2. The body weight in liver cirrhosis group was significantly lower than in control group(p<0.01),and ratio of between liver or spleen and body in liver cirrhosis group was significantly higher than in control group(p<0.01).
Although mammal's capacity of tissue regeneration is limited, the mammalian liver possesses a remarkable capacity of regeneration. Under normal circumstances, the human liver initiates regeneration within 3 days and reached its original size by 3-6 months. In most cases, liver function is restored to almost normal level within 3-6 weeks after Partial Hepatectomy(PH).
Research on regulation of liver regeneration could date from 70 years ago, in 1931 Higgins and Anderson described the process of rat liver generation after PH. In 1975, La Brecque et al first reported that in the liver of weanling rat or in the liver after PH, there existed a kind of substance, named HSS, which was found to be a specific stimulator of hepatic DNA synthesis both in vivo and in vitro.
Alcohol abuse is thought to be a risk factor for the cause of liver damage, hyperlipidemia and insulin resistance.
Hepatic glutathione, lipid peroxides, glutathione peroxidase, alcohol dehydrogenase, aldehyde dehydrogenase, glycogen and total protein in liver were also significantly altered.
glutamate cysteine ligase (GCL) and γ-glutamyl transpeptidase (γ-GT) from bovine filarial worms Setaria cervi and their counterparts from mammalian liver to known inhibitors i.e.
Antioxidant activity of melatonin and some new melatonin analogue indole derivatives were investigated, using lipid peroxidation and superoxide anion radical scavenger activity assays, in rat liver tissue homogenate.
The anticancer properties were evaluated using ras transformed liver epithelial cells.