect was seen but in rats older than 5 days a mixed low-dose (below 3×10-6 mole/l)/high-dose effect was apparent.