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ischemic brain injury
相关语句
  缺血性脑损伤
    Effects of Angelica sinensis on the neural plasticity following ischemic brain injury by MRI
    MRI研究当归对缺血性脑损伤神经可塑性的影响
    Objective To investigate the peripheral and central dynamic changes of levels of neuropeptide Y 1 36 and calcitonin gene related peptide after hyperbaric oxygen therapy(HBO) of hypoxic ischemic brain injury(HIBI) in neonatal rats.
    目的 观察高压氧 (HBO)治疗新生大鼠缺氧缺血性脑损伤后血浆和大脑皮层的神经肽Y1 - 36 (NPY)和降钙素基因相关肽 (CGRP)含量的动态变化。
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  “ischemic brain injury”译为未确定词的双语例句
    Methods Fifteen male SD rats were used, and randomly divided into three groups: group A ( n =3) underwent no operation, group B ( n =4) underwent sham operation, group C ( n =8) underwent an operation for ischemic brain injury.
    方法  1 5只雄性SD大鼠 ,体重 1 50~ 1 80g,随机分成正常对照组 (n =3)、假手术组 (n =4)和缺血损伤组 (n =8)。
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  ischemic brain injury
Inhibition of neurotransmitter release may, in part, be responsible for the protective effect of pentobarbital in ischemic brain injury.
      
This study demonstrated that bradykinin postconditioning induces protection against ischemic brain injury and promotes neuronal survival.
      
Plasticity of Neurons and Glia Following Neonatal Hypoxic-Ischemic Brain Injury in Rats
      
We propose the monitoring of serine, asparagine, and threonine, together with excitatory amino acids, as an index of the degree of ischemic brain injury.
      
Research on ischemic brain injury has established a central role of mitochondria in neuron death (1-3).
      
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Objective To evaluate the effects of behavioral training on the brain plasticity and its role in functional outcome after brain damage in rats. Methods Thirtytwo 2 month male Wistar rats were divided randomly and equally into 2 groups after the establishment of models of ischemic brain injuries. Motor training was given to the rats of the experimental group (40 min/d and 6 times per week),while those in the control group were reared in their original living state. Synaptic substructure...

Objective To evaluate the effects of behavioral training on the brain plasticity and its role in functional outcome after brain damage in rats. Methods Thirtytwo 2 month male Wistar rats were divided randomly and equally into 2 groups after the establishment of models of ischemic brain injuries. Motor training was given to the rats of the experimental group (40 min/d and 6 times per week),while those in the control group were reared in their original living state. Synaptic substructure in the sensori motor cortex and hippocampus CA 3 area were assessed morphologically and quantitatively. Results The synaptic curvatures and postsynaptic density (PSD) as well as the percentage of perforated synapses were significantly increased in the rats of the experimental group in comparing with those of the control group ( P <0.05).Both the learning and the memory abilities were improved in these rats following the rehabilitative motor training. Conclusion It is postulated that the improved ability of the learning and memory in rats following motor training are likely to be related to the changes of synaptic substructure and increased synaptic plasticity.

目的 研究运动训练后脑缺血大鼠健侧突触结构参数的变化 ,探讨其代偿机理。方法 选用Wistar雄性大鼠制成右侧大脑中动脉缺血模型 ,采用运动训练进行干预 ,观察左侧大脑感觉运动皮层和海马CA3区突触超微结构参数的变化。结果 电镜下观察到康复组大脑感觉运动皮层和海马CA3区突触界面曲率、PSD厚度和穿孔性突触百分率增加 ,与对照组比较有意义 (P <0 .0 5 ) ,并有“U”形突触出现。相应行为学检测康复组在Y 迷宫分辨学习和一次性被动回避反应记忆能力均明显优于对照组 (P <0 .0 5 )。结论 运动训练对脑缺血大鼠学习记忆的改善可能与健侧突触超微结构参数的改变有关

Objective To investigate the imaging and spectroscopy of the cerebrum and cerebellum in ischemic and reperfusion brain injury with nuclear magnetic resonance (NMR) in rats, and explore the changes of the metabolites' levels in the brain. Methods Fifteen male SD rats were used, and randomly divided into three groups: group A ( n =3) underwent no operation, group B ( n =4) underwent sham operation, group C ( n =8) underwent an operation for ischemic brain injury. The NMR images and its related...

Objective To investigate the imaging and spectroscopy of the cerebrum and cerebellum in ischemic and reperfusion brain injury with nuclear magnetic resonance (NMR) in rats, and explore the changes of the metabolites' levels in the brain. Methods Fifteen male SD rats were used, and randomly divided into three groups: group A ( n =3) underwent no operation, group B ( n =4) underwent sham operation, group C ( n =8) underwent an operation for ischemic brain injury. The NMR images and its related spectroscopic characteristics, as well as the changes of the metabolites levels of the brain were then evaluated retrospectively. Results The hyperintense signals in the right cerebrum in group C were increased compared to those of the group B, the T 2 values were increased, while the values of the neural metabolites N acetylaspartate(NAA) decreased, and the ratio of Cr/NAA and Cho/NAA was increased. The T 2 values in the right cerebrum of the group C were larger than that in the left. The values of NAA decreased in the right cerebellum in group C, the ratio of Cr/NAA and Cho/NAA were larger than that in the control groups. Conclusion The results of our study demonstrated that, neuronal viability and metabolism of the brain may seriously influenced by ischemic and reperfusion brain injury.

目的 观察大鼠脑缺血及再灌注损伤对大、小脑成像和波谱的影响。方法  1 5只雄性SD大鼠 ,体重 1 50~ 1 80g,随机分成正常对照组 (n =3)、假手术组 (n =4)和缺血损伤组 (n =8)。制作右大脑中动脉血供阻断的模型。缺血 2h后 ,恢复灌注 ,进行T2 加权成像和局域质子谱检测 ,时间点是缺血后即刻、1~2h及再灌注后 1h、2h、3~ 4h、5~ 6h、7h、8h、9h、1 0h、2 4h和 36h,观察大、小脑成像和N 乙酰天门冬氨酸 (NAA)、肌酸 /磷酸肌酸 (Cr/PCr)、胆碱 (Cho)和乳酸 (Lac)的变化。结果 与假手术组比较 ,缺血损伤组右大脑高信号强度区T2 值增加 ,Cr/NAA和Cho/NAA比值增大 ;右小脑Cr/NAA和Cho/NAA比值增大。结论缺血严重影响大、小脑神经元的存活和物质代谢

Objective To investigate whether transplantation of neural stem cells can ameliorate memory deficits in neonatal hypoxic ischemic brain ischemia injury in rats.Methods The neural stem cells from the embryonic rat cortex were mechanically dissociated N2 medium was adapted to culture the cells. EGF and bFGF were added to expand the cells. Neural stem cells and differentiated cells were identified by immunocytochemistry. Newborn rats were sustained hypoxic ischemic brain injury. One week later, animals...

Objective To investigate whether transplantation of neural stem cells can ameliorate memory deficits in neonatal hypoxic ischemic brain ischemia injury in rats.Methods The neural stem cells from the embryonic rat cortex were mechanically dissociated N2 medium was adapted to culture the cells. EGF and bFGF were added to expand the cells. Neural stem cells and differentiated cells were identified by immunocytochemistry. Newborn rats were sustained hypoxic ischemic brain injury. One week later, animals received neural stem cells transplants(operated group=16) or PBS transplants(control group=8). At 8~10 weeks after transplantation, animals memory ability were observed by Y maze test. After the animals were sacrificed and their brains were examined histologically. Results Neural stem cells from embryonic brains had been successfully cultured.It was found that they formed typical neurospheres in suspension, and the majorities of the cells expressed nestin, which was the marker for neural stem cells. The animals received neural stem cells grafts 7 days following the hypoxic ischemic brain injury performed significantly better as adults on measures of memory ability, the Y maze test, than didcontrolled animals that received sham transplants. Survival of transplants were demonstrated in animals.Conclusions Neural stem cells could be cultured from embryonic brains, they could form the typical neurospheres in suspention in vitro. Transplantation of neural stem cells can ameliorate memory deficits following neonatal IH brain ischemia injury in rats.

目的 研究神经干细胞移植治疗缺氧缺血性脑损伤的可行性。方法 取孕龄为 12~ 16天的母鼠 ,从胎脑中分离神经细胞 ,进行培养、鉴定。用出生 7天的SD大鼠的新生鼠制作缺氧缺血性脑损伤的动物模型 ,7天后接受神经干细胞移植 (移植组 ,n =16只 ) ,同时设置对照组 ,只注射磷酸缓冲液 (对照组 ,n=8只 )。 8~ 10周后 ,作Y迷宫实验检测大鼠的学习能力和记忆能力。取脑组织作免疫组织化学检查。结果 从大鼠胎脑中成功培养出神经干细胞 ,培养条件下呈悬浮状态生长 ,形成神经球 ,绝大多数的细胞表达神经干细胞的标志物神经巢蛋白 (nestin)。接受神经干细胞移植组大鼠的学习能力、记忆能力和对照组相比 ,有明显提高 ,差异具有显著性 (P <0 0 5 )。接受神经干细胞移植大鼠脑组织中可见存活的移植细胞 ,并和宿主脑组织融合在一起。结论 在体外培养条件下 ,可从胎脑组织中培养出神经干细胞 ,移植到缺氧缺血性脑损伤大鼠脑内后 ,细胞与宿主的脑组织融合在一起 ,动物的学习、记忆能力有改善。移植神经干细胞是治疗缺氧缺血性脑损伤的有效方法之一。

 
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