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hypothermia     
相关语句
  低温
    Establishment of Severe Traumatic Brain Injury Model Induced by Fluid Percussion in Rabbits and the Effects of Posttraumatic Mild Hypothermia Therapy
    兔液压冲击重型脑创伤模型的建立及亚低温治疗的影响
短句来源
    A Study of Cell Membrane Damage after Severe Traumatic Brain Injury and the Effect of Hypothermia on It
    重型脑创伤后细胞膜损伤及亚低温对其影响的研究
短句来源
    Effects of the mild hypothermia of the whole brain of the amounts of 6-keto-PGF_(1a) and TXB_2 in brain tissues after canine cardiac arrest and resuscitation.
    心脏停跳复苏后全脑浅低温对脑组织前列环素和血栓素A_2含量的影响
短句来源
    The dogs in the hypothermia group were treated by intravenous infusion of cold physiological saline at(1.2±0.34)℃(5% body weight) during the operation and their body temperatures were decreased to 33~35℃ with ice blanket after the operation for 48 hours.
    亚低温组在术中采用静脉内输入1.2℃±0.34℃冷冻生理盐水,输液量为体重的5%,术后采用降温毯降温,体温控制在33~35℃,持续48h。
短句来源
    Results The dogs' vital signs were stable and the mortality was 40%(12/30) in mild hypothermia group.
    结果亚低温组动物生命体征平稳,死亡率40%(12/30);
短句来源
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  亚低温
    Establishment of Severe Traumatic Brain Injury Model Induced by Fluid Percussion in Rabbits and the Effects of Posttraumatic Mild Hypothermia Therapy
    兔液压冲击重型脑创伤模型的建立及亚低温治疗的影响
短句来源
    A Study of Cell Membrane Damage after Severe Traumatic Brain Injury and the Effect of Hypothermia on It
    重型脑创伤后细胞膜损伤及亚低温对其影响的研究
短句来源
    The dogs in the hypothermia group were treated by intravenous infusion of cold physiological saline at(1.2±0.34)℃(5% body weight) during the operation and their body temperatures were decreased to 33~35℃ with ice blanket after the operation for 48 hours.
    亚低温组在术中采用静脉内输入1.2℃±0.34℃冷冻生理盐水,输液量为体重的5%,术后采用降温毯降温,体温控制在33~35℃,持续48h。
短句来源
    Results The dogs' vital signs were stable and the mortality was 40%(12/30) in mild hypothermia group.
    结果亚低温组动物生命体征平稳,死亡率40%(12/30);
短句来源
    Methods All 157 patients with acute severe brain injury were divided into mild hypothermia group (54 pts), Xingnaojing with mild hypothermia group (48 pts) and routine treatment group (55 pts) randomly.
    方法157例急性重型颅脑创伤病人,随机分为亚低温组(54例)、亚低温加醒脑静组(48例)和常规治疗组(55例)。
短句来源
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  低体温
    Effect of Hypothermia on the Early Stage of Intestine Mucosal Barrier Function after Traumatic and Hemorrhagic Shock
    低体温对创伤失血性休克后早期小肠粘膜屏障功能的影响
短句来源
    Experiment methods Thirty-two New zealand rabbits were randomly divided into four groups: control group(groupⅠ,n=8), normal temperature group(groupⅡ,n=8), mild hypothermia group(groupⅢ,n=8), moderate hypothermia group(groupⅣ,n=8).
    方法:新西兰大白兔32只,随机分为正常对照组(Ⅰ组,n=8)、常温组(Ⅱ组,n=8)、浅低体温组(Ⅲ组,n=8)、中低体温组(Ⅳ组,n=8)。
短句来源
    88(34.11%) patients were diagnosed as SIRS. When adjusted for age and ISS,hypothermia and leukocytosis were the most significant predictors of infection(P < 0.01).
    统计发现,共有88例(34.11%)诊断为SIRS,当作了年龄和ISS变量调整后,低体温和白细胞增多最能预示感染(P<0.01)。
短句来源
    Objective To observe the effect of varying hypothermia on inflammatory reaction, ischemical reperfusion injury and gut endotoxin transition by traumatic and hemorrhagic shock animal model. To investigate effect of hypothermia on intestinal mucous barrier function, and provide instruction for clinical therapy of trauma patients.
    目的:本实验通过创伤失血性休克动物模型,观察不同程度的低体温状态下,小肠组织炎症反应和缺血再灌注损害以及肠道内毒素移位的变化等,探讨低体温对肠粘膜屏障功能的影响,为创伤患者的临床救治提供理论依据。
短句来源
    Of the four SIRS variables,hypothermia and leukocytosis were the most sensitive predictors of infection.
    4个SIRS可变参数 (体温、心率、白细胞计数、呼吸频率 )中 ,低体温、白细胞增加比年龄和ISS等指标对预测感染较为敏感。
短句来源
  体温过低
    The experimental study of hypothermia from immersing in sea water
    3种方法对海水浸泡致重度体温过低症犬的复温效果研究
短句来源
    Methods The clinical data of 289 patients with SIRS were analyzed. The patients met at least two of the criteria for SIRS such as fever,hypothermia,tachycardia,tachypnea of abnormal white blood cell count,while MODS accorded with the criteria for functional disorders of all organs and in 24 hours after the body was injured,more than two organs showed functional disorder in succession.
    方法 分析 2 89例SIRS患者的临床资料 ,病人至少符合 2个SIRS标准 ,包括发热、体温过低、心动过速、呼吸急促或白细胞计数异常 ; MODS则符合各器官功能标准 ,而且在机体遭受打击 2 4小时后序贯出现两个或两个以上器官功能不全。
短句来源
    Objective: Accidental hypothermia from immersing in cold sea water has a high mortality. Rewarming core temperature is the key of treatment.
    目的 冷海水浸泡所致的体温过低症死亡率很高 ,有效地复温是治疗的关键。
短句来源
    Methods The clinical date of 152 patients accepted by our hospital from January 1995 to December 1999 were analyzed. The patients met at least two of the criteria for SIRS such as fever,hypothermia,tachycardia or abnormal white blood cell count.
    方法 分析 15 2例恶性阻塞性黄疸患者SIRS的临床资料 ,患者至少符合 2项SIRS诊断标准 ,包括发热 ,体温过低 ,心动过速 ,呼吸急促或白细胞计数异常。
短句来源
    All patients accorded with at least two of the revised SIRS criteria, including fever, hypothermia, tachycardia, tachypnea, and abnormal white blood cell count or lower PaCO 2. In addition, those with MODS also accorded with the diagnostic criteria for MODS.
    患者至少符合修订后SIRS标准 2项以上 (包括发热、体温过低、心动过速、呼吸急促或PaCO2 下降、白细胞计数异常 ) ; MODS患者则符合各器官功能障碍的诊断标准。
短句来源

 

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  hypothermia
Cooling strategies and transport theories for brain hypothermia resuscitation
      
Under such adverse situations, the potential for cerebral protection through hypothermia has been intensively investigated in clinics by lowering brain temperature to restrain the cerebral oxygen demands.
      
It is now clear that hypothermia would serve as the principal way for neurologic protection in a wide variety of emergency medicines, especially in cerebral damage, anoxia, circulatory arrest, respiratory occlusion, etc.
      
Compared with the expanded trials in clinics, only very limited efforts were made to probe the engineering issues involved, which turns out to be a major obstacle for the successful operation of brain hypothermia resuscitation.
      
Aiming to provide a complete overview of the brain hypothermia resuscitation, this article comprehensively summarizes the recent progresses made in theoretical, practical and experimental techniques in the area.
      
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To investigate the effects of mild hypothermia of whole brain (MHWB, 34℃) on the levels of prostacyclin and thromboxaneA2 in brain tissues after cardiac arrest and resuscitation,seventeen dogs were randomly divided into three groups:group A undergoing all procedures but cardiac arrest and treatment (n=5);group B given the routine cerebral resuscitation treatment (RCRT)after cardiac arrest lasting ten minutes and resuscitation (CAR) (n= 6);and group C receiving RCRT combined with MHWB after CAR (n=6), The...

To investigate the effects of mild hypothermia of whole brain (MHWB, 34℃) on the levels of prostacyclin and thromboxaneA2 in brain tissues after cardiac arrest and resuscitation,seventeen dogs were randomly divided into three groups:group A undergoing all procedures but cardiac arrest and treatment (n=5);group B given the routine cerebral resuscitation treatment (RCRT)after cardiac arrest lasting ten minutes and resuscitation (CAR) (n= 6);and group C receiving RCRT combined with MHWB after CAR (n=6), The samples of brain tissues were taken in group C following the MHWB duration of four hours,in group B immediately after the RCRT period of four hours and in group A after completing the required procedures,in which the contents of TXB2 and 6-keto-PGF1a were measured by radioimmunoassay. The results showed that as compared with those in group A, the 6-keto-PGF1a levels remained substantially unchanged in group B and C (P>0. 05 ), and the levels of TXB2 and TXB2/6-keto-PGF1a ratio increased significantly in group B (P<0. 01). but both maintained basically stable in group C (P>0. 05). In comparison with those in group B, the 6-keto-PGF1a level was kept essentially stable (P>0. 05 ), but the levels of TXB2 and TXB2/6-keto-PGF1a ratio decreased dramatically (P<0. 05). It is concluded that MHWB can depress the arachidonic acid metabolism through cyclooxygenase and keep a certain banlance between the activities of TXA2 and PGI2 during cerebral resuscitation.

观察犬心脏停跳复跳后全脑浅低温(34℃)对脑组织前列环素和血栓素 A2 含量的影响。结 果表明,脑缺血再灌注后常规治疗4小时,6-keto-PGF1a水平无明显变化,TXB2含量明显上升(P< 0. 01),TXB2/6-kteo-PGF1a(T/K)比值明显升高(P<0.01);浅低温治疗组与缺血再灌常规治疗组比较 6-keto-PGF1a水平仍无明显变化,而TXB2含量下降(P<0.05),T/K比值降低(P<0.05)。提示全脑浅 低温能抑制脑缺血再灌后花生四烯酸环氧酶途径代谢,调整脑内前列环素与血栓素A2的平衡,有利于 脑复苏。

Our previous experimental studies have demonstrated that selective head cooling had multifaceted beneficial effects on brain resuscitation.It is was worthwhile to explore further the histomor phological evidences in relation to it.32 Newzealand rabbits were allocated into group Ⅰ(normal control),group Ⅱ(simply global ischemia), group Ⅲ(postischemic normothermic reperfusion), and group Ⅳ(reperfusion with selective head cooling, to lower the brain temperature to 28±0 5℃ by means of “ice cap”),latter two groups...

Our previous experimental studies have demonstrated that selective head cooling had multifaceted beneficial effects on brain resuscitation.It is was worthwhile to explore further the histomor phological evidences in relation to it.32 Newzealand rabbits were allocated into group Ⅰ(normal control),group Ⅱ(simply global ischemia), group Ⅲ(postischemic normothermic reperfusion), and group Ⅳ(reperfusion with selective head cooling, to lower the brain temperature to 28±0 5℃ by means of “ice cap”),latter two groups were further divided, according to the duration of reperfusion for 30,180,and 360 min, into 1,2 and 3 subgroups, with 4 rabbits in each. Global ischemia was accomplished by modified “4 vessel mode” and lasted for 30min. As all requirements were fulfilled, rabbits were sacrificed. Brains were fixed in situ, and taken out for coronary sections, which were stained and treated as routine. Slides were sent for computerized image analysis. Neurons of 12 regions were differentiated respectively into type A(normal), type B(mildly damaged), type C(severely damaged)and type D(necrotic).Each neuron type was counted and calculated into percentage. Results: As compared with group Ⅰ,in group Ⅱ, the percentage of type A neuron was markedly decreased, while that of type B,C,D neurons increased significantly. In group Ⅲ, type A and B neurons decreased further, while type C and D neurons markedly increased. In contrast, in group Ⅳ the percentage of type A and B neurons was markedly higher, while type D neuron significantly lower, as compared with group Ⅲ. As the duration of reperfusion prolonged up to 360min, the percentage of type C,D neurons remained relatively unchanged. Conclusions:Selective head cooling has marked inhibitory effects on reperfusion damage in cerebral ischemia, thus, the normal neurons will be saved. As duration of hypothermia prolonged appropriately, slightly damaged neurons may be salvagable, but severely damaged and necrotic neurons not.

在以往系列实验研究初步阐明头部重点低温具有多方面有利于脑复苏的生化机理的基础上,本文试图从细胞形态学方面予以佐证。应用新西兰白兔32只,4只为正常对照(Ⅰ组),其余均用改良“四血管法”造成脑缺血(30min)模型,分为缺血对照(Ⅱ组)、常温再灌注(Ⅲ组)和头部重点低温(28±0.5℃)再灌注(Ⅳ组)三组,Ⅲ、Ⅳ组再分为再灌注30、180和360min三亚组,每组各4只。处死后在体灌注固定液固定脑组织,将全脑作冠状切片制成常规石腊切片。采用计算机图像分析技术,将脑组织12个部位的神经元按预定标准判为A(正常)、B(轻伤)、C(重伤)和D(坏死)四类,予以分别计数和算出所占百分比。结果:Ⅱ组与Ⅰ组相比,A类神经元所占百分比明显减少,B、C、D类明显增多;Ⅲ组A、B类神经元进一步减少,而C、D类更显著增多;Ⅳ组A、B类神经元所占百分比显著高于Ⅲ组,D类则明显减少,随着时间从30~360min,C、D类所占百分比基本恒定。结论:头部重点低温(脑温28℃上下)对缺血后再灌注损伤具有明显的抑制作用,正常神经元得以免于受损。随着低温时间适当延长,轻伤神经元可能获救,而重伤和坏死神经元则无复苏可能。

Objective:To evaluate the effect of hypothermia, vasodilator (chlorpromazine), hyperbaric oxygenation and osmotherapy for brain resuscitation. Method and Results: Eighteen patients with complete circulation arrest of >4min were retrospectively analysed. The data including cardiac arrest time, CPR time, the time of spontaneous respiration restoration, pain reaction, cranial nerve function, therapeutic process and outcome evaluation were collected. Thirteen patients were treated with mild or moderate hypothermia,...

Objective:To evaluate the effect of hypothermia, vasodilator (chlorpromazine), hyperbaric oxygenation and osmotherapy for brain resuscitation. Method and Results: Eighteen patients with complete circulation arrest of >4min were retrospectively analysed. The data including cardiac arrest time, CPR time, the time of spontaneous respiration restoration, pain reaction, cranial nerve function, therapeutic process and outcome evaluation were collected. Thirteen patients were treated with mild or moderate hypothermia, chlorpromazine, osmotherapy and in 5 patients hyperbaric oxygenation was given together. Twelve patients including 9 patients of prehospital cardiac arrest obtained good cerebral functon, only one patients survived with severe neurologic deficit. In contrast, cardiac arrest of 5 patients occured within hospital,after restoration of spontaneous circulation, no therapeutic interventions of cerebral resuscitation were taken except for cardiopulmonary support. Four of the five patients died and one was in persistent vegetative state. Conclusion: The combination of hypothermia, hyperbaric oxygenation, chlorpromazine and osmotherapy could improve neurologic recovery after >4 minutes cardiac arrest.

目的:评价低温、冬眠、高压氧和脱水疗法对心搏停止超过4min患者的脑复苏效应。方法与结果:回顾性分析了18例心搏停止超过4min患者的脑复苏效应。以心搏停止时间、脑功能恢复的时项变化、脑缺氧后全身性抽搐的治疗反应及脑复苏结局等作为指标,8例早期采用低温、冬眠、脱水治疗及5例同时采用高压氧治疗的患者12例恢复了意识,1例因心搏停止时间过长而遗有脑缺氧后遗症。而5例心搏停搏时间相似者,因未适当采用上述疗法4例脑死亡。结论:及早采用低温、冬眠、脱水和高压氧为主的脑复苏疗法,对较长时间心搏停止患者有良好的脑复苏疗效。

 
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