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major elements
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  常量元素
    The serum and hair contents of trace elements Zn, Cu, Fe, Mn, and major elements K,Na, Ca, Mg in stroke-prone patients (SPP) of Tibetan and Han Nationality were determined with Atomic Abeorption Spectrophotometer and Flame Photometer. The data were analysed statistically,and the relationship between eight elements and blood pressure(BP), biochemical targets were studied.
    应用原子吸收和火焰光谱分析法,检测了藏族和汉族脑中风高危人群头发和血清微量元素Zn、Cu、Fe、Mn和常量元素K、Na、Ca、Mg的含量,经统计学处理,探讨了8种元素与血压(BP)、生化指标的关系。
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  major elements
Organic Carbon versus Major Elements Relationship in Rocks of the Bazhenov Formation, Western Siberia
      
These components chiefly determine the spectrum of major elements in the Bazhenov Formation.
      
Distribution of rare earth, trace, and major elements was studied in sandy rocks and early diagenetic formations (glauconites and phosphorites).
      
The major elements of the evolution of carbon isotope signature could be retained since the sedimentation stage.
      
The coefficients of migration in water are evaluated, and the major elements with respect to which surface waters enrich under anthropogenic load are identified.
      
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The serum and hair contents of trace elements Zn, Cu, Fe, Mn, and major elements K,Na, Ca, Mg in stroke-prone patients (SPP) of Tibetan and Han Nationality were determined with Atomic Abeorption Spectrophotometer and Flame Photometer. The data were analysed statistically,and the relationship between eight elements and blood pressure(BP), biochemical targets were studied. It was found that the contents of Na, Mn, and Na/K of the SPP in Tibetan were significantly higher than those in the Han Nationality...

The serum and hair contents of trace elements Zn, Cu, Fe, Mn, and major elements K,Na, Ca, Mg in stroke-prone patients (SPP) of Tibetan and Han Nationality were determined with Atomic Abeorption Spectrophotometer and Flame Photometer. The data were analysed statistically,and the relationship between eight elements and blood pressure(BP), biochemical targets were studied. It was found that the contents of Na, Mn, and Na/K of the SPP in Tibetan were significantly higher than those in the Han Nationality and the control group, while K, Ca/Mg were significantly lower than those in the Han Nationality and the control group. There was a significant positive correlation between Na/K, Fe, Mg, Mn and BP, between Zn, Zn/Cu and HCT, Ch, TG,LDL-ch VLDL-ch, C-peptide, between Fe and HCT, while a significant negative correlation between Ca/Mg and BP. It is suggested that incidence and prevalence of HP and stroke in Tibetan is closely related to the higher contents of Mn, Fe, Na/K, and lower K, Ca, Ca/Mg.

应用原子吸收和火焰光谱分析法,检测了藏族和汉族脑中风高危人群头发和血清微量元素Zn、Cu、Fe、Mn和常量元素K、Na、Ca、Mg的含量,经统计学处理,探讨了8种元素与血压(BP)、生化指标的关系。结果发现藏族的Na、Mn、Na/K明显高于汉族和对照组,而K、Ca/Mg则低于汉族和对照组。Na/K、Fe、Mg、Mn与BP;Zn,Zn/Cu与红细胞压积(HCT)、胆固醇(Ch)、甘油三酯(TG)、低密度脂蛋白(LDL-ch)、极低密度脂蛋白(VLDL-ch)、C肽;Fe与HCT均呈正相关,Ca/Mg与BP呈负相关。提示:藏族的高血压、脑中风发病率高,与Mn、Fe、Na/K较高,与Ca/Mg较低有密切的关系。

OBJECTIVE:Neurogenic inflammation has been confirmed to exist in migraine by pathological research;therefore,it is necessary to deepen the understanding of related content on neurogenic inflammation in migraine,which is meaningful to guide the clinical research.DATA SOURCES:A computer-based online search of PUBMED database was undertaken to identify related articles published in English between January 1995 and December 2005 with the of "migraine,neurogenic inflammation". STUDY SELECTION:The data were examined...

OBJECTIVE:Neurogenic inflammation has been confirmed to exist in migraine by pathological research;therefore,it is necessary to deepen the understanding of related content on neurogenic inflammation in migraine,which is meaningful to guide the clinical research.DATA SOURCES:A computer-based online search of PUBMED database was undertaken to identify related articles published in English between January 1995 and December 2005 with the of "migraine,neurogenic inflammation". STUDY SELECTION:The data were examined firstly,and the quotations of every article were looked over.Inclusive criteria:Articles correlated with the neurogenic inflammation involved in migraine.Exclusive criteria:Repeated search or Meta analytic articles. DATA EXTRACTION:Among the 97 collected articles,29 ones were consistent with the inclusive criteria and 69 ones were out of date or repetitive.In the 29 inclusive articles,17 ones involved in neuropeptide,6 involved in inflammatory related factors,1 related to cortical spreading depression,2 involved in serotonin,2 involved in endothelin and 1 involved in gamma-aminobutyric acid. DATA SYNTHESIS:The trigeminovascular theory is dominant in the pathogenesis of migraine,and neurogenic inflammation is the key element of it.Previous research has confirmed that neurogenic inflammation exist in migraine.Release of neuropeptide,mainly calcitonin gene-related peptide,substance P and neurokinin A and the following neurogenic inflammation are proposed to be the pathophysiogical foundation.Release of inflammatory factors such as β-transforming growth factor,interleukin-8,histamine and so on and increased activated platelet also participate in this course.Animal experiments have shown that cortical spreading depression and endothelin play important roles in rat dural neurogenic inflammation;5-hydroxytryptamine1B/1D receptor agonist and valproic acid block dural neurogenic inflammation by different mechanism.However,a few clinical and animal experiments show that neurogenic inflammation is not the major element in migraine.CONCLUSION:Migraine is the complex result of multiple factor,which is a chain reaction of collective participation of internal nerve-vessel and many biochemical factors after a certain causative factor triggers a migraine attack.Now neurogenin inflammation is considered as the basic pathological process of migraine accompanying participation of many other factors.

目的:病理学研究证实神经源性炎症在偏头痛中确实存在,围绕偏头痛中神经源性炎症的相关内容加深认识对指导临床工作颇有意义。资料来源:应用计算机检索PUBMED1995-01/2005-12期间的相关文章,检索词为“migraine,neurogenicinflammation”,并限定文章语言种类为English。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与偏头痛的神经源性炎症研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到97篇相关文献,29篇文献符合纳入标准,排除的68篇文献为内容陈旧或重复。符合纳入标准的29篇文献中,17篇涉及神经肽,6篇涉及炎症相关因子,1篇涉及皮层扩布性抑制,2篇涉及5-羟色胺,2篇涉及内皮素,1篇涉及γ-氨基丁酸。资料综合:三叉神经血管学说在偏头痛发病机制中占主导地位,神经源性炎症是其中的关键环节,而以往的病理学研究也证实了神经源性炎症在偏头痛中确实存在。降钙素基因相关肽、P物质和神经激肽A等神经肽的释放及其所导致的神经源性炎症被认为是偏头痛的病理生理基础;β-转化生长因子、白介素8、组胺等炎症因子的释放及血小板激活的增加也参与其中...

目的:病理学研究证实神经源性炎症在偏头痛中确实存在,围绕偏头痛中神经源性炎症的相关内容加深认识对指导临床工作颇有意义。资料来源:应用计算机检索PUBMED1995-01/2005-12期间的相关文章,检索词为“migraine,neurogenicinflammation”,并限定文章语言种类为English。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与偏头痛的神经源性炎症研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到97篇相关文献,29篇文献符合纳入标准,排除的68篇文献为内容陈旧或重复。符合纳入标准的29篇文献中,17篇涉及神经肽,6篇涉及炎症相关因子,1篇涉及皮层扩布性抑制,2篇涉及5-羟色胺,2篇涉及内皮素,1篇涉及γ-氨基丁酸。资料综合:三叉神经血管学说在偏头痛发病机制中占主导地位,神经源性炎症是其中的关键环节,而以往的病理学研究也证实了神经源性炎症在偏头痛中确实存在。降钙素基因相关肽、P物质和神经激肽A等神经肽的释放及其所导致的神经源性炎症被认为是偏头痛的病理生理基础;β-转化生长因子、白介素8、组胺等炎症因子的释放及血小板激活的增加也参与其中。动物实验结果表明,皮层扩布性抑制和内皮素对大鼠硬脑膜神经源性炎症起重要作用;5-羟色胺1B/1D受体激动剂、丙戊酸是通过各自不同的机制阻滞硬脑膜内的神经源性炎症。但少数临床和动物实验的研究结果却表明,神经源性炎症并不是偏头痛的主要因素。结论:偏头痛的发作是多因素作用的结果,是当某一诱发因素启动时,体内神经-血管及诸多生化因子共同参与的连锁反应。目前认为神经源性炎症是偏头痛的基本病理过程,在这一过程中也有诸多因素的参与。

 
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