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dna repair genes     
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  dna修复基因
     In this article,the polymorphisms of phase Ⅰ,Ⅱ metabolism and DNA repair genes are reviewed. The article empharizes on the relationship between bladder cancer and some susceptible genes,such as CYP1A1,CYP1A2,CYP2C19,CYP2D6,CYP2E1,NAT1,NAT2,GSTM1,XRCC1 and so on.
     本文综述了Ⅰ、Ⅱ相代谢酶基因和DNA修复基因多态性与膀胱癌易感性的关系,重点讨论了CYP1A1、CYP1A2、CYP2C19、CYP2D6、CYP2E1、NAT1、NAT2、GSTM1和XRCC1基因多态性与膀胱癌的相关性。
短句来源
     Polymorphism of DNA Repair Genes: ERCC2/XPD A35 931C in Han Chinese from Liaoning Province
     中国辽宁汉族群体DNA修复基因:ERCC2/XPDA35 931C遗传多态性
短句来源
     Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning
     DNA修复基因XRCC1和XRCC3多态性与慢性苯中毒易感性的关系
短句来源
     Correlation of Genetic Polymorphisms in DNA Repair Genes ADPRT and XRCC1 to Risk of Gastric Cancer
     DNA修复基因ADPRT和XRCC1遗传变异与胃癌发病风险
短句来源
     The study on polymorphism of DNA repair genes,smoking and DNA damagein a sample of healthy subjects
     健康人群吸烟、DNA损伤与DNA修复基因多态研究
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  dna损伤修复基因
     Conclusions As DNA repair genes, MGMT,XRCC1 and hMSH2 may play importance roles in skin arsenism.
     结论MGMT、XRCC1、hMSH2作为DNA损伤修复基因,在砷性皮肤病变过程中起重要作用;
短句来源
     Studies on polymorphisms of metabolic enzymes(CYP,NAT,GST,EH,ALDH) and DNA repair genes(XRCC1,hOGG1,XPD),and susceptibility to hepatocellualr carcinoma are reviewed in this paper.
     本文对毒物代谢酶(CYP、NAT、GST、EH、ALDH)和DNA损伤修复基因(XRCC1h、OGG1、XPD)多态与肝癌遗传易感性的研究作一综述。
短句来源
     Expression analyses of multiple DNA repair genes in glioma by TaqMan low-density array
     TaqMan低密度表达芯片检测DNA损伤修复基因在原发胶质瘤中的表达研究
短句来源
     Background and objective Xeroderma pigmentosum group D (XPD) is one of the important DNA repair genes. XPD polymorphism at Lys751Gln site has been shown to alter XPD protein function, modulate DNA repair capacity and therefore affect cancer risk.
     背景与目的着色性干皮病互补基因D(xerodermapigmentosumgroupD,XPD)是一种重要的DNA损伤修复基因,其常见的多态是位于751密码子的A→C多态。
短句来源
     The CpG island methylation in promoter region of tumor suppressor genes (TSG) , cell cycle controlling genes, DNA repair genes and tumor invasion related genes is closely correlated with the development of glioma.
     大量肿瘤抑制基因、细胞周期调控基因、DNA损伤修复基因、肿瘤侵袭相关基因等启动子区域CpG岛甲基化,与胶质瘤的发生发展密切相关。
短句来源
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  修复基因
     In this article,the polymorphisms of phase Ⅰ,Ⅱ metabolism and DNA repair genes are reviewed. The article empharizes on the relationship between bladder cancer and some susceptible genes,such as CYP1A1,CYP1A2,CYP2C19,CYP2D6,CYP2E1,NAT1,NAT2,GSTM1,XRCC1 and so on.
     本文综述了Ⅰ、Ⅱ相代谢酶基因和DNA修复基因多态性与膀胱癌易感性的关系,重点讨论了CYP1A1、CYP1A2、CYP2C19、CYP2D6、CYP2E1、NAT1、NAT2、GSTM1和XRCC1基因多态性与膀胱癌的相关性。
短句来源
     Polymorphism of DNA Repair Genes: ERCC2/XPD A35 931C in Han Chinese from Liaoning Province
     中国辽宁汉族群体DNA修复基因:ERCC2/XPDA35 931C遗传多态性
短句来源
     Association between genetic polymorphisms of DNA repair genes XRCC1, XRCC3 and susceptibility to chronic benzene poisoning
     DNA修复基因XRCC1和XRCC3多态性与慢性苯中毒易感性的关系
短句来源
     Correlation of Genetic Polymorphisms in DNA Repair Genes ADPRT and XRCC1 to Risk of Gastric Cancer
     DNA修复基因ADPRT和XRCC1遗传变异与胃癌发病风险
短句来源
     Conclusions As DNA repair genes, MGMT,XRCC1 and hMSH2 may play importance roles in skin arsenism.
     结论MGMT、XRCC1、hMSH2作为DNA损伤修复基因,在砷性皮肤病变过程中起重要作用;
短句来源
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  修复酶基因
     A Review of Research on the Relationship between Polymorphisms of DNA Repair Genes and Lung Cancer Susceptibility
     DNA修复酶基因多态性与肺癌易感性研究进展
短句来源
     Relationship between polymorphisms of DNA repair genes and esophageal cancer susceptibility
     修复酶基因多态性与食管癌易感性关系
短句来源
     Relationship between polymorphisms of DNA repair genes and esophageal cancer risk
     修复酶基因多态性与食管癌发生危险性的关系
     The review gave a brief for studies in genetic susceptibility to lung cancer and related polymorphism of DNA repair genes.
     本文就肺癌易感性与其相关的DNA修复酶基因多态性的国内外研究进展作一简要介绍。
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  dna repair genes
Polymorphic microsatellites in three DNA repair genes, XRCC1, XRCC3 and XRCC5, were analyzed for possible linkage to cancer status or clinical radiosensitivity.
      
We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors.
      
Genomic copy number changes of DNA repair genes ERCC1 and ERCC2 in human gliomas
      
Also, forced expression of NM23-H1 in NM23-deficient and metastatic cell lines results in coordinate downregulation of multiple DNA repair genes, possibly reflecting genomic instability associated with the NM23-deficient state.
      
The molecular cloning of human DNA repair genes by transfection into drug sensitive rodent cells has been attempted.
      
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The paper reviews the recent progress in application of molecularbiology techniques in the study of radiation, biology. The three sections are asfollows: (1) the study of DNA damage on molecular level, (2) the molecular mech-anism of radiation cell genetics, including chromosome abberation and cell mutation,(3) the study on DNA repair gene with DNA mediated gene transfer techniques.

本文综述了近年来运用分子生物学的理论和技术研究放射生物学的主要进展:在DNA损伤研究方面用序列分析及限制性酶切技术对DNA链断裂及碱基损伤在分子内的定位获得了新的信息,基因探针有可能成为研究哺乳动物细胞DNA结构损伤的敏感的新方法;染色体畸变及细胞突变的分子机理已有所阐明;哺乳动物DNA修复基因的研究正在兴起阶段,已克隆出人的DNA修复基因;在哺乳动物细胞上进行外源基因转移的成就为辐射损伤的防治开辟了新的前景。

In the recent years the study of DNA damage and repair in themammalian cells has gone deeply at gene level and got the following advances: (1)For a long time DNA has been considered to be an uniform unit in case of damageand repair. Now this concept should be replaced by the non-random distribution ofdamage and heterogenous repair in the genome. These would allow us to study cellu-lar mutagensis, carcinogenesis. aging and dying processes in great detail, and would bebeneficial...

In the recent years the study of DNA damage and repair in themammalian cells has gone deeply at gene level and got the following advances: (1)For a long time DNA has been considered to be an uniform unit in case of damageand repair. Now this concept should be replaced by the non-random distribution ofdamage and heterogenous repair in the genome. These would allow us to study cellu-lar mutagensis, carcinogenesis. aging and dying processes in great detail, and would bebeneficial to the elucidation of mechanisms of radiation sickness and chemical toxico-logy. (2) The advent of new techniques in molecular biology has made it possible toisolate and clone the human DNA repair genes. Up to now more than ten humanDNA repair genes have been cloned and these works would have an important impacton the theoretical and practical study in this field. Because DNA repair system is verycomplicate. voluminous work should be done in the future. (3) The technique of genetransfer has been efficiently used in the study of DNA repair in mammalian cells andhas made great contribution in the cellular engineering. It could modify the geneticbehavior of the gene-accepting cells. and enhance the DNA repair ability to physicaland chemical damages. Human gene therapy for DNA deficient diseases is now on theday.

哺乳动物细胞DNA损伤修复的研究近年来已深入到基因水平并取得以下进展:(1)长期以来人们将DNA看成是一个损伤和修复的均一单位,这种观念现已被基因组内损伤的非随机分布和修复的不均一性所代替。这对于深入细致研究细胞突变、癌变、老化和死亡等过程具有重要理论意义,对于阐明放射病发病机理和化学药物毒理也有指导作用;(2)随着分子生物学技术发展,哺乳动物和人的DNA修复基因的分离和克隆已成为可能。现已克隆出十几个修复基因,推进了理论和实际应用研究,但由于DNA修复系统十分复杂,还有大量工作要做;(3)基因转移技术已被有效地用于哺乳动物细胞DNA修复的深入研究,在细胞工程上作出了重要贡献,改变了受体细胞的遗传特性,提高了细胞对物理化学损伤的修复能力。对DNA修复缺陷症的基因治疗已经提到议事日程。

Ataxia-telangiectasia (AT) is a rare human autosomal recessivedisease characterized by hypersensitivity to ionizing radiation, neurological disorders, immunodeficiency, chromosomal instability and a high incidence of cancers.It was thought that the cause for hypersensitivity was due to the putative DNA repair gene deficiency. Recently. studies on genetic linkage analysis of families with. AT carriers had suggested that a genetic defect in a region of chromosome 11 q 22-23 was responsible for the AT disorder....

Ataxia-telangiectasia (AT) is a rare human autosomal recessivedisease characterized by hypersensitivity to ionizing radiation, neurological disorders, immunodeficiency, chromosomal instability and a high incidence of cancers.It was thought that the cause for hypersensitivity was due to the putative DNA repair gene deficiency. Recently. studies on genetic linkage analysis of families with. AT carriers had suggested that a genetic defect in a region of chromosome 11 q 22-23 was responsible for the AT disorder. The SV 40--transformed ATSBIVA cells(group D), from skin fibroblast of AT patients, was hypersensitive to Gamma--ray. The karyotype analysis had previously shown there were abnormalities of chromosome 11, 13, 14, 15 and 22 in ATSBIVA cells. In order to study the molecular mechanism of hyper--radiosensitivity in AT cells and to map DNA repair gene, a new strategy to introduce intact chromosomes into AT 5 BIVA cells by the technique of microcell--mediated chromosome transfer(MMCT) was used.Two human x mouse hybrid cells(FD 3 and FD 8) and a mouse cell line(LM/ TK-) were used. FD 3 cells contain human chromosome 11 while FD & does not.The microcells of these three cell lines were prepared and fused with AT 5 DIVA cells. After twice selection by 3 Gy V- irradiation, the clones which were resistant to y--irradiation were isolated. AT/FD 3--1 cells, the AT 5 BIVA x FD 3 mircocell fused hybrid, showed enhancement of radioresistance. Karyotype analysis had also shown AT/FD 3-1 cells contained an additional copy of chromosome 11. The results indicated the genes responsible for cell resistance to ionizing irradiation existed in human chromosome 11.

AT5BIVA细胞是一株经SV40病毒转化的AT病人皮肤成纤维细胞,对γ射线高度敏感。实验用FD3(含人第11号染色体的人鼠杂种细胞)、FD8(不含人第11号染色体的人鼠杂种细胞)、LM/TK鼠细胞)为洪体,通过微细胞介导染色体转移(MMCT)向HT5BIVA细胞导入人或鼠的完整染色体,经两次3Gyγ射线照射筛选后,获得AT5BIVA与FD3微细胞融合的杂合细胞AT/FD3-1,对γ射线抗性有显著提高。而FD8或LM/TK的微细胞与AT5BIVA细胞的杂合细胞,对γ射线抗性未增加。枝型分析表明AT/FD3—1细胞中包含了来源于FD3细胞的人第11,14号染色体和数条鼠染色体。通过对照实验,排除了人14号和鼠染色体提高AT/FD3-1细胞对γ射线抗性的可能性.确认人第11号染色体与AT细胞对电离辐射敏感性相关,提示人第11号染色体上可能存在决定细胞对γ射线抗性的相关基因。

 
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