Experiment methods Thirty-two New zealand rabbits were randomly divided into four groups: control group(groupⅠ,n=8), normal temperature group(groupⅡ,n=8), mild hypothermia group(groupⅢ,n=8), moderate hypothermia group(groupⅣ,n=8).
Methods Thirty-eight healthy Newzealand rabbits were randomly divided into five groups: normal control group(group Ⅰ ,n=6), normal temperature group(group Ⅱ ,n=8), mild hypothermia group(groupⅢ,n=8), moderate hypothermia group(groupⅣ,n=8), regional hypothermia group(groupⅤ,n=8).
An animal model to study deep hypothermia in rabbits was established, and some functions of rabbits' eythrocytes were observed successively after being rewarmed The various changes of the erythrocytic indices were found with time sequence as following increasing of erythrocytic osmotic fragility, inhibition of G-6-PD activity from 616.7 ± 73.2 down to 514.2 ± 48.8 relative activity unit (P<0.05);
Aim:To observe the effect of three different rewarming methods on the contents of cre- atine kinase(CK)and lipid-peroxide(LPO)in serum during rewarming in hypothermia rabbits,and to verify the usefulness of electromagnetic regional hyperthermia method during rewarming.
Cooling strategies and transport theories for brain hypothermia resuscitation
Under such adverse situations, the potential for cerebral protection through hypothermia has been intensively investigated in clinics by lowering brain temperature to restrain the cerebral oxygen demands.
It is now clear that hypothermia would serve as the principal way for neurologic protection in a wide variety of emergency medicines, especially in cerebral damage, anoxia, circulatory arrest, respiratory occlusion, etc.
Compared with the expanded trials in clinics, only very limited efforts were made to probe the engineering issues involved, which turns out to be a major obstacle for the successful operation of brain hypothermia resuscitation.
Aiming to provide a complete overview of the brain hypothermia resuscitation, this article comprehensively summarizes the recent progresses made in theoretical, practical and experimental techniques in the area.